메뉴 건너뛰기




Volumn 212, Issue 9, 2015, Pages 1387-1396

A murine viral outgrowth assay to detect residual HIV type 1 in patients with undetectable viral loads

Author keywords

cure; HIV; humanized mouse; quantitative viral outgrowth assay (QVOA); SIV

Indexed keywords

ATAZANAVIR; DARUNAVIR; EFAVIRENZ; INTEGRASE INHIBITOR; L 000870812; LAMIVUDINE; RALTEGRAVIR; RITONAVIR; TENOFOVIR; UNCLASSIFIED DRUG; VIRUS RNA; INTERLEUKIN 2;

EID: 84946147894     PISSN: 00221899     EISSN: 15376613     Source Type: Journal    
DOI: 10.1093/infdis/jiv230     Document Type: Article
Times cited : (57)

References (43)
  • 1
    • 84924159785 scopus 로고    scopus 로고
    • Rapid viral rebound after 4 years of suppressive therapy in a seronegative HIV-1 infected infant treated from birth
    • Butler K, Gavin P, Coughlan S, et al. Rapid viral rebound after 4 years of suppressive therapy in a seronegative HIV-1 infected infant treated from birth. Pediatr Infect Dis J 2015; 34: e48-51
    • (2015) Pediatr Infect Dis J , vol.34 , pp. e48-51
    • Butler, K.1    Gavin, P.2    Coughlan, S.3
  • 2
    • 84906970468 scopus 로고    scopus 로고
    • Antiretroviral-free HIV-1 remission and viral rebound after allogeneic stem cell transplantation: Report of 2 cases
    • Henrich TJ, Hanhauser E, Marty FM, et al. Antiretroviral-free HIV-1 remission and viral rebound after allogeneic stem cell transplantation: report of 2 cases. Ann Inter Med 2014; 161: 319-27
    • (2014) Ann Inter Med , vol.161 , pp. 319-327
    • Henrich, T.J.1    Hanhauser, E.2    Marty, F.M.3
  • 3
    • 84915800900 scopus 로고    scopus 로고
    • No cure of HIV infection in a child despite early treatment and apparent viral clearance
    • Giacomet V, Trabattoni D, Zanchetta N, et al. No cure of HIV infection in a child despite early treatment and apparent viral clearance. Lancet 2014; 384: 1320
    • (2014) Lancet , vol.384 , pp. 1320
    • Giacomet, V.1    Trabattoni, D.2    Zanchetta, N.3
  • 4
    • 84904545962 scopus 로고    scopus 로고
    • An HIV cure: Feasibility, discovery, and implementation
    • Fauci AS, Marston HD, Folkers GK. An HIV cure: feasibility, discovery, and implementation. JAMA 2013; 312: 335-6
    • (2013) Jama , vol.312 , pp. 335-336
    • Fauci, A.S.1    Marston, H.D.2    Folkers, G.K.3
  • 5
    • 84893812611 scopus 로고    scopus 로고
    • Absence of HIV-1 after treatment cessation in an infant
    • Persaud D, Luzuriaga K. Absence of HIV-1 after treatment cessation in an infant. N Engl J Med 2014; 370: 678
    • (2014) N Engl J Med , vol.370 , pp. 678
    • Persaud, D.1    Luzuriaga, K.2
  • 6
    • 84904868629 scopus 로고    scopus 로고
    • HIV is detected in child thought to have been cured
    • McCarthy M. HIV is detected in child thought to have been cured. BMJ 2014; 349: g4614
    • (2014) Bmj , vol.349 , pp. g4614
    • McCarthy, M.1
  • 7
    • 84923064466 scopus 로고    scopus 로고
    • Viremic relapse after HIV-1 remission in a perinatally infected child
    • Luzuriaga K, Gay H, Ziemniak C, et al. Viremic relapse after HIV-1 remission in a perinatally infected child. N Eng J Med 2015; 372: 786-8
    • (2015) N Eng J Med , vol.372 , pp. 786-788
    • Luzuriaga, K.1    Gay, H.2    Ziemniak, C.3
  • 8
    • 84924159785 scopus 로고    scopus 로고
    • Rapid viral rebound after 4 years of suppressive therapy in a seronegative HIV-1 infected infant treated from birth
    • Butler KM, Gavin P, Coughlan S, et al. Rapid viral rebound after 4 years of suppressive therapy in a seronegative HIV-1 infected infant treated from birth. Pediatr Infect Dis J 2015; 34: 51
    • (2015) Pediatr Infect Dis J , vol.34 , pp. 51
    • Butler, K.M.1    Gavin, P.2    Coughlan, S.3
  • 9
    • 24944518559 scopus 로고    scopus 로고
