-
1
-
-
84978097525
-
-
US Renal Data System. 2011 Annual Data Report: Atlas of Chronic Kidney Disease and End-Stage Renal Disease in the United States. Bethesda, MD, National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases.
-
1 US Renal Data System. 2011 Annual Data Report: Atlas of Chronic Kidney Disease and End-Stage Renal Disease in the United States. 2011. Bethesda, MD, National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases.
-
(2011)
-
-
-
2
-
-
84855183026
-
Focal segmental glomerulosclerosis
-
2 D'Agati, V.D., Kaskel, F.J., Falk, R.J., Focal segmental glomerulosclerosis. N Engl J Med 365 (2011), 2398–2411.
-
(2011)
N Engl J Med
, vol.365
, pp. 2398-2411
-
-
D'Agati, V.D.1
Kaskel, F.J.2
Falk, R.J.3
-
3
-
-
84880874176
-
Measuring the global burden of disease
-
3 Murray, C.J., Lopez, A.D., Measuring the global burden of disease. N Engl J Med 369 (2013), 448–457.
-
(2013)
N Engl J Med
, vol.369
, pp. 448-457
-
-
Murray, C.J.1
Lopez, A.D.2
-
4
-
-
84902826499
-
Decline in estimated glomerular filtration rate and subsequent risk of end-stage renal disease and mortality
-
4 Coresh, J., Turin, T.C., Matsushita, K., et al. Decline in estimated glomerular filtration rate and subsequent risk of end-stage renal disease and mortality. JAMA 311 (2014), 2518–2531.
-
(2014)
JAMA
, vol.311
, pp. 2518-2531
-
-
Coresh, J.1
Turin, T.C.2
Matsushita, K.3
-
5
-
-
84903276794
-
Early change in proteinuria as a surrogate end point for kidney disease progression: an individual patient meta-analysis
-
5 Inker, L.A., Levey, A.S., Pandya, K., et al. Early change in proteinuria as a surrogate end point for kidney disease progression: an individual patient meta-analysis. Am J Kidney Dis 64 (2014), 74–85.
-
(2014)
Am J Kidney Dis
, vol.64
, pp. 74-85
-
-
Inker, L.A.1
Levey, A.S.2
Pandya, K.3
-
6
-
-
84958254256
-
Complete and partial remission as surrogate end points in membranous nephropathy
-
6 Thompson, A., Cattran, D.C., Blank, M., et al. Complete and partial remission as surrogate end points in membranous nephropathy. J Am Soc Nephrol 26 (2015), 2930–2937.
-
(2015)
J Am Soc Nephrol
, vol.26
, pp. 2930-2937
-
-
Thompson, A.1
Cattran, D.C.2
Blank, M.3
-
7
-
-
84889009158
-
Urine podocyte mRNAs, proteinuria, and progression in human glomerular diseases
-
7 Wickman, L., Afshinnia, F., Wang, S.Q., et al. Urine podocyte mRNAs, proteinuria, and progression in human glomerular diseases. J Am Soc Nephrol 24 (2013), 2081–2095.
-
(2013)
J Am Soc Nephrol
, vol.24
, pp. 2081-2095
-
-
Wickman, L.1
Afshinnia, F.2
Wang, S.Q.3
-
8
-
-
80051926768
-
Trial quality in nephrology: how are we measuring up?
-
8 Palmer, S.C., Sciancalepore, M., Strippoli, G.F., Trial quality in nephrology: how are we measuring up?. Am J Kidney Dis 58 (2011), 335–337.
-
(2011)
Am J Kidney Dis
, vol.58
, pp. 335-337
-
-
Palmer, S.C.1
Sciancalepore, M.2
Strippoli, G.F.3
-
9
-
-
0034126357
-
Getting a foothold in nephrotic syndrome
-
9 Somlo, S., Mundel, P., Getting a foothold in nephrotic syndrome. Nat Genet 24 (2000), 333–335.
-
(2000)
Nat Genet
, vol.24
, pp. 333-335
-
-
Somlo, S.1
Mundel, P.2
-
10
-
-
0033529312
-
Nephrin is specifically located at the slit diaphragm of glomerular podocytes
-
10 Ruotsalainen, V., Ljungberg, P., Wartiovaara, J., et al. Nephrin is specifically located at the slit diaphragm of glomerular podocytes. Proc Natl Acad Sci U S A 96 (1999), 7962–7967.
-
(1999)
Proc Natl Acad Sci U S A
, vol.96
, pp. 7962-7967
-
-
Ruotsalainen, V.1
Ljungberg, P.2
Wartiovaara, J.3
-
11
-
-
0032730875
-
Unraveling the mechanisms of glomerular ultrafiltration: nephrin, a key component of the slit diaphragm
-
11 Tryggvason, K., Unraveling the mechanisms of glomerular ultrafiltration: nephrin, a key component of the slit diaphragm. J Am Soc Nephrol 10 (1999), 2440–2445.
-
(1999)
J Am Soc Nephrol
, vol.10
, pp. 2440-2445
-
-
Tryggvason, K.1
-
12
-
-
0035210580
-
Caught flat-footed: podocyte damage and the molecular bases of focal glomerulosclerosis
-
12 Kerjaschki, D., Caught flat-footed: podocyte damage and the molecular bases of focal glomerulosclerosis. J Clin Invest 108 (2001), 1583–1587.
-
(2001)
J Clin Invest
, vol.108
, pp. 1583-1587
-
-
Kerjaschki, D.1
-
13
-
-
0346788786
-
The role of podocytes in glomerular pathobiology
-
13 Asanuma, K., Mundel, P., The role of podocytes in glomerular pathobiology. Clin Exp Nephrol 7 (2003), 255–259.
-
(2003)
Clin Exp Nephrol
, vol.7
, pp. 255-259
-
-
Asanuma, K.1
Mundel, P.2
-
14
-
-
84882245010
-
Molecular fingerprinting of the podocyte reveals novel gene and protein regulatory networks
-
14 Boerries, M., Grahammer, F., Eiselein, S., et al. Molecular fingerprinting of the podocyte reveals novel gene and protein regulatory networks. Kidney Int 83 (2013), 1052–1064.
-
(2013)
Kidney Int
, vol.83
, pp. 1052-1064
-
-
Boerries, M.1
Grahammer, F.2
Eiselein, S.3
-
15
-
-
84926180628
-
Discovery of new glomerular disease-relevant genes by translational profiling of podocytes in vivo
-
15 Grgic, I., Hofmeister, A.F., Genovese, G., et al. Discovery of new glomerular disease-relevant genes by translational profiling of podocytes in vivo. Kidney Int 86 (2014), 1116–1129.
-
(2014)
Kidney Int
, vol.86
, pp. 1116-1129
-
-
Grgic, I.1
Hofmeister, A.F.2
Genovese, G.3
-
16
-
-
84455208254
-
The podocyte as a target for therapies—new and old
-
16 Mathieson, P.W., The podocyte as a target for therapies—new and old. Nat Rev Nephrol 8 (2012), 52–56.
-
(2012)
Nat Rev Nephrol
, vol.8
, pp. 52-56
-
-
Mathieson, P.W.1
-
17
-
-
84962373263
-
Podocytes as a therapeutic target
-
17 Arif, E., Nihalani, D., Podocytes as a therapeutic target. Ann Clin Exp Hypertens 1 (2013), 1003–1013.
-
(2013)
Ann Clin Exp Hypertens
, vol.1
, pp. 1003-1013
-
-
Arif, E.1
Nihalani, D.2
-
18
-
-
84901946024
-
Lessons learned from the fate of AstraZeneca's drug pipeline: a five-dimensional framework
-
18 Cook, D., Brown, D., Alexander, R., et al. Lessons learned from the fate of AstraZeneca's drug pipeline: a five-dimensional framework. Nat Rev Drug Discov 13 (2014), 419–431.
