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Volumn 22, Issue 8, 2016, Pages 839-850

International AIDS Society global scientific strategy: Towards an HIV cure 2016

(55)  Deeks, Steven G a   Lewin, Sharon R b,c   Ross, Anna Laura d   Ananworanich, Jintanat e,f   Benkirane, Monsef g   Cannon, Paula h   Chomont, Nicolas i   Douek, Daniel j   Lifson, Jeffrey D k   Lo, Ying Ru l   Kuritzkes, Daniel m   Margolis, David n   Mellors, John o   Persaud, Deborah p   Tucker, Joseph D q   Barre Sinoussi, Françoise r   Alter, Galit s   Auerbach, Judith a   Autran, Brigitte t,u,v   Barouch, Dan H s,w   more..

d ANRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ACQUIRED IMMUNE DEFICIENCY SYNDROME; CELL ENGINEERING; CELL THERAPY; COHORT ANALYSIS; GENE THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; IMMUNE SYSTEM; IN VITRO STUDY; LATENT PERIOD; LYMPHOCYTE SUBPOPULATION; MEDICAL RESEARCH; MOLECULAR BIOLOGY; NONHUMAN; PRIORITY JOURNAL; PROVIRUS; REMISSION; REVIEW; VIRUS REPLICATION; VIRUS TRANSCRIPTION; ACQUIRED IMMUNODEFICIENCY SYNDROME; HIV INFECTIONS; INTERNATIONAL COOPERATION; MEDICAL SOCIETY; MOTIVATION; ORGANIZATION; RESEARCH;

EID: 84978120368     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.4108     Document Type: Review
Times cited : (359)

References (126)
  • 1
    • 84969715606 scopus 로고    scopus 로고
    • (accessed 23 April 2015)
    • UN Joint Programme on HIV/AIDS (UNAIDS). The Gap Report, 2014; available at: http://www.refworld.org/docid/53f1e1604.html (accessed 23 April 2015).
    • (2014) The Gap Report
  • 3
    • 84864345953 scopus 로고    scopus 로고
    • International AIDS society scientific working group on HIV cure. Towards an HIV cure: A global scientific strategy
    • Deeks, S.G. et al. International AIDS Society Scientific Working Group on HIV Cure. Towards an HIV cure: a global scientific strategy. Nat. Rev. Immunol. 12, 607-614 (2012).
    • (2012) Nat. Rev. Immunol. , vol.12 , pp. 607-614
    • Deeks, S.G.1
  • 4
    • 0029919356 scopus 로고    scopus 로고
    • Transcriptional activation and chromatin remodeling of the HIV-1 promoter in response to histone acetylation
    • Van Lint, C., Emiliani, S., Ott, M. & Verdin, E. Transcriptional activation and chromatin remodeling of the HIV-1 promoter in response to histone acetylation. EMBO J. 15, 1112-1120 (1996).
    • (1996) EMBO J. , vol.15 , pp. 1112-1120
    • Van Lint, C.1    Emiliani, S.2    Ott, M.3    Verdin, E.4
  • 5
    • 0033929108 scopus 로고    scopus 로고
    • The human factors YY1 and LSF repress the human immunodeficiency virus type 1 long terminal repeat via recruitment of histone deacetylase 1
    • Coull, J.J. et al. The human factors YY1 and LSF repress the human immunodeficiency virus type 1 long terminal repeat via recruitment of histone deacetylase 1. J. Virol. 74, 6790-6799 (2000).
    • (2000) J. Virol. , vol.74 , pp. 6790-6799
    • Coull, J.J.1
  • 6
    • 77953313393 scopus 로고    scopus 로고
    • + cells is due to epigenetic transcriptional silencing and P-TEFb restriction
    • + cells is due to epigenetic transcriptional silencing and P-TEFb restriction. J. Virol. 84, 6425-6437 (2010).
    • (2010) J. Virol. , vol.84 , pp. 6425-6437
    • Tyagi, M.1    Pearson, R.J.2    Karn, J.3
  • 7
    • 48649085472 scopus 로고    scopus 로고
    • Orientation-dependent regulation of integrated HIV-1 expression by host gene transcriptional readthrough
    • Han, Y. et al. Orientation-dependent regulation of integrated HIV-1 expression by host gene transcriptional readthrough. Cell Host Microbe 4, 134-146 (2008).
    • (2008) Cell Host Microbe , vol.4 , pp. 134-146
    • Han, Y.1
  • 8
    • 84886769508 scopus 로고    scopus 로고
    • Replication-competent noninduced proviruses in the latent reservoir increase barrier to HIV-1 cure
    • Ho, Y.C. et al. Replication-competent noninduced proviruses in the latent reservoir increase barrier to HIV-1 cure. Cell 155, 540-551 (2013).
    • (2013) Cell , vol.155 , pp. 540-551
    • Ho, Y.C.1
  • 9
    • 77950537810 scopus 로고    scopus 로고
    • HIV-1 replication and immune dynamics are affected by raltegravir intensification of HAART-suppressed subjects
    • Buzón, M.J. et al. HIV-1 replication and immune dynamics are affected by raltegravir intensification of HAART-suppressed subjects. Nat. Med. 16, 460-465 (2010).
    • (2010) Nat. Med. , vol.16 , pp. 460-465
    • Buzón, M.J.1
  • 10
    • 84885411247 scopus 로고    scopus 로고
    • Increase in 2-long terminal repeat circles and decrease in D-dimer after raltegravir intensification in patients with treated HIV infection: A randomized, placebo-controlled trial
    • Hatano, H. et al. Increase in 2-long terminal repeat circles and decrease in D-dimer after raltegravir intensification in patients with treated HIV infection: a randomized, placebo-controlled trial. J. Infect. Dis. 208, 1436-1442 (2013).
    • (2013) J. Infect. Dis. , vol.208 , pp. 1436-1442
    • Hatano, H.1
  • 11
    • 84893830170 scopus 로고    scopus 로고
    • Persistent HIV-1 replication is associated with lower antiretroviral drug concentrations in lymphatic tissues
    • Fletcher, C.V. et al. Persistent HIV-1 replication is associated with lower antiretroviral drug concentrations in lymphatic tissues. Proc. Natl. Acad. Sci. USA 111, 2307-2312 (2014).
    • (2014) Proc. Natl. Acad. Sci. USA , vol.111 , pp. 2307-2312
    • Fletcher, C.V.1
  • 12
    • 84980679261 scopus 로고    scopus 로고
    • Persistent HIV-1 replication maintains the HIV-1 reservoir during therapy
    • (in the press)
    • Lorenzo-Redondol, R. et al. Persistent HIV-1 replication maintains the HIV-1 reservoir during therapy. Nature (in the press).
