Overexpression of Toll-like receptor 8 correlates with the progression of podocyte injury in murine autoimmune glomerulonephritis

Scientific Reports

Volumn 4, Issue , 2014, Pages

  Kimura, Junpei ^a   Ichii, Osamu ^a   Miyazono, Kosuke ^a   Nakamura, Teppei ^a,b   Horino, Taro ^c   Otsuka Kanazawa, Saori ^a   Kon, Yasuhiro ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

^b JAPAN FOOD RESEARCH LABORATORIES   (Japan)

^c KOCHI UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; MICRORNA; TLR8 PROTEIN, MOUSE; TOLL LIKE RECEPTOR 8;

ANIMAL; AUTOIMMUNE DISEASE; DISEASE COURSE; DISEASE MODEL; GENETICS; GLOMERULONEPHRITIS; GLOMERULUS; MOUSE; PATHOLOGY; PODOCYTE;

ANIMALS; AUTOIMMUNE DISEASES; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; GLOMERULONEPHRITIS; KIDNEY GLOMERULUS; MICE; MICRORNAS; PODOCYTES; RNA, MESSENGER; TOLL-LIKE RECEPTOR 8;

EID: 84931289771     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep07290     Document Type: Article

References (37)

1. Ahearn, J. M., Liu, C. C., Kao, A. H. & Manzi, S. Biomarkers for systemic lupus erythematosus. Transl Res 159, 326-342 (2012).
2. Lech, M. & Anders, H. J. The pathogenesis of lupus nephritis. J Am Soc Nephrol 24, 1357-1366 (2013).
3. Santiago-Raber, M. L., Laporte, C., Reininger, L. & Izui, S. Genetic basis of murine lupus. Autoimmun Rev 3, 33-39 (2004).
4. Kimura, J. et al. BXSB-type genome causes murine autoimmune glomerulonephritis; pathological correlation between telomeric region of chromosome 1 and Yaa. Genes Immun 15, 182-189 (2014).
5. Kimura, J. et al. Quantitative and qualitative urinary cellular patterns correlate with progression of murine glomerulonephritis. PLoS One 31, e16472 (2011).
6. Kimura, J. et al. Close relations between podocyte injuries and membranous proliferative glomerulonephritis in autoimmune murine models. Am J Nephrol 38, 27-38 (2013).
7. Subramanian, S. et al. A Tlr7 translocation accelerates systemic autoimmunity in murine lupus. Proc Natl Acad Sci U S A 103, 9970-9975 (2006).
8. Kawai, T. & Akira, S. The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat Immunol 11, 373-384 (2010).
9. Baccala, R. et al. Sensors of the innate immune system: their mode of action. Nat Rev Rheumatol 5, 448-456 (2009).
10. Garraud, O. & Cognasse, F. Platelet Toll-like receptor expression: the link between "danger" ligands and inflammation. Inflamm Allergy Drug Targets 9, 322-333 (2010).
11. Mersmann, J. et al. Attenuation of myocardial injury by HMGB1 blockade during ischemia/reperfusion is Toll-like receptor 2-dependent. Mediators Inflamm 2013, 174168 (2013).
12. Shichita, T. et al. Peroxiredoxin family proteins are key initiators of post-ischemic inflammation in the brain. Nat Med 18, 911-917 (2012).
13. Eleftheriadis, T., Pissas, G., Liakopoulos, V., Stefanidis, I. & Lawson, B. R. Toll-like receptors and their role in renal pathologies. Inflamm Allergy Drug Targets 11, 464-477 (2012).
14. Chassin, C. et al. TLR4 facilitates translocation of bacteria across renal collecting duct cells. J Am Soc Nephrol 19, 2364-2374 (2008).
15. -/- mice are more susceptible to Escherichia coli urinary tract infection. J Immunol 178, 4717-4720 (2007).
16. Zhang, D. et al. A toll-like receptor that prevents infection by uropathogenic bacteria. Science 303, 1522-1526 (2004).
17. Wolfs, T. G. et al. In vivo expression of Toll-like receptor 2 and 4 by renal epithelial cells: IFN-gamma and TNF-alpha mediated up-regulation during inflammation. J Immunol 168, 1286-1293 (2002).