-
(2014)
Nat Rev Drug Discov
, vol.13
, pp. 419-431
-
-
Cook, D.1
Brown, D.2
Alexander, R.3
-
19
-
-
84938292742
-
The support of human genetic evidence for approved drug indications
-
19 Nelson, M.R., Tipney, H., Painter, J.L., et al. The support of human genetic evidence for approved drug indications. Nat Genet 47 (2015), 856–860.
-
(2015)
Nat Genet
, vol.47
, pp. 856-860
-
-
Nelson, M.R.1
Tipney, H.2
Painter, J.L.3
-
20
-
-
84881315517
-
Validating therapeutic targets through human genetics
-
20 Plenge, R.M., Scolnick, E.M., Altshuler, D., Validating therapeutic targets through human genetics. Nat Rev Drug Discov 12 (2013), 581–594.
-
(2013)
Nat Rev Drug Discov
, vol.12
, pp. 581-594
-
-
Plenge, R.M.1
Scolnick, E.M.2
Altshuler, D.3
-
21
-
-
22844436647
-
TRPC6 is a glomerular slit diaphragm-associated channel required for normal renal function
-
21 Reiser, J., Polu, K.R., Moller, C.C., et al. TRPC6 is a glomerular slit diaphragm-associated channel required for normal renal function. Nat Genet 37 (2005), 739–744.
-
(2005)
Nat Genet
, vol.37
, pp. 739-744
-
-
Reiser, J.1
Polu, K.R.2
Moller, C.C.3
-
22
-
-
20844461826
-
A mutation in the TRPC6 cation channel causes familial focal segmental glomerulosclerosis
-
22 Winn, M.P., Conlon, P.J., Lynn, K.L., et al. A mutation in the TRPC6 cation channel causes familial focal segmental glomerulosclerosis. Science 308 (2005), 1801–1804.
-
(2005)
Science
, vol.308
, pp. 1801-1804
-
-
Winn, M.P.1
Conlon, P.J.2
Lynn, K.L.3
-
23
-
-
33846028228
-
Induction of TRPC6 channel in acquired forms of proteinuric kidney disease
-
23 Moller, C.C., Wei, C., Altintas, M.M., et al. Induction of TRPC6 channel in acquired forms of proteinuric kidney disease. J Am Soc Nephrol 18 (2007), 29–36.
-
(2007)
J Am Soc Nephrol
, vol.18
, pp. 29-36
-
-
Moller, C.C.1
Wei, C.2
Altintas, M.M.3
-
24
-
-
77949756180
-
Novel siRNA delivery system to target podocytes in vivo
-
24 Hauser, P.V., Pippin, J.W., Kaiser, C., et al. Novel siRNA delivery system to target podocytes in vivo. PLoS One, 5, 2010, e9463.
-
(2010)
PLoS One
, vol.5
, pp. e9463
-
-
Hauser, P.V.1
Pippin, J.W.2
Kaiser, C.3
-
25
-
-
84928994314
-
Gq signaling causes glomerular injury by activating TRPC6
-
25 Wang, L., Jirka, G., Rosenberg, P.B., et al. Gq signaling causes glomerular injury by activating TRPC6. J Clin Invest 125 (2015), 1913–1926.
-
(2015)
J Clin Invest
, vol.125
, pp. 1913-1926
-
-
Wang, L.1
Jirka, G.2
Rosenberg, P.B.3
-
26
-
-
84890024099
-
Inhibition of the TRPC5 ion channel protects the kidney filter
-
26 Schaldecker, T., Kim, S., Tarabanis, C., et al. Inhibition of the TRPC5 ion channel protects the kidney filter. J Clin Invest 123 (2013), 5298–5309.
-
(2013)
J Clin Invest
, vol.123
, pp. 5298-5309
-
-
Schaldecker, T.1
Kim, S.2
Tarabanis, C.3
-
27
-
-
80052991459
-
Identification of ML204, a novel potent antagonist that selectively modulates native TRPC4/C5 ion channels
-
27 Miller, M., Shi, J., Zhu, Y., et al. Identification of ML204, a novel potent antagonist that selectively modulates native TRPC4/C5 ion channels. J Biol Chem 286 (2011), 33436–33446.
-
(2011)
J Biol Chem
, vol.286
, pp. 33436-33446
-
-
Miller, M.1
Shi, J.2
Zhu, Y.3
-
28
-
-
84924009565
-
Integrative biology identifies shared transcriptional networks in CKD
-
28 Martini, S., Nair, V., Keller, B.J., et al. Integrative biology identifies shared transcriptional networks in CKD. J Am Soc Nephrol 25 (2014), 2559–2572.
-
(2014)
J Am Soc Nephrol
, vol.25
, pp. 2559-2572
-
-
Martini, S.1
Nair, V.2
Keller, B.J.3
-
29
-
-
84937976810
-
Introduction: precision medicine for glomerular disease: the road forward
-
29 Kretzler, M., Sedor, J.R., Introduction: precision medicine for glomerular disease: the road forward. Semin Nephrol 35 (2015), 209–211.
-
(2015)
Semin Nephrol
, vol.35
, pp. 209-211
-
-
Kretzler, M.1
Sedor, J.R.2
-
30
-
-
84890038202
-
ADCK4 mutations promote steroid-resistant nephrotic syndrome through CoQ10 biosynthesis disruption
-
30 Ashraf, S., Gee, H.Y., Woerner, S., et al. ADCK4 mutations promote steroid-resistant nephrotic syndrome through CoQ10 biosynthesis disruption. J Clin Invest 123 (2013), 5179–5189.
-
(2013)
J Clin Invest
, vol.123
, pp. 5179-5189
-
-
Ashraf, S.1
Gee, H.Y.2
Woerner, S.3
-
31
-
-
84953331151
-
Glomerular aging and focal global glomerulosclerosis: a podometric perspective
-
31 Hodgin, J.B., Bitzer, M., Wickman, L., et al. Glomerular aging and focal global glomerulosclerosis: a podometric perspective. J Am Soc Nephrol 26 (2015), 3162–3178.
-
(2015)
J Am Soc Nephrol
, vol.26
, pp. 3162-3178
-
-
Hodgin, J.B.1
Bitzer, M.2
Wickman, L.3
-
32
-
-
84901428363
-
Glomerular regeneration: when can the kidney regenerate from injury and what turns failure into success?
-
32 Peired, A., Lazzeri, E., Lasagni, L., et al. Glomerular regeneration: when can the kidney regenerate from injury and what turns failure into success?. Nephron Exp Nephrol, 126, 2014, 70.
-
(2014)
Nephron Exp Nephrol
, vol.126
, pp. 70
-
-
Peired, A.1
Lazzeri, E.2
Lasagni, L.3
-
33
-
-
83655191972
-
Angiotensin II-dependent persistent podocyte loss from destabilized glomeruli causes progression of end stage kidney disease
-
33 Fukuda, A., Wickman, L.T., Venkatareddy, M.P., et al. Angiotensin II-dependent persistent podocyte loss from destabilized glomeruli causes progression of end stage kidney disease. Kidney Int 81 (2012), 40–55.