    • Nature
    • Lorenzo-Redondol, R.1
  • 13
    • 84897437605 scopus 로고    scopus 로고
    • Lack of detectable HIV-1 molecular evolution during suppressive antiretroviral therapy
    • Kearney, M.F. et al. Lack of detectable HIV-1 molecular evolution during suppressive antiretroviral therapy. PLoS Pathog. 10, e1004010 (2014).
    • (2014) PLoS Pathog. , vol.10 , pp. e1004010
    • Kearney, M.F.1
  • 14
    • 84890847660 scopus 로고    scopus 로고
    • The HIV-1 reservoir in eight patients on long-term suppressive antiretroviral therapy is stable with few genetic changes over time
    • Josefsson, L. et al. The HIV-1 reservoir in eight patients on long-term suppressive antiretroviral therapy is stable with few genetic changes over time. Proc. Natl. Acad. Sci. USA 110, E4987-E4996 (2013).
    • (2013) Proc. Natl. Acad. Sci. USA , vol.110 , pp. E4987-E4996
    • Josefsson, L.1
  • 15
    • 84864203255 scopus 로고    scopus 로고
    • Administration of vorinostat disrupts HIV-1 latency in patients on antiretroviral therapy
    • Archin, N.M. et al. Administration of vorinostat disrupts HIV-1 latency in patients on antiretroviral therapy. Nature 487, 482-485 (2012).
    • (2012) Nature , vol.487 , pp. 482-485
    • Archin, N.M.1
  • 16
    • 84943557984 scopus 로고    scopus 로고
    • The depsipeptide romidepsin reverses HIV-1 latency in vivo
    • Søgaard, O.S. et al. The depsipeptide romidepsin reverses HIV-1 latency in vivo. PLoS Pathog. 11, e1005142 (2015).
    • (2015) PLoS Pathog. , vol.11 , pp. e1005142
    • Søgaard, O.S.1
  • 17
    • 84977937246 scopus 로고    scopus 로고
    • Short-term administration of disulfiram for reversal of latent HIV infection: A phase 2 dose-escalation study
    • Elliott, J.H. et al. Short-term administration of disulfiram for reversal of latent HIV infection: a phase 2 dose-escalation study. Lancet HIV 2, e520-e529 (2015).
    • (2015) Lancet HIV , vol.2 , pp. e520-e529
    • Elliott, J.H.1
  • 18
    • 84911460971 scopus 로고    scopus 로고
    • Panobinostat, a histone deacetylase inhibitor, for latent-virus reactivation in HIV-infected patients on suppressive antiretroviral therapy: A phase 1/2, single group, clinical trial
    • Rasmussen, T.A. et al. Panobinostat, a histone deacetylase inhibitor, for latent-virus reactivation in HIV-infected patients on suppressive antiretroviral therapy: a phase 1/2, single group, clinical trial. Lancet HIV 1, e13-e21 (2014).
    • (2014) Lancet HIV , vol.1 , pp. e13-e21
    • Rasmussen, T.A.1
  • 19
    • 84863337769 scopus 로고    scopus 로고
    • Stimulation of HIV-1-specific cytolytic T lymphocytes facilitates elimination of latent viral reservoir after virus reactivation
    • Shan, L. et al. Stimulation of HIV-1-specific cytolytic T lymphocytes facilitates elimination of latent viral reservoir after virus reactivation. Immunity 36, 491-501 (2012).
    • (2012) Immunity , vol.36 , pp. 491-501
    • Shan, L.1
  • 20
    • 84892845657 scopus 로고    scopus 로고
    • + T cells from aviremic patients
    • + T cells from aviremic patients. PLoS Pathog. 9, e1003834 (2013).
    • (2013) PLoS Pathog. , vol.9 , pp. e1003834
    • Spina, C.A.1
  • 21
    • 84928986546 scopus 로고    scopus 로고
    • Ex vivo analysis identifies effective HIV-1 latency-reversing drug combinations
    • Laird, G.M. et al. Ex vivo analysis identifies effective HIV-1 latency-reversing drug combinations. J. Clin. Invest. 125, 1901-1912 (2015).
    • (2015) J. Clin. Invest , vol.125 , pp. 1901-1912
    • Laird, G.M.1
  • 22
    • 84912122037 scopus 로고    scopus 로고
    • Activation of HIV transcription with short-course vorinostat in HIV-infected patients on suppressive antiretroviral therapy
    • Elliott, J.H. et al. Activation of HIV transcription with short-course vorinostat in HIV-infected patients on suppressive antiretroviral therapy. PLoS Pathog. 10, e1004473 (2014).
    • (2014) PLoS Pathog. , vol.10 , pp. e1004473
    • Elliott, J.H.1
  • 24
    • 84958078498 scopus 로고    scopus 로고
    • HIV-1 virion production from single inducible proviruses following T-cell activation ex vivo
    • Bui, J.K., Mellors, J.W. & Cillo, A.R. HIV-1 virion production from single inducible proviruses following T-cell activation ex vivo. J. Virol. 90, 1673-1676 (2015).
    • (2015) J. Virol. , vol.90 , pp. 1673-1676
    • Bui, J.K.1    Mellors, J.W.2    Cillo, A.R.3
  • 25
    • 84879302206 scopus 로고    scopus 로고
    • Interleukin-7 promotes HIV persistence during antiretroviral therapy
    • Vandergeeten, C. et al. Interleukin-7 promotes HIV persistence during antiretroviral therapy. Blood 121, 4321-4329 (2013).
    • (2013) Blood , vol.121 , pp. 4321-4329
    • Vandergeeten, C.1
  • 26
    • 84912530131 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors impair the elimination of HIV-infected cells by cytotoxic T-lymphocytes
    • Jones, R.B. et al. Histone deacetylase inhibitors impair the elimination of HIV-infected cells by cytotoxic T-lymphocytes. PLoS Pathog. 10, e1004287 (2014).
    • (2014) PLoS Pathog. , vol.10 , pp. e1004287
    • Jones, R.B.1
  • 28
    • 84940853263 scopus 로고    scopus 로고
    • The tat inhibitor didehydro-cortistatin A prevents HIV-1 reactivation from latency
    • Mousseau, G. et al. The Tat inhibitor didehydro-cortistatin A prevents HIV-1 reactivation from latency. MBio 6, e00465 (2015).
    • (2015) MBio , vol.6 , pp. e00465
    • Mousseau, G.1
  • 29
    • 84904128252 scopus 로고    scopus 로고
    • Immunologic strategies for HIV-1 remission and eradication
    • Barouch, D.H. & Deeks, S.G. Immunologic strategies for HIV-1 remission and eradication. Science 345, 169-174 (2014).
    • (2014) Science , vol.345 , pp. 169-174
    • Barouch, D.H.1    Deeks, S.G.2
  • 30
    • 68349139711 scopus 로고    scopus 로고
    • HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation
    • Chomont, N. et al. HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation. Nat. Med. 15, 893-900 (2009).
