The AMPK-PPARGC1A pathway is required for antimicrobial host defense through activation of autophagy

Autophagy

Volumn 10, Issue 5, 2014, Pages 785-802

  Yang, Chul Su ^a   Kim, Jwa Jin ^a   Lee, Hye Mi ^a   Jin, Hyo Sun ^a   Lee, Sang Hee ^b   Park, Ji Hoon ^a   Kim, Soung Jung ^a   Kim, Jin Man ^a   Han, Yong Mahn ^b   Lee, Myung Shik ^c   Kweon, Gi Ryang ^a   Shong, Minho ^a   Jo, Eun Kyeong ^a  

^a Chungnam National University   (South Korea)

^b Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

^c Sungkyunkwan University School of Medicine   (South Korea)

Author keywords

AICAR; AMP activated protein kinase; Autophagy; MTOR; Mycobacterium tuberculosis; PPARGC1A

Indexed keywords

5 AMINO 4 IMIDAZOLECARBOXAMIDE RIBOSIDE; AUTOPHAGY PROTEIN 5; AUTOPHAGY PROTEIN 7; BAFILOMYCIN A1; BECLIN 1; CCAAT ENHANCER BINDING PROTEIN; CCAAT ENHANCER BINDING PROTEIN BETA; CHLOROQUINE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MAMMALIAN TARGET OF RAPAMYCIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; UNCLASSIFIED DRUG; PPARGC1A PROTEIN, HUMAN; TRANSCRIPTION FACTOR;

ANIMAL CELL; ANTIBIOTIC RESISTANCE; ANTIMICROBIAL ACTIVITY; ARTICLE; AUTOPHAGOSOME; CELL MATURATION; COLONY FORMING UNIT; CONTROLLED STUDY; ENZYME ACTIVATION; FEMALE; GROWTH INHIBITION; HOST RESISTANCE; IN VIVO STUDY; MACROPHAGE; MALE; MOUSE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; OXIDATIVE PHOSPHORYLATION; PHAGOSOME; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; UPREGULATION; XENOPHAGY; ANIMAL; AUTOPHAGY; C57BL MOUSE; CELL CULTURE; DROSOPHILA MELANOGASTER; GENETICS; HOST PATHOGEN INTERACTION; HUMAN; IMMUNOLOGY; INNATE IMMUNITY; MYCOBACTERIUM; PHYSIOLOGY; TRANSGENIC MOUSE;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; AUTOPHAGY; CELLS, CULTURED; DROSOPHILA MELANOGASTER; HOST-PATHOGEN INTERACTIONS; HUMANS; IMMUNITY, INNATE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MYCOBACTERIUM; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

EID: 84899723367     PISSN: 15548627     EISSN: 15548635     Source Type: Journal    
DOI: 10.4161/auto.28072     Document Type: Article

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