The synthetic curcuminoid BHMC restores endotoxin-stimulated HUVEC dysfunction:Specific disruption on enzymatic activity of p38 MAPK

European Journal of Pharmacology

Volumn 749, Issue , 2015, Pages 1-11

  Tham, Chau Ling ^a   Hazeera Harith, Hanis ^a   Wai Lam, Kok ^b   Joong Chong, Yi ^a   Singh Cheema, Manraj ^a   Roslan Sulaiman, Mohd ^a   Hj Lajis, Nordin ^c   Ahmad Israf, Daud ^a  

^a UNIVERSITY PUTRA MALAYSIA   (Malaysia)

^b UNIVERSITI KEBANGSAAN MALAYSIA   (Malaysia)

^c TAIBAH UNIVERSITY   (Saudi Arabia)

Author keywords

BHMC; Curcumin; HUVECs; Monocytes; NF Absp; p38 MAPK

Indexed keywords

2,6 BIS (4 HYDROXYL 3 METHOXYBENZYLIDINE)CYCLOHEXANONE; CURCUMIN; ENDOTOXIN; ENZYME INHIBITOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; MONOCYTE CHEMOTACTIC PROTEIN 1; TRANSCRIPTION FACTOR AP 1; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1; 2,6-BIS-4-(HYDROXY-3-METHOXYBENZYLIDENE)CYCLOHEXANONE; CCL2 PROTEIN, HUMAN; CYCLOHEXANONE DERIVATIVE; DNA; LIPOPOLYSACCHARIDE;

ARTICLE; CELL ADHESION; CELL MIGRATION; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY TEST; DOWN REGULATION; DRUG EFFECT; DRUG STRUCTURE; ENDOTHELIAL DYSFUNCTION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; MCP 1 GENE; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSCRIPTION REGULATION; UMBILICAL VEIN ENDOTHELIAL CELL; UPREGULATION; WESTERN BLOTTING; ANALOGS AND DERIVATIVES; CELL CULTURE; CELL SURVIVAL; DRUG EFFECTS; GENETICS; METABOLISM; MONOCYTE; PHYSIOLOGY; U937 CELL LINE;

CELL ADHESION; CELL SURVIVAL; CELLS, CULTURED; CHEMOKINE CCL2; CURCUMIN; CYCLOHEXANONES; DNA; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; INTERCELLULAR ADHESION MOLECULE-1; LIPOPOLYSACCHARIDES; MONOCYTES; NF-KAPPA B; P38 MITOGEN-ACTIVATED PROTEIN KINASES; TRANSCRIPTION FACTOR AP-1; U937 CELLS; VASCULAR CELL ADHESION MOLECULE-1;

EID: 84921421518     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2014.12.015     Document Type: Article

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