-
2
-
-
0015138902
-
Nerve growth factor from mouse submaxillary gland: amino acid sequence
-
Angeletti RH, Bradshaw RA. Nerve growth factor from mouse submaxillary gland: amino acid sequence. Proc Natl Acad Sci U S A 1971;68:2417-2420.
-
(1971)
Proc Natl Acad Sci U S A
, vol.68
, pp. 2417-2420
-
-
Angeletti, R.H.1
Bradshaw, R.A.2
-
3
-
-
0032936111
-
Therapeutic potential of nerve growth factors in Parkinson's disease
-
Collier TJ, Sortwell CE. Therapeutic potential of nerve growth factors in Parkinson's disease. Drugs Aging 1999;14:261-287.
-
(1999)
Drugs Aging
, vol.14
, pp. 261-287
-
-
Collier, T.J.1
Sortwell, C.E.2
-
4
-
-
0027285510
-
GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons
-
Lin LF, Doherty DH, Lile JD, Bektesh S, Collins F. GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons. Science 1993;260:1130-1132.
-
(1993)
Science
, vol.260
, pp. 1130-1132
-
-
Lin, L.F.1
Doherty, D.H.2
Lile, J.D.3
Bektesh, S.4
Collins, F.5
-
5
-
-
84873445906
-
Trophic factor gene therapy for Parkinson's disease
-
Kordower JH, Bjorklund A. Trophic factor gene therapy for Parkinson's disease. Mov Disord 2013;28:96-109.
-
(2013)
Mov Disord
, vol.28
, pp. 96-109
-
-
Kordower, J.H.1
Bjorklund, A.2
-
6
-
-
79951475570
-
Parkinson's disease, primates, and gene therapy: vive la difference?
-
Lewis TB, Standaert DG. Parkinson's disease, primates, and gene therapy: vive la difference? Mov Disord 2011;26:2-3.
-
(2011)
Mov Disord
, vol.26
, pp. 2-3
-
-
Lewis, T.B.1
Standaert, D.G.2
-
7
-
-
0029614333
-
Morphological and functional effects of intranigrally administered GDNF in normal rhesus monkeys
-
Gash DM, Zhang Z, Cass WA, et al. Morphological and functional effects of intranigrally administered GDNF in normal rhesus monkeys. J Comp Neurol 1995;363:345-358.
-
(1995)
J Comp Neurol
, vol.363
, pp. 345-358
-
-
Gash, D.M.1
Zhang, Z.2
Cass, W.A.3
-
8
-
-
0028109526
-
Glial cell line-derived neurotrophic factor reverses toxin-induced injury to midbrain dopaminergic neurons in vivo
-
Hoffer BJ, Hoffman A, Bowenkamp K, et al. Glial cell line-derived neurotrophic factor reverses toxin-induced injury to midbrain dopaminergic neurons in vivo. Neurosci Lett 1994;182:107-111.
-
(1994)
Neurosci Lett
, vol.182
, pp. 107-111
-
-
Hoffer, B.J.1
Hoffman, A.2
Bowenkamp, K.3
-
9
-
-
0028795044
-
Mesencephalic dopaminergic neurons protected by GDNF from axotomy-induced degeneration in the adult brain
-
Beck KD, Valverde J, Alexi T, et al. Mesencephalic dopaminergic neurons protected by GDNF from axotomy-induced degeneration in the adult brain. Nature 1995;373:339-341.
-
(1995)
Nature
, vol.373
, pp. 339-341
-
-
Beck, K.D.1
Valverde, J.2
Alexi, T.3
-
10
-
-
0029053195
-
Glial cell line-derived neurotrophic factor supports survival of injured midbrain dopaminergic neurons
-
Bowenkamp KE, Hoffman AF, Gerhardt GA, et al. Glial cell line-derived neurotrophic factor supports survival of injured midbrain dopaminergic neurons. J Comp Neurol 1995;355:479-489.
-
(1995)
J Comp Neurol
, vol.355
, pp. 479-489
-
-
Bowenkamp, K.E.1
Hoffman, A.F.2
Gerhardt, G.A.3
-
11
-
-
0029803454
-
Short-term GDNF treatment provides long-term rescue of lesioned nigral dopaminergic neurons in a rat model of Parkinson's disease
-
Winkler C, Sauer H, Lee CS, Bjorklund A. Short-term GDNF treatment provides long-term rescue of lesioned nigral dopaminergic neurons in a rat model of Parkinson's disease. J Neurosci 1996;16:7206-7215.
