Polygenic mutations in the cytotoxicity pathway increase susceptibility to develop HLH immunopathology in mice

Blood

Volumn 127, Issue 17, 2016, Pages 2113-2121

  Sepulveda, Fernando E ^a,b   Garrigue, Alexandrine ^a,b   Maschalidi, Sophia ^a,b   Garfa Traore, Meriem ^c   Ménasché, Gaël ^a,b   Fischer, Alain ^a,b,d   De Saint Basile, Geneviève ^a,b  

^a HÔPITAL NECKER ENFANTS MALADES   (France)

^b Imagine Institute   (France)

^c CNRS   (France)

^d l'alimentation et l'Environnement   (France)

Author keywords

[No Author keywords available]

Indexed keywords

HEMOGLOBIN; HERMES ANTIGEN; PERFORIN; RAS RELATED PROTEIN RAB 27A; PERFORIN, MOUSE; PORE FORMING CYTOTOXIC PROTEIN; RAB PROTEIN; RAB27A PROTEIN, MOUSE; SYNTAXIN;

ANEMIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CD8+ T LYMPHOCYTE; CELL MEDIATED CYTOTOXICITY; DEGRANULATION; GENE; GENE MUTATION; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; HEMOPHAGOCYTIC SYNDROME; HETEROZYGOTE; KILLER CELL; LYMPHOCYTIC CHORIOMENINGITIS; MACROPHAGE ACTIVATION; MOUSE; MULTIFACTORIAL INHERITANCE; MUTATION; NONHUMAN; PRIORITY JOURNAL; SYNTAXIN 11 GENE; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; ANIMAL; C57BL MOUSE; CROSS BREEDING; CYTOTOXIC T LYMPHOCYTE; CYTOTOXICITY; GENE DOSAGE; GENETIC PREDISPOSITION; GENETICS; GERMFREE ANIMAL; IMMUNOLOGICAL SYNAPSE; IMMUNOLOGY; KNOCKOUT MOUSE; NATURAL KILLER CELL; PHYSIOLOGY;

ANIMALS; CELL DEGRANULATION; CROSSES, GENETIC; CYTOTOXICITY, IMMUNOLOGIC; GENE DOSAGE; GENETIC PREDISPOSITION TO DISEASE; HETEROZYGOTE; IMMUNOLOGICAL SYNAPSES; KILLER CELLS, NATURAL; LYMPHOHISTIOCYTOSIS, HEMOPHAGOCYTIC; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MODELS, ANIMAL; MULTIFACTORIAL INHERITANCE; MUTATION; PORE FORMING CYTOTOXIC PROTEINS; QA-SNARE PROTEINS; RAB GTP-BINDING PROTEINS; SPECIFIC PATHOGEN-FREE ORGANISMS; T-LYMPHOCYTES, CYTOTOXIC;

EID: 84978098211     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2015-12-688960     Document Type: Article

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