메뉴 건너뛰기




Volumn 20, Issue , 2015, Pages 8-13

NMDA receptor dysfunction in autism spectrum disorders

Author keywords

[No Author keywords available]

Indexed keywords

AMANTADINE; CYCLOSERINE; MEMANTINE; MEMBRANE PROTEIN; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NEUROLIGIN 1; PROTEIN IRSP53; PROTEIN TBR1; SHANK2 PROTEIN; UNCLASSIFIED DRUG;

EID: 84921980319     PISSN: 14714892     EISSN: 14714973     Source Type: Journal    
DOI: 10.1016/j.coph.2014.10.007     Document Type: Review
Times cited : (150)

References (52)
  • 2
    • 84893844183 scopus 로고    scopus 로고
    • Disentangling the heterogeneity of autism spectrum disorder through genetic findings
    • Jeste SS, Geschwind DH: Disentangling the heterogeneity of autism spectrum disorder through genetic findings. Nat Rev Neurol 2014, 10:74-81.
    • (2014) Nat Rev Neurol , vol.10 , pp. 74-81
    • Jeste, S.S.1    Geschwind, D.H.2
  • 3
    • 84893708713 scopus 로고    scopus 로고
    • A de novo convergence of autism genetics and molecular neuroscience
    • Krumm N, O'Roak BJ, Shendure J, Eichler EE: A de novo convergence of autism genetics and molecular neuroscience. Trends Neurosci 2014, 37:95-105.
    • (2014) Trends Neurosci , vol.37 , pp. 95-105
    • Krumm, N.1    O'Roak, B.J.2    Shendure, J.3    Eichler, E.E.4
  • 4
    • 84869213888 scopus 로고    scopus 로고
    • Synapse dysfunction in autism: A molecular medicine approach to drug discovery in neurodevelopmental disorders
    • Spooren W, Lindemann L, Ghosh A, Santarelli L: Synapse dysfunction in autism: a molecular medicine approach to drug discovery in neurodevelopmental disorders. Trends Pharmacol Sci 2012, 33:669-684.
    • (2012) Trends Pharmacol Sci , vol.33 , pp. 669-684
    • Spooren, W.1    Lindemann, L.2    Ghosh, A.3    Santarelli, L.4
  • 5
    • 84862637069 scopus 로고    scopus 로고
    • The pathophysiology of fragile X (and what it teaches us about synapses)
    • Bhakar AL, Dolen G, Bear MF: The pathophysiology of fragile X (and what it teaches us about synapses). Annu Rev Neurosci 2012, 35:417-443.
    • (2012) Annu Rev Neurosci , vol.35 , pp. 417-443
    • Bhakar, A.L.1    Dolen, G.2    Bear, M.F.3
  • 6
    • 84862659562 scopus 로고    scopus 로고
    • Synaptic dysfunction in neurodevelopmental disorders associated with autism and intellectual disabilities
    • Zoghbi HY, Bear MF: Synaptic dysfunction in neurodevelopmental disorders associated with autism and intellectual disabilities. Cold Spring Harb Perspect Biol 2012:4.
    • (2012) Cold Spring Harb Perspect Biol , pp. 4
    • Zoghbi, H.Y.1    Bear, M.F.2
  • 7
    • 84896722575 scopus 로고    scopus 로고
    • The role of ionotropic glutamate receptors in childhood neurodevelopmental disorders: Autism spectrum disorders and fragile X syndrome
    • Uzunova G, Hollander E, Shepherd J: The role of ionotropic glutamate receptors in childhood neurodevelopmental disorders: autism spectrum disorders and fragile X syndrome. Curr Neuropharmacol 2014, 12:71-98.
    • (2014) Curr Neuropharmacol , vol.12 , pp. 71-98
    • Uzunova, G.1    Hollander, E.2    Shepherd, J.3
  • 13
    • 84862807515 scopus 로고    scopus 로고
    • Family based association of GRIN2A and GRIN2B with Korean autism spectrum disorders
    • Yoo HJ, Cho IH, Park M, Yang SY, Kim SA: Family based association of GRIN2A and GRIN2B with Korean autism spectrum disorders. Neurosci Lett 2012, 512:89-93.