-
(1996)
J Neurosci
, vol.16
, pp. 7206-7215
-
-
Winkler, C.1
Sauer, H.2
Lee, C.S.3
Bjorklund, A.4
-
12
-
-
0036787532
-
Chronic, controlled GDNF infusion promotes structural and functional recovery in advanced parkinsonian monkeys
-
Grondin R, Zhang Z, Yi A, et al. Chronic, controlled GDNF infusion promotes structural and functional recovery in advanced parkinsonian monkeys. Brain. 2002;125(Pt 10):2191-2201.
-
(2002)
Brain.
, vol.125
, pp. 2191-2201
-
-
Grondin, R.1
Zhang, Z.2
Yi, A.3
-
13
-
-
13344277993
-
Functional recovery in parkinsonian monkeys treated with GDNF
-
Gash DM, Zhang Z, Ovadia A, et al. Functional recovery in parkinsonian monkeys treated with GDNF. Nature 1996;380:252-255.
-
(1996)
Nature
, vol.380
, pp. 252-255
-
-
Gash, D.M.1
Zhang, Z.2
Ovadia, A.3
-
14
-
-
0035910367
-
Glial cell line-derived neurotrophic factor concentration dependently improves disability and motor activity in MPTP-treated common marmosets
-
Costa S, Iravani MM, Pearce RK, Jenner P. Glial cell line-derived neurotrophic factor concentration dependently improves disability and motor activity in MPTP-treated common marmosets. Eur J Pharmacol 2001;412:45-50.
-
(2001)
Eur J Pharmacol
, vol.412
, pp. 45-50
-
-
Costa, S.1
Iravani, M.M.2
Pearce, R.K.3
Jenner, P.4
-
15
-
-
0035131350
-
GDNF reverses priming for dyskinesia in MPTP-treated, L-DOPA-primed common marmosets
-
Iravani MM, Costa S, Jackson MJ, et al. GDNF reverses priming for dyskinesia in MPTP-treated, L-DOPA-primed common marmosets. Eur J Neurosci 2001;13:597-608.
-
(2001)
Eur J Neurosci
, vol.13
, pp. 597-608
-
-
Iravani, M.M.1
Costa, S.2
Jackson, M.J.3
-
16
-
-
33746105694
-
Continuous dopamine receptor stimulation in the treatment of Parkinson's disease: scientific rationale and clinical implications
-
Olanow CW, Obeso JA, Stocchi F. Continuous dopamine receptor stimulation in the treatment of Parkinson's disease: scientific rationale and clinical implications. Lancet Neurol 2006;5:677-687.
-
(2006)
Lancet Neurol
, vol.5
, pp. 677-687
-
-
Olanow, C.W.1
Obeso, J.A.2
Stocchi, F.3
-
17
-
-
0034659835
-
Long-term rAAV-mediated gene transfer of GDNF in the rat Parkinson's model: intrastriatal but not intranigral transduction promotes functional regeneration in the lesioned nigrostriatal system
-
Kirik D, Rosenblad C, Bjorklund A, Mandel RJ. Long-term rAAV-mediated gene transfer of GDNF in the rat Parkinson's model: intrastriatal but not intranigral transduction promotes functional regeneration in the lesioned nigrostriatal system. J Neurosci 2000;20:4686-4700.
-
(2000)
J Neurosci
, vol.20
, pp. 4686-4700
-
-
Kirik, D.1
Rosenblad, C.2
Bjorklund, A.3
Mandel, R.J.4
-
18
-
-
0034097605
-
Sequential administration of GDNF into the substantia nigra and striatum promotes dopamine neuron survival and axonal sprouting but not striatal reinnervation or functional recovery in the partial 6-OHDA lesion model
-
Rosenblad C, Kirik D, Bjorklund A. Sequential administration of GDNF into the substantia nigra and striatum promotes dopamine neuron survival and axonal sprouting but not striatal reinnervation or functional recovery in the partial 6-OHDA lesion model. Exp Neurol 2000;161:503-516.
-
(2000)
Exp Neurol
, vol.161
, pp. 503-516
-
-
Rosenblad, C.1
Kirik, D.2
Bjorklund, A.3
-
19
-
-
0031019795
-
Dopaminergic neurons protected from degeneration by GDNF gene therapy
-
Choi-Lundberg DL, Lin Q, Chang YN, et al. Dopaminergic neurons protected from degeneration by GDNF gene therapy. Science 1997;275:838-841.
-
(1997)
Science
, vol.275
, pp. 838-841
-
-
Choi-Lundberg, D.L.1
Lin, Q.2
Chang, Y.N.3
-
20
-
-
0034721690
-
Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease
-
Kordower JH, Emborg ME, Bloch J, et al. Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease. Science 2000;290:767-773.