-
(2012)
Kidney Int
, vol.81
, pp. 40-55
-
-
Fukuda, A.1
Wickman, L.T.2
Venkatareddy, M.P.3
-
34
-
-
0036189998
-
A conditionally immortalized human podocyte cell line demonstrating nephrin and podocin expression
-
34 Saleem, M.A., O'Hare, M.J., Reiser, J., et al. A conditionally immortalized human podocyte cell line demonstrating nephrin and podocin expression. J Am Soc Nephrol 13 (2002), 630–638.
-
(2002)
J Am Soc Nephrol
, vol.13
, pp. 630-638
-
-
Saleem, M.A.1
O'Hare, M.J.2
Reiser, J.3
-
35
-
-
84864439398
-
Podocyte culture: tricks of the trade
-
35 Ni, L., Saleem, M., Mathieson, P.W., Podocyte culture: tricks of the trade. Nephrology 17 (2012), 525–531.
-
(2012)
Nephrology
, vol.17
, pp. 525-531
-
-
Ni, L.1
Saleem, M.2
Mathieson, P.W.3
-
36
-
-
84892596817
-
A novel source of cultured podocytes
-
36 Da Sacco, S., Lemley, K.V., Sedrakyan, S., et al. A novel source of cultured podocytes. PLoS One, 8, 2013, e81812.
-
(2013)
PLoS One
, vol.8
, pp. e81812
-
-
Da Sacco, S.1
Lemley, K.V.2
Sedrakyan, S.3
-
37
-
-
84867027380
-
The directed differentiation of human iPS cells into kidney podocytes
-
37 Song, B., Smink, A.M., Jones, C.V., et al. The directed differentiation of human iPS cells into kidney podocytes. PLoS One, 7, 2012, e46453.
-
(2012)
PLoS One
, vol.7
, pp. e46453
-
-
Song, B.1
Smink, A.M.2
Jones, C.V.3
-
38
-
-
79957836560
-
Rituximab targets podocytes in recurrent focal segmental glomerulosclerosis
-
38 Fornoni, A., Sageshima, J., Wei, C., et al. Rituximab targets podocytes in recurrent focal segmental glomerulosclerosis. Sci Transl Med, 3, 2011, 85ra46.
-
(2011)
Sci Transl Med
, vol.3
, pp. 85ra46
-
-
Fornoni, A.1
Sageshima, J.2
Wei, C.3
-
39
-
-
84891688019
-
Cyclodextrin protects podocytes in diabetic kidney disease
-
39 Merscher-Gomez, S., Guzman, J., Pedigo, C.E., et al. Cyclodextrin protects podocytes in diabetic kidney disease. Diabetes 62 (2013), 3817–3827.
-
(2013)
Diabetes
, vol.62
, pp. 3817-3827
-
-
Merscher-Gomez, S.1
Guzman, J.2
Pedigo, C.E.3
-
40
-
-
84938310769
-
A podocyte-based automated screening assay identifies protective small molecules
-
40 Lee, H.W., Khan, S.Q., Faridi, M.H., et al. A podocyte-based automated screening assay identifies protective small molecules. J Am Soc Nephrol 26 (2015), 2741–2752.
-
(2015)
J Am Soc Nephrol
, vol.26
, pp. 2741-2752
-
-
Lee, H.W.1
Khan, S.Q.2
Faridi, M.H.3
-
41
-
-
84934441012
-
Novel in vivo techniques to visualize kidney anatomy and function
-
41 Peti-Peterdi, J., Kidokoro, K., Riquier-Brison, A., Novel in vivo techniques to visualize kidney anatomy and function. Kidney Int 88 (2015), 44–51.
-
(2015)
Kidney Int
, vol.88
, pp. 44-51
-
-
Peti-Peterdi, J.1
Kidokoro, K.2
Riquier-Brison, A.3
-
42
-
-
84930752224
-
Pharmacological targeting of actin-dependent dynamin oligomerization ameliorates chronic kidney disease in diverse animal models
-
42 Schiffer, M., Teng, B., Gu, C., et al. Pharmacological targeting of actin-dependent dynamin oligomerization ameliorates chronic kidney disease in diverse animal models. Nat Med 21 (2015), 601–609.
-
(2015)
Nat Med
, vol.21
, pp. 601-609
-
-
Schiffer, M.1
Teng, B.2
Gu, C.3
-
43
-
-
80053439688
-
CD2AP in mouse and human podocytes controls a proteolytic program that regulates cytoskeletal structure and cellular survival
-
43 Yaddanapudi, S., Altintas, M.M., Kistler, A.D., et al. CD2AP in mouse and human podocytes controls a proteolytic program that regulates cytoskeletal structure and cellular survival. J Clin Invest 121 (2011), 3965–3980.
-
(2011)
J Clin Invest
, vol.121
, pp. 3965-3980
-
-
Yaddanapudi, S.1
Altintas, M.M.2
Kistler, A.D.3
-
44
-
-
84875053763
-
Active proteases in nephrotic plasma lead to a podocin-dependent phosphorylation of VASP in podocytes via protease activated receptor-1
-
44 Harris, J.J., McCarthy, H.J., Ni, L., et al. Active proteases in nephrotic plasma lead to a podocin-dependent phosphorylation of VASP in podocytes via protease activated receptor-1. J Pathol 229 (2013), 660–671.
-
(2013)
J Pathol
, vol.229
, pp. 660-671
-
-
Harris, J.J.1
McCarthy, H.J.2
Ni, L.3
-
45
-
-
84880997931
-
Opposing effects of podocin on the gating of podocyte TRPC6 channels evoked by membrane stretch or diacylglycerol
-
45 Anderson, M., Kim, E.Y., Hagmann, H., et al. Opposing effects of podocin on the gating of podocyte TRPC6 channels evoked by membrane stretch or diacylglycerol. Am J Physiol Cell Physiol 305 (2013), C276–C289.
-
(2013)
Am J Physiol Cell Physiol
, vol.305
, pp. C276-C289
-
-
Anderson, M.1
Kim, E.Y.2
Hagmann, H.3
-
46
-
-
77949350034
-
Identification of a primary target of thalidomide teratogenicity
-
46 Ito, T., Ando, H., Suzuki, T., et al. Identification of a primary target of thalidomide teratogenicity. Science 327 (2010), 1345–1350.
-
(2010)
Science
, vol.327
, pp. 1345-1350
-
-
Ito, T.1
Ando, H.2
Suzuki, T.3
-
47
-
-
84882590738
-
Human kidney proximal tubule-on-a-chip for drug transport and nephrotoxicity assessment
-
47 Jang, K.J., Mehr, A.P., Hamilton, G.A., et al. Human kidney proximal tubule-on-a-chip for drug transport and nephrotoxicity assessment. Integr Biol (Camb) 5 (2013), 1119–1129.
-
(2013)
Integr Biol (Camb)
, vol.5
, pp. 1119-1129
-
-
Jang, K.J.1
Mehr, A.P.2
Hamilton, G.A.3
-
48
-
-
84869126274
-
A human disease model of drug toxicity-induced pulmonary edema in a lung-on-a-chip microdevice
-
48 Huh, D., Leslie, D.C., Matthews, B.D., et al. A human disease model of drug toxicity-induced pulmonary edema in a lung-on-a-chip microdevice. Sci Transl Med, 4, 2012, 159ra147.
