Grouping 34 chemicals based on mode of action using connectivity mapping

Toxicological Sciences

Volumn 151, Issue 2, 2016, Pages 447-461

  De Abrew, K Nadira ^a   Kainkaryam, Raghunandan M ^a   Shan, Yuqing K ^a   Overmann, Gary J ^a   Settivari, Raja S ^b   Wang, Xiaohong ^a   Xu, Jun ^a   Adams, Rachel L ^a   Tiesman, Jay P ^a   Carney, Edward W ^b   Naciff, Jorge M ^a   Daston, George P ^a  

^a PROCTER AND GAMBLE COMPANY   (United States)

^b DOW CHEMICAL COMPANY   (United States)

Author keywords

21st century tox; Connectivity mapping; Toxicogenomics

Indexed keywords

1 NAPHTHYL ISOTHIOCYANATE; 4,4' ISOPROPYLIDENEDIPHENOL; 6 AMINONICOTINAMIDE; AMOXICILLIN; CALCITRIOL; CHEMICAL COMPOUND; CHENODEOXYCHOLIC ACID; CLOBETASOL; CLOFIBRATE; DEFEROXAMINE; ETHINYLESTRADIOL; FARNESOL; FLUTAMIDE; GENISTEIN; KETOCONAZOLE; METFORMIN; METHOTREXATE; MIFEPRISTONE; PHENFORMIN; PHENOBARBITAL; PHTHALIC ACID BIS(2 ETHYLHEXYL) ESTER; PRASTERONE; PROGESTERONE; RETINOIC ACID; TAMOXIFEN; THYROXINE; TRENBOLONE; TROGLITAZONE; VALPROIC ACID; VINBLASTINE; DRUG; TRANSCRIPTOME;

ARTICLE; CELL SPECIFICITY; COMPARATIVE STUDY; CONNECTIVITY MAPPING; CONNECTOME; CONTROLLED STUDY; DATA BASE; DRUG MECHANISM; ENDOMETRIAL CANCER CELL LINE; GENE EXPRESSION PROFILING; HEPATOMA CELL; HUMAN; HUMAN CELL; MCF 7 CELL LINE; MODE OF ACTION; TOXICOLOGY; BIOLOGY; CHEMICAL STRUCTURE; CHEMISTRY; CLASSIFICATION; DNA MICROARRAY; DOSE RESPONSE; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETIC DATABASE; HEP-G2 CELL LINE; MCF-7 CELL LINE; PROCEDURES; STRUCTURE ACTIVITY RELATION; TIME FACTOR;

COMPUTATIONAL BIOLOGY; DATABASES, GENETIC; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HEP G2 CELLS; HUMANS; MCF-7 CELLS; MOLECULAR STRUCTURE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PHARMACEUTICAL PREPARATIONS; STRUCTURE-ACTIVITY RELATIONSHIP; TIME FACTORS; TRANSCRIPTOME;

EID: 84979034960     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfw058     Document Type: Article

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