Nitric oxide inhibitory activity and antioxidant evaluations of 2-benzoyl-6-benzylidenecyclohexanone analogs, a novel series of curcuminoid and diarylpentanoid derivatives

Bioorganic and Medicinal Chemistry Letters

Volumn 25, Issue 16, 2015, Pages 3330-3337

  Leong, Sze Wei ^a   Mohd Faudzi, Siti Munirah ^a   Abas, Faridah ^a   Mohd Aluwi, Mohd Fadhlizil Fasihi ^b   Rullah, Kamal ^b   Lam, Kok Wai ^b   Abdul Bahari, Mohd Nazri ^a   Ahmad, Syahida ^a   Tham, Chau Ling ^a   Shaari, Khozirah ^a   Lajis, Nordin H ^a  

^a UNIVERSITY PUTRA MALAYSIA   (Malaysia)

^b UNIVERSITI KEBANGSAAN MALAYSIA   (Malaysia)

Author keywords

2 Benzoyl 6 benzylidenecyclohexanone; Anti inflammatory; Antioxidant; RAW 264.7; Stability

Indexed keywords

2 BENZOYL 6 BENZYLIDENECYCLOHEXANONE DERIVATIVE; 2 CHLOROPHENYL; 2 METHOXYPHENYL; 2,3 DIMETHOXYPHENYL; 2,3,4 TRIMETHOXYPHENYL; 2,5 DIMETHOXYPHENYL; 3 BROMO 4 HYDROXYPHENYL; 3 CHLORO 4 HYDROXYPHENYL; 3 CHLOROPHENYL; 3 FLUOROPHENYL; 3 HYDROXYPHENYL; 3 METHOXYPHENYL; 3,4 DIHYDROXYPHENYL; 3,4 DIMETHOXYPHENYL; 3,4,5 TRIMETHOXYPHENYL; 4 CHLOROPHENYL; 4 HYDROXY 3 METHOXYPHENYL; 4 HYDROXYPHENYL; 4 METHOXYPHENYL; 5 METHYLFURAN 2 YL; 5 METHYLTHIOPHEN 2 YL; ANTIINFLAMMATORY AGENT; CYCLOHEXANONE DERIVATIVE; NAPHTHALEN 1 YL; NAPHTHALEN 2 YL; NITRIC OXIDE; THIOPHEN 2 YL; UNCLASSIFIED DRUG; ANTIOXIDANT; BENZYLIDENE DERIVATIVE; CURCUMIN; CYCLOHEXANONE; VALERIC ACID DERIVATIVE;

ALDOL REACTION; ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CYTOTOXICITY; IC50; MACROPHAGE; STRUCTURE ACTIVITY RELATION; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL SURVIVAL; CHEMISTRY; DRUG EFFECTS; HUMAN; LIVER MICROSOME; MOUSE; RAW 264.7 CELL LINE; SYNTHESIS;

ANIMALS; ANTIOXIDANTS; BENZYLIDENE COMPOUNDS; CELL SURVIVAL; CURCUMIN; CYCLOHEXANONES; HUMANS; INHIBITORY CONCENTRATION 50; MACROPHAGES; MICE; MICROSOMES, LIVER; NITRIC OXIDE; PENTANOIC ACIDS; RAW 264.7 CELLS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84934847281     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2015.05.056     Document Type: Article

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