-
1
-
-
0038015943
-
An Italian family affected by Nasu-Hakola disease with a novel genetic mutation in the TREM2 gene
-
Soragna D, Papi L, Ratti MT, Sestini R, Tupler R, Montalbetti L. An Italian family affected by Nasu-Hakola disease with a novel genetic mutation in the TREM2 gene. J Neurol Neurosurg Psychiatry 2003;74:825-826.
-
(2003)
J Neurol Neurosurg Psychiatry
, vol.74
, pp. 825-826
-
-
Soragna, D.1
Papi, L.2
Ratti, M.T.3
Sestini, R.4
Tupler, R.5
Montalbetti, L.6
-
2
-
-
0037805700
-
TREMs in the immune system and beyond
-
Colonna M. TREMs in the immune system and beyond. Nat Rev Immunol 2003;3:445-453.
-
(2003)
Nat Rev Immunol
, vol.3
, pp. 445-453
-
-
Colonna, M.1
-
3
-
-
0037314230
-
Osteopetrosis and thalamic hypomyelinosis with synaptic degeneration in DAP12-deficient mice
-
Kaifu T, Nakahara J, Inui M, Mishima K, Momiyama T, Kaji M, Sugahara A, Koito H, Ujike-Asai A, Nakamura A, Kanazawa K, Tan-Takeuchi K, Iwasaki K, Yokoyama WM, Kudo A, et al. Osteopetrosis and thalamic hypomyelinosis with synaptic degeneration in DAP12-deficient mice. J Clin Invest 2003;111:323-332.
-
(2003)
J Clin Invest
, vol.111
, pp. 323-332
-
-
Kaifu, T.1
Nakahara, J.2
Inui, M.3
Mishima, K.4
Momiyama, T.5
Kaji, M.6
Sugahara, A.7
Koito, H.8
Ujike-Asai, A.9
Nakamura, A.10
Kanazawa, K.11
Tan-Takeuchi, K.12
Iwasaki, K.13
Yokoyama, W.M.14
Kudo, A.15
-
5
-
-
51349085578
-
TREM2 is upregulated in amyloid plaque-associated microglia in aged APP23 transgenic mice
-
Frank S, Burbach GJ, Bonin M, Walter M, Streit W, Bechmann I, Deller T. TREM2 is upregulated in amyloid plaque-associated microglia in aged APP23 transgenic mice. Glia 2008;56:1438-1447.
-
(2008)
Glia
, vol.56
, pp. 1438-1447
-
-
Frank, S.1
Burbach, G.J.2
Bonin, M.3
Walter, M.4
Streit, W.5
Bechmann, I.6
Deller, T.7
-
6
-
-
77956238665
-
Dual induction of TREM2 and tolerance-related transcript, Tmem176b, in amyloid transgenic mice: implications for vaccine-based therapies for Alzheimer's disease
-
Melchior B, Garcia AE, Hsiung BK, Lo KM, Doose JM, Thrash JC, Stalder AK, Staufenbiel M, Neumann H, Carson MJ. Dual induction of TREM2 and tolerance-related transcript, Tmem176b, in amyloid transgenic mice: implications for vaccine-based therapies for Alzheimer's disease. ASN Neuro 2010;2:e00037.
-
(2010)
ASN Neuro
, vol.2
, pp. e00037
-
-
Melchior, B.1
Garcia, A.E.2
Hsiung, B.K.3
Lo, K.M.4
Doose, J.M.5
Thrash, J.C.6
Stalder, A.K.7
Staufenbiel, M.8
Neumann, H.9
Carson, M.J.10
-
7
-
-
84872586508
-
Using exome sequencing to reveal mutations in TREM2 presenting as a frontotemporal dementia-like syndrome without bone involvement
-
Guerreiro RJ, Lohmann E, Bras JM, Gibbs JR, Rohrer JD, Gurunlian N, Dursun B, Bilgic B, Hanagasi H, Gurvit H, Emre M, Singleton A, Hardy J. Using exome sequencing to reveal mutations in TREM2 presenting as a frontotemporal dementia-like syndrome without bone involvement. JAMA Neurol 2013;70:78-84.
