Erratum: CD2AP in mouse and human podocytes controls a proteolytic program that regulates cytoskeletal structure and cellular survival (The Journal of Clinical Investigation (2011) 121, 10, (3965-3980) DOI: 10.1172/JCI58552);CD2AP in mouse and human podocytes controls a proteolytic program that regulates cytoskeletal structure and cellular survival

Journal of Clinical Investigation

Volumn 121, Issue 10, 2011, Pages 3965-3980

  Yaddanapudi, Suma ^a   Altintas, Mehmet M ^b   Kistler, Andreas D ^b   Fernandez, Isabel ^b   Möller, Clemens C ^a   Wei, Changli ^b   Peev, Vasil ^b   Flesche, Jan B ^a   Forst, Anna Lena ^b   Li, Jing ^b   Patrakka, Jaakko ^c,d   Xiao, Zhijie ^c   Grahammer, Florian ^e   Schiffer, Mario ^f   Lohmüller, Tobias ^g   Reinheckel, Thomas ^g   Gu, Changkyu ^a   Huber, Tobias B ^e,g   Ju, Wenjun ^h   Bitzer, Markus ^h   Rastaldi, Maria P ⁱ   Ruiz, Phillip ^b   Tryggvason, Karl ^c   Shaw, Andrey S ^j   Faul, Christian ^b   Sever, Sanja ^a   Reiser, Jochen ^b   more..

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^c KAROLINSKA INSTITUTE   (Sweden)

^d KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^e UNIVERSITY OF FREIBURG   (Germany)

^f HANNOVER MEDICAL SCHOOL   (Germany)

^g UNIVERSITY OF FREIBURG   (Germany)

^h UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

ⁱ FONDAZIONE IRCCS CA GRANDA OSPEDALE MAGGIORE POLICLINICO   (Italy)

^j WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

CATHEPSIN L; CD2 ASSOCIATED PROTEIN; DYNAMIN; PROTEIN DENDRIN; SYNAPTOPODIN; TRANSCRIPTION FACTOR; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DAMAGE; CELL JUNCTION; CELL NUCLEUS; CELL STRUCTURE; CELL SURVIVAL; CYTOSKELETON; HUMAN; HUMAN CELL; MICROFILAMENT; MOUSE; NONHUMAN; PODOCYTE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEINURIA; SIGNAL TRANSDUCTION; SLIT DIAPHRAGM;

EID: 80053439688     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI62812     Document Type: Erratum

References (54)

