-
1
-
-
0036176509
-
The challenge of viral reservoirs in hiv-1 infection
-
DOI 10.1146/annurev.med.53.082901.104024
-
Blankson JN, Persaud D, Siliciano RF (2002) The challenge of viral reservoirs in HIV-1 infection. Annu Rev Med 53:557-593. (Pubitemid 34177896)
-
(2002)
Annual Review of Medicine
, vol.53
, pp. 557-593
-
-
Blankson, J.N.1
Persaud, D.2
Siliciano, R.F.3
-
2
-
-
73449117263
-
Modeling latently infected cell activation: Viral and latent reservoir persistence, and viral blips in HIV-infected patients on potent therapy
-
Rong L, Perelson AS (2009) Modeling latently infected cell activation: Viral and latent reservoir persistence, and viral blips in HIV-infected patients on potent therapy. PLOS Comput Biol 5:e1000533.
-
(2009)
PLOS Comput Biol
, vol.5
-
-
Rong, L.1
Perelson, A.S.2
-
3
-
-
66149118152
-
Human immunodeficiency virus integrates directly into naive resting CD4+ T cells but enters naive cells less efficiently than memory cells
-
Dai J, et al. (2009) Human immunodeficiency virus integrates directly into naive resting CD4+ T cells but enters naive cells less efficiently than memory cells. J Virol 83:4528-4537.
-
(2009)
J Virol
, vol.83
, pp. 4528-4537
-
-
Dai, J.1
-
4
-
-
68349139711
-
HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation
-
Chomont N, et al. (2009) HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation. Nat Med 15:893-900.
-
(2009)
Nat Med
, vol.15
, pp. 893-900
-
-
Chomont, N.1
-
5
-
-
33750451933
-
Viral and latent reservoir persistence in HIV-1-infected patients on therapy
-
Kim H, Perelson AS (2006) Viral and latent reservoir persistence in HIV-1-infected patients on therapy. PLOS Comput Biol 2:e135.
-
(2006)
PLOS Comput Biol
, vol.2
-
-
Kim, H.1
Perelson, A.S.2
-
6
-
-
68949196315
-
Modeling HIV persistence, the latent reservoir, and viral blips
-
Rong L, Perelson AS (2009) Modeling HIV persistence, the latent reservoir, and viral blips. J Theor Biol 260:308-331.
-
(2009)
J Theor Biol
, vol.260
, pp. 308-331
-
-
Rong, L.1
Perelson, A.S.2
-
7
-
-
79955918570
-
Cross-sectional detection of acute HIV infection: Timing of transmission, inflammation and antiretroviral therapy
-
Gay C, et al. (2011) Cross-sectional detection of acute HIV infection: Timing of transmission, inflammation and antiretroviral therapy. PLoS ONE 6:e19617.
-
(2011)
PLoS ONE
, vol.6
-
-
Gay, C.1
-
8
-
-
50949131800
-
Valproic acid without intensified antiviral therapy has limited impact on persistent HIV infection of resting CD4+ T cells
-
Archin NM, et al. (2008) Valproic acid without intensified antiviral therapy has limited impact on persistent HIV infection of resting CD4+ T cells. AIDS 22:1131-1135.
-
(2008)
AIDS
, vol.22
, pp. 1131-1135
-
-
Archin, N.M.1
-
9
-
-
0030952479
-
Decay characteristics of HIV-1-infected compartments during combination therapy
-
DOI 10.1038/387188a0
-
Perelson AS, et al. (1997) Decay characteristics of HIV-1-infected compartments during combination therapy. Nature 387:188-191. (Pubitemid 27209434)
-
(1997)
Nature
, vol.387
, Issue.6629
, pp. 188-191
-
-
Perelson, A.S.1
Essunger, P.2
Cao, Y.3
Vesanen, M.4
Hurley, A.5
Saksela, K.6
Markowitz, M.7
Ho, D.D.8
-
10
-
-
0034547869
-
Management of acute and early HIV-1 infection
-
Little SJ, Perrin L (2000) Management of acute and early HIV-1 infection. AIDS Rev 2:136-143. (Pubitemid 33121184)
-
(2000)
AIDS Reviews
, vol.2
, Issue.3
, pp. 136-143
-
-
Little, S.J.1
Perrin, L.2
-
11
-
-
0029016192
-
Effects of primary HIV-1 infection on subsets of CD4+ and CD8+ T lymphocytes
-
Zaunders J, Carr A, McNally L, Penny R, Cooper DA (1995) Effects of primary HIV-1 infection on subsets of CD4+ and CD8+ T lymphocytes. AIDS 9:561-566.