-
(2000)
Science
, vol.290
, pp. 767-773
-
-
Kordower, J.H.1
Emborg, M.E.2
Bloch, J.3
-
21
-
-
0034672304
-
Towards a neuroprotective gene therapy for Parkinson's disease: use of adenovirus, AAV and lentivirus vectors for gene transfer of GDNF to the nigrostriatal system in the rat Parkinson model
-
Bjorklund A, Kirik D, Rosenblad C, Georgievska B, Lundberg C, Mandel RJ. Towards a neuroprotective gene therapy for Parkinson's disease: use of adenovirus, AAV and lentivirus vectors for gene transfer of GDNF to the nigrostriatal system in the rat Parkinson model. Brain Res 2000;886:82-98.
-
(2000)
Brain Res
, vol.886
, pp. 82-98
-
-
Bjorklund, A.1
Kirik, D.2
Rosenblad, C.3
Georgievska, B.4
Lundberg, C.5
Mandel, R.J.6
-
22
-
-
0031456051
-
Midbrain injection of recombinant adeno-associated virus encoding rat glial cell line-derived neurotrophic factor protects nigral neurons in a progressive 6-hydroxydopamine-induced degeneration model of Parkinson's disease in rats
-
Mandel RJ, Spratt SK, Snyder RO, Leff SE. Midbrain injection of recombinant adeno-associated virus encoding rat glial cell line-derived neurotrophic factor protects nigral neurons in a progressive 6-hydroxydopamine-induced degeneration model of Parkinson's disease in rats. Proc Natl Acad Sci U S A 1997;94:14083-14088.
-
(1997)
Proc Natl Acad Sci U S A
, vol.94
, pp. 14083-14088
-
-
Mandel, R.J.1
Spratt, S.K.2
Snyder, R.O.3
Leff, S.E.4
-
23
-
-
0029827559
-
Neurturin, a relative of glial-cell-line-derived neurotrophic factor
-
Kotzbauer PT, Lampe PA, Heuckeroth RO, Golden JP, Creedon DJ, Johnson EM Jr., Milbrandt J. Neurturin, a relative of glial-cell-line-derived neurotrophic factor. Nature 1996;384:467-470.
-
(1996)
Nature
, vol.384
, pp. 467-470
-
-
Kotzbauer, P.T.1
Lampe, P.A.2
Heuckeroth, R.O.3
Golden, J.P.4
Creedon, D.J.5
Johnson, E.M.6
Milbrandt, J.7
-
24
-
-
34250336916
-
AAV2-mediated delivery of human neurturin to the rat nigrostriatal system: long-term efficacy and tolerability of CERE-120 for Parkinson's disease
-
Gasmi M, Brandon EP, Herzog CD, et al. AAV2-mediated delivery of human neurturin to the rat nigrostriatal system: long-term efficacy and tolerability of CERE-120 for Parkinson's disease. Neurobiol Dis 2007;27:67-76.
-
(2007)
Neurobiol Dis
, vol.27
, pp. 67-76
-
-
Gasmi, M.1
Brandon, E.P.2
Herzog, C.D.3
-
25
-
-
33845993229
-
Delivery of neurturin by AAV2 (CERE-120)-mediated gene transfer provides structural and functional neuroprotection and neurorestoration in MPTP-treated monkeys
-
Kordower JH, Herzog CD, Dass B, Bakay RA, Stansell J 3rd, Gasmi M, Bartus RT. Delivery of neurturin by AAV2 (CERE-120)-mediated gene transfer provides structural and functional neuroprotection and neurorestoration in MPTP-treated monkeys. Ann Neurol 2006;60:706-715.
-
(2006)
Ann Neurol
, vol.60
, pp. 706-715
-
-
Kordower, J.H.1
Herzog, C.D.2
Dass, B.3
Bakay, R.A.4
Stansell, J.5
Gasmi, M.6
Bartus, R.T.7
-
26
-
-
34447572589
-
Striatal delivery of CERE-120, an AAV2 vector encoding human neurturin, enhances activity of the dopaminergic nigrostriatal system in aged monkeys
-
Herzog CD, Dass B, Holden JE, et al. Striatal delivery of CERE-120, an AAV2 vector encoding human neurturin, enhances activity of the dopaminergic nigrostriatal system in aged monkeys. Mov Disord 2007;22:1124-1132.
-
(2007)
Mov Disord
, vol.22
, pp. 1124-1132
-
-
Herzog, C.D.1
Dass, B.2
Holden, J.E.3
-
27
-
-
0037199818
-
Dopaminergic neuroprotection and regeneration by neurturin assessed by using behavioral, biochemical and histochemical measurements in a model of progressive Parkinson's disease
-
Oiwa Y, Yoshimura R, Nakai K, Itakura T. Dopaminergic neuroprotection and regeneration by neurturin assessed by using behavioral, biochemical and histochemical measurements in a model of progressive Parkinson's disease. Brain Res 2002;947:271-283.
