Positive selection of mC46-expressing CD4+ T cells and maintenance of virus specific immunity in a primate AIDS model

Blood

Volumn 122, Issue 2, 2013, Pages 179-187

  Younan, Patrick M ^a   Polacino, Patricia ^b,c   Kowalski, John P ^a   Peterson, Christopher W ^a   Maurice, Nicholas J ^a   Williams, Nathaniel P ^a   Ho, On ^b,c   Trobridge, Grant D ^d   Von Laer, Dorothee ^e   Prlic, Martin ^a   Beard, Brian C ^a   DeRosa, Stephen ^a   Hu, Shiu Lok ^b,c   Kiem, Hans Peter ^a,b  

^a Fred Hutchinson Cancer Research Center   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c Washington National Primate Research Center   (United States)

^d WASHINGTON STATE UNIVERSITY   (United States)

^e INNSBRUCK MEDICAL UNIVERSITY   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

GREEN FLUORESCENT PROTEIN; MC 46 PEPTIDE; PEPTIDE; UNCLASSIFIED DRUG; VIRUS RNA; C46 HIV 1 FUSION INHIBITORY PEPTIDE; C46 HIV-1 FUSION INHIBITORY PEPTIDE; HYBRID PROTEIN; VIRUS ANTIGEN;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY RESPONSE; ARTICLE; AUTOLOGOUS HEMATOPOIETIC STEM CELL TRANSPLANTATION; B LYMPHOCYTE; BLOOD; CD4 LYMPHOCYTE COUNT; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL SELECTION; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; GASTROINTESTINAL TRACT; GENE FREQUENCY; HEMATOPOIETIC STEM CELL; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LYMPH NODE; LYMPHOCYTE FUNCTION; MACACA NEMESTRINA; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIMIAN HUMAN IMMUNODEFICIENCY VIRUS; SIMIAN VIRUS; ANIMAL; BIOLOGICAL THERAPY; CD4 CD8 RATIO; GENE EXPRESSION; GENETICS; HEMATOPOIETIC STEM CELL TRANSPLANTATION; IMMUNOLOGY; METABOLISM; SIMIAN ACQUIRED IMMUNODEFICIENCY SYNDROME; SIMIAN IMMUNODEFICIENCY VIRUS; VIREMIA; VIROLOGY; VIRUS LOAD;

ANIMALS; ANTIGENS, VIRAL; B-LYMPHOCYTES; CD4 LYMPHOCYTE COUNT; CD4-CD8 RATIO; CD4-POSITIVE T-LYMPHOCYTES; GENE EXPRESSION; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HEMATOPOIETIC STEM CELLS; MACACA NEMESTRINA; RECOMBINANT FUSION PROTEINS; SIMIAN ACQUIRED IMMUNODEFICIENCY SYNDROME; SIMIAN IMMUNODEFICIENCY VIRUS; TISSUE THERAPY; VIRAL LOAD; VIREMIA;

EID: 84884485564     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2013-01-482224     Document Type: Article

References (44)