    • (2009) Nat. Med. , vol.15 , pp. 893-900
    • Chomont, N.1
  • 31
    • 84885038080 scopus 로고    scopus 로고
    • The distribution of HIV DNA and RNA in cell subsets differs in gut and blood of HIV-positive patients on ART: Implications for viral persistence
    • Yukl, S.A. et al. The distribution of HIV DNA and RNA in cell subsets differs in gut and blood of HIV-positive patients on ART: implications for viral persistence. J. Infect. Dis. 208, 1212-1220 (2013).
    • (2013) J. Infect. Dis. , vol.208 , pp. 1212-1220
    • Yukl, S.A.1
  • 32
    • 84936946990 scopus 로고    scopus 로고
    • + T cells and can induce remission
    • + T cells and can induce remission. J. Antimicrob. Chemother. 70, 2108-2120 (2015).
    • (2015) J. Antimicrob. Chemother , vol.70 , pp. 2108-2120
    • Chéret, A.1
  • 33
    • 84893761231 scopus 로고    scopus 로고
    • + T cells with stem cell-like properties
    • + T cells with stem cell-like properties. Nat. Med. 20, 139-142 (2014).
    • (2014) Nat. Med. , vol.20 , pp. 139-142
    • Buzon, M.J.1
  • 34
    • 34249800097 scopus 로고    scopus 로고
    • CTL fail to accumulate at sites of HIV-1 replication in lymphoid tissue
    • Connick, E. et al. CTL fail to accumulate at sites of HIV-1 replication in lymphoid tissue. J. Immunol. 178, 6975-6983 (2007).
    • (2007) J. Immunol. , vol.178 , pp. 6975-6983
    • Connick, E.1
  • 35
    • 84922611542 scopus 로고    scopus 로고
    • B cell follicle sanctuary permits persistent productive simian immunodeficiency virus infection in elite controllers
    • Fukazawa, Y. et al. B cell follicle sanctuary permits persistent productive simian immunodeficiency virus infection in elite controllers. Nat. Med. 21, 132-139 (2015).
    • (2015) Nat. Med. , vol.21 , pp. 132-139
    • Fukazawa, Y.1
  • 36
    • 84973131619 scopus 로고    scopus 로고
    • PD-1 and follicular helper T cells are responsible for persistent HIV-1 transcription in treated aviremic individuals
    • Banga, R. et al. PD-1 and follicular helper T cells are responsible for persistent HIV-1 transcription in treated aviremic individuals. Nat. Med. http://dx.doi.org/10.1038/nm.4113 (2016).
    • (2016) Nat. Med.
    • Banga, R.1
  • 37
    • 84907996442 scopus 로고    scopus 로고
    • Tissue myeloid cells in SIV-infected primates acquire viral DNA through phagocytosis of infected T cells
    • Calantone, N. et al. Tissue myeloid cells in SIV-infected primates acquire viral DNA through phagocytosis of infected T cells. Immunity 41, 493-502 (2014).
    • (2014) Immunity , vol.41 , pp. 493-502
    • Calantone, N.1
  • 38
    • 84939879196 scopus 로고    scopus 로고
    • HIV-1 transcriptional regulation in the central nervous system and implications for HIV cure research
    • Churchill, M.J., Cowley, D.J., Wesselingh, S.L., Gorry, P.R. & Gray, L.R. HIV-1 transcriptional regulation in the central nervous system and implications for HIV cure research. J. Neurovirol. 21, 290-300 (2015).
    • (2015) J. Neurovirol. , vol.21 , pp. 290-300
    • Churchill, M.J.1    Cowley, D.J.2    Wesselingh, S.L.3    Gorry, P.R.4    Gray, L.R.5
  • 39
    • 84964575208 scopus 로고    scopus 로고
    • Macrophages sustain HIV replication in vivo independently of T cells
    • Honeycutt, J.B. et al. Macrophages sustain HIV replication in vivo independently of T cells. J. Clin. Invest. 126, 1353-1366 (2016).
    • (2016) J. Clin. Invest , vol.126 , pp. 1353-1366
    • Honeycutt, J.B.1
  • 40
    • 84905917318 scopus 로고    scopus 로고
    • HIV latency. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection
    • Wagner, T.A. et al. HIV latency. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science 345, 570-573 (2014).
    • (2014) Science , vol.345 , pp. 570-573
    • Wagner, T.A.1
  • 41
    • 84904115855 scopus 로고    scopus 로고
    • HIV latency. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells
    • Maldarelli, F. et al. HIV latency. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science 345, 179-183 (2014).
    • (2014) Science , vol.345 , pp. 179-183
    • Maldarelli, F.1
  • 42
    • 84925515846 scopus 로고    scopus 로고
    • + T cells determined by replication-incompetent integrated HIV-1 provirus
    • + T cells determined by replication-incompetent integrated HIV-1 provirus. AIDS 28, 1091-1099 (2014).
    • (2014) AIDS , vol.28 , pp. 1091-1099
    • Imamichi, H.1
  • 43
    • 84959016948 scopus 로고    scopus 로고
    • + T cells can produce infectious HIV-1 in vivo
    • + T cells can produce infectious HIV-1 in vivo. Proc. Natl. Acad. Sci. USA 113, 1883-1888 (2016).
    • (2016) Proc. Natl. Acad. Sci. USA , vol.113 , pp. 1883-1888
    • Simonetti, F.R.1
  • 44
  • 45
    • 84877949177 scopus 로고    scopus 로고
    • VRC 101 study team. Therapeutic vaccination expands and improves the function of the HIV-specific memory T-cell repertoire
    • Casazza, J.P. et al. VRC 101 Study Team. Therapeutic vaccination expands and improves the function of the HIV-specific memory T-cell repertoire. J. Infect. Dis. 207, 1829-1840 (2013).
    • (2013) J. Infect. Dis. , vol.207 , pp. 1829-1840
    • Casazza, J.P.1
  • 46
    • 84877957880 scopus 로고    scopus 로고
    • + T cell epitope recognition paradigms
    • + T cell epitope recognition paradigms. Science 340, 1237874 (2013).
    • (2013) Science , vol.340 , pp. 1237874
    • Hansen, S.G.1
  • 47
    • 84885669019 scopus 로고    scopus 로고
    • Immune clearance of highly pathogenic SIV infection
    • Hansen, S.G. et al. Immune clearance of highly pathogenic SIV infection. Nature 502, 100-104 (2013).
    • (2013) Nature , vol.502 , pp. 100-104
    • Hansen, S.G.1
  • 48
    • 84957928037 scopus 로고    scopus 로고
    • + T cell responses restricted by major histocompatibility complex E
    • + T cell responses restricted by major histocompatibility complex E. Science 351, 714-720 (2016).