1. Kriz W, et al. Tracer studies in the rat demonstrate misdirected filtration and peritubular filtrate spreading in nephrons with segmental glomerulosclerosis. J Am Soc Nephrol. 2001;12(3):496-506. (Pubitemid 32180018)
2. Tryggvason K, Pikkarainen T, Patrakka J. Nck links nephrin to actin in kidney podocytes. Cell. 2006;125(2):221-224.
3. Kriz W, Lemley KV. The role of the podocyte in glomerulosclerosis. Curr Opin Nephrol Hypertens. 1999;8(4):489-497. (Pubitemid 30004174)
4. Wharram BL, et al. Podocyte depletion causes glomerulosclerosis: Diphtheria toxin-induced podocyte depletion in rats expressing human diphtheria toxin receptor transgene. J Am Soc Nephrol. 2005;16(10):2941-2952. (Pubitemid 44743492)
5. Tryggvason K, Patraaka J, Wartiovaara J. Hereditary proteinuria syndromes and mechanisms of proteinuria. N Engl J Med. 2006;354(13):1387-1401.
6. Sever S, et al. Processing of the GTPase dynamin by extralysosomal cathepsin L defines a mechanism for proteinuric kidney disease. J Clin Invest. 2007;117(8):2095-2104. (Pubitemid 47219554)
7. Faul C, et al. The actin cytoskeleton of kidney podocytes is a direct target of the antiproteinuric effect of cyclosporine A. Nat Med. 2008;14(9):931-938.
8. He L, et al. Glomerulus-specific mRNA transcripts and proteins identified through kidney expressed sequence tag database analysis. Kidney Int. 2007;71(9):889-900. (Pubitemid 46663792)
9. Reiser J, Adair B, Reinheckel T. Specialized roles for cysteine cathepsins in health and disease. J Clin Invest. 2010;120(10):3421-3431.
10. Goulet B, et al. A cathepsin L isoform that is devoid of a signal peptide localizes to the nucleus in S phase and processes the CDP/Cux transcription factor. Mol Cell. 2004;14(2):207-219. (Pubitemid 38515648)
11. Duncan EM, et al. Cathepsin L proteolytically processes histone H3 during mouse embryonic stem cell differentiation. Cell. 2008;135(2):284-294.
12. Shih NY, et al. Congenital nephrotic syndrome in mice lacking CD2-associated protein. Science. 1999;286(5438):312-315.
13. Shih NY, Li J, Cotran R, Mundel P, Miner JH, Shaw AS. CD2AP localizes to the slit diaphragm and binds to nephrin via a novel C-terminal domain. Am J Pathol. 2001;159(6):2303-2308. (Pubitemid 33104283)
14. Lehtonen S, Zhao F, Lehtonen E. CD2-associated protein directly interacts with the actin cytoskeleton. Am J Physiol Renal Physiol. 2002;283(4):F734-F743. (Pubitemid 35033961)
15. Kim JM, et al. CD2-associated protein haploinsufficiency is linked to glomerular disease susceptibility. Science. 2003;300(5623):1298-1300.
16. Huber TB, et al. Bigenic mouse models of focal segmental glomerulosclerosis involving pairwise interaction of CD2AP, Fyn, and synaptopodin. J Clin Invest. 2006;116(5):1337-1345.
17. Grunkemeyer JA, Kwoh C, Huber TB, Shaw AS. CD2-associated protein (CD2AP) expression in podocytes rescues lethality of CD2AP deficiency. J Biol Chem. 2005;280(33):29677-29681. (Pubitemid 41177044)
18. Schiffer M, Mundel P, Shaw AS, Bottinger EP. A novel role for the adaptor molecule CD2-associated protein in transforming growth factor-beta-induced apoptosis. J Biol Chem. 2004;279(35):37004-37012. (Pubitemid 39129050)
19. Woroniecki RP, Schiffer M, Shaw AS, Kaskel FJ, Bottinger EP. Glomerular expression of transforming growth factor-beta (TGF-beta) isoforms in mice lacking CD2-associated protein. Pediatr Nephrol. 2006;21(3):333-338. (Pubitemid 43280347)
20. Asanuma K, Campbell KN, Kim K, Faul C, Mundel P. Nuclear relocation of the nephrin and CD2AP-binding protein dendrin promotes apoptosis of podocytes. Proc Natl Acad Sci U S A. 2007;104(24):10134-10139. (Pubitemid 47175275)
21. Bottinger EP, Bitzer M. TGF-beta signaling in renal disease. J Am Soc Nephrol. 2002;13(10):2600-2610.
22. Schiffer M, et al. Apoptosis in podocytes induced by TGF-β and Smad7. J Clin Invest. 2001;108(6):807-816. (Pubitemid 32880291)
23. Ju W, et al. Renal gene and protein expression signatures for prediction of kidney disease progression. Am J Pathol. 2009;174(6):2073-2085.
24. Reiser J, et al. Induction of B7-1 in podocytes is associated with nephrotic syndrome. J Clin Invest. 2004;113(10):1390-1397. (Pubitemid 39071694)
25. Lohmuller T, et al. Toward computer-based cleavage site prediction of cysteine endopeptidases. Biol Chem. 2003;384(6):899-909. (Pubitemid 36874504)
26. Huber TB, et al. Nephrin and CD2AP associate with phosphoinositide 3-OH kinase and stimulate AKT-dependent signaling. Mol Cell Biol. 2003;23(14):4917-4928. (Pubitemid 36793337)
27. Clement LC, et al. Podocyte-secreted angiopoietin-like-4 mediates proteinuria in glucocorticoid-sensitive nephrotic syndrome. Nat Med. 2011;17(1):117-122.