    • Enhanced culture assay for detection and quantitation of latently infected, resting CD4+ T-cells carrying replicationcompetent virus in HIV-1-infected individuals
    • Siliciano JD, Siliciano RF. Enhanced culture assay for detection and quantitation of latently infected, resting CD4+ T-cells carrying replicationcompetent virus in HIV-1-infected individuals. Methods Mol Biol 2004; 304: 3-15
    • (2004) Methods Mol Biol , vol.304 , pp. 3-15
    • Siliciano, J.D.1    Siliciano, R.F.2
  • 10
    • 84886769508 scopus 로고    scopus 로고
    • Replication-competent noninduced proviruses in the latent reservoir increase barrier to HIV-1 cure
    • Ho Y-CC, Shan L, Hosmane NN, et al. Replication-competent noninduced proviruses in the latent reservoir increase barrier to HIV-1 cure. Cell 2013; 155: 540-51
    • (2013) Cell , vol.155 , pp. 540-551
    • Ho, Y.-C.C.1    Shan, L.2    Hosmane, N.N.3
  • 11
    • 84873472629 scopus 로고    scopus 로고
    • Comparative analysis of measures of viral reservoirs in HIV-1 eradication studies
    • Eriksson S, Graf EH, Dahl V, et al. Comparative analysis of measures of viral reservoirs in HIV-1 eradication studies. PLoS Path 2013; 9
    • (2013) Plos Path , vol.9
    • Eriksson, S.1    Graf, E.H.2    Dahl, V.3
  • 12
    • 0017159219 scopus 로고
    • The mouse inoculation test in rabies diagnosis: Early diagnosis in mice during the incubation period
    • Webster WA, Casey GA, Charlton KM. The mouse inoculation test in rabies diagnosis: early diagnosis in mice during the incubation period. Can J Comp Med 1976; 40: 322-5
    • (1976) Can J Comp Med , vol.40 , pp. 322-325
    • Webster, W.A.1    Casey, G.A.2    Charlton, K.M.3
  • 13
    • 80755150060 scopus 로고    scopus 로고
    • Humanized mouse models of HIV infection
    • Denton PW, García JV. Humanized mouse models of HIV infection. AIDS Rev 2010; 13: 135-48
    • (2010) AIDS Rev , vol.13 , pp. 135-148
    • Denton, P.W.1    García, J.V.2
  • 14
    • 84855927237 scopus 로고    scopus 로고
    • Generation of HIV latency in humanized BLT mice
    • Denton P, Olesen R, Choudhary S, et al. Generation of HIV latency in humanized BLT mice. J Virol 2012; 86: 630-4
    • (2012) J Virol , vol.86 , pp. 630-634
    • Denton, P.1    Olesen, R.2    Choudhary, S.3
  • 15
    • 84893815335 scopus 로고    scopus 로고
    • Targeted cytotoxic therapy kills persisting HIV infected cells during art
    • Denton PW, Long JM, Wietgrefe SW, et al. Targeted cytotoxic therapy kills persisting HIV infected cells during ART. PLoS Path 2013; 10
    • (2013) Plos Path , vol.10
    • Denton, P.W.1    Long, J.M.2    Wietgrefe, S.W.3
  • 16
    • 51449113166 scopus 로고    scopus 로고
    • The accelerated simian immunodeficiency virus macaque model of human immunodeficiency virus-associated neurological disease: From mechanism to treatment
    • Clements J, Mankowski J, Gama L, Zink M. The accelerated simian immunodeficiency virus macaque model of human immunodeficiency virus-associated neurological disease: from mechanism to treatment. J Neurovirol 2008; 14: 309-17
    • (2008) J Neurovirol , vol.14 , pp. 309-317
    • Clements, J.1    Mankowski, J.2    Gama, L.3    Zink, M.4
  • 17
    • 69449083091 scopus 로고    scopus 로고
    • A simian immunodeficiency virusinfected macaque model to study viral reservoirs that persist during highly active antiretroviral therapy
    • Dinoso J, Rabi S, Blankson J, et al. A simian immunodeficiency virusinfected macaque model to study viral reservoirs that persist during highly active antiretroviral therapy. J Virol 2009; 83: 9247-57
    • (2009) J Virol , vol.83 , pp. 9247-9257
    • Dinoso, J.1    Rabi, S.2    Blankson, J.3
  • 18
    • 84859167158 scopus 로고    scopus 로고
    • Host factors dictate control of viral replication in two HIV-1 controller/chronic progressor transmission pairs