-
(2002)
Brain Res
, vol.947
, pp. 271-283
-
-
Oiwa, Y.1
Yoshimura, R.2
Nakai, K.3
Itakura, T.4
-
28
-
-
34250336916
-
AAV2-mediated delivery of human neurturin to the rat nigrostriatal system: long-term efficacy and tolerability of CERE-120 for Parkinson's disease
-
Gasmi M, Brandon EP, Herzog CD, et al. AAV2-mediated delivery of human neurturin to the rat nigrostriatal system: long-term efficacy and tolerability of CERE-120 for Parkinson's disease. Neurobiol Dis 2007;27:67-76.
-
(2007)
Neurobiol Dis
, vol.27
, pp. 67-76
-
-
Gasmi, M.1
Brandon, E.P.2
Herzog, C.D.3
-
29
-
-
54849391400
-
Transgene expression, bioactivity, and safety of CERE-120 (AAV2-neurturin) following delivery to the monkey striatum
-
Herzog CD, Dass B, Gasmi M, et al. Transgene expression, bioactivity, and safety of CERE-120 (AAV2-neurturin) following delivery to the monkey striatum. Mol Ther 2008;16:1737-1744
-
(2008)
Mol Ther
, vol.16
, pp. 1737-1744
-
-
Herzog, C.D.1
Dass, B.2
Gasmi, M.3
-
30
-
-
84855972240
-
Neuropathology of sporadic Parkinson's disease: evaluation and changes of concepts
-
Jellinger KA. Neuropathology of sporadic Parkinson's disease: evaluation and changes of concepts. Mov Disord 2012;27:8-30.
-
(2012)
Mov Disord
, vol.27
, pp. 8-30
-
-
Jellinger, K.A.1
-
31
-
-
84873458538
-
Parkinson's disease and alpha synuclein: is Parkinson's disease a prion-like disorder?
-
Olanow CW, Brundin P. Parkinson's disease and alpha synuclein: is Parkinson's disease a prion-like disorder? Mov Disord 2013;28:31-40.
-
(2013)
Mov Disord
, vol.28
, pp. 31-40
-
-
Olanow, C.W.1
Brundin, P.2
-
32
-
-
80051985178
-
GDNF fails to exert neuroprotection in a rat alpha-synuclein model of Parkinson's disease
-
Decressac M, Ulusoy A, Mattsson B, et al. GDNF fails to exert neuroprotection in a rat alpha-synuclein model of Parkinson's disease. Brain 2011;134(Pt 8):2302-2311.
-
(2011)
Brain
, vol.134
, pp. 2302-2311
-
-
Decressac, M.1
Ulusoy, A.2
Mattsson, B.3
-
33
-
-
5144225578
-
Lentiviral nigral delivery of GDNF does not prevent neurodegeneration in a genetic rat model of Parkinson's disease
-
Lo Bianco C, Deglon N, Pralong W, Aebischer P. Lentiviral nigral delivery of GDNF does not prevent neurodegeneration in a genetic rat model of Parkinson's disease. Neurobiol Dis 2004;17:283-289.
-
(2004)
Neurobiol Dis
, vol.17
, pp. 283-289
-
-
Lo Bianco, C.1
Deglon, N.2
Pralong, W.3
Aebischer, P.4
-
34
-
-
84870687953
-
alpha-Synuclein-induced down-regulation of Nurr1 disrupts GDNF signaling in nigral dopamine neurons
-
Decressac M, Kadkhodaei B, Mattsson B, Laguna A, Perlmann T, Bjorklund A. alpha-Synuclein-induced down-regulation of Nurr1 disrupts GDNF signaling in nigral dopamine neurons. Sci Transl Med 2012;4:163ra156.
-
(2012)
Sci Transl Med
, vol.4
, pp. 163ra156
-
-
Decressac, M.1
Kadkhodaei, B.2
Mattsson, B.3
Laguna, A.4
Perlmann, T.5
Bjorklund, A.6
-
35
-
-
0033964411
-
The GDNF family ligands and receptors—implications for neural development
-
Baloh RH, Enomoto H, Johnson EM, Jr., Milbrandt J. The GDNF family ligands and receptors—implications for neural development. Curr Opin Neurobiol 2000;10:103-110.