-
(2013)
JAMA Neurol
, vol.70
, pp. 78-84
-
-
Guerreiro, R.J.1
Lohmann, E.2
Bras, J.M.3
Gibbs, J.R.4
Rohrer, J.D.5
Gurunlian, N.6
Dursun, B.7
Bilgic, B.8
Hanagasi, H.9
Gurvit, H.10
Emre, M.11
Singleton, A.12
Hardy, J.13
-
8
-
-
84884143091
-
Novel compound heterozygous mutation in TREM2 found in a Turkish frontotemporal dementia-like family
-
Guerreiro R, Bilgic B, Guven G, Bras J, Rohrer J, Lohmann E, Hanagasi H, Gurvit H, Emre M. Novel compound heterozygous mutation in TREM2 found in a Turkish frontotemporal dementia-like family. Neurobiol Aging 2013;34:2890.e1-2890.e5.
-
(2013)
Neurobiol Aging
, vol.34
, pp. 2890e1-2890e5
-
-
Guerreiro, R.1
Bilgic, B.2
Guven, G.3
Bras, J.4
Rohrer, J.5
Lohmann, E.6
Hanagasi, H.7
Gurvit, H.8
Emre, M.9
-
9
-
-
84879113935
-
TREM2 in neurodegeneration: evidence for association of the p.R47H variant with frontotemporal dementia and Parkinson's disease
-
Rayaprolu S, Mullen B, Baker M, Lynch T, Finger E, Seeley WW, Hatanpaa KJ, Lomen-Hoerth C, Kertesz A, Bigio EH, Lippa C, Josephs KA, Knopman DS, White CL, Caselli R, et al. TREM2 in neurodegeneration: evidence for association of the p.R47H variant with frontotemporal dementia and Parkinson's disease. Mol Neurodegener 2013;8:19.
-
(2013)
Mol Neurodegener
, vol.8
, pp. 19
-
-
Rayaprolu, S.1
Mullen, B.2
Baker, M.3
Lynch, T.4
Finger, E.5
Seeley, W.W.6
Hatanpaa, K.J.7
Lomen-Hoerth, C.8
Kertesz, A.9
Bigio, E.H.10
Lippa, C.11
Josephs, K.A.12
Knopman, D.S.13
White, C.L.14
Caselli, R.15
-
10
-
-
84897398469
-
TREM2 variant p.R47H as a risk factor for sporadic amyotrophic lateral sclerosis
-
Cady J, Koval ED, Benitez BA, Zaidman C, Jockel-Balsarotti J, Allred P, Baloh RH, Ravits J, Simpson E, Appel SH, Pestronk A, Goate AM, Miller TM, Cruchaga C, Harms MB. TREM2 variant p.R47H as a risk factor for sporadic amyotrophic lateral sclerosis. JAMA Neurol 2014;71:449-453.
-
(2014)
JAMA Neurol
, vol.71
, pp. 449-453
-
-
Cady, J.1
Koval, E.D.2
Benitez, B.A.3
Zaidman, C.4
Jockel-Balsarotti, J.5
Allred, P.6
Baloh, R.H.7
Ravits, J.8
Simpson, E.9
Appel, S.H.10
Pestronk, A.11
Goate, A.M.12
Miller, T.M.13
Cruchaga, C.14
Harms, M.B.15
-
11
-
-
84889590173
-
Investigating the role of rare heterozygous TREM2 variants in Alzheimer's disease and frontotemporal dementia
-
Cuyvers E, Bettens K, Philtjens S, Van Langenhove T, Gijselinck I, van der Zee J, Engelborghs S, Vandenbulcke M, Van Dongen J, Geerts N, Maes G, Mattheijssens M, Peeters K, Cras P, Vandenberghe R, et al. Investigating the role of rare heterozygous TREM2 variants in Alzheimer's disease and frontotemporal dementia. Neurobiol Aging 2014;35:726.e11-726.e19.