    • Buckheit RW, Allen TG, Alme A, et al. Host factors dictate control of viral replication in two HIV-1 controller/chronic progressor transmission pairs. Nat Com 2011; 3: 716
    • (2011) Nat Com , vol.3 , pp. 716
    • Buckheit, R.W.1    Allen, T.G.2    Alme, A.3
  • 19
    • 10744228049 scopus 로고    scopus 로고
    • New real-time reverse transcriptase-initiated PCR assay with single-copy sensitivity for human immunodeficiency virus type 1 RNA in plasma
    • Palmer S, Wiegand AP, Maldarelli F, et al. New real-time reverse transcriptase-initiated PCR assay with single-copy sensitivity for human immunodeficiency virus type 1 RNA in plasma. J Clin Micro 2003; 41: 4531-6
    • (2003) J Clin Micro , vol.41 , pp. 4531-4536
    • Palmer, S.1    Wiegand, A.P.2    Maldarelli, F.3
  • 20
    • 84866500589 scopus 로고    scopus 로고
    • Early minocycline treatment prevents a decrease in striatal dopamine in an SIV model of HIV-associated neurological disease
    • Meulendyke K, Pletnikov M, Engle E, Tarwater P, Graham D, Zink M. Early minocycline treatment prevents a decrease in striatal dopamine in an SIV model of HIV-associated neurological disease. J Neuroimmune Pharmacol 2012; 7: 454-64
    • (2012) J Neuroimmune Pharmacol , vol.7 , pp. 454-464
    • Meulendyke, K.1    Pletnikov, M.2    Engle, E.3    Tarwater, P.4    Graham, D.5    Zink, M.6
  • 21
    • 84878482232 scopus 로고    scopus 로고
    • Rapid quantification of the latent reservoir for HIV-1 using a viral outgrowth assay
    • Laird GM, Eisele EE, Rabi SA, et al. Rapid quantification of the latent reservoir for HIV-1 using a viral outgrowth assay. PLoS Path 2012; 9
    • (2012) Plos Path , vol.9
    • Laird, G.M.1    Eisele, E.E.2    Rabi, S.A.3
  • 22
    • 33847176917 scopus 로고    scopus 로고
    • Isolation and characterization of replication-competent human immunodeficiency virus type 1 from a subset of elite suppressors
    • Blankson JN, Bailey JR, Thayil S, et al. Isolation and characterization of replication-competent human immunodeficiency virus type 1 from a subset of elite suppressors. J Virol 2007; 81: 2508-18
    • (2007) J Virol , vol.81 , pp. 2508-2518
    • Blankson, J.N.1    Bailey, J.R.2    Thayil, S.3
  • 23
    • 84894533767 scopus 로고    scopus 로고
    • HLA-B∗57 elite suppressor and chronic progressor HIV-1 isolates replicate vigorously and cause CD4+ T cell depletion in humanized BLT mice
    • Salgado M, Swanson MD, Pohlmeyer CW, et al. HLA-B∗57 elite suppressor and chronic progressor HIV-1 isolates replicate vigorously and cause CD4+ T cell depletion in humanized BLT mice. J Virol 2014; 88: 3340-52
    • (2014) J Virol , vol.88 , pp. 3340-3352
    • Salgado, M.1    Swanson, M.D.2    Pohlmeyer, C.W.3
  • 24
    • 84898423894 scopus 로고    scopus 로고
    • New ex vivo approaches distinguish effective and ineffective single agents for reversing HIV-1 latency in vivo
    • Bullen CK, Laird GM, Durand CM, Siliciano JD, Siliciano RF. New ex vivo approaches distinguish effective and ineffective single agents for reversing HIV-1 latency in vivo. Nat Med 2014; 20: 425-9
    • (2014) Nat Med , vol.20 , pp. 425-429
    • Bullen, C.K.1    Laird, G.M.2    Durand, C.M.3    Siliciano, J.D.4    Siliciano, R.F.5
  • 25
    • 0038579210 scopus 로고    scopus 로고
    • Long-term follow-up studies confirm the stability of the latent reservoir for HIV-1 in resting CD4+T cells
    • Siliciano JD, Kajdas J, Finzi D, et al. Long-term follow-up studies confirm the stability of the latent reservoir for HIV-1 in resting CD4+T cells. Nat Med 2003; 9: 727-8
    • (2003) Nat Med , vol.9 , pp. 727-728
    • Siliciano, J.D.1    Kajdas, J.2    Finzi, D.3
  • 26
    • 34548689151 scopus 로고    scopus 로고
    • Human immunodeficiency virus controllers: Mechanisms of durable virus control in the absence of antiretroviral therapy