-
(1995)
AIDS
, vol.9
, pp. 561-566
-
-
Zaunders, J.1
Carr, A.2
McNally, L.3
Penny, R.4
Cooper, D.A.5
-
12
-
-
0035863088
-
Maximum likelihood inference for left-censored HIV RNA data
-
Lynn HS (2001) Maximum likelihood inference for left-censored HIV RNA data. Stat Med 20:33-45.
-
(2001)
Stat Med
, vol.20
, pp. 33-45
-
-
Lynn, H.S.1
-
13
-
-
77952686145
-
Estimation of the initial viral growth rate and basic reproductive number during acute HIV-1 infection
-
Ribeiro RM, et al. (2010) Estimation of the initial viral growth rate and basic reproductive number during acute HIV-1 infection. J Virol 84:6096-6102.
-
(2010)
J Virol
, vol.84
, pp. 6096-6102
-
-
Ribeiro, R.M.1
-
14
-
-
0034615789
-
Modeling plasma virus concentration during primary HIV infection
-
Stafford MA, et al. (2000) Modeling plasma virus concentration during primary HIV infection. J Theor Biol 203:285-301.
-
(2000)
J Theor Biol
, vol.203
, pp. 285-301
-
-
Stafford, M.A.1
-
15
-
-
0033984045
-
The decay of the latent reservoir of replication-competent HIV-1 is inversely correlated with the extent of residual viral replication during prolonged anti-retroviral therapy
-
DOI 10.1038/71577
-
Ramratnam B, et al. (2000) The decay of the latent reservoir of replication-competent HIV-1 is inversely correlated with the extent of residual viral replication during prolonged anti-retroviral therapy. Nat Med 6:82-85. (Pubitemid 30048531)
-
(2000)
Nature Medicine
, vol.6
, Issue.1
, pp. 82-85
-
-
Ramratnam, B.1
Mittler, J.E.2
Zhang, L.3
Boden, D.4
Hurley, A.5
Fang, F.6
Macken, C.A.7
Perelson, A.S.8
Markowitz, M.9
Ho, D.D.10
-
16
-
-
0033609373
-
Quantifying residual HIV-1 replication in patients receiving combination antiretroviral therapy
-
DOI 10.1056/NEJM199905273402101
-
Zhang L, et al. (1999) Quantifying residual HIV-1 replication in patients receiving combination antiretroviral therapy. N Engl J Med 340:1605-1613. (Pubitemid 29249429)
-
(1999)
New England Journal of Medicine
, vol.340
, Issue.21
, pp. 1605-1613
-
-
Zhang, L.1
Ramratnam, B.2
Tenner-Racz, K.3
He, Y.4
Vesanen, M.5
Lewin, S.6
Talal, A.7
Racz, P.8
Perelson, A.S.9
Korber, B.T.10
Markowitz, M.11
Ho, D.D.12
-
17
-
-
0037444053
-
Determining the relative efficacy of highly active antiretroviral therapy
-
DOI 10.1086/368164
-
Louie M, et al. (2003) Determining the relative efficacy of highly active antiretroviral therapy. J Infect Dis 187:896-900. (Pubitemid 36337901)
-
(2003)
Journal of Infectious Diseases
, vol.187
, Issue.6
, pp. 896-900
-
-
Louie, M.1
Hogan, C.2
Di, M.M.3
Hurley, A.4
Simon, V.5
Rooney, J.6
Ruiz, N.7
Brun, S.8
Sun, E.9
Perelson, A.S.10
Ho, D.D.11
Markowitz, M.12
-
18
-
-
0032953920
-
+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy
-
DOI 10.1038/8394
-
Finzi D, et al. (1999) Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy. Nat Med 5:512-517. (Pubitemid 29220209)
-
(1999)
Nature Medicine
, vol.5
, Issue.5
, pp. 512-517
-
-
Finzi, D.1
Blankson, J.2
Siliciano, J.D.3
Margolick, J.B.4
Chadwick, K.5
Pierson, T.6
Smith, K.7
Lisziewicz, J.8
Lori, F.9
Flexner, C.10
Quinn, T.C.11
Chaisson, R.E.12
Rosenberg, E.13
Walker, B.14
Gange, S.15
Gallant, J.16
Siliciano, R.F.17
-
19
-
-
0038579210
-
+ T cells
-
DOI 10.1038/nm880
-
Siliciano JD, et al. (2003) Long-term follow-up studies confirm the stability of the latent reservoir for HIV-1 in resting CD4+ T cells. Nat Med 9:727-728. (Pubitemid 36749221)
-
(2003)
Nature Medicine
, vol.9
, Issue.6
, pp. 727-728
-
-
Siliciano, J.D.1
Kajdas, J.2
Finzi, D.3
Quinn, T.C.4
Chadwick, K.5
Margolick, J.B.6
Kovacs, C.7
Gange, S.J.8
Siliciano, R.F.9
-
20
-
-
0026605594
-
Laboratory control values for CD4 and CD8 T lymphocytes. Implications for HIV-1 diagnosis
-
Bofill M, et al. (1992) Laboratory control values for CD4 and CD8 T lymphocytes. Implications for HIV-1 diagnosis. Clin Exp Immunol 88:243-252.