-
(2012)
Sci Transl Med
, vol.4
, pp. 159ra147
-
-
Huh, D.1
Leslie, D.C.2
Matthews, B.D.3
-
49
-
-
13344285352
-
Circulating factor associated with increased glomerular permeability to albumin in recurrent focal segmental glomerulosclerosis
-
49 Savin, V.J., Sharma, R., Sharma, M., et al. Circulating factor associated with increased glomerular permeability to albumin in recurrent focal segmental glomerulosclerosis. N Engl J Med 334 (1996), 878–883.
-
(1996)
N Engl J Med
, vol.334
, pp. 878-883
-
-
Savin, V.J.1
Sharma, R.2
Sharma, M.3
-
50
-
-
84947611236
-
The Rho-GTPase binding protein IQGAP2 is required for the glomerular filtration barrier
-
50 Sugano, Y., Lindenmeyer, M.T., Auberger, I., et al. The Rho-GTPase binding protein IQGAP2 is required for the glomerular filtration barrier. Kidney Int 88 (2015), 1047–1056.
-
(2015)
Kidney Int
, vol.88
, pp. 1047-1056
-
-
Sugano, Y.1
Lindenmeyer, M.T.2
Auberger, I.3
-
51
-
-
80054682663
-
The translational challenge in the development of new and effective therapies for endometriosis: a review of confidence from published preclinical efficacy studies
-
51 Pullen, N., Birch, C.L., Douglas, G.J., et al. The translational challenge in the development of new and effective therapies for endometriosis: a review of confidence from published preclinical efficacy studies. Hum Reprod Update 17 (2011), 791–802.
-
(2011)
Hum Reprod Update
, vol.17
, pp. 791-802
-
-
Pullen, N.1
Birch, C.L.2
Douglas, G.J.3
-
52
-
-
80055088241
-
Believe it or not: how much can we rely on published data on potential drug targets?
-
52 Prinz, F., Schlange, T., Asadullah, K., Believe it or not: how much can we rely on published data on potential drug targets?. Nat Rev Drug Discov, 10, 2011, 712.
-
(2011)
Nat Rev Drug Discov
, vol.10
, pp. 712
-
-
Prinz, F.1
Schlange, T.2
Asadullah, K.3
-
53
-
-
84859169880
-
Drug development: raise standards for preclinical cancer research
-
53 Begley, C.G., Ellis, L.M., Drug development: raise standards for preclinical cancer research. Nature 483 (2012), 531–533.
-
(2012)
Nature
, vol.483
, pp. 531-533
-
-
Begley, C.G.1
Ellis, L.M.2
-
54
-
-
84926612863
-
A reassessment of soluble urokinase-type plasminogen activator receptor in glomerular disease
-
54 Spinale, J.M., Mariani, L.H., Kapoor, S., et al. A reassessment of soluble urokinase-type plasminogen activator receptor in glomerular disease. Kidney Int 87 (2015), 564–574.
-
(2015)
Kidney Int
, vol.87
, pp. 564-574
-
-
Spinale, J.M.1
Mariani, L.H.2
Kapoor, S.3
-
55
-
-
35748934487
-
The influence of drug-like concepts on decision-making in medicinal chemistry
-
55 Leeson, P.D., Springthorpe, B., The influence of drug-like concepts on decision-making in medicinal chemistry. Nat Rev Drug Discov 6 (2007), 881–890.
-
(2007)
Nat Rev Drug Discov
, vol.6
, pp. 881-890
-
-
Leeson, P.D.1
Springthorpe, B.2
-
56
-
-
84860690620
-
Can the flow of medicines be improved? Fundamental pharmacokinetic and pharmacological principles toward improving Phase II survival
-
56 Morgan, P., Van Der Graaf, P.H., Arrowsmith, J., et al. Can the flow of medicines be improved? Fundamental pharmacokinetic and pharmacological principles toward improving Phase II survival. Drug Discov Today 17 (2012), 419–424.
-
(2012)
Drug Discov Today
, vol.17
, pp. 419-424
-
-
Morgan, P.1
Van Der Graaf, P.H.2
Arrowsmith, J.3
-
57
-
-
84929045385
-
Endothelin and the glomerulus in chronic kidney disease
-
57 Barton, M., Sorokin, A., Endothelin and the glomerulus in chronic kidney disease. Semin Nephrol 35 (2015), 156–167.
-
(2015)
Semin Nephrol
, vol.35
, pp. 156-167
-
-
Barton, M.1
Sorokin, A.2
-
58
-
-
80053377598
-
Systemic administration of naked plasmid encoding HGF attenuates puromycin aminonucleoside-induced damage of murine glomerular podocytes
-
58 Bu, X., Zhou, Y., Zhang, H., et al. Systemic administration of naked plasmid encoding HGF attenuates puromycin aminonucleoside-induced damage of murine glomerular podocytes. Am J Physiol Renal Physiol 301 (2011), F784–F792.
-
(2011)
Am J Physiol Renal Physiol
, vol.301
, pp. F784-F792
-
-
Bu, X.1
Zhou, Y.2
Zhang, H.3
-
59
-
-
84896867400
-
β-Arrestin-1 drives endothelin-1-mediated podocyte activation and sustains renal injury
-
59 Buelli, S., Rosano, L., Gagliardini, E., et al. β-Arrestin-1 drives endothelin-1-mediated podocyte activation and sustains renal injury. J Am Soc Nephrol 25 (2014), 523–533.
-
(2014)
J Am Soc Nephrol
, vol.25
, pp. 523-533
-
-
Buelli, S.1
Rosano, L.2
Gagliardini, E.3
-
60
-
-
84954288448
-
Tissue transcriptome-driven identification of epidermal growth factor as a chronic kidney disease biomarker
-
60 Ju, W., Nair, V., Smith, S., et al. Tissue transcriptome-driven identification of epidermal growth factor as a chronic kidney disease biomarker. Sci Transl Med, 7, 2015, 316ra193.
-
(2015)
Sci Transl Med
, vol.7
, pp. 316ra193
-
-
Ju, W.1
Nair, V.2
Smith, S.3
-
61
-
-
84926429026
-
MicroRNA-21 in glomerular injury
-
61 Lai, J.Y., Luo, J., O'Connor, C., et al. MicroRNA-21 in glomerular injury. J Am Soc Nephrol 26 (2015), 805–816.
-
(2015)
J Am Soc Nephrol
, vol.26
, pp. 805-816
-
-
Lai, J.Y.1
Luo, J.2
O'Connor, C.3
-
62
-
-
84921677205
-
MicroRNA-29a promotion of nephrin acetylation ameliorates hyperglycemia-induced podocyte dysfunction
-
62 Lin, C.L., Lee, P.H., Hsu, Y.C., et al. MicroRNA-29a promotion of nephrin acetylation ameliorates hyperglycemia-induced podocyte dysfunction. J Am Soc Nephrol 25 (2014), 1698–1709.
-
(2014)
J Am Soc Nephrol
, vol.25
, pp. 1698-1709
-
-
Lin, C.L.1
Lee, P.H.2
Hsu, Y.C.3
-
63
-
-
84895806339
-
Mineralocorticoid receptor blocker protects against podocyte-dependent glomerulosclerosis
-
63 Takagi, N., Tanizawa, T., Kon, V., et al. Mineralocorticoid receptor blocker protects against podocyte-dependent glomerulosclerosis. Nephron Extra 2 (2012), 17–26.
-
(2012)
Nephron Extra
, vol.2
, pp. 17-26
-
-
Takagi, N.1
Tanizawa, T.2
Kon, V.3
-
64
-
-
84920829391
-
A mutation in Ampd2 is associated with nephrotic syndrome and hypercholesterolemia in mice
-
64 Helmering, J., Juan, T., Li, C.M., et al. A mutation in Ampd2 is associated with nephrotic syndrome and hypercholesterolemia in mice. Lipids Health Dis, 13, 2014, 167.