28. Zhang SY, et al. c-mip impairs podocyte proximal signaling and induces heavy proteinuria. Sci Signal. 2010;3(147):ra39.
29. Löwik MM, et al. Focal segmental glomerulosclerosis in a patient homozygous for a CD2AP mutation. Kidney Int. 2007;72(10):1198-1203. (Pubitemid 350059656)
30. Gigante M, et al. CD2AP mutations are associated with sporadic nephrotic syndrome and focal segmental glomerulosclerosis (FSGS). Nephrol Dial Transplant. 2009;24(6):1858-1864.
31. Derynck R, Zhang YE. Smad-dependent and Smadindependent pathways in TGF-beta family signaling. Nature. 2003;425(6958):577-584. (Pubitemid 37280136)
32. Xavier S, et al. TbetaRI independently activates Smad- and CD2AP-dependent pathways in podocytes. J Am Soc Nephrol. 2009;20(10):2127-2137.
33. Patrakka J, Tryggvason K. New insights into the role of podocytes in proteinuria. Nat Rev Nephrol. 2009;5(8):463-468.
34. Benzing T. Signaling at the slit diaphragm. J Am Soc Nephrol. 2004;15(6):1382-1391. (Pubitemid 38679663)
35. Jones N, et al. Nck adaptor proteins link nephrin to the actin cytoskeleton of kidney podocytes. Nature. 2006;440(7085):818-823.
36. Verma R, Kovari I, Soofi A, Nihalani D, Patrie K, Holzman LB. Nephrin ectodomain engagement results in Src kinase activation, nephrin phosphorylation, Nck recruitment, and actin polymerization. J Clin Invest. 2006;116(5):1346- 1359.
37. Robinson PJ, et al. Oligomerization cycle of dynamin directly regulates actin cytoskeleton. Nat Med. In press.
38. Liu G, Clement L, Kanwar YS, Avila-Casado C, Chugh SS. ZHX proteins regulate podocyte gene expression during the development of nephrotic syndrome. J Biol Chem. 2006;281(51):39681-39692. (Pubitemid 46041927)
39. Susztak K, Raff AC, Schiffer M, Bottinger EP. Glucose-induced reactive oxygen species cause apoptosis of podocytes and podocyte depletion at the onset of diabetic nephropathy. Diabetes. 2006;55(1):225-233. (Pubitemid 43343319)
40. Asanuma K, et al. Dendrin location in podocytes is associated with disease progression in animal and human glomerulopathy. Am J Nephrol. 2011;33(6):537-549.
41. Campbell KN, Gupta R, Patrakka J, Shaw AS, Tryggvason K, Mundel PH. Genetic deletion of dendrin delays the onset of proteinuria and improves survival of CD2AP null mice. ASN Renal Week 2010, Abstract F-PO1915.
42. Mundel P, et al. Rearrangements of the cytoskeleton and cell contacts induce process formation during differentiation of conditionally immortalized mouse podocyte cell lines. Exp Cell Res. 1997;236(1):248-258. (Pubitemid 27452369)
43. Dustin ML, et al. A novel adaptor protein orchestrates receptor patterning and cytoskeletal polarity in T-cell contacts. Cell. 1998;94(5):667-677. (Pubitemid 28427585)
44. Mundel P, Heid HW, Mundel TM, Krüger M, Reiser J, Kriz W. Synaptopodin: an actin-associated protein in telencephalic dendrites and renal podocytes. J Cell Biol. 1997;139(1):193-204. (Pubitemid 27444091)
45. Ishidoh K, Kominami E. Multi-step processing of procathepsin L in vitro. FEBS Lett. 1994;352(3):281-284. (Pubitemid 24302453)
46. Kaplan JM, et al. Mutations in ACTN4, encoding alpha-actinin-4, cause familial focal segmental glomerulosclerosis. Nat Genet. 2000;24(3):251-256. (Pubitemid 30132192)
47. Holzman LB, St. John P, Kovari I, Verma R, Holthofer H, Abrahamson D. Nephrin is localized to the slit pore of the glomerular epithelial cell. Kidney Int. 1999;56(4):1481-1491. (Pubitemid 29451254)
48. Kopp JB, et al. Transgenic mice with increased plasma levels of TGF-beta1 develop progressive renal disease. Lab Invest. 1996;74(6):991-1003. (Pubitemid 26182412)
49. Xiao Z. Identification and Characterization of Novel Glomerulus- Associated Genes and Proteins [dissertation]. Stockholm, Sweden: Karolinska Institutet; 2010.
50. Reiser J, et al. Podocyte migration during nephrotic syndrome requires a coordinated interplay between cathepsin L and 3α integrin. J Biol Chem. 2004;279(33):34827-34832. (Pubitemid 39318116)
51. Kim SW, et al. Increased expression and apical targeting of renal ENaC subunits in puromycin aminonucleoside- induced nephrotic syndrome in rats. Am J Physiol Renal Physiol. 2004;286(5):F922-F935. (Pubitemid 38508993)
52. Wei C, et al. Modification of kidney barrier function by the urokinase receptor. Nat Med. 2008;14(1):55-63
53. Ju W, et al. Deletion of Smad2 in mouse liver reveals novel functions in hepatocyte growth and differentiation. Mol Cell Biol. 2006;26(2):654-667. (Pubitemid 43089776)
54. Damke H, Baba T, Warnock DE, Schmid SL. Induction of mutant dynamin specifically blocks endocytic coated vesicle formation. J Cell Biol. 1994;127(4):915-934. (Pubitemid 24355982)