-
(2000)
Curr Opin Neurobiol
, vol.10
, pp. 103-110
-
-
Baloh, R.H.1
Enomoto, H.2
Johnson, E.M.3
Milbrandt, J.4
-
36
-
-
0036581222
-
The GDNF family: signalling, biological functions and therapeutic value
-
Airaksinen MS, Saarma M. The GDNF family: signalling, biological functions and therapeutic value. Nat Rev Neurosci 2002;3:383-394.
-
(2002)
Nat Rev Neurosci
, vol.3
, pp. 383-394
-
-
Airaksinen, M.S.1
Saarma, M.2
-
37
-
-
0034967978
-
Docking protein FRS2 links the protein tyrosine kinase RET and its oncogenic forms with the mitogen-activated protein kinase signaling cascade
-
Melillo RM, Santoro M, Ong SH, et al. Docking protein FRS2 links the protein tyrosine kinase RET and its oncogenic forms with the mitogen-activated protein kinase signaling cascade. Mol Cell Biol 2001;21:4177-4187.
-
(2001)
Mol Cell Biol
, vol.21
, pp. 4177-4187
-
-
Melillo, R.M.1
Santoro, M.2
Ong, S.H.3
-
38
-
-
0034671913
-
Signaling complexes and protein-protein interactions involved in the activation of the Ras and phosphatidylinositol 3-kinase pathways by the c-Ret receptor tyrosine kinase
-
Besset V, Scott RP, Ibanez CF. Signaling complexes and protein-protein interactions involved in the activation of the Ras and phosphatidylinositol 3-kinase pathways by the c-Ret receptor tyrosine kinase. J Biol Chem 2000;275:39159-39166.
-
(2000)
J Biol Chem
, vol.275
, pp. 39159-39166
-
-
Besset, V.1
Scott, R.P.2
Ibanez, C.F.3
-
39
-
-
80052173590
-
Signaling of glial cell line-derived neurotrophic factor and its receptor GFRalpha1 induce Nurr1 and Pitx3 to promote survival of grafted midbrain-derived neural stem cells in a rat model of Parkinson disease
-
Lei Z, Jiang Y, Li T, Zhu J, Zeng S. Signaling of glial cell line-derived neurotrophic factor and its receptor GFRalpha1 induce Nurr1 and Pitx3 to promote survival of grafted midbrain-derived neural stem cells in a rat model of Parkinson disease. J Neuropathol Exp Neurol 2011;70:736-747.
-
(2011)
J Neuropathol Exp Neurol
, vol.70
, pp. 736-747
-
-
Lei, Z.1
Jiang, Y.2
Li, T.3
Zhu, J.4
Zeng, S.5
-
40
-
-
77954706922
-
Nurr1 regulates RET expression in dopamine neurons of adult rat midbrain
-
Galleguillos D, Fuentealba JA, Gomez LM, et al. Nurr1 regulates RET expression in dopamine neurons of adult rat midbrain. J Neurochem 2010;114:1158-1167.
-
(2010)
J Neurochem
, vol.114
, pp. 1158-1167
-
-
Galleguillos, D.1
Fuentealba, J.A.2
Gomez, L.M.3
-
41
-
-
0037435511
-
Randomized, double-blind trial of glial cell line-derived neurotrophic factor (GDNF) in PD
-
Nutt JG, Burchiel KJ, Comella CL, et al. Randomized, double-blind trial of glial cell line-derived neurotrophic factor (GDNF) in PD. Neurology 2003;60:69-73.
-
(2003)
Neurology
, vol.60
, pp. 69-73
-
-
Nutt, J.G.1
Burchiel, K.J.2
Comella, C.L.3
-
42
-
-
0032850453
-
Clinicopathological findings following intraventricular glial-derived neurotrophic factor treatment in a patient with Parkinson's disease
-
Kordower JH, Palfi S, Chen EY, et al. Clinicopathological findings following intraventricular glial-derived neurotrophic factor treatment in a patient with Parkinson's disease. Ann Neurol 1999;46:419-424.
-
(1999)
Ann Neurol
, vol.46
, pp. 419-424
-
-
Kordower, J.H.1
Palfi, S.2
Chen, E.Y.3
-
43
-
-
0038249170
-
Direct brain infusion of glial cell line-derived neurotrophic factor in Parkinson disease
-
Gill SS, Patel NK, Hotton GR, et al. Direct brain infusion of glial cell line-derived neurotrophic factor in Parkinson disease. Nat Med 2003;9:589-595.