-
(2014)
Lipids Health Dis
, vol.13
, pp. 167
-
-
Helmering, J.1
Juan, T.2
Li, C.M.3
-
65
-
-
38049032013
-
Modification of kidney barrier function by the urokinase receptor
-
65 Wei, C., Moller, C.C., Altintas, M.M., et al. Modification of kidney barrier function by the urokinase receptor. Nat Med 14 (2008), 55–63.
-
(2008)
Nat Med
, vol.14
, pp. 55-63
-
-
Wei, C.1
Moller, C.C.2
Altintas, M.M.3
-
66
-
-
84890409760
-
Abatacept in B7-1-positive proteinuric kidney disease
-
66 Yu, C.C., Fornoni, A., Weins, A., et al. Abatacept in B7-1-positive proteinuric kidney disease. N Engl J Med 369 (2013), 2416–2423.
-
(2013)
N Engl J Med
, vol.369
, pp. 2416-2423
-
-
Yu, C.C.1
Fornoni, A.2
Weins, A.3
-
67
-
-
84861832879
-
Inhibition of integrin alpha2beta1 ameliorates glomerular injury
-
67 Borza, C.M., Su, Y., Chen, X., et al. Inhibition of integrin alpha2beta1 ameliorates glomerular injury. J Am Soc Nephrol 23 (2012), 1027–1038.
-
(2012)
J Am Soc Nephrol
, vol.23
, pp. 1027-1038
-
-
Borza, C.M.1
Su, Y.2
Chen, X.3
-
68
-
-
79956019655
-
Bradykinin receptor 1 activation exacerbates experimental focal and segmental glomerulosclerosis
-
68 Pereira, R.L., Buscariollo, B.N., Correa-Costa, M., et al. Bradykinin receptor 1 activation exacerbates experimental focal and segmental glomerulosclerosis. Kidney Int 79 (2011), 1217–1227.
-
(2011)
Kidney Int
, vol.79
, pp. 1217-1227
-
-
Pereira, R.L.1
Buscariollo, B.N.2
Correa-Costa, M.3
-
69
-
-
84862832878
-
Stimulation of the calcium-sensing receptor stabilizes the podocyte cytoskeleton, improves cell survival, and reduces toxin-induced glomerulosclerosis
-
69 Oh, J., Beckmann, J., Bloch, J., et al. Stimulation of the calcium-sensing receptor stabilizes the podocyte cytoskeleton, improves cell survival, and reduces toxin-induced glomerulosclerosis. Kidney Int 80 (2011), 483–492.
-
(2011)
Kidney Int
, vol.80
, pp. 483-492
-
-
Oh, J.1
Beckmann, J.2
Bloch, J.3
-
70
-
-
84863066779
-
Crk1/2-dependent signaling is necessary for podocyte foot process spreading in mouse models of glomerular disease
-
70 George, B., Verma, R., Soofi, A.A., et al. Crk1/2-dependent signaling is necessary for podocyte foot process spreading in mouse models of glomerular disease. J Clin Invest 122 (2012), 674–692.
-
(2012)
J Clin Invest
, vol.122
, pp. 674-692
-
-
George, B.1
Verma, R.2
Soofi, A.A.3
-
71
-
-
84857117783
-
Functional metabotropic glutamate receptors 1 and 5 are expressed in murine podocytes
-
71 Gu, L., Liang, X., Wang, L., et al. Functional metabotropic glutamate receptors 1 and 5 are expressed in murine podocytes. Kidney Int 81 (2012), 458–468.
-
(2012)
Kidney Int
, vol.81
, pp. 458-468
-
-
Gu, L.1
Liang, X.2
Wang, L.3
-
72
-
-
69849093919
-
Podocyte glutamatergic signaling contributes to the function of the glomerular filtration barrier
-
72 Giardino, L., Armelloni, S., Corbelli, A., et al. Podocyte glutamatergic signaling contributes to the function of the glomerular filtration barrier. J Am Soc Nephrol 20 (2009), 1929–1940.
-
(2009)
J Am Soc Nephrol
, vol.20
, pp. 1929-1940
-
-
Giardino, L.1
Armelloni, S.2
Corbelli, A.3
-
73
-
-
84864742398
-
Nicorandil, a K(atp) channel opener, alleviates chronic renal injury by targeting podocytes and macrophages
-
73 Tamura, Y., Tanabe, K., Kitagawa, W., et al. Nicorandil, a K(atp) channel opener, alleviates chronic renal injury by targeting podocytes and macrophages. Am J Physiol Renal Physiol 303 (2012), F339–F349.
-
(2012)
Am J Physiol Renal Physiol
, vol.303
, pp. F339-F349
-
-
Tamura, Y.1
Tanabe, K.2
Kitagawa, W.3
-
74
-
-
84946780880
-
MicroRNA-30 family members regulate calcium/calcineurin signaling in podocytes
-
74 Wu, J., Zheng, C., Wang, X., et al. MicroRNA-30 family members regulate calcium/calcineurin signaling in podocytes. J Clin Invest 125 (2015), 4091–4106.
-
(2015)
J Clin Invest
, vol.125
, pp. 4091-4106
-
-
Wu, J.1
Zheng, C.2
Wang, X.3
-
75
-
-
85011743819
-
-
Macrophage migration inhibitory factor mediates proliferative GN via CD74 [e-pub ahead of print]. J Am Soc Nephrol., accessed April 18, 2016.
-
75 Djudjaj S, Lue H, Rong S, et al. Macrophage migration inhibitory factor mediates proliferative GN via CD74 [e-pub ahead of print]. J Am Soc Nephrol. http://dx.doi.org/10.1681/ASN.2015020149, accessed April 18, 2016.
-
-
-
Djudjaj, S.1
Lue, H.2
Rong, S.3
-
76
-
-
84902683099
-
Phosphodiesterase 5 inhibition ameliorates angiotensin II-induced podocyte dysmotility via the protein kinase G-mediated downregulation of TRPC6 activity
-
76 Hall, G., Rowell, J., Farinelli, F., et al. Phosphodiesterase 5 inhibition ameliorates angiotensin II-induced podocyte dysmotility via the protein kinase G-mediated downregulation of TRPC6 activity. Am J Physiol Renal Physiol 306 (2014), F1442–F1450.
-
(2014)
Am J Physiol Renal Physiol
, vol.306
, pp. F1442-F1450
-
-
Hall, G.1
Rowell, J.2
Farinelli, F.3
-
77
-
-
84888383730
-
Rituximab is a safe and effective long-term treatment for children with steroid and calcineurin inhibitor-dependent idiopathic nephrotic syndrome
-
77 Ravani, P., Ponticelli, A., Siciliano, C., et al. Rituximab is a safe and effective long-term treatment for children with steroid and calcineurin inhibitor-dependent idiopathic nephrotic syndrome. Kidney Int 84 (2013), 1025–1033.
-
(2013)
Kidney Int
, vol.84
, pp. 1025-1033
-
-
Ravani, P.1
Ponticelli, A.2
Siciliano, C.3
-
78
-
-
80053282316
-
Angiotensin II contributes to podocyte injury by increasing TRPC6 expression via an NFAT-mediated positive feedback signaling pathway
-
78 Nijenhuis, T., Sloan, A.J., Hoenderop, J.G., et al. Angiotensin II contributes to podocyte injury by increasing TRPC6 expression via an NFAT-mediated positive feedback signaling pathway. Am J Pathol 179 (2011), 1719–1732.