-
(1992)
Clin Exp Immunol
, vol.88
, pp. 243-252
-
-
Bofill, M.1
-
21
-
-
0042415149
-
Differences in CD4 cell counts at seroconversion and decline among 5739 HIV-1-infected individuals with well-estimated dates of seroconversion
-
CASCADE Collaboration
-
CASCADE Collaboration (2003) Differences in CD4 cell counts at seroconversion and decline among 5739 HIV-1-infected individuals with well-estimated dates of seroconversion. J Acquir Immune Defic Syndr 34:76-83.
-
(2003)
J Acquir Immune Defic Syndr
, vol.34
, pp. 76-83
-
-
-
22
-
-
0025787276
-
Lymphocyte subset reference ranges in adult Caucasians
-
Reichert T, et al. (1991) Lymphocyte subset reference ranges in adult Caucasians. Clin Immunol Immunopathol 60:190-208.
-
(1991)
Clin Immunol Immunopathol
, vol.60
, pp. 190-208
-
-
Reichert, T.1
-
23
-
-
0025761245
-
High titers of cytopathic virus in plasma of patients with symptomatic primary HIV-1 infection
-
Clark SJ, et al. (1991) High titers of cytopathic virus in plasma of patients with symptomatic primary HIV-1 infection. N Engl J Med 324:954-960.
-
(1991)
N Engl J Med
, vol.324
, pp. 954-960
-
-
Clark, S.J.1
-
24
-
-
0025735965
-
Transient high levels of viremia in patients with primary human immunodeficiency virus type 1 infection
-
Daar ES, Moudgil T, Meyer RD, Ho DD (1991) Transient high levels of viremia in patients with primary human immunodeficiency virus type 1 infection. N Engl J Med 324:961-964.
-
(1991)
N Engl J Med
, vol.324
, pp. 961-964
-
-
Daar, E.S.1
Moudgil, T.2
Meyer, R.D.3
Ho, D.D.4
-
25
-
-
0030070991
-
Prognosis in HIV-1 infection predicted by the quantity of virus in plasma
-
Mellors JW, et al. (1996) Prognosis in HIV-1 infection predicted by the quantity of virus in plasma. Science 272:1167-1170. (Pubitemid 26001148)
-
(1996)
Science
, vol.272
, Issue.5265
, pp. 1167-1170
-
-
Mellors, J.W.1
Rinaldo Jr., C.R.2
Gupta, P.3
White, R.M.4
Todd, J.A.5
Kingsley, L.A.6
-
26
-
-
0027410369
-
High levels of HIV-1 in plasma during all stages of infection determined by competitive PCR
-
Piatak M, Jr., et al. (1993) High levels of HIV-1 in plasma during all stages of infection determined by competitive PCR. Science 259:1749-1754.
-
(1993)
Science
, vol.259
, pp. 1749-1754
-
-
Piatak Jr., M.1
-
27
-
-
0029006189
-
Massive activation of immune cells with an intact T cell repertoire in acute human immunodeficiency virus syndrome
-
Cossarizza A, et al. (1995) Massive activation of immune cells with an intact T cell repertoire in acute human immunodeficiency virus syndrome. J Infect Dis 172:105-112.