-
(2003)
Nat Med
, vol.9
, pp. 589-595
-
-
Gill, S.S.1
Patel, N.K.2
Hotton, G.R.3
-
44
-
-
33644833272
-
Randomized controlled trial of intraputamenal glial cell line-derived neurotrophic factor infusion in Parkinson disease
-
Lang AE, Gill S, Patel NK, et al. Randomized controlled trial of intraputamenal glial cell line-derived neurotrophic factor infusion in Parkinson disease. Ann Neurol 2006;59:459-466.
-
(2006)
Ann Neurol
, vol.59
, pp. 459-466
-
-
Lang, A.E.1
Gill, S.2
Patel, N.K.3
-
45
-
-
35748939368
-
Six-month continuous intraputamenal infusion toxicity study of recombinant methionyl human glial cell line-derived neurotrophic factor (r-metHuGDNF in rhesus monkeys
-
Hovland DN, Jr., Boyd RB, Butt MT, et al. Six-month continuous intraputamenal infusion toxicity study of recombinant methionyl human glial cell line-derived neurotrophic factor r-metHuGDNF in rhesus monkeys. Toxicol Pathol 2007;35:1013-1029.
-
(2007)
Toxicol Pathol
, vol.35
, pp. 1013-1029
-
-
Hovland, D.N.1
Boyd, R.B.2
Butt, M.T.3
-
46
-
-
35748939368
-
Six-month continuous intraputamenal infusion toxicity study of recombinant methionyl human glial cell line-derived neurotrophic factor (r-metHuGDNF) in rhesus monkeys
-
Hovland DN, Jr., Boyd RB, Butt MT, et al. Six-month continuous intraputamenal infusion toxicity study of recombinant methionyl human glial cell line-derived neurotrophic factor (r-metHuGDNF) in rhesus monkeys. Toxicol Pathol 2007;35:676-692.
-
(2007)
Toxicol Pathol
, vol.35
, pp. 676-692
-
-
Hovland, D.N.1
Boyd, R.B.2
Butt, M.T.3
-
47
-
-
33750609664
-
Point source concentration of GDNF may explain failure of phase II clinical trial
-
Salvatore MF, Ai Y, Fischer B, et al. Point source concentration of GDNF may explain failure of phase II clinical trial. Exp Neurol 2006;202:497-505.
-
(2006)
Exp Neurol
, vol.202
, pp. 497-505
-
-
Salvatore, M.F.1
Ai, Y.2
Fischer, B.3
-
48
-
-
33644938239
-
Crossroads in GDNF therapy for Parkinson's disease
-
Sherer TB, Fiske BK, Svendsen CN, Lang AE, Langston JW. Crossroads in GDNF therapy for Parkinson's disease. Mov Disord 2006;21:136-141.
-
(2006)
Mov Disord
, vol.21
, pp. 136-141
-
-
Sherer, T.B.1
Fiske, B.K.2
Svendsen, C.N.3
Lang, A.E.4
Langston, J.W.5
-
49
-
-
34347403884
-
Convective delivery of glial cell line-derived neurotrophic factor in the human putamen
-
Morrison PF, Lonser RR, Oldfield EH. Convective delivery of glial cell line-derived neurotrophic factor in the human putamen. J Neurosurg 2007;107:74-83.
-
(2007)
J Neurosurg
, vol.107
, pp. 74-83
-
-
Morrison, P.F.1
Lonser, R.R.2
Oldfield, E.H.3
-
50
-
-
77649270699
-
Differential transduction following basal ganglia administration of distinct pseudotyped AAV capsid serotypes in nonhuman primates
-
Dodiya HB, Bjorklund T, Stansell J 3rd, Mandel RJ, Kirik D, Kordower JH. Differential transduction following basal ganglia administration of distinct pseudotyped AAV capsid serotypes in nonhuman primates. Mol Ther 2010;18:579-587.
-
(2010)
Mol Ther
, vol.18
, pp. 579-587
-
-
Dodiya, H.B.1
Bjorklund, T.2
Stansell, J.3
Mandel, R.J.4
Kirik, D.5
Kordower, J.H.6
-
51
-
-
33746874152
-
Adeno-associated virus serotypes: vector toolkit for human gene therapy
-
Wu Z, Asokan A, Samulski RJ. Adeno-associated virus serotypes: vector toolkit for human gene therapy. Mol Ther 2006;14:316-327.