-
(2014)
Neurobiol Aging
, vol.35
, pp. 726e11-726e19
-
-
Cuyvers, E.1
Bettens, K.2
Philtjens, S.3
Van Langenhove, T.4
Gijselinck, I.5
van der Zee, J.6
Engelborghs, S.7
Vandenbulcke, M.8
Van Dongen, J.9
Geerts, N.10
Maes, G.11
Mattheijssens, M.12
Peeters, K.13
Cras, P.14
Vandenberghe, R.15
-
12
-
-
85058205970
-
Heterozygous TREM2 mutations in frontotemporal dementia
-
Borroni B, Ferrari F, Galimberti D, Nacmias B, Barone C, Bagnoli S, Fenoglio C, Piaceri I, Archetti S, Bonvicini C, Gennarelli M, Turla M, Scarpini E, Sorbi S, Padovani A. Heterozygous TREM2 mutations in frontotemporal dementia. Neurobiol Aging 2014;35:934.e7-934.e10.
-
(2014)
Neurobiol Aging
, vol.35
, pp. 934e7-934e10
-
-
Borroni, B.1
Ferrari, F.2
Galimberti, D.3
Nacmias, B.4
Barone, C.5
Bagnoli, S.6
Fenoglio, C.7
Piaceri, I.8
Archetti, S.9
Bonvicini, C.10
Gennarelli, M.11
Turla, M.12
Scarpini, E.13
Sorbi, S.14
Padovani, A.15
-
13
-
-
0041920899
-
Impaired differentiation of osteoclasts in TREM-2-deficient individuals
-
Cella M, Buonsanti C, Strader C, Kondo T, Salmaggi A, Colonna M. Impaired differentiation of osteoclasts in TREM-2-deficient individuals. J Exp Med 2003;198:645-651.
-
(2003)
J Exp Med
, vol.198
, pp. 645-651
-
-
Cella, M.1
Buonsanti, C.2
Strader, C.3
Kondo, T.4
Salmaggi, A.5
Colonna, M.6
-
14
-
-
84884185631
-
Microglial beclin 1 regulates retromer trafficking and phagocytosis and is impaired in Alzheimer's disease
-
Lucin KM, O'Brien CE, Bieri G, Czirr E, Mosher KI, Abbey RJ, Mastroeni DF, Rogers J, Spencer B, Masliah E, Wyss-Coray T. Microglial beclin 1 regulates retromer trafficking and phagocytosis and is impaired in Alzheimer's disease. Neuron 2013;79:873-886.
-
(2013)
Neuron
, vol.79
, pp. 873-886
-
-
Lucin, K.M.1
O'Brien, C.E.2
Bieri, G.3
Czirr, E.4
Mosher, K.I.5
Abbey, R.J.6
Mastroeni, D.F.7
Rogers, J.8
Spencer, B.9
Masliah, E.10
Wyss-Coray, T.11
-
15
-
-
3543005360
-
Endocytosis, actin cytoskeleton, and signaling
-
Samaj J, Baluska F, Voigt B, Schlicht M, Volkmann D, Menzel D. Endocytosis, actin cytoskeleton, and signaling. Plant Physiol 2004;135:1150-1161.
-
(2004)
Plant Physiol
, vol.135
, pp. 1150-1161
-
-
Samaj, J.1
Baluska, F.2
Voigt, B.3
Schlicht, M.4
Volkmann, D.5
Menzel, D.6
-
16
-
-
41449104661
-
ARF GEF-dependent transcytosis and polar delivery of PIN auxin carriers in Arabidopsis
-
Kleine-Vehn J, Dhonukshe P, Sauer M, Brewer PB, Wiśniewska J, Paciorek T, Benkova E, Friml J. ARF GEF-dependent transcytosis and polar delivery of PIN auxin carriers in Arabidopsis. Curr Biol 2008;18:526-531.
-
(2008)
Curr Biol
, vol.18
, pp. 526-531
-
-
Kleine-Vehn, J.1
Dhonukshe, P.2
Sauer, M.3
Brewer, P.B.4
Wiśniewska, J.5
Paciorek, T.6
Benkova, E.7
Friml, J.8
-
17
-
-
84887228821
-
Enzymatic deglycosylation of glycoproteins
-
Kim MS, Leahy D. Enzymatic deglycosylation of glycoproteins. Methods Enzymol 2013;533:259-263.