    • (2016) Science , vol.351 , pp. 714-720
    • Hansen, S.G.1
  • 49
    • 84907379431 scopus 로고    scopus 로고
    • Broadly neutralizing antibodies and viral inducers decrease rebound from HIV-1 latent reservoirs in humanized mice
    • Halper-Stromberg, A. et al. Broadly neutralizing antibodies and viral inducers decrease rebound from HIV-1 latent reservoirs in humanized mice. Cell 158, 989-999 (2014).
    • (2014) Cell , vol.158 , pp. 989-999
    • Halper-Stromberg, A.1
  • 50
    • 84887626950 scopus 로고    scopus 로고
    • Therapeutic efficacy of potent neutralizing HIV-1-specific monoclonal antibodies in SHIV-infected rhesus monkeys
    • Barouch, D.H. et al. Therapeutic efficacy of potent neutralizing HIV-1-specific monoclonal antibodies in SHIV-infected rhesus monkeys. Nature 503, 224-228 (2013).
    • (2013) Nature , vol.503 , pp. 224-228
    • Barouch, D.H.1
  • 51
    • 84954445565 scopus 로고    scopus 로고
    • VRC 601 study team. Virologic effects of broadly neutralizing antibody VRC01 administration during chronic HIV-1 infection
    • Lynch, R.M. et al. VRC 601 Study Team. Virologic effects of broadly neutralizing antibody VRC01 administration during chronic HIV-1 infection. Sci. Transl. Med. 7, 319ra206 (2015).
    • (2015) Sci. Transl. Med. , vol.7 , pp. 319ra206
    • Lynch, R.M.1
  • 52
    • 84928405730 scopus 로고    scopus 로고
    • Viraemia suppressed in HIV-1-infected humans by broadly neutralizing antibody 3BNC117
    • Caskey, M. et al. Viraemia suppressed in HIV-1-infected humans by broadly neutralizing antibody 3BNC117. Nature 522, 487-491 (2015).
    • (2015) Nature , vol.522 , pp. 487-491
    • Caskey, M.1
  • 53
    • 84906968862 scopus 로고    scopus 로고
    • Broadly neutralizing antibodies suppress HIV in the persistent viral reservoir
    • Chun, T.W. et al. Broadly neutralizing antibodies suppress HIV in the persistent viral reservoir. Proc. Natl. Acad. Sci. USA 111, 13151-13156 (2014).
    • (2014) Proc. Natl. Acad. Sci. USA , vol.111 , pp. 13151-13156
    • Chun, T.W.1
  • 54
    • 84928557851 scopus 로고    scopus 로고
    • Exploring the potential of monoclonal antibody therapeutics for HIV-1 eradication
    • Euler, Z. & Alter, G. Exploring the potential of monoclonal antibody therapeutics for HIV-1 eradication. AIDS Res. Hum. Retroviruses 31, 13-24 (2015).
    • (2015) AIDS Res. Hum. Retroviruses , vol.31 , pp. 13-24
    • Euler, Z.1    Alter, G.2
  • 55
    • 84945162086 scopus 로고    scopus 로고
    • Activation and lysis of human CD4 cells latently infected with HIV-1
    • Pegu, A. et al. Activation and lysis of human CD4 cells latently infected with HIV-1. Nat. Commun. 6, 8447 (2015).
    • (2015) Nat. Commun. , vol.6 , pp. 8447
    • Pegu, A.1
  • 56
    • 84946811219 scopus 로고    scopus 로고
    • Dual-affinity re-targeting proteins direct T cell-mediated cytolysis of latently HIV-infected cells
    • Sung, J.A. et al. Dual-affinity re-targeting proteins direct T cell-mediated cytolysis of latently HIV-infected cells. J. Clin. Invest. 125, 4077-4090 (2015).
    • (2015) J. Clin. Invest , vol.125 , pp. 4077-4090
    • Sung, J.A.1
  • 57
    • 84948807352 scopus 로고    scopus 로고
    • Interleukin-21 combined with ART reduces inflammation and viral reservoir in SIV-infected macaques
    • Micci, L. et al. Interleukin-21 combined with ART reduces inflammation and viral reservoir in SIV-infected macaques. J. Clin. Invest. 125, 4497-4513 (2015).
    • (2015) J. Clin. Invest , vol.125 , pp. 4497-4513
    • Micci, L.1
  • 58
    • 84906970468 scopus 로고    scopus 로고
    • Antiretroviral-free HIV-1 remission and viral rebound after allogeneic stem cell transplantation: Report of 2 cases
    • Henrich, T.J. et al. Antiretroviral-free HIV-1 remission and viral rebound after allogeneic stem cell transplantation: report of 2 cases. Ann. Intern. Med. 161, 319-327 (2014).
    • (2014) Ann. Intern. Med. , vol.161 , pp. 319-327
    • Henrich, T.J.1
  • 59
    • 84899449343 scopus 로고    scopus 로고
    • Reduction of HIV persistence following transplantation in HIV-infected kidney transplant recipients
    • Stock, P.G. et al. Reduction of HIV persistence following transplantation in HIV-infected kidney transplant recipients. Am. J. Transplant. 14, 1136-1141 (2014).
    • (2014) Am. J. Transplant , vol.14 , pp. 1136-1141
    • Stock, P.G.1
  • 60
    • 84922279077 scopus 로고    scopus 로고
    • Effect of ipilimumab on the HIV reservoir in an HIV-infected individual with metastatic melanoma
    • Wightman, F. et al. Effect of ipilimumab on the HIV reservoir in an HIV-infected individual with metastatic melanoma. AIDS 29, 504-506 (2015).
    • (2015) AIDS , vol.29 , pp. 504-506
    • Wightman, F.1
  • 61
    • 78650084232 scopus 로고    scopus 로고
    • The major genetic determinants of HIV-1 control affect HLA class I peptide presentation
    • International HIV Controllers Study. et al. The major genetic determinants of HIV-1 control affect HLA class I peptide presentation. Science 330, 1551-1557 (2010).
    • (2010) Science , vol.330 , pp. 1551-1557
  • 62
    • 84875985311 scopus 로고    scopus 로고
    • ANRS VISCONTI study group. Post-treatment HIV-1 controllers with a long-term virological remission after the interruption of early initiated antiretroviral therapy ANRS VISCONTI study
    • Sáez-Cirión, A. et al. ANRS VISCONTI Study Group. Post-treatment HIV-1 controllers with a long-term virological remission after the interruption of early initiated antiretroviral therapy ANRS VISCONTI Study. PLoS Pathog. 9, e1003211 (2013).
