Antibiotic amoxicillin induces DNA lesions in mammalian cells possibly via the reactive oxygen species

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 629, Issue 2, 2007, Pages 133-139

  Li, Pei Yi ^a,b,c   Chang, Yu Ching ^a   Tzang, Bor Show ^b   Chen, Chung Chu ^c   Liu, Yin Chang ^a  

^a NATIONAL TSING HUA UNIVERSITY   (Taiwan)

^b CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

^c MACKAY MEMORIAL HOSPITAL   (Taiwan)

Author keywords

Amoxicillin; Base excision repair; Comet nuclear extract assay; DNA lesions; Reactive oxygen species

Indexed keywords

AMOXICILLIN; AMPICILLIN; DNA; KANAMYCIN; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; ARTICLE; CELL CULTURE; CHO CELL; COMET ASSAY; CONTROLLED STUDY; DNA DAMAGE; DRUG EFFECT; EXCISION REPAIR; FEMALE; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL;

AMOXICILLIN; AMPICILLIN; ANIMALS; ANTI-BACTERIAL AGENTS; CHO CELLS; COMET ASSAY; CRICETINAE; CRICETULUS; DNA DAMAGE; DNA REPAIR; HUMANS; KANAMYCIN; LEUKEMIA, PLASMACYTIC; REACTIVE OXYGEN SPECIES;

BACTERIA (MICROORGANISMS); CRICETINAE; CRICETULUS GRISEUS; MAMMALIA;

EID: 34247127562     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrgentox.2007.02.005     Document Type: Article

References (16)

1. Belal F., El-Kerdawy M.M., El-Ashry S.M., and El-Wasseef D.R. Kinetic spectrophotometric determination of ampicillin and amoxicillin in dosage forms. Farmaco 55 (2000) 680-686
2. Rolinson G.N. Forty years of beta-lactam research. J. Antimicrob. Chemother. 41 (1998) 589-603
3. Rolinson G.N. 6-APA and the development of the beta-lactam antibiotics. J. Antimicrob. Chemother. 5 (1979) 7-14
4. Arabski M., Kazmierczak P., Wisniewska-Jarosinska M., Poplawski T., Klupinska G., Chojnacki J., Drzewoski J., and Blasiak J. Interaction of amoxicillin with DNA in human lymphocytes and H. pylori-infected and non-infected gastric mucosa cells. Chem. Biol. Interact. 152 (2005) 13-24
5. Arabski M., Klupinska G., Chojnacki J., Kazmierczak P., Wisniewska-Jarosinska M., Drzewoski J., and Blasiak J. DNA damage and repair in Helicobacter pylori-infected gastric mucosa cells. Mutat. Res. 570 (2005) 129-135
6. Wang A.S., Ramanathan B., Chien Y.H., Goparaju C.M., and Jan K.Y. Comet assay with nuclear extract incubation. Anal. Biochem. 337 (2005) 70-75
7. Collins A.R. The comet assay for DNA damage and repair: principles, applications, and limitations. Mol. Biotechnol. 26 (2004) 249-261
8. Costa R.M., Chigancas V., Galhardo Rda S., Carvalho H., and Menck C.F. The eukaryotic nucleotide excision repair pathway. Biochimie 85 (2003) 1083-1099
9. Fortini P., Pascucci B., Parlanti E., D'Errico M., Simonelli V., and Dogliotti E. The base excision repair: mechanisms and its relevance for cancer susceptibility. Biochimie 85 (2003) 1053-1071
10. Li H., Chang T.W., Tsai Y.C., Chu S.F., Wu Y.Y., Tzang B.S., Liao C.B., and Liu Y.C. Colcemid inhibits the rejoining of the nucleotide excision repair of UVC-induced DNA damages in Chinese hamster ovary cells. Mutat. Res. 588 (2005) 118-128
11. Bergstein T., Henis Y., and Cavari B.Z. Investigations on the photosynthetic sulfur bacterium Chlorobium phaeobacteroides causing seasonal blooms in Lake Kinneret. Can. J. Microbiol. 25 (1979) 999-1007
12. Yang Y., Cheng J.Z., Singhal S.S., Saini M., Pandya U., Awasthi S., and Awasthi Y.C. Role of glutathione S-transferases in protection against lipid peroxidation. Overexpression of hGSTA2-2 in K562 cells protects against hydrogen peroxide-induced apoptosis and inhibits JNK and caspase 3 activation. J. Biol. Chem. 276 (2001) 19220-19230
13. Vrieling H., Zhang L.H., van Zeeland A.A., and Zdzienicka M.Z. UV-induced hprt mutations in a UV-sensitive hamster cell line from complementation group 3 are biased towards the transcribed strand. Mutat. Res. 274 (1992) 147-155
14. Fortini P., Pascucci B., Parlanti E., D'Errico M., Simonelli V., and Dogliotti E. 8-Oxoguanine DNA damage: at the crossroad of alternative repair pathways. Mutat. Res. 531 (2003) 127-139
15. Quinlan G.J., and Gutteridge J.M. Oxidative damage to DNA and deoxyribose by beta-lactam antibiotics in the presence of iron and copper salts. Free Radic. Res. Commun. 5 (1988) 149-158
16. Quinlan G.J., and Gutteridge J.M. DNA base damage by beta-lactam, tetracycline, bacitracin and rifamycin antibacterial antibiotics. Biochem. Pharmacol. 42 (1991) 1595-1599