-
(2013)
Methods Enzymol
, vol.533
, pp. 259-263
-
-
Kim, M.S.1
Leahy, D.2
-
18
-
-
36249022072
-
How sugars convey information on protein conformation in the endoplasmic reticulum
-
Caramelo JJ, Parodi AJ. How sugars convey information on protein conformation in the endoplasmic reticulum. Semin Cell Dev Biol 2007;18:732-742.
-
(2007)
Semin Cell Dev Biol
, vol.18
, pp. 732-742
-
-
Caramelo, J.J.1
Parodi, A.J.2
-
19
-
-
0036462601
-
Protein N-glycosylation along the secretory pathway: relationship to organelle topography and function, protein quality control, and cell interactions
-
Roth J. Protein N-glycosylation along the secretory pathway: relationship to organelle topography and function, protein quality control, and cell interactions. Chem Rev 2002;102:285-303.
-
(2002)
Chem Rev
, vol.102
, pp. 285-303
-
-
Roth, J.1
-
20
-
-
10344255689
-
Processing of Notch and amyloid precursor protein by gamma-secretase is spatially distinct
-
Tarassishin L, Yin YI, Bassit B, Li YM. Processing of Notch and amyloid precursor protein by gamma-secretase is spatially distinct. Proc Natl Acad Sci USA 2004;101:17050-17055.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 17050-17055
-
-
Tarassishin, L.1
Yin, Y.I.2
Bassit, B.3
Li, Y.M.4
-
21
-
-
84887504831
-
An essential role for the N-terminal fragment of Toll-like receptor 9 in DNA sensing
-
Onji M, Kanno A, Saitoh S, Fukui R, Motoi Y, Shibata T, Matsumoto F, Lamichhane A, Sato S, Kiyono H, Yamamoto K, Miyake K. An essential role for the N-terminal fragment of Toll-like receptor 9 in DNA sensing. Nat Commun 2013;4:1949.
-
(2013)
Nat Commun
, vol.4
, pp. 1949
-
-
Onji, M.1
Kanno, A.2
Saitoh, S.3
Fukui, R.4
Motoi, Y.5
Shibata, T.6
Matsumoto, F.7
Lamichhane, A.8
Sato, S.9
Kiyono, H.10
Yamamoto, K.11
Miyake, K.12
-
22
-
-
33751333201
-
Substrate-specific translocational attenuation during ER stress defines a pre-emptive quality control pathway
-
Kang SW, Rane NS, Kim SJ, Garrison JL, Taunton J, Hegde RS. Substrate-specific translocational attenuation during ER stress defines a pre-emptive quality control pathway. Cell 2006;127:999-1013.
-
(2006)
Cell
, vol.127
, pp. 999-1013
-
-
Kang, S.W.1
Rane, N.S.2
Kim, S.J.3
Garrison, J.L.4
Taunton, J.5
Hegde, R.S.6
-
23
-
-
84874525357
-
Suppression of the macrophage proteasome by ethanol impairs MHC class I antigen processing and presentation
-
D'Souza AJ, Desai SD, Rudner XL, Kelly MN, Ruan S, Shellito JE. Suppression of the macrophage proteasome by ethanol impairs MHC class I antigen processing and presentation. PLoS One 2013;8:e56890.
-
(2013)
PLoS One
, vol.8
, pp. e56890
-
-
D'Souza, A.J.1
Desai, S.D.2
Rudner, X.L.3
Kelly, M.N.4
Ruan, S.5
Shellito, J.E.6
-
24
-
-
69249104575
-
Endoplasmic reticulum-associated degradation (ERAD) and autophagy cooperate to degrade polymerogenic mutant serpins
-
Kroeger H, Miranda E, MacLeod I, Perez J, Crowther DC, Marciniak SJ, Lomas DA. Endoplasmic reticulum-associated degradation (ERAD) and autophagy cooperate to degrade polymerogenic mutant serpins. J Biol Chem 2009;284:22793-22802.