    • (2013) PLoS Pathog. , vol.9 , pp. e1003211
    • Sáez-Cirión, A.1
  • 63
    • 84952896973 scopus 로고    scopus 로고
    • ANRS EPF-CO10 pediatric cohort and the ANRS EP47 VISCONTI study group. HIV-1 virological remission lasting more than 12 years after interruption of early antiretroviral therapy in a perinatally infected teenager enrolled in the French ANRS EPF-CO10 paediatric cohort: A case report
    • Frange, P. et al. ANRS EPF-CO10 Pediatric Cohort and the ANRS EP47 VISCONTI study group. HIV-1 virological remission lasting more than 12 years after interruption of early antiretroviral therapy in a perinatally infected teenager enrolled in the French ANRS EPF-CO10 paediatric cohort: a case report. Lancet HIV 3, e49-e54 (2016).
    • (2016) Lancet HIV , vol.3 , pp. e49-e54
    • Frange, P.1
  • 64
    • 84905565097 scopus 로고    scopus 로고
    • Rapid seeding of the viral reservoir prior to SIV viraemia in rhesus monkeys
    • Whitney, J.B. et al. Rapid seeding of the viral reservoir prior to SIV viraemia in rhesus monkeys. Nature 512, 74-77 (2014).
    • (2014) Nature , vol.512 , pp. 74-77
    • Whitney, J.B.1
  • 65
    • 84893815335 scopus 로고    scopus 로고
    • Targeted cytotoxic therapy kills persisting HIV infected cells during ART
    • Denton, P.W. et al. Targeted cytotoxic therapy kills persisting HIV infected cells during ART. PLoS Pathog. 10, e1003872 (2014).
    • (2014) PLoS Pathog. , vol.10 , pp. e1003872
    • Denton, P.W.1
  • 66
    • 84960426869 scopus 로고    scopus 로고
    • Elevated plasma viral loads in romidepsin-treated simian immunodeficiency virus-infected rhesus macaques on suppressive combination antiretroviral therapy
    • Del Prete, G.Q. et al. Elevated plasma viral loads in romidepsin-treated simian immunodeficiency virus-infected rhesus macaques on suppressive combination antiretroviral therapy. Antimicrob. Agents Chemother. 60, 1560-1572 (2015).
    • (2015) Antimicrob. Agents Chemother , vol.60 , pp. 1560-1572
    • Del Prete, G.Q.1
  • 67
    • 84855982473 scopus 로고    scopus 로고
    • HIV latency in the humanized BLT mouse
    • Marsden, M.D. et al. HIV latency in the humanized BLT mouse. J. Virol. 86, 339-347 (2012).
    • (2012) J. Virol. , vol.86 , pp. 339-347
    • Marsden, M.D.1
  • 68
    • 84930742652 scopus 로고    scopus 로고
    • Pediatric HIV/AIDS cohort study. Influence of age at virologic control on peripheral blood human immunodeficiency virus reservoir size and serostatus in perinatally infected adolescents
    • Persaud, D. et al. Pediatric HIV/AIDS Cohort Study. Influence of age at virologic control on peripheral blood human immunodeficiency virus reservoir size and serostatus in perinatally infected adolescents. JAMA Pediatr. 168, 1138-1146 (2014).
    • (2014) JAMA Pediatr , vol.168 , pp. 1138-1146
    • Persaud, D.1
  • 69
    • 84897553850 scopus 로고    scopus 로고
    • HIV-NAT 194 study group. Reduced markers of HIV persistence and restricted HIV-specific immune responses after early antiretroviral therapy in children
    • Ananworanich, J. et al. HIV-NAT 194 Study Group. Reduced markers of HIV persistence and restricted HIV-specific immune responses after early antiretroviral therapy in children. AIDS 28, 1015-1020 (2014).
    • (2014) AIDS , vol.28 , pp. 1015-1020
    • Ananworanich, J.1
  • 70
    • 84954031399 scopus 로고    scopus 로고
    • Cell-associated HIV-1 DNA and RNA decay dynamics during early combination antiretroviral therapy in HIV-1-infected infants
    • Uprety, P. et al. Cell-associated HIV-1 DNA and RNA decay dynamics during early combination antiretroviral therapy in HIV-1-infected infants. Clin. Infect. Dis. 61, 1862-1870 (2015).
    • (2015) Clin. Infect. Dis. , vol.61 , pp. 1862-1870
    • Uprety, P.1
  • 72
    • 60549090253 scopus 로고    scopus 로고
    • Long-term control of HIV by CCR5 Δ32/Δ32 stem-cell transplantation
    • Hütter, G. et al. Long-term control of HIV by CCR5 Δ32/Δ32 stem-cell transplantation. N. Engl. J. Med. 360, 692-698 (2009).
    • (2009) N. Engl. J. Med. , vol.360 , pp. 692-698
    • Hütter, G.1
  • 73
    • 79953123523 scopus 로고    scopus 로고
    • Chemokine receptor 5 knockout strategies
    • Cannon, P. & June, C. Chemokine receptor 5 knockout strategies. Curr. Opin. HIV AIDS 6, 74-79 (2011).
    • (2011) Curr. Opin. HIV AIDS , vol.6 , pp. 74-79
    • Cannon, P.1    June, C.2
  • 74
    • 77955608799 scopus 로고    scopus 로고
    • + cells in patients undergoing transplantation for AIDS-related lymphoma
    • + cells in patients undergoing transplantation for AIDS-related lymphoma. Sci. Transl. Med. 2, 36ra43 (2010).
    • (2010) Sci. Transl. Med. , vol.2 , pp. 36ra43
    • DiGiusto, D.L.1
  • 75
    • 84884485564 scopus 로고    scopus 로고
    • + T cells and maintenance of virus specific immunity in a primate AIDS model
    • + T cells and maintenance of virus specific immunity in a primate AIDS model. Blood 122, 179-187 (2013).
    • (2013) Blood , vol.122 , pp. 179-187
    • Younan, P.M.1
  • 76
    • 84905643812 scopus 로고    scopus 로고
    • RNA-directed gene editing specifically eradicates latent and prevents new HIV-1 infection
    • Hu, W. et al. RNA-directed gene editing specifically eradicates latent and prevents new HIV-1 infection. Proc. Natl. Acad. Sci. USA 111, 11461-11466 (2014).
    • (2014) Proc. Natl. Acad. Sci. USA , vol.111 , pp. 11461-11466
    • Hu, W.1
  • 77
    • 84861206611 scopus 로고    scopus 로고
    • In vivo suppression of HIV by antigen specific T cells derived from engineered hematopoietic stem cells
    • Kitchen, S.G. et al. In vivo suppression of HIV by antigen specific T cells derived from engineered hematopoietic stem cells. PLoS Pathog. 8, e1002649 (2012).
    • (2012) PLoS Pathog. , vol.8 , pp. e1002649
    • Kitchen, S.G.1
  • 78
    • 84876325876 scopus 로고    scopus 로고
    • Chimeric antigen receptor-modified T cells for acute lymphoid leukemia
    • Grupp, S.A. et al. Chimeric antigen receptor-modified T cells for acute lymphoid leukemia. N. Engl. J. Med. 368, 1509-1518 (2013).
