Protein evolution by molecular tinkering: Diversification of the nuclear receptor superfamily from a ligand-dependent ancestor

PLoS Biology

Volumn 8, Issue 10, 2010, Pages

  Bridgham, Jamie T ^a,b   Eick, Geeta N ^b   Larroux, Claire ^c,e   Deshpande, Kirti ^d   Harms, Michael J ^b   Gauthier, Marie E A ^c   Ortlund, Eric A ^d   Degnan, Bernard M ^c   Thornton, Joseph W ^a,b  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^b UNIVERSITY OF OREGON   (United States)

^c UNIVERSITY OF QUEENSLAND   (Australia)

^d EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CELL NUCLEUS RECEPTOR; FATTY ACID;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; GENE MUTATION; LAST COMMON ANCESTOR; METAZOON; MOLECULAR EVOLUTION; MOLECULAR PHYLOGENY; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN CONFORMATION; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN MODIFICATION; PROTEIN STRUCTURE; SEQUENCE HOMOLOGY; SPONGE (PORIFERA);

ANIMALS; CELL LINE; EVOLUTION, MOLECULAR; GENE DUPLICATION; GENOME; LIGANDS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MULTIGENE FAMILY; PHYLOGENY; PORIFERA; PROTEIN CONFORMATION; RECEPTORS, CYTOPLASMIC AND NUCLEAR; TRANSCRIPTIONAL ACTIVATION;

ANIMALIA; METAZOA;

EID: 78149390724     PISSN: 15449173     EISSN: 15457885     Source Type: Journal    
DOI: 10.1371/journal.pbio.1000497     Document Type: Article

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