-
(1995)
J Infect Dis
, vol.172
, pp. 105-112
-
-
Cossarizza, A.1
-
28
-
-
0032555117
-
Early establishment of a pool of latently infected, resting CD4 (+) T cells during primary HIV-1 infection
-
Chun TW, et al. (1998) Early establishment of a pool of latently infected, resting CD4 (+) T cells during primary HIV-1 infection. Proc Natl Acad Sci USA 95:8869-8873.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 8869-8873
-
-
Chun, T.W.1
-
29
-
-
17444367748
-
The latent HIV-1 reservoir in patients undergoing HAART: An archive of pre-HAART drug resistance
-
Noë A, Plum J, Verhofstede C (2005) The latent HIV-1 reservoir in patients undergoing HAART: An archive of pre-HAART drug resistance. J Antimicrob Chemother 55:410-412.
-
(2005)
J Antimicrob Chemother
, vol.55
, pp. 410-412
-
-
Noë, A.1
Plum, J.2
Verhofstede, C.3
-
30
-
-
34247584237
-
ART suppresses plasma HIV-1 RNA to a stable set point predicted by pretherapy viremia
-
Maldarelli F, et al. (2007) ART suppresses plasma HIV-1 RNA to a stable set point predicted by pretherapy viremia. PLoS Pathog 3:e46.
-
(2007)
PLoS Pathog
, vol.3
-
-
Maldarelli, F.1
-
31
-
-
79955402159
-
Clonal sequences recovered from plasma from patients with residual HIV-1 viremia and on intensified antiretroviral therapy are identical to replicating viral RNAs recovered from circulating resting CD4+ T cells
-
Anderson JA, et al. (2011) Clonal sequences recovered from plasma from patients with residual HIV-1 viremia and on intensified antiretroviral therapy are identical to replicating viral RNAs recovered from circulating resting CD4+ T cells. J Virol 85:5220-5223.
-
(2011)
J Virol
, vol.85
, pp. 5220-5223
-
-
Anderson, J.A.1
-
32
-
-
33745245733
-
+ T cells
-
DOI 10.1128/JVI.00591-06
-
Bailey JR, et al. (2006) Residual human immunodeficiency virus type 1 viremia in some patients on antiretroviral therapy is dominated by a small number of invariant clones rarely found in circulating CD4+ T cells. J Virol 80:6441-6457. (Pubitemid 43927447)
-
(2006)
Journal of Virology
, vol.80
, Issue.13
, pp. 6441-6457
-
-
Bailey, J.R.1
Sedaghat, A.R.2
Kieffer, T.3
Brennan, T.4
Lee, P.K.5
Wind-Rotolo, M.6
Haggerty, C.M.7
Kamireddi, A.R.8
Liu, Y.9
Lee, J.10
Persaud, D.11
Gallant, J.E.12
Cofrancesco Jr., J.13
Quinn, T.C.14
Wilke, C.O.15
Ray, S.C.16
Siliciano, J.D.17
Nettles, R.E.18
Siliciano, R.F.19
-
33
-
-
10744228049
-
New real-time reverse transcriptase-initiated PCR assay with single-copy sensitivity for human immunodeficiency virus type 1 RNA in plasma
-
DOI 10.1128/JCM.41.10.4531-4536.2003
-
Palmer S, et al. (2003) New real-time reverse transcriptase-initiated PCR assay with single-copy sensitivity for human immunodeficiency virus type 1 RNA in plasma. J Clin Microbiol 41:4531-4536. (Pubitemid 37259753)
-
(2003)
Journal of Clinical Microbiology
, vol.41
, Issue.10
, pp. 4531-4536
-
-
Palmer, S.1
Wiegand, A.P.2
Maldarelli, F.3
Bazmi, H.4
Mican, J.M.5
Polis, M.6
Dewar, R.L.7
Planta, A.8
Liu, S.9
Metcalf, J.A.10
Mellors, J.W.11
Coffin, J.M.12
-
34
-
-
34249883292
-
Decay of the HIV reservoir in patients receiving antiretroviral therapy for extended periods: Implications for eradication of virus
-
Chun TW, et al. (2007) Decay of the HIV reservoir in patients receiving antiretroviral therapy for extended periods: Implications for eradication of virus. J Infect Dis 195:1762-1764.
