Targeted nanogel conjugate for improved stability and cellular permeability of curcumin: Synthesis, pharmacokinetics, and tumor growth inhibition

Molecular Pharmaceutics

Volumn 11, Issue 9, 2014, Pages 3112-3122

  Wei, Xin ^a   Senanayake, Thulani H ^a   Bohling, Anna ^a   Vinogradov, Serguei V ^a  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

animal cancer models; Curcumin; nanogel drug conjugate; NF B inhibition; PK PD parameters

Indexed keywords

ANTINEOPLASTIC AGENT; CURCUMIN; CYCLOOXYGENASE 2; DELAYED RELEASE FORMULATION; ESTER; HERMES ANTIGEN; HYALURONIC ACID; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MACROGOL DERIVATIVE; NANOGEL; POLYETHYLENEIMINE; PTGS2 PROTEIN, HUMAN; TUMOR NECROSIS FACTOR ALPHA;

ADENOMA; ANIMAL; APOPTOSIS; BAGG ALBINO MOUSE; CELL PROLIFERATION; CHEMISTRY; DELAYED RELEASE FORMULATION; DIET THERAPY; DRUG DELIVERY SYSTEM; DRUG EFFECTS; DRUG RESISTANCE; DRUG SCREENING; EXPERIMENTAL MAMMARY NEOPLASM; FEMALE; HUMAN; METABOLISM; MOUSE; NUDE MOUSE; ORAL DRUG ADMINISTRATION; PANCREATIC NEOPLASMS; PERMEABILITY; PHARMACOKINETICS; PHARMACOLOGY; PROCEDURES; SOLUBILITY; TUMOR CELL LINE;

ADENOMA; ADMINISTRATION, ORAL; ANIMALS; ANTIGENS, CD44; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; CURCUMIN; CYCLOOXYGENASE 2; DELAYED-ACTION PREPARATIONS; DRUG DELIVERY SYSTEMS; DRUG RESISTANCE, NEOPLASM; DRUG SCREENING ASSAYS, ANTITUMOR; ESTERS; FEMALE; HUMANS; HYALURONIC ACID; MAMMARY NEOPLASMS, ANIMAL; MICE; MICE, INBRED BALB C; MICE, NUDE; NF-KAPPA B; PANCREATIC NEOPLASMS; PERMEABILITY; POLYETHYLENE GLYCOLS; POLYETHYLENEIMINE; SOLUBILITY; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84906898076     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp500290f     Document Type: Article

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