-
(2009)
J Biol Chem
, vol.284
, pp. 22793-22802
-
-
Kroeger, H.1
Miranda, E.2
MacLeod, I.3
Perez, J.4
Crowther, D.C.5
Marciniak, S.J.6
Lomas, D.A.7
-
25
-
-
50249116184
-
The endoplasmic reticulum stress response in immunity and autoimmunity
-
Todd DJ, Lee AH, Glimcher LH. The endoplasmic reticulum stress response in immunity and autoimmunity. Nat Rev Immunol 2008;8:663-674.
-
(2008)
Nat Rev Immunol
, vol.8
, pp. 663-674
-
-
Todd, D.J.1
Lee, A.H.2
Glimcher, L.H.3
-
26
-
-
84874752073
-
20-O-(β-D-glucopyranosyl)-20(S)-protopanaxadiol induces apoptosis via induction of endoplasmic reticulum stress in human colon cancer cells
-
Zhang R, Chung Y, Kim HS, Kim DH, Kim HS, Chang WY, Hyun JW. 20-O-(β-D-glucopyranosyl)-20(S)-protopanaxadiol induces apoptosis via induction of endoplasmic reticulum stress in human colon cancer cells. Oncol Rep 2013;29:1365-1370.
-
(2013)
Oncol Rep
, vol.29
, pp. 1365-1370
-
-
Zhang, R.1
Chung, Y.2
Kim, H.S.3
Kim, D.H.4
Kim, H.S.5
Chang, W.Y.6
Hyun, J.W.7
-
27
-
-
0033671650
-
Upregulation of BiP and CHOP by the unfolded-protein response is independent of presenilin expression
-
Sato N, Urano F, Yoon Leem J, Kim SH, Li M, Donoviel D, Bernstein A, Lee AS, Ron D, Veselits ML, Sisodia SS, Thinakaran G. Upregulation of BiP and CHOP by the unfolded-protein response is independent of presenilin expression. Nat Cell Biol 2000;2:863-870.
-
(2000)
Nat Cell Biol
, vol.2
, pp. 863-870
-
-
Sato, N.1
Urano, F.2
Yoon Leem, J.3
Kim, S.H.4
Li, M.5
Donoviel, D.6
Bernstein, A.7
Lee, A.S.8
Ron, D.9
Veselits, M.L.10
Sisodia, S.S.11
Thinakaran, G.12
-
28
-
-
10644233167
-
CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum
-
Marciniak SJ, Yun CY, Oyadomari S, Novoa I, Zhang Y, Jungreis R, Nagata K, Harding HP, Ron D. CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum. Genes Dev 2004;18:3066-3077.
-
(2004)
Genes Dev
, vol.18
, pp. 3066-3077
-
-
Marciniak, S.J.1
Yun, C.Y.2
Oyadomari, S.3
Novoa, I.4
Zhang, Y.5
Jungreis, R.6
Nagata, K.7
Harding, H.P.8
Ron, D.9
-
29
-
-
84887853222
-
Sequential proteolytic processing of the triggering receptor expressed on myeloid cells-2 (TREM2) protein by ectodomain shedding and γ-secretase-dependent intramembranous cleavage
-
Wunderlich P, Glebov K, Kemmerling N, Tien NT, Neumann H, Walter J. Sequential proteolytic processing of the triggering receptor expressed on myeloid cells-2 (TREM2) protein by ectodomain shedding and γ-secretase-dependent intramembranous cleavage. J Biol Chem 2013;288:33027-33036.
-
(2013)
J Biol Chem
, vol.288
, pp. 33027-33036
-
-
Wunderlich, P.1
Glebov, K.2
Kemmerling, N.3
Tien, N.T.4
Neumann, H.5
Walter, J.6
-
30
-
-
84904479732
-
TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis
-
Kleinberger G, Yamanishi Y, Suarez-Calvet M, Czirr E, Lohmann E, Cuyvers E, Struyfs H, Pettkus N, Wenninger-Weinzierl A, Mazaheri F, Tahirovic S, Lleo A, Alcolea D, Fortea J, Willem M, et al. TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis. Sci Transl Med 2014;6:243ra286.