-
(2007)
J Infect Dis
, vol.195
, pp. 1762-1764
-
-
Chun, T.W.1
-
35
-
-
0029967721
-
HIV-1 dynamics in vivo: Virion clearance rate, infected cell life-span, and viral generation time
-
Perelson AS, Neumann AU, Markowitz M, Leonard JM, Ho DD (1996) HIV-1 dynamics in vivo: Virion clearance rate, infected cell life-span, and viral generation time. Science 271:1582-1586. (Pubitemid 26097216)
-
(1996)
Science
, vol.271
, Issue.5255
, pp. 1582-1586
-
-
Perelson, A.S.1
Neumann, A.U.2
Markowitz, M.3
Leonard, J.M.4
Ho, D.D.5
-
36
-
-
0028792184
-
In vivo fate of HIV-1-infected T cells: Quantitative analysis of the transition to stable latency
-
Chun TW, et al. (1995) In vivo fate of HIV-1-infected T cells: Quantitative analysis of the transition to stable latency. Nat Med 1:1284-1290.
-
(1995)
Nat Med
, vol.1
, pp. 1284-1290
-
-
Chun, T.W.1
-
37
-
-
0242584383
-
Heterogeneous clearance rates of long-lived lymphocytes infected with HIV: Intrinsic stability predicts lifelong persistence
-
DOI 10.1073/pnas.0736332100
-
Strain MC, et al. (2003) Heterogeneous clearance rates of long-lived lymphocytes infected with HIV: Intrinsic stability predicts lifelong persistence. Proc Natl Acad Sci USA 100:4819-4824. (Pubitemid 36457812)
-
(2003)
Proceedings of the National Academy of Sciences of the United States of America
, vol.100
, Issue.8
, pp. 4819-4824
-
-
Strain, M.C.1
Gunthard, H.F.2
Havlir, D.V.3
Ignacio, C.C.4
Smith, D.M.5
Leigh-Brown, A.J.6
Macaranas, T.R.7
Lam, R.Y.8
Daly, O.A.9
Fischer, M.10
Opravil, M.11
Levine, H.12
Bacheler, L.13
Spina, C.A.14
Richman, D.D.15
Wong, J.K.16
-
38
-
-
78549235738
-
Rebound of plasma viremia following cessation of anti-retroviral therapy despite profoundly low levels of HIV reservoir: Implications for eradication
-
Chun TW, et al. (2010) Rebound of plasma viremia following cessation of anti-retroviral therapy despite profoundly low levels of HIV reservoir: Implications for eradication. AIDS 24:2803-2808.
-
(2010)
AIDS
, vol.24
, pp. 2803-2808
-
-
Chun, T.W.1
-
39
-
-
41649083599
-
Low-level viremia persists for at least 7 years in patients on suppressive antiretroviral therapy
-
DOI 10.1073/pnas.0800050105
-
Palmer S, et al. (2008) Low-level viremia persists for at least 7 years in patients on suppressive antiretroviral therapy. Proc Natl Acad Sci USA 105:3879-3884. (Pubitemid 351723493)
-
(2008)
Proceedings of the National Academy of Sciences of the United States of America
, vol.105
, Issue.10
, pp. 3879-3884
-
-
Palmer, S.1
Maldarelli, F.2
Wiegand, A.3
Bernstein, B.4
Hanna, G.J.5
Brun, S.C.6
Kempf, D.J.7
Mellors, J.W.8
Coffin, J.M.9
King, M.S.10
-
40
-
-
77949592502
-
Antiretroviral intensification and valproic acid lack sustained effect on residual HIV-1 viremia or resting CD4+ cell infection
-
Archin NM, et al. (2010) Antiretroviral intensification and valproic acid lack sustained effect on residual HIV-1 viremia or resting CD4+ cell infection. PLoS ONE 5:e9390.
-
(2010)
PLoS ONE
, vol.5
-
-
Archin, N.M.1
-
41
-
-
23744500093
-
Depletion of latent HIV-1 infection in vivo: A proof-of-concept study
-
DOI 10.1016/S0140-6736(05)67098-5, PII S0140673605670985
-
Lehrman G, et al. (2005) Depletion of latent HIV-1 infection in vivo: A proof-of-concept study. Lancet 366:549-555. (Pubitemid 41140329)
-
(2005)
Lancet
, vol.366
, Issue.9485
, pp. 549-555
-
-
Lehrman, G.1
Hogue, I.B.2
Palmer, S.3
Jennings, C.4
Spina, C.A.5
Wiegand, A.6
Landay, A.L.7
Coombs, R.W.8
Richman, D.D.9
Mellors, J.W.10
Coffin, J.M.11
Bosch, R.J.12
Margolis, D.M.13
|