Design, synthesis and biological activity of novel asymmetric C66 analogs as anti-inflammatory agents for the treatment of acute lung injury

European Journal of Medicinal Chemistry

Volumn 94, Issue , 2015, Pages 436-446

  Yu, Pengtian ^a   Dong, Lili ^a   Zhang, Yali ^a   Chen, Wenbo ^a   Xu, Shanmei ^a   Wang, Zhe ^a   Shan, Xiaoou ^a   Zhou, Jianmin ^a   Liu, Zhiguo ^a,b   Liang, Guang ^a  

^a WENZHOU MEDICAL UNIVERSITY   (China)

^b Wenzhou Undersun Biotechnology Company   (China)

Author keywords

Acute lung injury; Chemical stability; Curcumin; Cytokines; Drug design

Indexed keywords

2 (3 HYDROXY 4 METHOXYBENZYLIDENE) 5 (2 NITROBENZYLIDENE)CYCLOPENTANONE; ANTIINFLAMMATORY AGENT; CARBONYL DERIVATIVE; CURCUMIN; CYCLOOXYGENASE 2; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; CYTOKINE; NONSTEROID ANTIINFLAMMATORY AGENT;

ACUTE LUNG INJURY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; CRITICALLY ILL PATIENT; DRUG DESIGN; DRUG EFFICACY; DRUG SYNTHESIS; HISTOPATHOLOGY; INFLAMMATORY CELL; LUNG LAVAGE; MALE; MORBIDITY; MORTALITY; NONHUMAN; PROTEIN CONTENT; PROTEIN EXPRESSION; RAT; STRUCTURE ACTIVITY RELATION; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; HUMAN; SYNTHESIS;

ACUTE LUNG INJURY; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CURCUMIN; CYTOKINES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; HUMANS; LIPOPOLYSACCHARIDES; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84925768799     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.11.054     Document Type: Article

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