18. Shigeoka, A. A. et al. TLR2 is constitutively expressed within the kidney and participates in ischemic renal injury through both MyD88-dependent and - independent pathways. J Immunol 178, 6252-6258 (2007).
19. Ichii, O. et al. Altered expression of microRNA miR-146a correlates with the development of chronic renal inflammation. Kidney Int 81, 280-292 (2012).
20. Fabbri, M. et al. MicroRNAs bind to Toll-like receptors to induce prometastatic inflammatory response. Proc Natl Acad Sci U S A 109, E2110-2116 (2012).
21. Gurkan, S. et al. Inhibition of type I interferon signalling prevents TLR ligandmediated proteinuria. J Pathol 231, 248-256 (2013).
22. Pawar, R. D. et al. Ligands to nucleic acid-specific toll-like receptors and the onset of lupus nephritis. J Am Soc Nephrol 17, 3365-3373 (2006).
23. Fu, Y. et al. Innate stimuli accentuate end-organ damage by nephrotoxic antibodies via Fc receptor and TLR stimulation and IL-1/TNF-alpha production. J Immunol 176, 632-639 (2006).
24. Muzio, M. et al. Differential expression and regulation of toll-like receptors (TLR) in human leukocytes: selective expression of TLR3 in dendritic cells. J Immunol 164, 5998-6004 (2000).
25. Choubey, D. Interferon-inducible Ifi200-family genes as modifiers of lupus susceptibility. Immunol Lett 147, 10-17 (2012).
26. Osnes, L. T., Nakken, B., Bodolay, E. & Szodoray, P. Assessment of intracellular cytokines and regulatory cells in patients with autoimmune diseases and primary immunodeficiencies - novel tool for diagnostics and patient follow-up. Autoimmun Rev 12, 967-971 (2013).
27. Peng, G. et al. Toll-like receptor 8-mediated reversal of CD4+ regulatory T cell function. Science 309, 1380-1384 (2005).
28. Banas, M. C. et al. TLR4 links podocytes with the innate immune system to mediate glomerular injury. J Am Soc Nephrol 19, 704-713 (2008).
29. Machida, H. et al. Expression of Toll-like receptor 9 in renal podocytes in childhood-onset active and inactive lupus nephritis. Nephrol Dial Transplant 25, 2530-2537 (2010).
30. Bartel, D. P. MicroRNAs: target recognition and regulatory functions. Cell 136, 215-233 (2009).
31. Ceribelli, A. et al. MicroRNAs in systemic rheumatic diseases. Arthritis Res Ther 13, 229 (2011).
32. Pan, W. et al. MicroRNA-21 and microRNA-148a contribute to DNA hypomethylation in lupus CD4+T cells by directly and indirectly targeting DNA methyltransferase 1. J Immunol 184, 6773-6781 (2010).
33. Iyer, S. S. et al. Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome. Proc Natl Acad Sci U S A 106, 20388-20393 (2009).
34. Niemir, Z. I. et al. Podocytes are the major source of IL-1 alpha and IL-1 beta in human glomerulonephritides. Kidney Int 52, 393-403 (1997).
35. Takano, Y. et al. Transcriptional suppression of nephrin in podocytes by macrophages: roles of inflammatory cytokines and involvement of the PI3K/Akt pathway. FEBS Lett 581, 421-426 (2007).
36. Timoshanko, J. R., Kitching, A. R., Iwakura, Y., Holdsworth, S. R. & Tipping, P. G. Leukocyte-derived interleukin-1beta interacts with renal interleukin-1 receptor I to promote renal tumor necrosis factor and glomerular injury in murine crescentic glomerulonephritis. Am J Pathol 164, 1967-1977 (2004).
37. Wickman, L. et al. Urine podocyte mRNAs, proteinuria, and progression in human glomerular diseases. J Am Soc Nephrol 24, 2081-2095 (2013).