    • (2013) N. Engl. J. Med. , vol.368 , pp. 1509-1518
    • Grupp, S.A.1
  • 79
    • 84908073316 scopus 로고    scopus 로고
    • Chimeric antigen receptor T cells for sustained remissions in leukemia
    • Maude, S.L. et al. Chimeric antigen receptor T cells for sustained remissions in leukemia. N. Engl. J. Med. 371, 1507-1517 (2014).
    • (2014) N. Engl. J. Med. , vol.371 , pp. 1507-1517
    • Maude, S.L.1
  • 80
    • 84896120124 scopus 로고    scopus 로고
    • Vectored immunoprophylaxis protects humanized mice from mucosal HIV transmission
    • Balazs, A.B. et al. Vectored immunoprophylaxis protects humanized mice from mucosal HIV transmission. Nat. Med. 20, 296-300 (2014).
    • (2014) Nat. Med. , vol.20 , pp. 296-300
    • Balazs, A.B.1
  • 81
    • 84924375707 scopus 로고    scopus 로고
    • AAV-expressed eCD4-Ig provides durable protection from multiple SHIV challenges
    • Gardner, M.R. et al. AAV-expressed eCD4-Ig provides durable protection from multiple SHIV challenges. Nature 519, 87-91 (2015).
    • (2015) Nature , vol.519 , pp. 87-91
    • Gardner, M.R.1
  • 82
    • 84922572646 scopus 로고    scopus 로고
    • Genetic engineering of hematopoietic stem cells to generate invariant natural killer T cells
    • Smith, D.J. et al. Genetic engineering of hematopoietic stem cells to generate invariant natural killer T cells. Proc. Natl. Acad. Sci. USA 112, 1523-1528 (2015).
    • (2015) Proc. Natl. Acad. Sci. USA , vol.112 , pp. 1523-1528
    • Smith, D.J.1
  • 83
    • 84895487305 scopus 로고    scopus 로고
    • Gene editing of CCR5 in autologous CD4 T cells of persons infected with HIV
    • Tebas, P. et al. Gene editing of CCR5 in autologous CD4 T cells of persons infected with HIV. N. Engl. J. Med. 370, 901-910 (2014).
    • (2014) N. Engl. J. Med. , vol.370 , pp. 901-910
    • Tebas, P.1
  • 84
    • 77955008489 scopus 로고    scopus 로고
    • Efficient and stable MGMT-mediated selection of long-term repopulating stem cells in nonhuman primates
    • Beard, B.C. et al. Efficient and stable MGMT-mediated selection of long-term repopulating stem cells in nonhuman primates. J. Clin. Invest. 120, 2345-2354 (2010).
    • (2010) J. Clin. Invest , vol.120 , pp. 2345-2354
    • Beard, B.C.1
  • 85
    • 84878482232 scopus 로고    scopus 로고
    • Rapid quantification of the latent reservoir for HIV-1 using a viral outgrowth assay
    • Laird, G.M. et al. Rapid quantification of the latent reservoir for HIV-1 using a viral outgrowth assay. PLoS Pathog. 9, e1003398 (2013).
    • (2013) PLoS Pathog. , vol.9 , pp. e1003398
    • Laird, G.M.1
  • 86
    • 23744500093 scopus 로고    scopus 로고
    • Depletion of latent HIV-1 infection in vivo: A proof-of-concept study
    • Lehrman, G. et al. Depletion of latent HIV-1 infection in vivo: a proof-of-concept study. Lancet 366, 549-555 (2005).
    • (2005) Lancet , vol.366 , pp. 549-555
    • Lehrman, G.1
  • 87
    • 84946096080 scopus 로고    scopus 로고
    • Precise quantitation of the latent HIV-1 reservoir: Implications for eradication strategies
    • Crooks, A.M. et al. Precise quantitation of the latent HIV-1 reservoir: implications for eradication strategies. J. Infect. Dis. 212, 1361-1365 (2015).
    • (2015) J. Infect. Dis. , vol.212 , pp. 1361-1365
    • Crooks, A.M.1
  • 88
    • 84900473405 scopus 로고    scopus 로고
    • + T cells from patients on suppressive antiretroviral therapy
    • + T cells from patients on suppressive antiretroviral therapy. Proc. Natl. Acad. Sci. USA 111, 7078-7083 (2014).
    • (2014) Proc. Natl. Acad. Sci. USA , vol.111 , pp. 7078-7083
    • Cillo, A.R.1
  • 89
    • 84951574056 scopus 로고    scopus 로고
    • A novel assay to measure the magnitude of the inducible viral reservoir in HIV-infected individuals
    • Procopio, F.A. et al. A novel assay to measure the magnitude of the inducible viral reservoir in HIV-infected individuals. EBioMedicine 2, 872-881 (2015).
    • (2015) EBioMedicine , vol.2 , pp. 872-881
    • Procopio, F.A.1
  • 90
    • 84946147894 scopus 로고    scopus 로고
    • A murine viral outgrowth assay to detect residual HIV type 1 in patients with undetectable viral loads
    • Metcalf Pate, K.A. et al. A murine viral outgrowth assay to detect residual HIV type 1 in patients with undetectable viral loads. J. Infect. Dis. 212, 1387-1396 (2015).
    • (2015) J. Infect. Dis. , vol.212 , pp. 1387-1396
    • Metcalf Pate, K.A.1
  • 91
    • 84873472629 scopus 로고    scopus 로고
    • Comparative analysis of measures of viral reservoirs in HIV-1 eradication studies
    • Eriksson, S. et al. Comparative analysis of measures of viral reservoirs in HIV-1 eradication studies. PLoS Pathog. 9, e1003174 (2013).
    • (2013) PLoS Pathog. , vol.9 , pp. e1003174
    • Eriksson, S.1
  • 92
    • 84899573008 scopus 로고    scopus 로고
    • HIV antibody characterization as a method to quantify reservoir size during curative interventions
    • Burbelo, P.D. et al. HIV antibody characterization as a method to quantify reservoir size during curative interventions. J. Infect. Dis. 209, 1613-1617 (2014).
    • (2014) J. Infect. Dis. , vol.209 , pp. 1613-1617
    • Burbelo, P.D.1
  • 93
    • 84925375640 scopus 로고    scopus 로고
    • HIV-1 DNA predicts disease progression and post-treatment virological control
    • Williams, J.P. et al. HIV-1 DNA predicts disease progression and post-treatment virological control. eLife 3, e03821 (2014).
    • (2014) ELife , vol.3 , pp. e03821
    • Williams, J.P.1
  • 94
    • 84957845066 scopus 로고    scopus 로고
    • The size of the expressed HIV reservoir predicts timing of viral rebound after treatment interruption
    • Li, J.Z. et al. The size of the expressed HIV reservoir predicts timing of viral rebound after treatment interruption. AIDS 30, 343-353 (2016).