-
(2011)
Am J Pathol
, vol.179
, pp. 1719-1732
-
-
Nijenhuis, T.1
Sloan, A.J.2
Hoenderop, J.G.3
-
79
-
-
79955520308
-
COQ6 mutations in human patients produce nephrotic syndrome with sensorineural deafness
-
79 Heeringa, S.F., Chernin, G., Chaki, M., et al. COQ6 mutations in human patients produce nephrotic syndrome with sensorineural deafness. J Clin Invest 121 (2011), 2013–2024.
-
(2011)
J Clin Invest
, vol.121
, pp. 2013-2024
-
-
Heeringa, S.F.1
Chernin, G.2
Chaki, M.3
-
80
-
-
84881245920
-
ARHGDIA mutations cause nephrotic syndrome via defective RHO GTPase signaling
-
80 Gee, H.Y., Saisawat, P., Ashraf, S., et al. ARHGDIA mutations cause nephrotic syndrome via defective RHO GTPase signaling. J Clin Invest 123 (2013), 3243–3253.
-
(2013)
J Clin Invest
, vol.123
, pp. 3243-3253
-
-
Gee, H.Y.1
Saisawat, P.2
Ashraf, S.3
-
81
-
-
51349162919
-
The actin cytoskeleton of kidney podocytes is a direct target of the antiproteinuric effect of cyclosporine A
-
81 Faul, C., Donnelly, M., Merscher-Gomez, S., et al. The actin cytoskeleton of kidney podocytes is a direct target of the antiproteinuric effect of cyclosporine A. Nat Med 14 (2008), 931–938.
-
(2008)
Nat Med
, vol.14
, pp. 931-938
-
-
Faul, C.1
Donnelly, M.2
Merscher-Gomez, S.3
-
82
-
-
84891869565
-
Circulating angiopoietin-like 4 links proteinuria with hypertriglyceridemia in nephrotic syndrome
-
82 Clement, L.C., Mace, C., Avila-Casado, C., et al. Circulating angiopoietin-like 4 links proteinuria with hypertriglyceridemia in nephrotic syndrome. Nat Med 20 (2014), 37–46.
-
(2014)
Nat Med
, vol.20
, pp. 37-46
-
-
Clement, L.C.1
Mace, C.2
Avila-Casado, C.3
-
83
-
-
43749098568
-
Sphingosine-1-phosphate receptors: biology and therapeutic potential in kidney disease
-
83 Jo, S.K., Bajwa, A., Awad, A.S., et al. Sphingosine-1-phosphate receptors: biology and therapeutic potential in kidney disease. Kidney Int 73 (2008), 1220–1230.
-
(2008)
Kidney Int
, vol.73
, pp. 1220-1230
-
-
Jo, S.K.1
Bajwa, A.2
Awad, A.S.3
-
84
-
-
36248947295
-
Blockade of cannabinoid CB1 receptors improves renal function, metabolic profile, and increased survival of obese Zucker rats
-
84 Janiak, P., Poirier, B., Bidouard, J.P., et al. Blockade of cannabinoid CB1 receptors improves renal function, metabolic profile, and increased survival of obese Zucker rats. Kidney Int 72 (2007), 1345–1357.
-
(2007)
Kidney Int
, vol.72
, pp. 1345-1357
-
-
Janiak, P.1
Poirier, B.2
Bidouard, J.P.3
-
85
-
-
71849107687
-
Phase 1 trial of adalimumab in focal segmental glomerulosclerosis (FSGS): II. Report of the FONT (Novel Therapies for Resistant FSGS) study group
-
85 Joy, M.S., Gipson, D.S., Powell, L., et al. Phase 1 trial of adalimumab in focal segmental glomerulosclerosis (FSGS): II. Report of the FONT (Novel Therapies for Resistant FSGS) study group. Am J Kidney Dis 55 (2010), 50–60.
-
(2010)
Am J Kidney Dis
, vol.55
, pp. 50-60
-
-
Joy, M.S.1
Gipson, D.S.2
Powell, L.3
-
86
-
-
78149297155
-
Circulating permeability factors in idiopathic nephrotic syndrome and focal segmental glomerulosclerosis
-
86 McCarthy, E.T., Sharma, M., Savin, V.J., Circulating permeability factors in idiopathic nephrotic syndrome and focal segmental glomerulosclerosis. Clin J Am Soc Nephrol 5 (2010), 2115–2121.
-
(2010)
Clin J Am Soc Nephrol
, vol.5
, pp. 2115-2121
-
-
McCarthy, E.T.1
Sharma, M.2
Savin, V.J.3
-
87
-
-
84959885241
-
Integrative genomics identifies novel associations with APOL1 risk genotypes in black NEPTUNE subjects
-
87 Sampson, M.G., Robertson, C.C., Martini, S., et al. Integrative genomics identifies novel associations with APOL1 risk genotypes in black NEPTUNE subjects. J Am Soc Nephrol 27 (2015), 814–823.
-
(2015)
J Am Soc Nephrol
, vol.27
, pp. 814-823
-
-
Sampson, M.G.1
Robertson, C.C.2
Martini, S.3
-
88
-
-
38749131227
-
Overexpression of connective tissue growth factor in podocytes worsens diabetic nephropathy in mice
-
88 Yokoi, H., Mukoyama, M., Mori, K., et al. Overexpression of connective tissue growth factor in podocytes worsens diabetic nephropathy in mice. Kidney Int 73 (2008), 446–455.
-
(2008)
Kidney Int
, vol.73
, pp. 446-455
-
-
Yokoi, H.1
Mukoyama, M.2
Mori, K.3
-
89
-
-
59149084125
-
Inhibition of C-jun N-terminal kinase improves insulin sensitivity but worsens albuminuria in experimental diabetes
-
89 Ijaz, A., Tejada, T., Catanuto, P., et al. Inhibition of C-jun N-terminal kinase improves insulin sensitivity but worsens albuminuria in experimental diabetes. Kidney Int 75 (2009), 381–388.
-
(2009)
Kidney Int
, vol.75
, pp. 381-388
-
-
Ijaz, A.1
Tejada, T.2
Catanuto, P.3
-
90
-
-
84930844430
-
Targeting NADPH oxidase with a novel dual Nox1/Nox4 inhibitor attenuates renal pathology in type 1 diabetes
-
90 Gorin, Y., Cavaglieri, R.C., Khazim, K., et al. Targeting NADPH oxidase with a novel dual Nox1/Nox4 inhibitor attenuates renal pathology in type 1 diabetes. Am J Physiol Renal Physiol 308 (2015), F1276–F1287.
-
(2015)
Am J Physiol Renal Physiol
, vol.308
, pp. F1276-F1287
-
-
Gorin, Y.1
Cavaglieri, R.C.2
Khazim, K.3
-
91
-
-
84875431757
-
Dual inhibition of classical protein kinase C-alpha and protein kinase C-beta isoforms protects against experimental murine diabetic nephropathy
-
91 Menne, J., Shushakova, N., Bartels, J., et al. Dual inhibition of classical protein kinase C-alpha and protein kinase C-beta isoforms protects against experimental murine diabetic nephropathy. Diabetes 62 (2013), 1167–1174.