    • Deeks SG, Walker BD. Human immunodeficiency virus controllers: mechanisms of durable virus control in the absence of antiretroviral therapy. Immunity 2007; 27: 406-16
    • (2007) Immunity , vol.27 , pp. 406-416
    • Deeks, S.G.1    Walker, B.D.2
  • 27
    • 70449657764 scopus 로고    scopus 로고
    • Elucidating the elite: Mechanisms of control in HIV-1 infection
    • O Connell KA, Bailey JR, Blankson JN. Elucidating the elite: mechanisms of control in HIV-1 infection. Trends Pharmacol Sci 2009; 30: 631-7
    • (2009) Trends Pharmacol Sci , vol.30 , pp. 631-637
    • Oconnell, K.A.1    Bailey, J.R.2    Blankson, J.N.3
  • 28
    • 77954617321 scopus 로고    scopus 로고
    • Long-term nonprogressive disease among untreated HIV-infected individuals: Clinical implications of understanding immune control of HIV
    • Migueles SA, Connors M. Long-term nonprogressive disease among untreated HIV-infected individuals: clinical implications of understanding immune control of HIV. JAMA 2010; 304: 194-201
    • (2010) Jama , vol.304 , pp. 194-201
    • Migueles, S.A.1    Connors, M.2
  • 29
    • 0033520846 scopus 로고    scopus 로고
    • Immuno-activation with anti-CD3 and recombinant human IL-2 in HIV-1-infected patients on potent antiretroviral therapy
    • Prins JM, Jurriaans S, van Praag RM, et al. Immuno-activation with anti-CD3 and recombinant human IL-2 in HIV-1-infected patients on potent antiretroviral therapy. AIDS 1999; 13: 2405-10
    • (1999) AIDS , vol.13 , pp. 2405-2410
    • Prins, J.M.1    Jurriaans, S.2    Van Praag, R.M.3
  • 30
    • 0036852179 scopus 로고    scopus 로고
    • HIV-specific CD8+ T cell proliferation is coupled to perforin expression and is maintained in nonprogressors
    • Migueles SA, Laborico AC, Shupert WL, et al. HIV-specific CD8+ T cell proliferation is coupled to perforin expression and is maintained in nonprogressors. Nat Immunol 2002; 3: 1061-8
    • (2002) Nat Immunol , vol.3 , pp. 1061-1068
    • Migueles, S.A.1    Laborico, A.C.2    Shupert, W.L.3
  • 31
    • 33646686040 scopus 로고    scopus 로고
    • HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T cells
    • Betts MR, Nason MC, West SM, et al. HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T cells. Blood 2006; 107: 4781-9
    • (2006) Blood , vol.107 , pp. 4781-4789
    • Betts, M.R.1    Nason, M.C.2    West, S.M.3
  • 32
    • 57449109484 scopus 로고    scopus 로고
    • Lytic granule loading of CD8+ T cells is required for HIV-infected cell elimination associated with immune control
    • Migueles SA, Osborne CM, Royce C, et al. Lytic granule loading of CD8+ T cells is required for HIV-infected cell elimination associated with immune control. Immunity 2008; 29: 1009-21
    • (2008) Immunity , vol.29 , pp. 1009-1021
    • Migueles, S.A.1    Osborne, C.M.2    Royce, C.3
  • 33
    • 77954080011 scopus 로고    scopus 로고
    • Perforin expression directly ex vivo by HIV-specific CD8 T-cells is a correlate of HIV elite control
    • Hersperger AR, Pereyra F, Nason M, et al. Perforin expression directly ex vivo by HIV-specific CD8 T-cells is a correlate of HIV elite control. PLoS Path 2010; 6
    • (2010) Plos Path , vol.6
    • Hersperger, A.R.1    Pereyra, F.2    Nason, M.3
  • 34
    • 34249852256 scopus 로고    scopus 로고
    • HIV controllers exhibit potent CD8T cell capacity to suppress HIV infection ex vivo and peculiar cytotoxic T lymphocyte activation phenotype
    • Sáez-Cirión A, Lacabaratz C, Lambotte O, et al. HIV controllers exhibit potent CD8T cell capacity to suppress HIV infection ex vivo and peculiar cytotoxic T lymphocyte activation phenotype. Proc Natl Acad Sci USA 2007; 104: 6776-81
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 6776-6781
    • Sáez-Cirión, A.1    Lacabaratz, C.2    Lambotte, O.3
  • 35
