Identification of ML204, a novel potent antagonist that selectively modulates native TRPC4/C5 ion channels

Journal of Biological Chemistry

Volumn 286, Issue 38, 2011, Pages 33436-33446

  Miller, Melissa ^a   Shi, Jie ^a   Zhu, Yingmin ^b   Kustov, Maksym ^c   Tian, Jin Bin ^b   Stevens, Amy ^a   Wu, Meng ^a   Xu, Jia ^a   Long, Shunyou ^a   Yang, Pu ^b   Zholos V, Alexander ^c   Salovich, James M ^d,e,f   Weaver, C David ^d   Hopkins, Corey R ^a,d,e,f   Lindsley, Craig W ^d,e,f   McManus, Owen ^a   Li, Min ^a   Zhu, Michael X ^b  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^c QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^d Department of Pharmacology ^*  (United States)

^e VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM CHANNELS; CARBACHOL; CHANNEL ACTIVATION; CHANNEL FUNCTIONS; CHANNEL INHIBITOR; DIRECT INTERACTIONS; DORSAL ROOT GANGLION NEURONS; GUANOSINES; GUINEA PIGS; HIGH THROUGHPUT; INTRACELLULAR CA; ION CHANNEL; MOLECULAR LIBRARIES; MYOCYTES; NON-SELECTIVE CATION CHANNELS; OPIOID RECEPTORS; PATCH CLAMP RECORDING; PHARMACOLOGICAL INHIBITORS; PHYSIOLOGICAL FUNCTIONS; PHYSIOLOGICAL SYSTEMS; SIGNAL TRANSDUCTION PATHWAYS; SMALL MOLECULES; SMOOTH MUSCLES; SYNAPTIC TRANSMISSION; TRANSIENT RECEPTOR POTENTIALS;

CALCIUM; DIALYSIS; ELECTROPHYSIOLOGY; FLUORESCENT SCREENS; MAMMALS; POSITIVE IONS;

SIGNAL TRANSDUCTION;

CALCIUM ION; CARBACHOL; CATION; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); ML 204; MU OPIATE RECEPTOR; MUSCARINIC RECEPTOR; POTASSIUM CHANNEL KCNQ2; TRANSIENT RECEPTOR POTENTIAL CHANNEL 4; TRANSIENT RECEPTOR POTENTIAL CHANNEL 5; TRANSIENT RECEPTOR POTENTIAL CHANNEL 6; TRANSIENT RECEPTOR POTENTIAL CHANNEL A1; TRANSIENT RECEPTOR POTENTIAL CHANNEL AFFECTING AGENT; TRANSIENT RECEPTOR POTENTIAL CHANNEL M8; UNCLASSIFIED DRUG; VANILLOID RECEPTOR 1; VANILLOID RECEPTOR 3; VOLTAGE GATED CALCIUM CHANNEL; VOLTAGE GATED POTASSIUM CHANNEL; VOLTAGE GATED SODIUM CHANNEL;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CALCIUM CURRENT; CONTROLLED STUDY; FLUORESCENCE ANALYSIS; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IC 50; MOUSE; MUSCLE CELL; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION; RECEPTOR BLOCKING; SIGNAL TRANSDUCTION; SPINAL GANGLION; STRUCTURE ACTIVITY RELATION;

ANIMALS; CATIONS; FEMALE; FLUORESCENT DYES; HEK293 CELLS; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; INDOLES; INTESTINES; ION CHANNEL GATING; MALE; MICE; MICE, INBRED C57BL; MYOCYTES, SMOOTH MUSCLE; PIPERIDINES; RECEPTORS, MUSCARINIC; RECEPTORS, OPIOID, MU; STRUCTURE-ACTIVITY RELATIONSHIP; TRPC CATION CHANNELS;

CAVIA;

EID: 80052991459     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.274167     Document Type: Article

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