1. Yeni PG, Hammer SM, Hirsch MS, et al. Treatment for adult HIV infection: 2004 recommendations of the International AIDS Society-USA Panel. JAMA. 2004;292(2):251-265. (Pubitemid 38918003)
2. Carr A. Toxicity of antiretroviral therapy and implications for drug development [Review]. Nat Rev Drug Discov. 2003;2(8):624-634. (Pubitemid 37361766)
3. Louie M, Hogan C, Di Mascio M, et al. Determining the relative efficacy of highly active antiretroviral therapy. J Infect Dis. 2003;187(6):896-900. (Pubitemid 36337901)
4. Autran B, Carcelain G, Li TS, et al. Positive effects of combined antiretroviral therapy on CD4+ T cell homeostasis and function in advanced HIV disease. Science. 1997;277(5322):112-116. (Pubitemid 27450659)
5. Autran B. Strategies toward restoration of immunity to HIV. AIDS. 2002;16(10):4-6. (Pubitemid 34722091)
6. Hirsch MS, Brun-Vézinet F, Clotet B, et al. Antiretroviral drug resistance testing in adults infected with human immunodeficiency virus type 1: 2003 recommendations of an International AIDS Society-USA Panel. Clin Infect Dis. 2003;37(1):113-128. (Pubitemid 36836653)
7. Eshleman SH, Krogstad P, Jackson JB, et al. Analysis of human immunodeficiency virus type 1 drug resistance in children receiving nucleoside analogue reverse-transcriptase inhibitors plus nevirapine, nelfinavir, or ritonavir (Pediatric AIDS Clinical Trials Group 377). J Infect Dis. 2001;183(12):1732-1738. (Pubitemid 32523235)
8. Smith KA. To cure chronic HIV infection, a new therapeutic strategy is needed [Review]. Curr Opin Immunol. 2001;13(5):617-624. (Pubitemid 32817045)
9. Hütter G, Nowak D, Mossner M, et al. Long-term control of HIV by CCR5 Delta32/Delta32 stem-cell transplantation. N Engl J Med. 2009;360(7):692-698.
10. Allers K, Hütter G, Hofmann J, Loddenkemper C, Rieger K, Thiel E, Schneider T. Evidence for the cure of HIV infection by CCR5D32/D32 stem cell transplantation. Blood. 2011;117(10):2791-2799.
11. van Lunzen J, Fehse B, Hauber J. Gene therapy strategies: can we eradicate HIV? Curr HIV/AIDS Rep. 2011;8(2):78-84.
12. Holt N, Wang J, Kim K, et al. Human hematopoietic stem/progenitor cells modified by zinc-finger nucleases targeted to CCR5 control HIV-1 in vivo. Nat Biotechnol. 2010;28(8):839-847.
13. Kimpel J, Braun SE, Qiu G, et al. Survival of the fittest: positive selection of CD4+ T cells expressing a membrane-bound fusion inhibitor following HIV-1 infection. PLoS ONE. 2010;5(8):e12357.
14. Perez EE, Wang J, Miller JC, et al. Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases. Nat Biotechnol. 2008;26(7):808-816. (Pubitemid 351961450)
15. Urnov FD, Rebar EJ, Holmes MC, Zhang HS, Gregory PD. Genome editing with engineered zinc finger nucleases [Review]. Nat Rev Genet. 2010;11(9):636-646.
16. Carter CC, Onafuwa-Nuga A, McNamara LA, et al. HIV-1 infects multipotent progenitor cells causing cell death and establishing latent cellular reservoirs. Nat Med. 2010;16(4):446-451.
17. Egelhofer M, Brandenburg G, Martinius H, et al. Inhibition of human immunodeficiency virus type 1 entry in cells expressing gp41-derived peptides. J Virol. 2004;78(2):568-575. (Pubitemid 38067578)
18. Trobridge GD, Wu RA, Beard BC, et al. Protection of stem cell-derived lymphocytes in a primate AIDS gene therapy model after in vivo selection. PLoS ONE. 2009;4(11):e7693.
19. Kiem H-P, Wu RA, Sun G, von Laer D, Rossi JJ, Trobridge GD. Foamy combinatorial anti-HIV vectors with MGMTP140K potently inhibit HIV-1 and SHIV replication and mediate selection in vivo. Gene Ther. 2010;17(1):37-49.
20. Trobridge GD, Beard BC, Gooch C, et al. Efficient transduction of pigtailed macaque hematopoietic repopulating cells with HIV-based lentiviral vectors. Blood. 2008;111(12):5537-5543.
21. Doria-Rose NA, Pierce CC, Hensel MT, et al. Multigene DNA prime-boost vaccines for SHIV89.6P. J Med Primatol. 2003;32(4-5):218-228. (Pubitemid 37021247)
22. Li Y, Cleveland B, Klots I, et al. Removal of a single N-linked glycan in human immunodeficiency virus type 1 gp120 results in an enhanced ability to induce neutralizing antibody responses. J Virol. 2008;82(2):638-651.
23. Kiem H-P, Heyward S, Winkler A, et al. Gene transfer into marrow repopulating cells: comparison between amphotropic and gibbon ape leukemia virus pseudotyped retroviral vectors in a competitive repopulation assay in baboons. Blood. 1997;90(11):4638-4645. (Pubitemid 27508472)
