메뉴 건너뛰기




Volumn 300, Issue 5, 2011, Pages 1152-1162

GSK3β inactivation in podocytes results in decreased phosphorylation of p70S6k accompanied by cytoskeletal rearrangements and inhibited motility

Author keywords

Proteinuria; Rapamycin; Slit diaphragm

Indexed keywords

2 (2,4 DICHLOROPHENYL) 3 (1 METHYL 3 INDOLYL)MALEIMIDE; GLYCOGEN SYNTHASE KINASE 3BETA; MAMMALIAN TARGET OF RAPAMYCIN; RAPAMYCIN; S6 KINASE;

EID: 79955782073     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00373.2010     Document Type: Article
Times cited : (20)

References (49)
  • 1
    • 34547213485 scopus 로고    scopus 로고
    • Nuclear relocation of the nephrin and CD2AP-binding protein dendrin promotes apoptosis of podocytes
    • Asanuma K, Campbell KN, Kim K, Faul C, Mundel P. Nuclear relocation of the nephrin and CD2AP-binding protein dendrin promotes apoptosis of podocytes. Proc Natl Acad Sci USA 104: 10134-10139, 2007.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 10134-10139
    • Asanuma, K.1    Campbell, K.N.2    Kim, K.3    Faul, C.4    Mundel, P.5
  • 4
    • 50049099923 scopus 로고    scopus 로고
    • Steroid hormone release as well as renal water and electrolyte excretion of mice expressing PKB/ SGK-resistant GSK3
    • Boini KM, Bhandaru M, Mack A, Lang F. Steroid hormone release as well as renal water and electrolyte excretion of mice expressing PKB/ SGK-resistant GSK3. Pflügers Arch 456: 1207-1216, 2008.
    • (2008) Pflügers Arch , vol.456 , pp. 1207-1216
    • Boini, K.M.1    Bhandaru, M.2    Mack, A.3    Lang, F.4
  • 5
    • 74549126028 scopus 로고    scopus 로고
    • Why do patients develop proteinuria with sirolimus? Do we have the answer?
    • Chapman JR, Rangan GK. Why do patients develop proteinuria with sirolimus? Do we have the answer? Am J Kidney Dis 55: 213-216, 2010.
    • (2010) Am J Kidney Dis , vol.55 , pp. 213-216
    • Chapman, J.R.1    Rangan, G.K.2
  • 7
    • 58749091500 scopus 로고    scopus 로고
    • Measuring GSK3 expression and activity in cells
    • Cole AR, Sutherland C. Measuring GSK3 expression and activity in cells. Methods Mol Biol 468: 45-65, 2008.
    • (2008) Methods Mol Biol , vol.468 , pp. 45-65
    • Cole, A.R.1    Sutherland, C.2
  • 8
    • 0035875098 scopus 로고    scopus 로고
    • Crystal structure of glycogen synthase kinase 3 beta: Structural basis for phosphate-primed substrate specificity and autoinhibition
    • Dajani R, Fraser E, Roe SM, Young N, Good V, Dale TC, Pearl LH. Crystal structure of glycogen synthase kinase 3 beta: structural basis for phosphate-primed substrate specificity and autoinhibition. Cell 105: 721-732, 2001.
    • (2001) Cell , vol.105 , pp. 721-732
    • Dajani, R.1    Fraser, E.2    Roe, S.M.3    Young, N.4    Good, V.5    Dale, T.C.6    Pearl, L.H.7
  • 10
    • 34848907421 scopus 로고    scopus 로고
    • Actin up: Regulation of podocyte structure and function by components of the actin cytoskeleton
    • Faul C, Asanuma K, Yanagida-Asanuma E, Kim K, Mundel P. Actin up: regulation of podocyte structure and function by components of the actin cytoskeleton. Trends Cell Biol 17: 428-437, 2007.
    • (2007) Trends Cell Biol , vol.17 , pp. 428-437
    • Faul, C.1    Asanuma, K.2    Yanagida-Asanuma, E.3    Kim, K.4    Mundel, P.5
  • 11
    • 0034969088 scopus 로고    scopus 로고
    • A common phosphate binding site explains the unique substrate specificity of GSK3 and its inactivation by phosphorylation
    • Frame S, Cohen P, Biondi RM. A common phosphate binding site explains the unique substrate specificity of GSK3 and its inactivation by phosphorylation. Mol Cell 7: 1321-1327, 2001.
    • (2001) Mol Cell , vol.7 , pp. 1321-1327
    • Frame, S.1    Cohen, P.2    Biondi, R.M.3
  • 12
    • 16644374992 scopus 로고    scopus 로고