    • (2012) Neurosci Lett , vol.512 , pp. 89-93
    • Yoo, H.J.1    Cho, I.H.2    Park, M.3    Yang, S.Y.4    Kim, S.A.5
  • 14
    • 84878254691 scopus 로고    scopus 로고
    • NMDA receptor subunit diversity: Impact on receptor properties, synaptic plasticity and disease
    • Paoletti P, Bellone C, Zhou Q: NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease. Nat Rev Neurosci 2013, 14:383-400.
    • (2013) Nat Rev Neurosci , vol.14 , pp. 383-400
    • Paoletti, P.1    Bellone, C.2    Zhou, Q.3
  • 16
    • 84901333522 scopus 로고    scopus 로고
    • A trial of D-cycloserine to treat stereotypies in older adolescents and young adults with autism spectrum disorder
    • Urbano M, Okwara L, Manser P, Hartmann K, Herndon A, Deutsch SI: A trial of D-cycloserine to treat stereotypies in older adolescents and young adults with autism spectrum disorder. Clin Neuropharmacol 2014, 37:69-72.
    • (2014) Clin Neuropharmacol , vol.37 , pp. 69-72
    • Urbano, M.1    Okwara, L.2    Manser, P.3    Hartmann, K.4    Herndon, A.5    Deutsch, S.I.6
  • 17
    • 84876933750 scopus 로고    scopus 로고
    • Memantine: A review of possible uses in child and adolescent psychiatry
    • Hosenbocus S, Chahal R: Memantine: a review of possible uses in child and adolescent psychiatry. J Can Acad Child Adolesc Psychiatry 2013, 22:166-171.
    • (2013) J Can Acad Child Adolesc Psychiatry , vol.22 , pp. 166-171
    • Hosenbocus, S.1    Chahal, R.2
  • 18
    • 84873644391 scopus 로고    scopus 로고
    • Amantadine: A review of use in child and adolescent psychiatry
    • Hosenbocus S, Chahal R: Amantadine: a review of use in child and adolescent psychiatry. J Can Acad Child Adolesc Psychiatry 2013, 22:55-60.
    • (2013) J Can Acad Child Adolesc Psychiatry , vol.22 , pp. 55-60
    • Hosenbocus, S.1    Chahal, R.2
  • 19
    • 82555196668 scopus 로고    scopus 로고
    • Mutations causing syndromic autism define an axis of synaptic pathophysiology
    • Auerbach BD, Osterweil EK, Bear MF: Mutations causing syndromic autism define an axis of synaptic pathophysiology. Nature 2011, 480:63-68.
    • (2011) Nature , vol.480 , pp. 63-68
    • Auerbach, B.D.1    Osterweil, E.K.2    Bear, M.F.3
  • 21
    • 34250211762 scopus 로고    scopus 로고
    • Activity-dependent validation of excitatory versus inhibitory synapses by neuroligin-1 versus neuroligin-2
    • Chubykin AA, Atasoy D, Etherton MR, Brose N, Kavalali ET, Gibson JR, Sudhof TC: Activity-dependent validation of excitatory versus inhibitory synapses by neuroligin-1 versus neuroligin-2 . Neuron 2007, 54:919-931.
    • (2007) Neuron , vol.54 , pp. 919-931
    • Chubykin, A.A.1    Atasoy, D.2    Etherton, M.R.3    Brose, N.4    Kavalali, E.T.5    Gibson, J.R.6    Sudhof, T.C.7
  • 24
    • 84862297282 scopus 로고    scopus 로고
    • Autistic-like social behaviour in Shank2-mutant mice improved by restoring NMDA receptor function
    • Won H, Lee HR, Gee HY, Mah W, Kim JI, Lee J, Ha S, Chung C, Jung ES, Cho YS et al.: Autistic-like social behaviour in Shank2-mutant mice improved by restoring NMDA receptor function. Nature 2012, 486:261-265.
    • (2012) Nature , vol.486 , pp. 261-265
    • Won, H.1    Lee, H.R.2    Gee, H.Y.3    Mah, W.4    Kim, J.I.5    Lee, J.6    Ha, S.7    Chung, C.8    Jung, E.S.9    Cho, Y.S.10
  • 25
    • 0034332480 scopus 로고    scopus 로고