24. Trobridge G, Beard BC, Kiem H-P. Hematopoietic stem cell transduction and amplification in large animal models. Hum Gene Ther. 2005;16(12):1355-1366. (Pubitemid 41829011)
25. Hu SL, Zarling JM, Chinn J, et al. Protection of macaques against simian AIDS by immunization with a recombinant vaccinia virus expressing the envelope glycoproteins of simian type D retrovirus. Proc Natl Acad Sci USA. 1989;86(18):7213-7217. (Pubitemid 19240896)
26. Ramsburg E, Rose NF, Marx PA, et al. Highly effective control of an AIDS virus challenge in macaques by using vesicular stomatitis virus and modified vaccinia virus Ankara vaccine vectors in a single-boost protocol. J Virol. 2004;78(8):3930-3940. (Pubitemid 38437199)
27. Alexaki A, Liu Y, Wigdahl B. Cellular reservoirs of HIV-1 and their role in viral persistence [Review]. Curr HIV Res. 2008;6(5):388-400.
28. Li Q, Duan L, Estes JD, et al. Peak SIV replication in resting memory CD4+ T cells depletes gut lamina propria CD4+ T cells. Nature. 2005;434(7037):1148-1152. (Pubitemid 40663495)
29. Badley AD, Dockrell DH, Algeciras A, et al. In vivo analysis of Fas/FasL interactions in HIV-infected patients. J Clin Invest. 1998;102(1):79-87. (Pubitemid 28323833)
30. Badley AD, Parato K, Cameron DW, et al. Dynamic correlation of apoptosis and immune activation during treatment of HIV infection. Cell Death Differ. 1999;6(5):420-432. (Pubitemid 29245956)
31. Alimonti JB, Ball TB, Fowke KR. Mechanisms of CD4+ T lymphocyte cell death in human immunodeficiency virus infection and AIDS [Review]. J Gen Virol. 2003;84(Pt 7):1649-1661. (Pubitemid 36805899)
32. Trinchieri G. The two faces of interleukin 12: a pro-inflammatory cytokine and a key immunoregulatory molecule produced by antigen-presenting cell [Review]. Ciba Found Symp 1995;195:203-214.
33. Brenchley JM, Ruff LE, Casazza JP, Koup RA, Price DA, Douek DC. Preferential infection shortens the life span of human immunodeficiency virus-specific CD4+ T cells in vivo. J Virol. 2006;80(14):6801-6809. (Pubitemid 44025180)
34. Perelson AS, Kirschner DE, De Boer R. Dynamics of HIV infection of CD4+ T cells. Math Biosci. 1993;114(1):81-125.
35. Zajac AJ, Blattman JN, Murali-Krishna K, et al. Viral immune evasion due to persistence of activated T cells without effector function. J Exp Med. 1998;188(12):2205-2213. (Pubitemid 29028493)
36. Aubert RD, Kamphorst AO, Sarkar S, et al. Antigen-specific CD4 T-cell help rescues exhausted CD8 T cells during chronic viral infection. Proc Natl Acad Sci USA. 2011;108(52):21182-21187.
37. Jonjić S, Mutter W, Weiland F, Reddehase MJ, Koszinowski UH. Site-restricted persistent cytomegalovirus infection after selective long-term depletion of CD4+ T lymphocytes. J Exp Med. 1989;169(4):1199-1212. (Pubitemid 19104957)
38. Porichis F, Kaufmann DE. HIV-specific CD4 T cells and immune control of viral replication [Review]. Curr Opin HIV AIDS. 2011;6(3):174-180.
39. Pitcher CJ, Quittner C, Peterson DM, et al. HIV-1-specific CD4+ T cells are detectable in most individuals with active HIV-1 infection, but decline with prolonged viral suppression. Nat Med. 1999;5(5):518-525. (Pubitemid 29220210)
40. Poropatich K, Sullivan DJ Jr. Human immunodeficiency virus type 1 long-term non-progressors: the viral, genetic and immunological basis for disease non-progression [Review]. J Gen Virol. 2011;92(Pt 2):247-268.
41. Doria-Rose NA, Ohlen C, Polacino P, et al. Multigene DNA priming-boosting vaccines protect macaques from acute CD4+-T-cell depletion after simian-human immunodeficiency virus SHIV89.6P mucosal challenge. J Virol. 2003;77(21):11563-11577. (Pubitemid 37271655)
42. Gorelick RJ, Benveniste RE, Lifson JD, et al. Protection of Macaca nemestrina from disease following pathogenic simian immunodeficiency virus (SIV) challenge: utilization of SIV nucleocapsid mutant DNA vaccines with and without an SIV protein boost. J Virol. 2000;74(24):11935-11949. (Pubitemid 32222344)
43. van Lunzen J, Glaunsinger T, Stahmer I, et al. Transfer of autologous gene-modified T cells in HIV-infected patients with advanced immunodeficiency and drug-resistant virus. Mol Ther. 2007;15(5):1024-1033. (Pubitemid 46621662)
44. Ho O, Larsen K, Polacino P, et al. Pathogenic infection of Macaca nemestrina with a CCR5-tropic subtype-C simian-human immunodeficiency virus. Retrovirology. 2009;6:65.