    • WT1 activates a glomerular- specific enhancer identified from the human nephrin gene
    • Guo G, Morrison DJ, Licht JD, Quaggin SE. WT1 activates a glomerular- specific enhancer identified from the human nephrin gene. J Am Soc Nephrol 15: 2851-2856, 2004.
    • (2004) J Am Soc Nephrol , vol.15 , pp. 2851-2856
    • Guo, G.1    Morrison, D.J.2    Licht, J.D.3    Quaggin, S.E.4
  • 13
    • 0037087593 scopus 로고    scopus 로고
    • WT1 is a key regulator of podocyte function: Reduced expression levels cause crescentic glomerulonephritis and mesangial sclerosis
    • Guo JK, Menke AL, Gubler MC, Clarke AR, Harrison D, Hammes A, Hastie ND, Schedl A. WT1 is a key regulator of podocyte function: reduced expression levels cause crescentic glomerulonephritis and mesangial sclerosis. Hum Mol Genet 11: 651-659, 2002.
    • (2002) Hum Mol Genet , vol.11 , pp. 651-659
    • Guo, J.K.1    Menke, A.L.2    Gubler, M.C.3    Clarke, A.R.4    Harrison, D.5    Hammes, A.6    Hastie, N.D.7    Schedl, A.8
  • 14
    • 39849110726 scopus 로고    scopus 로고
    • The GSK3 hypothesis of Alzheimer's disease
    • Hooper C, Killick R, Lovestone S. The GSK3 hypothesis of Alzheimer's disease. J Neurochem 104: 1433-1439, 2008.
    • (2008) J Neurochem , vol.104 , pp. 1433-1439
    • Hooper, C.1    Killick, R.2    Lovestone, S.3
  • 15
    • 59749091850 scopus 로고    scopus 로고
    • A complex interplay between Akt, TSC2 and the two mTOR complexes
    • Huang J, Manning BD. A complex interplay between Akt, TSC2 and the two mTOR complexes. Biochem Soc Trans 37: 217-222, 2009.
    • (2009) Biochem Soc Trans , vol.37 , pp. 217-222
    • Huang, J.1    Manning, B.D.2
  • 17
    • 79951674629 scopus 로고    scopus 로고
    • MTOR and rapamycin in the kidney: Signaling and therapeutic implications beyond immunosuppression
    • Huber TB, Walz G, Kuehn EW. mTOR and rapamycin in the kidney: signaling and therapeutic implications beyond immunosuppression. Kidney Int 79: 502-511, 2011.
    • (2011) Kidney Int , vol.79 , pp. 502-511
    • Huber, T.B.1    Walz, G.2    Kuehn, E.W.3
  • 21
    • 0442276554 scopus 로고    scopus 로고
    • The glamour and gloom of glycogen synthase kinase-3
    • Jope RS, Johnson GV. The glamour and gloom of glycogen synthase kinase-3. Trends Biochem Sci 29: 95-102, 2004.
    • (2004) Trends Biochem Sci , vol.29 , pp. 95-102
    • Jope, R.S.1    Johnson, G.V.2
  • 22
    • 33947597084 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3 (GSK3): Inflammation, diseases, and therapeutics
    • Jope RS, Yuskaitis CJ, Beurel E. Glycogen synthase kinase-3 (GSK3): inflammation, diseases, and therapeutics. Neurochem Res 32: 577-595, 2007.
    • (2007) Neurochem Res , vol.32 , pp. 577-595
    • Jope, R.S.1    Yuskaitis, C.J.2    Beurel, E.3
  • 29
    • 40649124774 scopus 로고    scopus 로고
    • MToR inhibitors-induced proteinuria: Mechanisms, significance, and management
    • Letavernier E, Legendre C. mToR inhibitors-induced proteinuria: mechanisms, significance, and management. Transplant Rev (Orlando) 22: 125-130, 2008.
    • (2008) Transplant Rev (Orlando) , vol.22 , pp. 125-130
    • Letavernier, E.1    Legendre, C.2
  • 30
    • 33847671000 scopus 로고    scopus 로고
    • Snail, a transcriptional regulator, represses nephrin expression in glomerular epithelial cells of nephrotic rats
    • Matsui I, Ito T, Kurihara H, Imai E, Ogihara T, Hori M. Snail, a transcriptional regulator, represses nephrin expression in glomerular epithelial cells of nephrotic rats. Lab Invest 87: 273-283, 2007.
    • (2007) Lab Invest , vol.87 , pp. 273-283
    • Matsui, I.1    Ito, T.2    Kurihara, H.3    Imai, E.4    Ogihara, T.5    Hori, M.6
  • 32
    • 77949541746 scopus 로고    scopus 로고
    • Proteinuria: An enzymatic disease of the podocyte?
    • Mundel P, Reiser J. Proteinuria: an enzymatic disease of the podocyte? Kidney Int 77: 571-580, 2010.