-
(2013)
Diabetes
, vol.62
, pp. 1167-1174
-
-
Menne, J.1
Shushakova, N.2
Bartels, J.3
-
92
-
-
77956302476
-
Podocytic PKC-alpha is regulated in murine and human diabetes and mediates nephrin endocytosis
-
92 Tossidou, I., Teng, B., Menne, J., et al. Podocytic PKC-alpha is regulated in murine and human diabetes and mediates nephrin endocytosis. PLoS One, 5, 2010, e10185.
-
(2010)
PLoS One
, vol.5
, pp. e10185
-
-
Tossidou, I.1
Teng, B.2
Menne, J.3
-
93
-
-
79956011495
-
A phase 1, single-dose study of fresolimumab, an anti-TGF-beta antibody, in treatment-resistant primary focal segmental glomerulosclerosis
-
93 Trachtman, H., Fervenza, F.C., Gipson, D.S., et al. A phase 1, single-dose study of fresolimumab, an anti-TGF-beta antibody, in treatment-resistant primary focal segmental glomerulosclerosis. Kidney Int 79 (2011), 1236–1243.
-
(2011)
Kidney Int
, vol.79
, pp. 1236-1243
-
-
Trachtman, H.1
Fervenza, F.C.2
Gipson, D.S.3
-
94
-
-
82455212863
-
Induction of progressive glomerulonephritis by podocyte-specific overexpression of platelet-derived growth factor-D
-
94 van Roeyen, C.R., Eitner, F., Boor, P., et al. Induction of progressive glomerulonephritis by podocyte-specific overexpression of platelet-derived growth factor-D. Kidney Int 80 (2011), 1292–1305.
-
(2011)
Kidney Int
, vol.80
, pp. 1292-1305
-
-
van Roeyen, C.R.1
Eitner, F.2
Boor, P.3
-
95
-
-
84870501767
-
Vitamin D receptor signaling in podocytes protects against diabetic nephropathy
-
95 Wang, Y., Deb, D.K., Zhang, Z., et al. Vitamin D receptor signaling in podocytes protects against diabetic nephropathy. J Am Soc Nephrol 23 (2012), 1977–1986.
-
(2012)
J Am Soc Nephrol
, vol.23
, pp. 1977-1986
-
-
Wang, Y.1
Deb, D.K.2
Zhang, Z.3
-
96
-
-
80052009791
-
Inhibition of the protein kinase MK-2 protects podocytes from nephrotic syndrome-related injury
-
96 Pengal, R., Guess, A.J., Agrawal, S., et al. Inhibition of the protein kinase MK-2 protects podocytes from nephrotic syndrome-related injury. Am J Physiol Renal Physiol 301 (2011), F509–F519.
-
(2011)
Am J Physiol Renal Physiol
, vol.301
, pp. F509-F519
-
-
Pengal, R.1
Guess, A.J.2
Agrawal, S.3
-
97
-
-
84940860220
-
Podocyte apoptosis is prevented by blocking the Toll-like receptor pathway
-
97 Saurus, P., Kuusela, S., Lehtonen, E., et al. Podocyte apoptosis is prevented by blocking the Toll-like receptor pathway. Cell Death Dis, 6, 2015, e1752.
-
(2015)
Cell Death Dis
, vol.6
, pp. e1752
-
-
Saurus, P.1
Kuusela, S.2
Lehtonen, E.3
-
98
-
-
77957866215
-
A maladaptive role for EP4 receptors in podocytes
-
98 Stitt-Cavanagh, E.M., Faour, W.H., Takami, K., et al. A maladaptive role for EP4 receptors in podocytes. J Am Soc Nephrol 21 (2010), 1678–1690.
-
(2010)
J Am Soc Nephrol
, vol.21
, pp. 1678-1690
-
-
Stitt-Cavanagh, E.M.1
Faour, W.H.2
Takami, K.3
-
99
-
-
84897798847
-
Twisted gastrulation, a BMP antagonist, exacerbates podocyte injury
-
99 Yamada, S., Nakamura, J., Asada, M., et al. Twisted gastrulation, a BMP antagonist, exacerbates podocyte injury. PLoS One, 9, 2014, e89135.
-
(2014)
PLoS One
, vol.9
, pp. e89135
-
-
Yamada, S.1
Nakamura, J.2
Asada, M.3
-
100
-
-
42549105123
-
Podocyte injury induced by albumin overload in vivo and in vitro: involvement of TGF-beta and p38 MAPK
-
100 Yoshida, S., Nagase, M., Shibata, S., et al. Podocyte injury induced by albumin overload in vivo and in vitro: involvement of TGF-beta and p38 MAPK. Nephron Exp Nephrol 108 (2008), e57–e68.
-
(2008)
Nephron Exp Nephrol
, vol.108
, pp. e57-e68
-
-
Yoshida, S.1
Nagase, M.2
Shibata, S.3
-
101
-
-
84926146451
-
Albumin-induced podocyte injury and protection are associated with regulation of COX-2
-
101 Agrawal, S., Guess, A.J., Chanley, M.A., et al. Albumin-induced podocyte injury and protection are associated with regulation of COX-2. Kidney Int 86 (2014), 1150–1160.
-
(2014)
Kidney Int
, vol.86
, pp. 1150-1160
-
-
Agrawal, S.1
Guess, A.J.2
Chanley, M.A.3
-
102
-
-
84918780044
-
JAK inhibition and progressive kidney disease
-
102 Brosius, F.C. 3rd, He, J.C., JAK inhibition and progressive kidney disease. Curr Opin Nephrol Hypertens 24 (2015), 88–95.
-
(2015)
Curr Opin Nephrol Hypertens
, vol.24
, pp. 88-95
-
-
Brosius, F.C.1
He, J.C.2
-
103
-
-
84897468255
-
Keap1 inhibition attenuates glomerulosclerosis
-
103 Miyazaki, Y., Shimizu, A., Pastan, I., et al. Keap1 inhibition attenuates glomerulosclerosis. Nephrol Dial Transplant 29 (2014), 783–791.
-
(2014)
Nephrol Dial Transplant
, vol.29
, pp. 783-791
-
-
Miyazaki, Y.1
Shimizu, A.2
Pastan, I.3
-
104
-
-
84866419120
-
The receptor of advanced glycation end products plays a central role in advanced oxidation protein products-induced podocyte apoptosis
-
104 Zhou, L.L., Cao, W., Xie, C., et al. The receptor of advanced glycation end products plays a central role in advanced oxidation protein products-induced podocyte apoptosis. Kidney Int 82 (2012), 759–770.
-
(2012)
Kidney Int
, vol.82
, pp. 759-770
-
-
Zhou, L.L.1
Cao, W.2
Xie, C.3
-
105
-
-
84924032998
-
Rhophilin-1 is a key regulator of the podocyte cytoskeleton and is essential for glomerular filtration
-
105 Lal, M.A., Andersson, A.C., Katayama, K., et al. Rhophilin-1 is a key regulator of the podocyte cytoskeleton and is essential for glomerular filtration. J Am Soc Nephrol 26 (2015), 647–662.
-
(2015)
J Am Soc Nephrol
, vol.26
, pp. 647-662
-
-
Lal, M.A.1
Andersson, A.C.2
Katayama, K.3
-
106
-
-
84878733723
-
Inverted formin 2 regulates actin dynamics by antagonizing Rho/diaphanous-related formin signaling
-
106 Sun, H., Schlondorff, J., Higgs, H.N., et al. Inverted formin 2 regulates actin dynamics by antagonizing Rho/diaphanous-related formin signaling. J Am Soc Nephrol 24 (2013), 917–929.
