Signal transmission through the CXC chemokine receptor 4 (CXCR4) transmembrane helices

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 35, 2016, Pages 9928-9933

  Wescott, Melanie P ^a   Kufareva, Irina ^b   Paes, Cheryl ^a   Goodman, Jason R ^a   Thaker, Yana ^a   Puffer, Bridget A ^a   Berdougo, Eli ^a   Rucker, Joseph B ^a   Handel, Tracy M ^b   Doranz, Benjamin J ^a  

^a Integral Molecular Inc   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

Chemokine receptor; G protein; GPCR activation; Hydrophobic bridge; Shotgun mutagenesis

Indexed keywords

AMINO ACID DERIVATIVE; CHEMOKINE RECEPTOR CXCR4; LIGAND; MONOCLONAL ANTIBODY; STROMAL CELL DERIVED FACTOR 1; CXCL12 PROTEIN, HUMAN; PROTEIN BINDING;

AMINO ACID ANALYSIS; ANTIGEN ANTIBODY REACTION; ARTICLE; CELL ADHESION; CELL MIGRATION; CONTROLLED STUDY; GENE MUTATION; GENETIC VARIABILITY; HYDROPHOBICITY; INTRACELLULAR SIGNALING; LIGAND BINDING; MEMBRANE STRUCTURE; PEPTIDE LIBRARY; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN MOTIF; PROTEIN STRUCTURE; RECEPTOR BINDING; AMINO ACID SEQUENCE; BINDING SITE; CHEMISTRY; GENETICS; HEK293 CELL LINE; HUMAN; METABOLISM; MOLECULAR MODEL; MUTATION; PROTEIN MULTIMERIZATION; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; BINDING SITES; CHEMOKINE CXCL12; HEK293 CELLS; HUMANS; LIGANDS; MODELS, MOLECULAR; MUTATION; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN MULTIMERIZATION; RECEPTORS, CXCR4; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION;

EID: 84978907768     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1601278113     Document Type: Article

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