    • Activation of metabotropic glutamate receptor 5 has direct excitatory effects and potentiates NMDA receptor currents in neurons of the subthalamic nucleus
    • Awad H, Hubert GW, Smith Y, Levey AI, Conn PJ: Activation of metabotropic glutamate receptor 5 has direct excitatory effects and potentiates NMDA receptor currents in neurons of the subthalamic nucleus. J Neurosci 2000, 20:7871-7879.
    • (2000) J Neurosci , vol.20 , pp. 7871-7879
    • Awad, H.1    Hubert, G.W.2    Smith, Y.3    Levey, A.I.4    Conn, P.J.5
  • 29
    • 84893751460 scopus 로고    scopus 로고
    • Tbr1 haploinsufficiency impairs amygdalar axonal projections and results in cognitive abnormality
    • Huang TN, Chuang HC, Chou WH, Chen CY, Wang HF, Chou SJ, Hsueh YP: Tbr1 haploinsufficiency impairs amygdalar axonal projections and results in cognitive abnormality. Nat Neurosci 2014, 17:240-247.
    • (2014) Nat Neurosci , vol.17 , pp. 240-247
    • Huang, T.N.1    Chuang, H.C.2    Chou, W.H.3    Chen, C.Y.4    Wang, H.F.5    Chou, S.J.6    Hsueh, Y.P.7
  • 31
  • 32
    • 84878804982 scopus 로고    scopus 로고
    • D-Cycloserine improves sociability in the BTBR T+ Itpr3tf/J mouse model of autism spectrum disorders with altered Ras/Raf/ERK1/2 signaling
    • Burket JA, Benson AD, Tang AH, Deutsch SI: D-Cycloserine improves sociability in the BTBR T+ Itpr3tf/J mouse model of autism spectrum disorders with altered Ras/Raf/ERK1/2 signaling. Brain Res Bull 2013, 96:62-70.
    • (2013) Brain Res Bull , vol.96 , pp. 62-70
    • Burket, J.A.1    Benson, A.D.2    Tang, A.H.3    Deutsch, S.I.4
  • 33
    • 76749128438 scopus 로고    scopus 로고
    • Repetitive self-grooming behavior in the BTBR mouse model of autism is blocked by the mGluR5 antagonist MPEP
    • Silverman JL, Tolu SS, Barkan CL, Crawley JN: Repetitive self-grooming behavior in the BTBR mouse model of autism is blocked by the mGluR5 antagonist MPEP. Neuropsychopharmacology 2010, 35:976-989.
    • (2010) Neuropsychopharmacology , vol.35 , pp. 976-989
    • Silverman, J.L.1    Tolu, S.S.2    Barkan, C.L.3    Crawley, J.N.4
  • 35
    • 84887176861 scopus 로고    scopus 로고
    • Balb/c mice treated with Dcycloserine arouse increased social interest in conspecifics
    • Benson AD, Burket JA, Deutsch SI: Balb/c mice treated with Dcycloserine arouse increased social interest in conspecifics. Brain Res Bull 2013, 99:95-99.
    • (2013) Brain Res Bull , vol.99 , pp. 95-99
    • Benson, A.D.1    Burket, J.A.2    Deutsch, S.I.3
  • 37
    • 52949113398 scopus 로고    scopus 로고
    • Expression of NR1, NR2A and NR2B NMDA receptor subunits is not altered in the genetically-inbred Balb/c mouse strain with heightened behavioral sensitivity to MK-801, a noncompetitive NMDA receptor antagonist
    • Perera PY, Lichy JH, Mastropaolo J, Rosse RB, Deutsch SI: Expression of NR1, NR2A and NR2B NMDA receptor subunits is not altered in the genetically-inbred Balb/c mouse strain with heightened behavioral sensitivity to MK-801, a noncompetitive NMDA receptor antagonist. Eur Neuropsychopharmacol 2008, 18:814-819.
    • (2008) Eur Neuropsychopharmacol , vol.18 , pp. 814-819
    • Perera, P.Y.1    Lichy, J.H.2    Mastropaolo, J.3    Rosse, R.B.4    Deutsch, S.I.5
  • 38
    • 84880331581 scopus 로고    scopus 로고
    • Rats selectively bred for low levels of play-induced 50 kHz vocalizations as a model for autism spectrum disorders: A role for NMDA receptors
