Synthesis of unsymmetrical monocarbonyl curcumin analogues with potent inhibition on prostaglandin E2 production in LPS-induced murine and human macrophages cell lines

Bioorganic and Medicinal Chemistry Letters

Volumn 26, Issue 10, 2016, Pages 2531-2538

  Mohd Aluwi, Mohd Fadhlizil Fasihi ^a   Rullah, Kamal ^a,d   Yamin, Bohari M ^a   Leong, Sze Wei ^b   Abdul Bahari, Mohd Nazri ^b   Lim, Sock Jin ^a   Mohd Faudzi, Siti Munirah ^b   Jalil, Juriyati ^a   Abas, Faridah ^b   Mohd Fauzi, Norsyahida ^a   Ismail, Nor Hadiani ^c   Jantan, Ibrahim ^a   Lam, Kok Wai ^a  

^a UNIVERSITI KEBANGSAAN MALAYSIA   (Malaysia)

^b UNIVERSITY PUTRA MALAYSIA   (Malaysia)

^c MARA Kampus Puncak Alam   (Malaysia)

^d UNIVERSITY OF RIAU   (Indonesia)

Author keywords

Cyclooxygenase 2; Prostaglandin E2; RAW264.7; Single crystal XRD; U937; Unsymmetrical curcumin analogues

Indexed keywords

CURCUMIN; CURCUMIN DERIVATIVE; CYCLOOXYGENASE 2; I KAPPA B KINASE BETA; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 14; PROSTAGLANDIN E2 DERIVATIVE; UNCLASSIFIED DRUG; VANILLIN; CYCLOOXYGENASE 2 INHIBITOR; I KAPPA B KINASE; IKBKB PROTEIN, HUMAN; MITOGEN ACTIVATED PROTEIN KINASE 9; NONSTEROID ANTIINFLAMMATORY AGENT; PROSTAGLANDIN E2; PTGS2 PROTEIN, HUMAN;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BIOLOGICAL ACTIVITY; CONTROLLED STUDY; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC50; MACROPHAGE; MOLECULAR DOCKING; NONHUMAN; RAW 264.7 CELL LINE; U937 CELL LINE; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL LINE; CHEMISTRY; DRUG EFFECTS; METABOLISM; MOUSE; SYNTHESIS; X RAY CRYSTALLOGRAPHY;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CELL LINE; CHEMISTRY TECHNIQUES, SYNTHETIC; CRYSTALLOGRAPHY, X-RAY; CURCUMIN; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; DINOPROSTONE; HUMANS; I-KAPPA B KINASE; INHIBITORY CONCENTRATION 50; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; MITOGEN-ACTIVATED PROTEIN KINASE 9; MOLECULAR DOCKING SIMULATION;

EID: 84978328039     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2016.03.092     Document Type: Article

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