    • 84879481622 scopus 로고    scopus 로고
    • Primary CD8+ T cells from elite suppressors effectively eliminate non-productively HIV-1 infected resting and activated CD4+ T cells
    • Buckheit RW, Siliciano RF, Blankson JN. Primary CD8+ T cells from elite suppressors effectively eliminate non-productively HIV-1 infected resting and activated CD4+ T cells. Retrovirology 2012; 10: 68
    • (2012) Retrovirology , vol.10 , pp. 68
    • Buckheit, R.W.1    Siliciano, R.F.2    Blankson, J.N.3
  • 36
    • 0033934286 scopus 로고    scopus 로고
    • Resistance to replication of human immunodeficiency virus challenge in SCID-Hu mice engrafted with peripheral blood mononuclear cells of nonprogressors is mediated by CD8(+) T cells and associated with a proliferative response to p24 antigen
    • De Quiros JC, Shupert WL, McNeil AC, et al. Resistance to replication of human immunodeficiency virus challenge in SCID-Hu mice engrafted with peripheral blood mononuclear cells of nonprogressors is mediated by CD8(+) T cells and associated with a proliferative response to p24 antigen. J Virol 2000; 74: 2023-8
    • (2000) J Virol , vol.74 , pp. 2023-2028
    • De Quiros, J.C.1    Shupert, W.L.2    McNeil, A.C.3
  • 37
    • 0019851727 scopus 로고
    • Treatment of acute renal allograft rejection with OKT3 monoclonal antibody
    • Cosimi AB, Burton RC, Colvin RB, et al. Treatment of acute renal allograft rejection with OKT3 monoclonal antibody. Transplantation 1981; 32: 535-9
    • (1981) Transplantation , vol.32 , pp. 535-539
    • Cosimi, A.B.1    Burton, R.C.2    Colvin, R.B.3
  • 38
    • 0019447825 scopus 로고
    • Use of monoclonal antibodies to T-cell subsets for immunologic monitoring and treatment in recipients of renal allografts
    • Cosimi AB, Colvin RB, Burton RC, et al. Use of monoclonal antibodies to T-cell subsets for immunologic monitoring and treatment in recipients of renal allografts. N Engl J Med 1981; 305: 308-14
    • (1981) N Engl J Med , vol.305 , pp. 308-314
    • Cosimi, A.B.1    Colvin, R.B.2    Burton, R.C.3
  • 39
    • 84876410605 scopus 로고    scopus 로고
    • Where does HIV hide? A focus on the central nervous system
    • Churchill M, Nath A. Where does HIV hide?. A focus on the central nervous system. Curr Opin HIV AIDS 2013; 8: 165-9
    • (2013) Curr Opin HIV AIDS , vol.8 , pp. 165-169
    • Churchill, M.1    Nath, A.2
  • 41
    • 15444380717 scopus 로고    scopus 로고
    • Safety of long-term interruption of successful antiretroviral therapy: The athena cohort study
    • Wit FW, Blanckenberg DH, Brinkman K, et al. Safety of long-term interruption of successful antiretroviral therapy: the ATHENA cohort study. AIDS 2005; 19: 345-8
    • (2005) AIDS , vol.19 , pp. 345-348
    • Wit, F.W.1    Blanckenberg, D.H.2    Brinkman, K.3
  • 42
    • 84865632697 scopus 로고    scopus 로고
    • Plasma HIV viral rebound following protocol-indicated cessation of art commenced in primary and chronic HIV infection
    • Hamlyn E, Ewings FM, Porter K, Cooper DA. Plasma HIV viral rebound following protocol-indicated cessation of ART commenced in primary and chronic HIV infection. PLoS One 2012
    • (2012) Plos One
    • Hamlyn, E.1    Ewings, F.M.2    Porter, K.3    Cooper, D.A.4
  • 43
    • 84884489062 scopus 로고    scopus 로고
    • Dynamics of theHIV-1 latent reservoir after discontinuation of the intensification of antiretroviral treatment: Results of two clinical trials
    • Gutiérrez C, Hernández-Novoa B, Vallejo A, et al. Dynamics of theHIV-1 latent reservoir after discontinuation of the intensification of antiretroviral treatment: results of two clinical trials. AIDS 2013; 27: 2081-8
    • (2013) AIDS , vol.27 , pp. 2081-2088
    • Gutiérrez, C.1    Hernández-Novoa, B.2    Vallejo, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.