-
(2006)
Mol Ther
, vol.14
, pp. 316-327
-
-
Wu, Z.1
Asokan, A.2
Samulski, R.J.3
-
52
-
-
84868156476
-
Advancing neurotrophic factors as treatments for age-related neurodegenerative diseases: developing and demonstrating “clinical proof-of-concept” for AAV-neurturin (CERE-120) in Parkinson's disease
-
Bartus RT, Baumann TL, Brown L, Kruegel BR, Ostrove JM, Herzog CD. Advancing neurotrophic factors as treatments for age-related neurodegenerative diseases: developing and demonstrating “clinical proof-of-concept” for AAV-neurturin (CERE-120) in Parkinson's disease. Neurobiol Aging 2013;34:35-61
-
(2013)
Neurobiol Aging
, vol.34
, pp. 35-61
-
-
Bartus, R.T.1
Baumann, T.L.2
Brown, L.3
Kruegel, B.R.4
Ostrove, J.M.5
Herzog, C.D.6
-
53
-
-
41949110690
-
Safety and tolerability of intraputaminal delivery of CERE-120 (adeno-associated virus serotype 2-neurturin) to patients with idiopathic Parkinson's disease: an open-label, phase I trial
-
Marks WJ, Jr., Ostrem JL, Verhagen L, et al. Safety and tolerability of intraputaminal delivery of CERE-120 (adeno-associated virus serotype 2-neurturin) to patients with idiopathic Parkinson's disease: an open-label, phase I trial. Lancet Neurol 2008;7:400-408.
-
(2008)
Lancet Neurol
, vol.7
, pp. 400-408
-
-
Marks, W.J.1
Ostrem, J.L.2
Verhagen, L.3
-
54
-
-
78349247631
-
Gene delivery of AAV2-neurturin for Parkinson's disease: a double-blind, randomised, controlled trial
-
Marks WJ, Jr., Bartus RT, Siffert J, et al. Gene delivery of AAV2-neurturin for Parkinson's disease: a double-blind, randomised, controlled trial. Lancet Neurol 2010;9:1164-1172.
-
(2010)
Lancet Neurol
, vol.9
, pp. 1164-1172
-
-
Marks, W.J.1
Bartus, R.T.2
Siffert, J.3
-
55
-
-
79951476995
-
Bioactivity of AAV2-neurturin gene therapy (CERE-120) in Parkinson's disease: a comparison of post-mortem and nonhuman primate brain tissue
-
Bartus RT, Herzog CD, Chu Y, et al. Bioactivity of AAV2-neurturin gene therapy (CERE-120) in Parkinson's disease: a comparison of post-mortem and nonhuman primate brain tissue. Mov Disord 2011;26:27-36.
-
(2011)
Mov Disord
, vol.26
, pp. 27-36
-
-
Bartus, R.T.1
Herzog, C.D.2
Chu, Y.3
-
56
-
-
84978515799
-
Short versus long-term expression/bioactivity of gene-delivered neurturin in human synucleinopathies
-
(in press)
-
Bartus RT, Kordower JH, Johnson EM, et al. Short versus long-term expression/bioactivity of gene-delivered neurturin in human synucleinopathies. Neurobiol Dis 2015 (in press).
-
(2015)
Neurobiol Dis
-
-
Bartus, R.T.1
Kordower, J.H.2
Johnson, E.M.3
-
57
-
-
84879394186
-
Enhanced neurotrophic distribution, cell signaling and neuroprotection following substantia nigral versus striatal delivery of AAV2-NRTN (CERE-120)
-
Herzog CD, Brown L, Kruegel BR, et al. Enhanced neurotrophic distribution, cell signaling and neuroprotection following substantia nigral versus striatal delivery of AAV2-NRTN (CERE-120). Neurobiol Dis 2013;58:38-48.
-
(2013)
Neurobiol Dis
, vol.58
, pp. 38-48
-
-
Herzog, C.D.1
Brown, L.2
Kruegel, B.R.3
-
58
-
-
79961126259
-
Properly scaled and targeted AAV2-NRTN (neurturin) to the substantia nigra is safe, effective and causes no weight loss: support for nigral targeting in Parkinson's disease
-
Bartus RT, Brown L, Wilson A, et al. Properly scaled and targeted AAV2-NRTN (neurturin) to the substantia nigra is safe, effective and causes no weight loss: support for nigral targeting in Parkinson's disease. Neurobiol Dis 2011;44:38-52.
-
(2011)
Neurobiol Dis
, vol.44
, pp. 38-52
-
-
Bartus, R.T.1
Brown, L.2
Wilson, A.3
-
59
-
-
84879086501
-
Safety/feasibility of targeting the substantia nigra with AAV2-neurturin in Parkinson patients
-
Bartus RT, Baumann TL, Siffert J, et al. Safety/feasibility of targeting the substantia nigra with AAV2-neurturin in Parkinson patients. Neurology 2013;80:1698-1701.