    • Burgdorf J, Moskal JR, Brudzynski SM, Panksepp J: Rats selectively bred for low levels of play-induced 50 kHz vocalizations as a model for autism spectrum disorders: a role for NMDA receptors. Behav Brain Res 2013, 251:18-24.
    • (2013) Behav Brain Res , vol.251 , pp. 18-24
    • Burgdorf, J.1    Moskal, J.R.2    Brudzynski, S.M.3    Panksepp, J.4
  • 43
    • 84898917488 scopus 로고    scopus 로고
    • Autism-related neuroligin-3 mutation alters social behavior and spatial learning
    • Jaramillo TC, Liu S, Pettersen A, Birnbaum SG, Powell CM: Autism-related neuroligin-3 mutation alters social behavior and spatial learning. Autism Res 2014, 7:264-272.
    • (2014) Autism Res , vol.7 , pp. 264-272
    • Jaramillo, T.C.1    Liu, S.2    Pettersen, A.3    Birnbaum, S.G.4    Powell, C.M.5
  • 45
    • 84877336575 scopus 로고    scopus 로고
    • Autism-associated neuroligin-3 mutations commonly disrupt tonic endocannabinoid signaling
    • Foldy C, Malenka RC, Sudhof TC: Autism-associated neuroligin-3 mutations commonly disrupt tonic endocannabinoid signaling. Neuron 2013, 78:498-509.
    • (2013) Neuron , vol.78 , pp. 498-509
    • Foldy, C.1    Malenka, R.C.2    Sudhof, T.C.3
  • 47
    • 60349108540 scopus 로고    scopus 로고
    • Synaptic ionotropic glutamate receptors and plasticity are developmentally altered in the CA1 field of Fmr1 knockout mice
    • Pilpel Y, Kolleker A, Berberich S, Ginger M, Frick A, Mientjes E, Oostra BA, Seeburg PH: Synaptic ionotropic glutamate receptors and plasticity are developmentally altered in the CA1 field of Fmr1 knockout mice. J Physiol 2009, 587:787-804.
    • (2009) J Physiol , vol.587 , pp. 787-804
    • Pilpel, Y.1    Kolleker, A.2    Berberich, S.3    Ginger, M.4    Frick, A.5    Mientjes, E.6    Oostra, B.A.7    Seeburg, P.H.8
  • 48
    • 34548085412 scopus 로고    scopus 로고
    • Elevated NMDA receptor levels and enhanced postsynaptic long-term potentiation induced by prenatal exposure to valproic acid
    • Rinaldi T, Kulangara K, Antoniello K, Markram H: Elevated NMDA receptor levels and enhanced postsynaptic long-term potentiation induced by prenatal exposure to valproic acid. Proc Natl Acad Sci U S A 2007, 104:13501-13506.
    • Proc Natl Acad Sci U S A 2007 , vol.104 , pp. 13501-13506
    • Rinaldi, T.1    Kulangara, K.2    Antoniello, K.3    Markram, H.4
  • 49
    • 80053929841 scopus 로고    scopus 로고
    • mGluR5-antagonist mediated reversal of elevated stereotyped, repetitive behaviors in the VPA model of autism
    • Mehta MV, Gandal MJ, Siegel SJ: mGluR5-antagonist mediated reversal of elevated stereotyped, repetitive behaviors in the VPA model of autism. PLoS ONE 2011, 6:e26077.
    • (2011) PLoS ONE , vol.6 , pp. e26077
    • Mehta, M.V.1    Gandal, M.J.2    Siegel, S.J.3
  • 52
    • 84863279487 scopus 로고    scopus 로고
    • Deletion of glutamate delta-1 receptor in mouse leads to aberrant emotional and social behaviors
    • Yadav R, Gupta SC, Hillman BG, Bhatt JM, Stairs DJ, Dravid SM: Deletion of glutamate delta-1 receptor in mouse leads to aberrant emotional and social behaviors. PLoS ONE 2012, 7:e32969.
    • (2012) PLoS ONE , vol.7 , pp. e32969
    • Yadav, R.1    Gupta, S.C.2    Hillman, B.G.3    Bhatt, J.M.4    Stairs, D.J.5    Dravid, S.M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.