Toward the identification of liver toxicity markers: A proteome study in human cell culture and rats

Proteomics

Volumn 3, Issue 10, 2003, Pages 1835-1862

  Thome Kromer, Birgit ^a,d   Bonk, Ines ^a,d   Klatt, Mathias ^a,d   Nebrich, Grit ^d   Taufmann, Marion ^a,d   Bryant, Stewart ^b   Wacker, Ulrich ^a,d   Köpke, Andreas ^c,d  

^a Eurogentec Proteomics GmbH   (Germany)

^b JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

^c Devgen   (Belgium)

^d WITA Proteomics   (Germany)

Author keywords

HepG2 proteome; Ionization mass spectrometry protein identification; Matrix assisted laser desorption; Nonequilibrium pH gradient electrophoresis; Nonequilibrium pH gradient gel electrophoresis; Predictive toxicology; Rat liver proteome

Indexed keywords

CARBAMOYL PHOSPHATE SYNTHASE; CATALASE; OXIDOREDUCTASE; PROTEOME;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DISEASE MARKER; GENE SEQUENCE; HUMAN; HUMAN CELL; LIVER METABOLISM; LIVER TOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEOMICS; RAT; TWO DIMENSIONAL GEL ELECTROPHORESIS;

1-NAPHTHYLISOTHIOCYANATE; ACETAMINOPHEN; ALCOHOL OXIDOREDUCTASES; ANIMALS; BIOLOGICAL MARKERS; CARBAMOYL-PHOSPHATE SYNTHASE (AMMONIA); CATALASE; CELL LINE, TUMOR; CISPLATIN; DATABASES, PROTEIN; DIMETHYLNITROSAMINE; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; HEXOKINASE; HUMANS; INDOMETHACIN; ISOELECTRIC POINT; LIVER; MALE; MOLECULAR WEIGHT; PROTEIN ISOFORMS; PROTEINS; PROTEOME; PROTEOMICS; RATS; RATS, SPRAGUE-DAWLEY; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TETRACYCLINE;

ANIMALIA;

EID: 0142244529     PISSN: 16159853     EISSN: None     Source Type: Journal    
DOI: 10.1002/pmic.200300552     Document Type: Article

References (34)

1. Bajorath, J., Nat. Rev. Drug Discov. 2002, 1, 88-894.
2. Dierickx, P. J., Scheers, E. M., J. Appl. Toxicol. 2002, 22, 61-65.
3. Waring, J. F., Jolly, R. A., Ciurlionis, R., Lum, R. Y. et al., Toxicol. Appl. Pharmacol. 2001, 175, 28-42.
4. Fountoulakis, M., Juranville, J.-P., Berndt, P., Langen, H., Suter, L., Electrophoresis 2001, 22, 1747-1763.
5. Zeindl-Eberhart, E., Klugbauer, S., Dimitrijevic, N., Jungblut, P. R. et al., Electropheresis 2001, 22, 3009-3018.
6. Wirth, P. J., Hoang, T. N., Benjamin, T., Electrophoresis 1995, 16, 1946-1960.
7. Seow, T. K., Liang, R. C. M. Y., Leow, C. K., Chung, M. C. M., Proteomics 2001, 1, 1249-1263.
8. Kim, J., Kim, S. H., Lee, S. U., Ha, G. H. et al., Electrophoresis 2001, 23, 4141-4156.
9. Sanchez, J.-C., Appel, R. D., Golaz, O., Pasquali, C., Ravier, F. et al., Electrophoresis 1995, 16, 1131-1151.
10. Appel, R. D., Bairoch, A., Sanchez, J. C., Vargas, J. R. et al., Electropheresis 1996, 17, 540-546.
11. http://ntp-server.niehs.nih.gev/, The National Toxicology Program (NTP).
12. http://www.link.med.ed.ac.uk/hew/tex/table1.html.
13. O'Farrell, P. H., J. Biol. Chem. 1975, 250, 4007-4021.
14. Klose, J., Kobalz, U., Electrophoresis 1995, 16, 1034-1059.
15. Appel, R. D., Vargas, J. R., Palagi, P. M., Walther, D., Hochstrasser, D. F., Electrophoresis 1997, 18, 2735-2748.
16. Perkins, D. N., Pappin, D. J., Creasy, D. M., Cottrell, J. S., Electrophoresis 1999, 20, 3551-3567.
17. Parkinson, A., in: Klaassen, C. D. (Ed.), Casarett and Doull's Toxicology, McGraw-Hill, New York 1996, pp. 113-186.
18. Xie, W., Barwick, J. L., Downes, M., Blumberg, B. et al., Nature 2000, 406, 435-439.
19. http://www.expasy.ch/cgi-bin/map2/def?HEPG2_HUMAN.
20. Lim, S. O., Park, S.-J., Kim, W., Sung, G. P. et al., Biochem. Biophys. Res. Commun. 2002, 291, 1031-1037.
21. Connolly, A. K., Price, S. C., Connelly, J. C., Hinton, R. H., Toxicol. Appl. Pharmacol. 1988, 93, 208-219.
22. Goldsworthy, T. L., Conolly, R. B., Fransson-Steen, R., Mutat. Res. 1996, 365, 71-90.
23. Hibino, Y., Hiraoka, Y., Kamiuchi, E., Sugano, N., Biochem. Pharmacol. 1999, 57, 1415-1422.
24. Whittle, B. J. R., Gastroenterology 1981, 80, 94-98.
25. Cervinkova, Z., Radvakova, D., Kohout, P., Acta Medica (Hradec Králové), 2002, 45, 13-18.
26. Mukherjee, D., Ghosh, H. N., Mukherjee, S., J. Antibiot. 1971, 24, 263-265.
27. Amacher, D. E., Martin, B. A., Fundam. Appl. Toxicol. 1997, 40, 256-263.
28. Lauterburg, B. H., Am. J. Ther. 2002, 9, 225-233.
29. Gujral, J, S., Knight, T. R., Farhood, A., Bajt, M. L., Jaeschke, H., Toxicol. Sci. 2002, 67, 322-328.
30. Boulares, A. H., Zoltoski, A. J., Stoica, B. A., Cuvillier, O., Smulson, M. E., Pharmacol. Toxicol. 2002, 90, 38-50.
31. White, I. R., Man, W. J., Bryant, D., Bugelski, P. et al., Proteomics 2003, 3, 505-512.
32. Ballot, E., Bruneel, A., Labas, V., Johanet, C., Clin. Chem. 2003, 49, 634-643.
33. Stolz, A., Hammond, L., Lou, H., Takikawa, H. et al., J. Biol. Chem. 1993, 268, 10448-10457.
34. Man, W. J., White, I. R., Bryant, D., Bugelski, P. et al., Proteomics 2002, 2, 1577-1585.