-
(2013)
Neurology
, vol.80
, pp. 1698-1701
-
-
Bartus, R.T.1
Baumann, T.L.2
Siffert, J.3
-
60
-
-
84937734362
-
Gene delivery of AAV2-neurturin to putamen and substantia nigra in Parkinson's disease: a double-blind, randomized, controlled trial
-
Olanow CW, Bartus RT, Baumann T, et al. Gene delivery of AAV2-neurturin to putamen and substantia nigra in Parkinson's disease: a double-blind, randomized, controlled trial. Ann Neurol 2015;78:248-257.
-
(2015)
Ann Neurol
, vol.78
, pp. 248-257
-
-
Olanow, C.W.1
Bartus, R.T.2
Baumann, T.3
-
61
-
-
0029114190
-
Retrograde axonal transport of glial cell line-derived neurotrophic factor n the adult nigrostriatal system suggests a trophic role in the adult
-
Tomac A, Widenfalk J, Lin LF, Kohno T, Ebenda T, Hoffer BJ, Olson L. Retrograde axonal transport of glial cell line-derived neurotrophic factor n the adult nigrostriatal system suggests a trophic role in the adult. Proc Natl Acad Sci U S A 1995;92:8274-8278.
-
(1995)
Proc Natl Acad Sci U S A
, vol.92
, pp. 8274-8278
-
-
Tomac, A.1
Widenfalk, J.2
Lin, L.F.3
Kohno, T.4
Ebenda, T.5
Hoffer, B.J.6
Olson, L.7
-
62
-
-
0034804675
-
Neurotrophins use the Erk5 pathway to mediate a retrograde survival response
-
Watson FL, Heerssen HM, Bhattacharyya A, Klesse L, Lin MZ, Segal RA. Neurotrophins use the Erk5 pathway to mediate a retrograde survival response. Nat Neurosci 2001;4:981-988.
-
(2001)
Nat Neurosci
, vol.4
, pp. 981-988
-
-
Watson, F.L.1
Heerssen, H.M.2
Bhattacharyya, A.3
Klesse, L.4
Lin, M.Z.5
Segal, R.A.6
-
63
-
-
0036322266
-
Novel antibodies to synuclein show abundant striatal pathology in Lewy body diseases
-
Duda JE, Giasson BI, Mabon ME, Lee VM, Trojanowski JQ. Novel antibodies to synuclein show abundant striatal pathology in Lewy body diseases. Ann Neurol 2002;52:205-210.
-
(2002)
Ann Neurol
, vol.52
, pp. 205-210
-
-
Duda, J.E.1
Giasson, B.I.2
Mabon, M.E.3
Lee, V.M.4
Trojanowski, J.Q.5
-
64
-
-
84919468220
-
Formation of α-synuclein Lewy neurite-like aggregates in axons impedes the transport of distinct endosomes
-
Volpicelli-Daley LA, Gamble KL, Schultheiss CE, Riddle DM, West AB, Lee VM. Formation of α-synuclein Lewy neurite-like aggregates in axons impedes the transport of distinct endosomes. Mol Biol Cell 2014;25:4010-4023.
-
(2014)
Mol Biol Cell
, vol.25
, pp. 4010-4023
-
-
Volpicelli-Daley, L.A.1
Gamble, K.L.2
Schultheiss, C.E.3
Riddle, D.M.4
West, A.B.5
Lee, V.M.6
-
65
-
-
84880932230
-
Disease duration and the integrity of the nigrostriatal system in Parkinson's disease
-
Kordower JH, Olanow CW, Dodiya HB, et al. Disease duration and the integrity of the nigrostriatal system in Parkinson's disease. Brain 2013;136:2419-2431.
-
(2013)
Brain
, vol.136
, pp. 2419-2431
-
-
Kordower, J.H.1
Olanow, C.W.2
Dodiya, H.B.3
-
66
-
-
84888041171
-
Yeast reveal a “druggable” Rsp5/Nedd4 network that ameliorates alpha-synuclein toxicity in neurons
-
Tardiff DF, Jui NT, Khurana V, et al. Yeast reveal a “druggable” Rsp5/Nedd4 network that ameliorates alpha-synuclein toxicity in neurons. Science 2013;342:979-983.
-
(2013)
Science
, vol.342
, pp. 979-983
-
-
Tardiff, D.F.1
Jui, N.T.2
Khurana, V.3
-
67
-
-
84888070126
-
Identification and rescue of alpha-synuclein toxicity in Parkinson patient-derived neurons
-
Chung CY, Khurana V, Auluck PK, et al. Identification and rescue of alpha-synuclein toxicity in Parkinson patient-derived neurons. Science 2013;342:983-987.
-
(2013)
Science
, vol.342
, pp. 983-987
-
-
Chung, C.Y.1
Khurana, V.2
Auluck, P.K.3
|