Signaling of glial cell line-derived neurotrophic factor and its receptor GFRα1 induce Nurr1 and Pitx3 to promote survival of grafted midbrain-derived neural stem cells in a rat model of Parkinson disease

Journal of Neuropathology and Experimental Neurology

Volumn 70, Issue 9, 2011, Pages 736-747

  Lei, Zhinian ^a   Jiang, Yu ^b   Li, Tao ^a   Zhu, Jianbao ^a   Zeng, Shuilin ^a  

^a SOUTHEAST UNIVERSITY   (China)

^b CLINICAL MEDICAL COLLEGE OF YANGZHOU UNIVERSITY   (China)

Author keywords

GDNF; Midbrain neural progenitor cells; Nurr1; Parkinson disease; Pitx3; Stem cells

Indexed keywords

APOMORPHINE; CASPASE 3; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR ALPHA1 RECEPTOR; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR RECEPTOR; NUCLEAR RECEPTOR RELATED FACTOR 1; OXIDOPAMINE; PROTEIN BCL 2; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR PITX3; TYROSINE 3 MONOOXYGENASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL ISOLATION; CELL SIZE; CELL SURVIVAL; CONTROLLED STUDY; CORPUS STRIATUM; EMBRYO; GENE SILENCING; IMMUNOCYTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; INTRACELLULAR SIGNALING; MALE; MESENCEPHALON; MOTOR PERFORMANCE; NERVE CELL CULTURE; NERVE CELL DIFFERENTIATION; NERVOUS SYSTEM DEVELOPMENT; NEURAL STEM CELL; NEURAL STEM CELL TRANSPLANTATION; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ANALYSIS OF VARIANCE; ANIMALS; BEHAVIOR, ANIMAL; CELL COUNT; CELLS, CULTURED; DISEASE MODELS, ANIMAL; GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR; GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR RECEPTORS; HOMEODOMAIN PROTEINS; MALE; NEURAL STEM CELLS; NEUROGENESIS; NUCLEAR RECEPTOR SUBFAMILY 4, GROUP A, MEMBER 2; OXIDOPAMINE; PARKINSON DISEASE; RATS; RATS, SPRAGUE-DAWLEY; RNA, SMALL INTERFERING; TIME FACTORS; TRANSCRIPTION FACTORS; TYROSINE 3-MONOOXYGENASE; VENTRAL TEGMENTAL AREA;

EID: 80052173590     PISSN: 00223069     EISSN: 15546578     Source Type: Journal    
DOI: 10.1097/NEN.0b013e31822830e5     Document Type: Article

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