    • (2010) Kidney Int , vol.77 , pp. 571-580
    • Mundel, P.1    Reiser, J.2
  • 33
    • 70350172912 scopus 로고    scopus 로고
    • Validating GSK3 as an in vivo target of lithium action
    • O'Brien WT, Klein PS. Validating GSK3 as an in vivo target of lithium action. Biochem Soc Trans 37: 1133-1138, 2009.
    • (2009) Biochem Soc Trans , vol.37 , pp. 1133-1138
    • O'Brien, W.T.1    Klein, P.S.2
  • 34
    • 77949882117 scopus 로고    scopus 로고
    • The tuberous sclerosis complex
    • Orlova KA, Crino PB. The tuberous sclerosis complex. Ann NY Acad Sci 1184: 87-105, 2010.
    • (2010) Ann NY Acad Sci , vol.1184 , pp. 87-105
    • Orlova, K.A.1    Crino, P.B.2
  • 35
    • 0037207471 scopus 로고    scopus 로고
    • Cell biology of the glomerular podocyte
    • Pavenstadt H, Kriz W, Kretzler M. Cell biology of the glomerular podocyte. Physiol Rev 83: 253-307, 2003.
    • (2003) Physiol Rev , vol.83 , pp. 253-307
    • Pavenstadt, H.1    Kriz, W.2    Kretzler, M.3
  • 37
    • 77951943796 scopus 로고    scopus 로고
    • Novel insights into lithium's mechanism of action: Neurotrophic and neuroprotective effects
    • Quiroz JA, Hado-Vieira R, Zarate CA Jr, Manji HK. Novel insights into lithium's mechanism of action: neurotrophic and neuroprotective effects. Neuropsychobiology 62: 50-60, 2010.
    • (2010) Neuropsychobiology , vol.62 , pp. 50-60
    • Quiroz, J.A.1    Hado-Vieira, R.2    Zarate Jr., C.A.3    Manji, H.K.4
  • 42
    • 0035191415 scopus 로고    scopus 로고
    • CD2AP localizes to the slit diaphragm and binds to nephrin via a novel C-terminal domain
    • Shih NY, Li J, Cotran R, Mundel P, Miner JH, Shaw AS. CD2AP localizes to the slit diaphragm and binds to nephrin via a novel C-terminal domain. Am J Pathol 159: 2303-2308, 2001.
    • (2001) Am J Pathol , vol.159 , pp. 2303-2308
    • Shih, N.Y.1    Li, J.2    Cotran, R.3    Mundel, P.4    Miner, J.H.5    Shaw, A.S.6
  • 45
    • 33646401549 scopus 로고    scopus 로고
    • Nephrin ectodomain engagement results in Src kinase activation, nephrin phosphorylation, Nck recruitment, and actin polymerization
    • Verma R, Kovari I, Soofi A, Nihalani D, Patrie K, Holzman LB. Nephrin ectodomain engagement results in Src kinase activation, nephrin phosphorylation, Nck recruitment, and actin polymerization. J Clin Invest 116: 1346-1359, 2006.
    • (2006) J Clin Invest , vol.116 , pp. 1346-1359
    • Verma, R.1    Kovari, I.2    Soofi, A.3    Nihalani, D.4    Patrie, K.5    Holzman, L.B.6
  • 47
    • 9644281578 scopus 로고    scopus 로고
    • The major podocyte protein nephrin is transcriptionally activated by the Wilms' tumor suppressor WT1
    • Wagner N, Wagner KD, Xing Y, Scholz H, Schedl A. The major podocyte protein nephrin is transcriptionally activated by the Wilms' tumor suppressor WT1. J Am Soc Nephrol 15: 3044-3051, 2004.
    • (2004) J Am Soc Nephrol , vol.15 , pp. 3044-3051
    • Wagner, N.1    Wagner, K.D.2    Xing, Y.3    Scholz, H.4    Schedl, A.5
  • 48
    • 73049096456 scopus 로고    scopus 로고
    • Review of lithium effects on brain and blood
    • Young W. Review of lithium effects on brain and blood. Cell Transplant 18: 951-975, 2009.
    • (2009) Cell Transplant , vol.18 , pp. 951-975
    • Young, W.1
  • 49
    • 39349104907 scopus 로고    scopus 로고
    • Nephrin mediates actin reorganization via phosphoinositide 3-kinase in podocytes
    • Zhu J, Sun N, Aoudjit L, Li H, Kawachi H, Lemay S, Takano T. Nephrin mediates actin reorganization via phosphoinositide 3-kinase in podocytes. Kidney Int 73: 556-566, 2008.
    • (2008) Kidney Int , vol.73 , pp. 556-566
    • Zhu, J.1    Sun, N.2    Aoudjit, L.3    Li, H.4    Kawachi, H.5    Lemay, S.6    Takano, T.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.