-
(2014)
Sci Transl Med
, vol.6
, pp. 243ra286
-
-
Kleinberger, G.1
Yamanishi, Y.2
Suarez-Calvet, M.3
Czirr, E.4
Lohmann, E.5
Cuyvers, E.6
Struyfs, H.7
Pettkus, N.8
Wenninger-Weinzierl, A.9
Mazaheri, F.10
Tahirovic, S.11
Lleo, A.12
Alcolea, D.13
Fortea, J.14
Willem, M.15
-
31
-
-
84911397783
-
Frontobasal gray matter loss is associated with the TREM2 p.R47H variant
-
Luis EO, Ortega-Cubero S, Lamet I, Razquin C, Cruchaga C, Benitez BA, Lorenzo E, Irigoyen J, Pastor MA, Pastor P. Frontobasal gray matter loss is associated with the TREM2 p.R47H variant. Neurobiol Aging 2014;35:2681-2690.
-
(2014)
Neurobiol Aging
, vol.35
, pp. 2681-2690
-
-
Luis, E.O.1
Ortega-Cubero, S.2
Lamet, I.3
Razquin, C.4
Cruchaga, C.5
Benitez, B.A.6
Lorenzo, E.7
Irigoyen, J.8
Pastor, M.A.9
Pastor, P.10
-
32
-
-
84885828745
-
TREM2 and neurodegenerative disease
-
Bird TD. TREM2 and neurodegenerative disease. N Engl J Med 2013;369:1568.
-
(2013)
N Engl J Med
, vol.369
, pp. 1568
-
-
Bird, T.D.1
-
33
-
-
84877618309
-
Variants in triggering receptor expressed on myeloid cells 2 are associated with both behavioral variant frontotemporal lobar degeneration and Alzheimer's disease
-
Giraldo M, Lopera F, Siniard AL, Corneveaux JJ, Schrauwen I, Carvajal J, Munoz C, Ramirez-Restrepo M, Gaiteri C, Myers AJ, Caselli RJ, Kosik KS, Reiman EM, Huentelman MJ. Variants in triggering receptor expressed on myeloid cells 2 are associated with both behavioral variant frontotemporal lobar degeneration and Alzheimer's disease. Neurobiol Aging 2013;34:2077.e11-2077.e18.
-
(2013)
Neurobiol Aging
, vol.34
, pp. 2077e11-2077e18
-
-
Giraldo, M.1
Lopera, F.2
Siniard, A.L.3
Corneveaux, J.J.4
Schrauwen, I.5
Carvajal, J.6
Munoz, C.7
Ramirez-Restrepo, M.8
Gaiteri, C.9
Myers, A.J.10
Caselli, R.J.11
Kosik, K.S.12
Reiman, E.M.13
Huentelman, M.J.14
-
34
-
-
1242274510
-
Dynamic and intracellular trafficking of P-glycoprotein-EGFP fusion protein: implications in multidrug resistance in cancer
-
Fu D, Bebawy M, Kable EP, Roufogalis BD. Dynamic and intracellular trafficking of P-glycoprotein-EGFP fusion protein: implications in multidrug resistance in cancer. Int J Cancer 2004;109:174-181.
-
(2004)
Int J Cancer
, vol.109
, pp. 174-181
-
-
Fu, D.1
Bebawy, M.2
Kable, E.P.3
Roufogalis, B.D.4
-
35
-
-
84909586870
-
Comparative characterization of mAb producing hapten-specific hybridoma cells by flow cytometric analysis and ELISA
-
Kuhne M, Dippong M, Flemig S, Hoffmann K, Petsch K, Schenk JA, Kunte HJ, Schneider RJ. Comparative characterization of mAb producing hapten-specific hybridoma cells by flow cytometric analysis and ELISA. J Immunol Methods 2014;413:45-56.
-
(2014)
J Immunol Methods
, vol.413
, pp. 45-56
-
-
Kuhne, M.1
Dippong, M.2
Flemig, S.3
Hoffmann, K.4
Petsch, K.5
Schenk, J.A.6
Kunte, H.J.7
Schneider, R.J.8
|