    • (2016) AIDS , vol.30 , pp. 343-353
    • Li, J.Z.1
  • 95
    • 84893732794 scopus 로고    scopus 로고
    • Absence of HIV-1 after treatment cessation in an infant
    • Persaud, D. & Luzuriaga, K. Absence of HIV-1 after treatment cessation in an infant. N. Engl. J. Med. 370, 678 (2014).
    • (2014) N. Engl. J. Med. , vol.370 , pp. 678
    • Persaud, D.1    Luzuriaga, K.2
  • 96
    • 84928880432 scopus 로고    scopus 로고
    • Whole-body immunoPET reveals active SIV dynamics in viremic and antiretroviral therapy-treated macaques
    • Santangelo, P.J. et al. Whole-body immunoPET reveals active SIV dynamics in viremic and antiretroviral therapy-treated macaques. Nat. Methods 12, 427-432 (2015).
    • (2015) Nat. Methods , vol.12 , pp. 427-432
    • Santangelo, P.J.1
  • 98
    • 84894554674 scopus 로고    scopus 로고
    • + T cells during antiretroviral therapy
    • + T cells during antiretroviral therapy. J. Virol. 88, 3516-3526 (2014).
    • (2014) J. Virol. , vol.88 , pp. 3516-3526
    • Murray, J.M.1
  • 99
    • 84980621492 scopus 로고    scopus 로고
    • + T-cells in HIV-infected individuals on antiretroviral therapy
    • (in the press)
    • + T-cells in HIV-infected individuals on antiretroviral therapy. AIDS (in the press).
    • AIDS
    • Khoury, G.1
  • 100
    • 84988723073 scopus 로고    scopus 로고
    • Dendritic cell type-specific HIV-1 activation in effector T cells: Implications for latent HIV-1 reservoir establishment
    • van der Sluis, R.M. et al. Dendritic cell type-specific HIV-1 activation in effector T cells: implications for latent HIV-1 reservoir establishment. AIDS 29, 1003-1014 (2015).
    • (2015) AIDS , vol.29 , pp. 1003-1014
    • Van Der-Sluis, R.M.1
  • 101
    • 84922479914 scopus 로고    scopus 로고
    • Social and ethical implications of HIV cure research
    • Tucker, J.D., Rennie, S. & Social and Ethical Working Group on HIV Cure. Social and ethical implications of HIV cure research. AIDS 28, 1247-1250 (2014).
    • (2014) AIDS , vol.28 , pp. 1247-1250
    • Tucker, J.D.1    Rennie, S.2
  • 102
    • 84937132239 scopus 로고    scopus 로고
    • The ethics of HIV "cure" research: What can we learn from consent forms?
    • Henderson, G.E. The ethics of HIV "cure" research: what can we learn from consent forms? AIDS Res. Hum. Retroviruses 31, 56-63 (2015).
    • (2015) AIDS Res. Hum. Retroviruses , vol.31 , pp. 56-63
    • Henderson, G.E.1
  • 103
    • 84937123279 scopus 로고    scopus 로고
    • What motivates participation in HIV cure trials? A call for real-time assessment to improve informed consent
    • Peay, H.L. & Henderson, G.E. What motivates participation in HIV cure trials? A call for real-time assessment to improve informed consent. J. Virus Erad. 1, 51-53 (2015).
    • (2015) J. Virus Erad. , vol.1 , pp. 51-53
    • Peay, H.L.1    Henderson, G.E.2
  • 104
    • 84959206972 scopus 로고    scopus 로고
    • HIV cure research in South Africa: A preliminary exploration of stakeholder perspectives
    • Moodley, K., Staunton, C., de Roubaix, M. & Cotton, M. HIV cure research in South Africa: a preliminary exploration of stakeholder perspectives. AIDS Care 28, 524-527 (2016).
    • (2016) AIDS Care , vol.28 , pp. 524-527
    • Moodley, K.1    Staunton, C.2    De Roubaix, M.3    Cotton, M.4
  • 105
    • 84937124578 scopus 로고    scopus 로고
    • Exploring the social meaning of curing HIV: A qualitative study of people who inject drugs in guangzhou, China
    • Chu, C.E. et al. Exploring the social meaning of curing HIV: a qualitative study of people who inject drugs in Guangzhou, China. AIDS Res. Hum. Retroviruses 31, 78-84 (2015).
    • (2015) AIDS Res. Hum. Retroviruses , vol.31 , pp. 78-84
    • Chu, C.E.1
  • 106
    • 84934285482 scopus 로고    scopus 로고
    • Stakeholder engagement in HIV cure research: Lessons learned from other HIV interventions and the way forward
    • Lo, Y.R., Chu, C., Ananworanich, J., Excler, J.L. & Tucker, J.D. Stakeholder engagement in HIV cure research: Lessons learned from other HIV interventions and the way forward. AIDS Patient Care STDS 29, 389-399 (2015).
    • (2015) AIDS Patient Care STDS , vol.29 , pp. 389-399
    • Lo, Y.R.1    Chu, C.2    Ananworanich, J.3    Excler, J.L.4    Tucker, J.D.5
  • 107
    • 84909581907 scopus 로고    scopus 로고
    • Advancing community stakeholder engagement in biomedical HIV prevention trials: Principles, practices and evidence
    • Newman, P.A. & Rubincam, C. Advancing community stakeholder engagement in biomedical HIV prevention trials: principles, practices and evidence. Expert Rev. Vaccines 13, 1553-1562 (2014).
    • (2014) Expert Rev. Vaccines , vol.13 , pp. 1553-1562
    • Newman, P.A.1    Rubincam, C.2
  • 108
    • 84911935103 scopus 로고    scopus 로고
    • HIV cure strategies: How good must they be to improve on current antiretroviral therapy?
    • Sax, P.E. et al. HIV cure strategies: how good must they be to improve on current antiretroviral therapy? PLoS One 9, e113031 (2014).
    • (2014) PLoS One , vol.9 , pp. e113031
    • Sax, P.E.1
  • 109
    • 84969443462 scopus 로고    scopus 로고
    • The HIV cure research agenda: The role of mathematical modelling and cost-effectiveness analysis
    • Freedberg, K.A. et al. The HIV cure research agenda: the role of mathematical modelling and cost-effectiveness analysis. J. Virus Erad. 1, 245-249 (2015).
    • (2015) J. Virus Erad. , vol.1 , pp. 245-249
    • Freedberg, K.A.1
  • 110
    • 42049104398 scopus 로고    scopus 로고
    • Dangerous medicines: Unproven AIDS cures and counterfeit antiretroviral drugs
    • Amon, J.J. Dangerous medicines: unproven AIDS cures and counterfeit antiretroviral drugs. Global. Health 4, 5 (2008).
