Distinction of microsomal prostaglandin E synthase-1 (mPGES-1) inhibition from cyclooxygenase-2 inhibition in cells using a novel, selective mPGES-1 inhibitor

Biochemical Pharmacology

Volumn 79, Issue 10, 2010, Pages 1445-1454

  Mbalaviele, Gabriel ^a   Pauley, Adele M ^a   Shaffer, Alexander F ^a   Zweifel, Ben S ^a   Mathialagan, Sumathy ^a   Mnich, Stephen J ^a   Nemirovskiy, Olga V ^a   Carter, Jeff ^a   Gierse, James K ^a   Wang, Jane L ^a   Vazquez, Michael L ^a   Moore, William M ^a   Masferrer, Jaime L ^a  

^a PFIZER INC   (United States)

Author keywords

Arthritis; Cyclooxygenase 2; Inflammation; mPGES 1; Prostaglandins

Indexed keywords

3 [3 TERT BUTYLTHIO 1 (4 CHLOROBENZYL) 5 ISOPROPYL 2 INDOLYL] 2,2 DIMETHYLPROPIONIC ACID; 4 [5 (4 CHLOROPHENYL) 3 TRIFLUOROMETHYL 1H PYRAZOL 1 YL]BENZENESULFONAMIDE; 6 OXOPROSTAGLANDIN F1 ALPHA; ARACHIDONIC ACID; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; INDOMETACIN; INTERLEUKIN 1BETA; N (3',4' DICHLOROBIPHENYL 4 YL) 4 HYDROXY 2H 1,2 BENZOTHIAZINE 3 CARBOXAMIDE 1,1, DIOXIDE; PF 9184; PROSTAGLANDIN E SYNTHASE 1; PROSTAGLANDIN E2; PROSTAGLANDIN F1 ALPHA; PROSTAGLANDIN F2 ALPHA; PROSTAGLANDIN SYNTHASE INHIBITOR; THROMBOXANE B2; THROMBOXANE SYNTHASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG TARGETING; FIBROBLAST; GENE EXPRESSION; HUMAN; HUMAN CELL; IC 50; NONHUMAN; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS INHIBITION; PROTEIN EXPRESSION; RAT; RHEUMATOID ARTHRITIS;

ANIMALS; ARTHRITIS, RHEUMATOID; CARRAGEENAN; CELLS, CULTURED; CYCLIC S-OXIDES; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; FIBROBLASTS; GENE EXPRESSION; HUMANS; IMMUNOBLOTTING; INTERLEUKIN-1BETA; INTRAMOLECULAR OXIDOREDUCTASES; MICROSOMES; RATS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; THIAZINES;

EID: 77649189835     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2010.01.003     Document Type: Article

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