Pharmacological evaluation and docking studies of α,β- unsaturated carbonyl based synthetic compounds as inhibitors of secretory phospholipase A2, cyclooxygenases, lipoxygenase and proinflammatory cytokines

Bioorganic and Medicinal Chemistry

Volumn 22, Issue 15, 2014, Pages 4151-4161

  Bukhari, Syed Nasir Abbas ^a   Lauro, Gianluigi ^b   Jantan, Ibrahim ^a   Bifulco, Giuseppe ^b   Amjad, Muhammad Wahab ^a  

^a UNIVERSITI KEBANGSAAN MALAYSIA   (Malaysia)

^b UNIVERSITY OF SALERNO   (Italy)

Author keywords

Claisen Schmidt condensation; Curcumin; Lipopolysaccharides; Tumor necrosis factor alpha

Indexed keywords

1,5 BIS (4 DIETHOXYMETHYL PHENYL) PENTA 1,4 DIEN 3 ONE; 1,5 BIS (4 DIMETHYLAMINO 2 NITRO PHENYL) PENTA 1,4 DIEN 3 ONE; 2,6 BIS (4 DIMETHYLAMINO 2 NITRO BENZYLIDENE) CYCLOHEXANONE; 2,6 BIS[4 (DIETHOXYMETHYL)BENZYLIDENE]CYCLOHEXANONE; 3,5 BIS (4 DIETHOXYMETHYL BENZYLIDENE) TETRAHYDROPYRAN 4 ONE; 3,5 BIS[4 (DIETHOXYMETHYL)BENZYLIDENE] 1 METHYLPIPERIDIN 4 ONE; 3,5 BIS[4 (DIETHOXYMETHYL)BENZYLIDENE]PIPERIDIN 4 ONE; 3,5 BIS[4 (DIMETHYLAMINO)2 NITRO BENZYLIDENE] 1 METHYLPIPERIDIN 4 ONE; 3,5 BIS[4 (DIMETHYLAMINO)2 NITRO BENZYLIDENE] TETRAHYDRO PYRAN 4 ONE; 3,5 BIS[4 (DIMETHYLAMINO)2 NITRO BENZYLIDENE]PIPERIDIN 4 ONE; ALPHA,BETA UNSATURATED CARBONYL; CARBONYL DERIVATIVE; ENZYME INHIBITOR; INTERLEUKIN 6; LIPOXYGENASE; LIPOXYGENASE INHIBITOR; PROSTAGLANDIN SYNTHASE; PROSTAGLANDIN SYNTHASE INHIBITOR; PROTEIN INHIBITOR; SECRETORY PHOSPHOLIPASE A2; SECRETORY PHOSPHOLIPASE A2 INHIBITOR; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA INHIBITOR; UNCLASSIFIED DRUG; CURCUMIN; PHOSPHOLIPASE A2 INHIBITOR; PROTEIN BINDING;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; IC 50; MACROPHAGE; MOLECULAR DOCKING; NONHUMAN; ANIMAL; ANTAGONISTS AND INHIBITORS; BINDING SITE; CELL LINE; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; ENZYMOLOGY; METABOLISM; MOUSE; PROTEIN TERTIARY STRUCTURE; SOYBEAN; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANIMALS; BINDING SITES; CELL LINE; CURCUMIN; CYCLOOXYGENASE INHIBITORS; INTERLEUKIN-6; LIPOXYGENASE; LIPOXYGENASE INHIBITORS; MACROPHAGES; MICE; MOLECULAR DOCKING SIMULATION; PHOSPHOLIPASE A2 INHIBITORS; PHOSPHOLIPASES A2, SECRETORY; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SOYBEANS; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84905113460     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2014.05.052     Document Type: Article

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