-
(2013)
J Am Soc Nephrol
, vol.24
, pp. 917-929
-
-
Sun, H.1
Schlondorff, J.2
Higgs, H.N.3
-
107
-
-
44349126743
-
TLR4 links podocytes with the innate immune system to mediate glomerular injury
-
107 Banas, M.C., Banas, B., Hudkins, K.L., et al. TLR4 links podocytes with the innate immune system to mediate glomerular injury. J Am Soc Nephrol 19 (2008), 704–713.
-
(2008)
J Am Soc Nephrol
, vol.19
, pp. 704-713
-
-
Banas, M.C.1
Banas, B.2
Hudkins, K.L.3
-
108
-
-
84908368946
-
A circulating antibody panel for pretransplant prediction of FSGS recurrence after kidney transplantation
-
108 Delville, M., Sigdel, T.K., Wei, C., et al. A circulating antibody panel for pretransplant prediction of FSGS recurrence after kidney transplantation. Sci Transl Med, 6, 2014, 256ra136.
-
(2014)
Sci Transl Med
, vol.6
, pp. 256ra136
-
-
Delville, M.1
Sigdel, T.K.2
Wei, C.3
-
109
-
-
84959922745
-
Podocyte purinergic P2X4 channels are mechanotransducers that mediate cytoskeletal disorganization
-
109 Forst, A.L., Olteanu, V.S., Mollet, G., et al. Podocyte purinergic P2X4 channels are mechanotransducers that mediate cytoskeletal disorganization. J Am Soc Nephrol 27 (2015), 848–862.
-
(2015)
J Am Soc Nephrol
, vol.27
, pp. 848-862
-
-
Forst, A.L.1
Olteanu, V.S.2
Mollet, G.3
-
110
-
-
79955782073
-
GSK3beta inactivation in podocytes results in decreased phosphorylation of p70S6K accompanied by cytoskeletal rearrangements and inhibited motility
-
110 George, B., Vollenbroker, B., Saleem, M.A., et al. GSK3beta inactivation in podocytes results in decreased phosphorylation of p70S6K accompanied by cytoskeletal rearrangements and inhibited motility. Am J Physiol Renal Physiol 300 (2011), F1152–F1162.
-
(2011)
Am J Physiol Renal Physiol
, vol.300
, pp. F1152-F1162
-
-
George, B.1
Vollenbroker, B.2
Saleem, M.A.3
-
111
-
-
79957881425
-
Role of mTOR in podocyte function and diabetic nephropathy in humans and mice
-
111 Godel, M., Hartleben, B., Herbach, N., et al. Role of mTOR in podocyte function and diabetic nephropathy in humans and mice. J Clin Invest 121 (2011), 2197–2209.
-
(2011)
J Clin Invest
, vol.121
, pp. 2197-2209
-
-
Godel, M.1
Hartleben, B.2
Herbach, N.3
-
112
-
-
84929311516
-
Deficient autophagy results in mitochondrial dysfunction and FSGS
-
112 Kawakami, T., Gomez, I.G., Ren, S., et al. Deficient autophagy results in mitochondrial dysfunction and FSGS. J Am Soc Nephrol 26 (2015), 1040–1052.
-
(2015)
J Am Soc Nephrol
, vol.26
, pp. 1040-1052
-
-
Kawakami, T.1
Gomez, I.G.2
Ren, S.3
-
113
-
-
84931289771
-
Overexpression of Toll-like receptor 8 correlates with the progression of podocyte injury in murine autoimmune glomerulonephritis
-
113 Kimura, J., Ichii, O., Miyazono, K., et al. Overexpression of Toll-like receptor 8 correlates with the progression of podocyte injury in murine autoimmune glomerulonephritis. Sci Rep, 4, 2014, 7290.
-
(2014)
Sci Rep
, vol.4
, pp. 7290
-
-
Kimura, J.1
Ichii, O.2
Miyazono, K.3
-
114
-
-
77954599877
-
Inhibition of podocyte FAK protects against proteinuria and foot process effacement
-
114 Ma, H., Togawa, A., Soda, K., et al. Inhibition of podocyte FAK protects against proteinuria and foot process effacement. J Am Soc Nephrol 21 (2010), 1145–1156.
-
(2010)
J Am Soc Nephrol
, vol.21
, pp. 1145-1156
-
-
Ma, H.1
Togawa, A.2
Soda, K.3
-
115
-
-
84863314417
-
Podocyte Wnt/ss-catenin pathway is activated by integrin-linked kinase in clinical and experimental focal segmental glomerulosclerosis
-
115 Naves, M.A., Requiao-Moura, L.R., Soares, M.F., et al. Podocyte Wnt/ss-catenin pathway is activated by integrin-linked kinase in clinical and experimental focal segmental glomerulosclerosis. J Nephrol 25 (2012), 401–409.
-
(2012)
J Nephrol
, vol.25
, pp. 401-409
-
-
Naves, M.A.1
Requiao-Moura, L.R.2
Soares, M.F.3
-
116
-
-
40449112321
-
The Notch pathway in podocytes plays a role in the development of glomerular disease
-
116 Niranjan, T., Bielesz, B., Gruenwald, A., et al. The Notch pathway in podocytes plays a role in the development of glomerular disease. Nat Med 14 (2008), 290–298.
-
(2008)
Nat Med
, vol.14
, pp. 290-298
-
-
Niranjan, T.1
Bielesz, B.2
Gruenwald, A.3
-
117
-
-
43049142649
-
Beneficial effects of the Rho kinase inhibitor Y27632 in murine puromycin aminonucleoside nephrosis
-
117 Wang, L., Ellis, M.J., Fields, T.A., et al. Beneficial effects of the Rho kinase inhibitor Y27632 in murine puromycin aminonucleoside nephrosis. Kidney Blood Press Res 31 (2008), 111–121.
-
(2008)
Kidney Blood Press Res
, vol.31
, pp. 111-121
-
-
Wang, L.1
Ellis, M.J.2
Fields, T.A.3
-
118
-
-
77955609123
-
Melanocortin 1 receptor agonists reduce proteinuria
-
118 Lindskog, A., Ebefors, K., Johansson, M.E., et al. Melanocortin 1 receptor agonists reduce proteinuria. J Am Soc Nephrol 21 (2010), 1290–1298.
-
(2010)
J Am Soc Nephrol
, vol.21
, pp. 1290-1298
-
-
Lindskog, A.1
Ebefors, K.2
Johansson, M.E.3
-
119
-
-
30344475768
-
Role of p38 mitogen-activated protein kinase activation in podocyte injury and proteinuria in experimental nephrotic syndrome
-
119 Koshikawa, M., Mukoyama, M., Mori, K., et al. Role of p38 mitogen-activated protein kinase activation in podocyte injury and proteinuria in experimental nephrotic syndrome. J Am Soc Nephrol 16 (2005), 2690–2701.
-
(2005)
J Am Soc Nephrol
, vol.16
, pp. 2690-2701
-
-
Koshikawa, M.1
Mukoyama, M.2
Mori, K.3
-
120
-
-
84893214045
-
Renal hemodynamic effect of sodium-glucose cotransporter 2 inhibition in patients with type 1 diabetes mellitus
-
120 Cherney, D.Z., Perkins, B.A., Soleymanlou, N., et al. Renal hemodynamic effect of sodium-glucose cotransporter 2 inhibition in patients with type 1 diabetes mellitus. Circulation 129 (2014), 587–597.
-
(2014)
Circulation
, vol.129
, pp. 587-597
-
-
Cherney, D.Z.1
Perkins, B.A.2
Soleymanlou, N.3
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