    • (2008) Global. Health , vol.4 , pp. 5
    • Amon, J.J.1
  • 111
    • 84878503062 scopus 로고    scopus 로고
    • Challenges in detecting HIV persistence during potentially curative interventions: A study of the Berlin patient
    • Yukl, S.A. et al. Challenges in detecting HIV persistence during potentially curative interventions: a study of the Berlin patient. PLoS Pathog. 9, e1003347 (2013).
    • (2013) PLoS Pathog. , vol.9 , pp. e1003347
    • Yukl, S.A.1
  • 112
    • 84904545962 scopus 로고    scopus 로고
    • An HIV cure: Feasibility, discovery, and implementation
    • Fauci, A.S., Marston, H.D. & Folkers, G.K. An HIV cure: feasibility, discovery, and implementation. J. Am. Med. Assoc. 312, 335-336 (2014).
    • (2014) J. Am. Med. Assoc. , vol.312 , pp. 335-336
    • Fauci, A.S.1    Marston, H.D.2    Folkers, G.K.3
  • 114
    • 84887028999 scopus 로고    scopus 로고
    • Absence of detectable HIV-1 viremia after treatment cessation in an infant
    • Persaud, D. et al. Absence of detectable HIV-1 viremia after treatment cessation in an infant. N. Engl. J. Med. 369, 1828-1835 (2013).
    • (2013) N. Engl. J. Med. , vol.369 , pp. 1828-1835
    • Persaud, D.1
  • 115
    • 84855927237 scopus 로고    scopus 로고
    • Generation of HIV latency in humanized BLT mice
    • Denton, P.W. et al. Generation of HIV latency in humanized BLT mice. J. Virol. 86, 630-634 (2012).
    • (2012) J. Virol. , vol.86 , pp. 630-634
    • Denton, P.W.1
  • 116
    • 84922764937 scopus 로고    scopus 로고
    • Broad CTL response is required to clear latent HIV-1 due to dominance of escape mutations
    • Deng, K. et al. Broad CTL response is required to clear latent HIV-1 due to dominance of escape mutations. Nature 517, 381-385 (2015).
    • (2015) Nature , vol.517 , pp. 381-385
    • Deng, K.1
  • 117
    • 84862189831 scopus 로고    scopus 로고
    • + cell HIV-1 infection without accelerating the decay of latent infection
    • + cell HIV-1 infection without accelerating the decay of latent infection. Proc. Natl. Acad. Sci. USA 109, 9523-9528 (2012).
    • (2012) Proc. Natl. Acad. Sci. USA , vol.109 , pp. 9523-9528
    • Archin, N.M.1
  • 118
    • 84944258447 scopus 로고    scopus 로고
    • Immunological biomarkers predict HIV-1 viral rebound after treatment interruption
    • Hurst, J. et al. Immunological biomarkers predict HIV-1 viral rebound after treatment interruption. Nat. Commun. 6, 8495 (2015).
    • (2015) Nat. Commun. , vol.6 , pp. 8495
    • Hurst, J.1
  • 119
    • 84965028141 scopus 로고    scopus 로고
    • ANRS 116 SALTO study group. A low HIV-DNA level in peripheral blood mononuclear cells at antiretroviral treatment interruption predicts a higher probability of maintaining viral control
    • Assoumou, L. et al. ANRS 116 SALTO study group. A low HIV-DNA level in peripheral blood mononuclear cells at antiretroviral treatment interruption predicts a higher probability of maintaining viral control. AIDS 29, 2003-2007 (2015).
    • (2015) AIDS , vol.29 , pp. 2003-2007
    • Assoumou, L.1
  • 120
    • 84952944336 scopus 로고    scopus 로고
    • EraMune-01 study team. Treatment intensification followed by interleukin-7 reactivates HIV without reducing total HIV DNA: A randomized trial
    • Katlama, C. et al. EraMune-01 study team. Treatment intensification followed by interleukin-7 reactivates HIV without reducing total HIV DNA: a randomized trial. AIDS 30, 221-230 (2016).
    • (2016) AIDS , vol.30 , pp. 221-230
    • Katlama, C.1
  • 121
    • 84957558724 scopus 로고    scopus 로고
    • Persistent HIV-1 replication maintains the tissue reservoir during therapy
    • Lorenzo-Redondo, R. et al. Persistent HIV-1 replication maintains the tissue reservoir during therapy. Nature 530, 51-56 (2016).
    • (2016) Nature , vol.530 , pp. 51-56
    • Lorenzo-Redondo, R.1
  • 122
    • 84888293183 scopus 로고    scopus 로고
    • Entinostat is a histone deacetylase inhibitor selective for class 1 histone deacetylases and activates HIV production from latently infected primary T cells
    • Wightman, F. et al. Entinostat is a histone deacetylase inhibitor selective for class 1 histone deacetylases and activates HIV production from latently infected primary T cells. AIDS 27, 2853-2862 (2013).
    • (2013) AIDS , vol.27 , pp. 2853-2862
    • Wightman, F.1
  • 123
    • 84904718063 scopus 로고    scopus 로고
    • Reactivation of HIV latency by a newly modified ingenol derivative via protein kinase Cδ-NF-κB signaling
    • Jiang, G. et al. Reactivation of HIV latency by a newly modified Ingenol derivative via protein kinase Cδ-NF-κB signaling. AIDS 28, 1555-1566 (2014).
    • (2014) AIDS , vol.28 , pp. 1555-1566
    • Jiang, G.1
  • 124
    • 84875525579 scopus 로고    scopus 로고
    • BET bromodomain-targeting compounds reactivate HIV from latency via a tat-independent mechanism
    • Boehm, D. et al. BET bromodomain-targeting compounds reactivate HIV from latency via a Tat-independent mechanism. Cell Cycle 12, 452-462 (2013).
    • (2013) Cell Cycle , vol.12 , pp. 452-462
    • Boehm, D.1
  • 125
    • 84911460971 scopus 로고    scopus 로고
    • Panobinostat, a histone deacetylase inhibitor, for latent-virus reactivation in HIV-infected patients on suppressive antiretroviral therapy: A phase 1/2, single group, clinical trial
    • Rasmussen, T.A. et al. Panobinostat, a histone deacetylase inhibitor, for latent-virus reactivation in HIV-infected patients on suppressive antiretroviral therapy: a phase 1/2, single group, clinical trial. Lancet HIV 1, e13-e21 (2014).
    • (2014) Lancet HIV , vol.1 , pp. e13-e21
    • Rasmussen, T.A.1
  • 126
    • 79957618772 scopus 로고    scopus 로고
    • Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine
    • Hansen, S.G. et al. Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine. Nature 473, 523-527 (2011).
    • (2011) Nature , vol.473 , pp. 523-527
    • Hansen, S.G.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.