Clonally expanded CD4+ T cells can produce infectious HIV-1 in vivo

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 7, 2016, Pages 1883-1888

  Simonetti, Francesco R ^a,b   Sobolewski, Michele D ^c   Fyne, Elizabeth ^c   Shao, Wei ^d   Spindler, Jonathan ^a   Hattori, Junko ^a   Anderson, Elizabeth M ^a   Watters, Sarah A ^a   Hill, Shawn ^a   Wu, Xiaolin ^d   Wells, David ^d   Su, Li ^d   Luke, Brian T ^d   Halvas, Elias K ^c   Besson, Guillaume ^c   Penrose, Kerri J ^c   Yang, Zhiming ^e   Kwan, Richard W ^f   Van Waes, Carter ^e,g   Uldrick, Thomas ^e   Citrin, Deborah E ^e   Kovacs, Joseph ^h   Polis, Michael A ^f   Rehm, Catherine A ^f   Gorelick, Robert ^d   Piatak, Michael ^d   Keele, Brandon F ^d   Kearney, Mary F ^a   Coffin, John M ⁱ   Hughes, Stephen H ^a   Mellors, John W ^c   Maldarelli, Frank ^a   more..

^a NATIONAL CANCER INSTITUTE   (United States)

^b UNIVERSITY OF MILAN   (Italy)

^c UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^d FREDERICK NATIONAL LABORATORY FOR CANCER RESEARCH   (United States)

^e NATIONAL CANCER INSTITUTE   (United States)

^f NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^g NATIONAL INSTITUTES OF HEALTH   (United States)

^h NATIONAL INSTITUTES OF HEALTH   (United States)

ⁱ TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Clonal expansion of infected cells; HIV persistence; Replication competent HIV

Indexed keywords

ANTINEOPLASTIC AGENT; ANTIRETROVIRUS AGENT; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT;

ADULT; ANTIVIRAL THERAPY; ARTICLE; CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; CASE REPORT; CD4 LYMPHOCYTE COUNT; CD4+ T LYMPHOCYTE; CELL EXPANSION; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN TISSUE; IN VIVO STUDY; LYMPHOCYTE CLONE; MALE; METASTASIS; MIDDLE AGED; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROVIRUS; TONGUE CARCINOMA; UNINDEXED SEQUENCE; VIREMIA; VIRUS DETECTION; VIRUS INFECTIVITY; BLOOD; HIV INFECTIONS; MOLECULAR GENETICS; PATHOGENICITY; PHYSIOLOGY; VIROLOGY; VIRULENCE; VIRUS REPLICATION;

ANTI-HIV AGENTS; CD4-POSITIVE T-LYMPHOCYTES; HIV INFECTIONS; HIV-1; HUMANS; MOLECULAR SEQUENCE DATA; VIRULENCE; VIRUS REPLICATION;

EID: 84959016948     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1522675113     Document Type: Article

References (22)

1. Baker JV, et al.; Terry Beirn Community Programs for Clinical Research on AIDS (CPCRA) (2008) CD4+ count and risk of non-AIDS diseases following initial treatment for HIV infection. AIDS 22(7): 841-848.
2. Wagner TA, et al. (2014) HIV latency. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science 345(6196): 570-573.
3. Maldarelli F, et al. (2014) HIV latency. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science 345(6193): 179-183.
4. Ho YC, et al. (2013) Replication-competent noninduced proviruses in the latent reservoir increase barrier to HIV-1 cure. Cell 155(3): 540-551.
5. Cohn LB, et al. (2015) HIV-1 integration landscape during latent and active infection. Cell 160(3): 420-432.
6. Bailey JR, et al. (2006) Residual human immunodeficiency virus type 1 viremia in some patients on antiretroviral therapy is dominated by a small number of invariant clones rarely found in circulating CD4+ T cells. J Virol 80(13): 6441-6457.
7. Kearney MF, et al. (2014) Lack of detectable HIV-1 molecular evolution during suppressive antiretroviral therapy. PLoS Pathog 10(3): E1004010.
8. Perelson AS, et al. (1997) Decay characteristics of HIV-1-infected compartments during combination therapy. Nature 387(6629): 188-191.
9. Cillo AR, et al. (2014) Quantification of HIV-1 latency reversal in resting CD4+ T cells from patients on suppressive antiretroviral therapy. Proc Natl Acad Sci USA 111(19): 7078-7083.
10. Chun TW (2013) Tracking replication-competent HIV reservoirs in infected individuals. Curr Opin HIV AIDS 8(2): 111-116.
11. Siliciano JD, Siliciano RF (2014) Recent developments in the search for a cure for HIV-1 infection: Targeting the latent reservoir for HIV-1. J Allergy Clin Immunol 134(1): 12-19.
12. Baker JV, et al.; Terry Beirn Community Programs for Clinical Research on AIDS (CPCRA) (2008) Poor initial CD4+ recovery with antiretroviral therapy prolongs immune depletion and increases risk for AIDS and non-AIDS diseases. J Acquir Immune Defic Syndr 48(5): 541-546.
13. Wilson EM, Sereti I (2013) Immune restoration after antiretroviral therapy: The pitfalls of hasty or incomplete repairs. Immunol Rev 254(1): 343-354.
14. Stecher G, et al. (2014) MEGA-MD: Molecular evolutionary genetics analysis software with mutational diagnosis of amino acid variation. Bioinformatics 30(9): 1305-1307.
15. Joos B, et al.; Swiss HIV Cohort Study (2008) HIV rebounds from latently infected cells, rather than from continuing low-level replication. Proc Natl Acad Sci USA 105(43): 16725-16730.
16. Rose PP, Korber BT (2015) HYPERMUT analysis and detection of APOBEC-induced hypermutation. Available at www.hiv.lanl.gov/content/sequence/HYPERMUT/hypermut.html. Accessed July 15, 2015.
17. Besson GJ, et al. (2014) HIV-1 DNA decay dynamics in blood during more than a decade of suppressive antiretroviral therapy. Clin Infect Dis 59(9): 1312-1321.
18. Somsouk M, et al. (2014) The immunologic effects of mesalamine in treated HIVinfected individuals with incomplete CD4+ T cell recovery: A randomized crossover trial. PLoS One 9(12): E116306.
19. Thomas JA, et al. (2006) Human immunodeficiency virus type 1 nucleocapsid zincfinger mutations cause defects in reverse transcription and integration. Virology 353(1): 41-51.
20. Siliciano JD, Siliciano RF (2005) Enhanced culture assay for detection and quantitation of latently infected, resting CD4+ T-cells carrying replication-competent virus in HIV- 1-infected individuals. Methods Mol Biol 304: 3-15.
21. Alfa-Wali M, et al. (2012) Chemoradiotherapy for anal cancer in HIV patients causes prolonged CD4 cell count suppression. Ann Oncol 23(1): 141-147.
22. Harshany ML, Polhemus ME (2004) Effects of adjuvant radiotherapy for testicular cancer on CD4+ cell count in HIV-positive patients: A case report. AIDS Read 14(4): 189-190, 192-193.