Neutralization of IFNγ defeats haemophagocytosis in LCMV-infected perforin - and Rab27a-deficient mice

EMBO Molecular Medicine

Volumn 1, Issue 2, 2009, Pages 112-124

  Schmid, Jana Pachlopnik ^a,b,c   Ho, Chen H ^a,b   Chrétien, Fabrice ^d   Lefebure, Juliette M ^a,b   Pivert, Gérard ^c   Kosco Vilbois, Marie ^e   Ferlin, Walter ^e   Geissmann, Frédéric ^c   Fischer, Alain ^a,b,c   De Saint Basile, Genevièue ^a,b,c  

^a INSERM   (France)

^b UNIVERSITÉ PARIS DESCARTES   (France)

^c HÔPITAL NECKER ENFANTS MALADES   (France)

^d HENRI MONDOR HOSPITAL   (France)

^e NOVIMMUNE SA   (Switzerland)

Author keywords

Haematology; Haemophagocytic lymphohistiocytosis; IFN ; Immunopathology; Immunotherapy

Indexed keywords

GAMMA INTERFERON; GAMMA INTERFERON ANTIBODY; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 12P70; INTERLEUKIN 17; PERFORIN; RAB27A PROTEIN; RANTES; TUMOR NECROSIS FACTOR ALPHA; CYTOKINE; NEUTRALIZING ANTIBODY; PERFORIN, MOUSE; PORE FORMING CYTOTOXIC PROTEIN; RAB PROTEIN; RAB27A PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD CELL COUNT; BODY TEMPERATURE DISORDER; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; CYTOPENIA; GENETIC MODEL; HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS; LIVER CELL; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; ANIMAL; BIOSYNTHESIS; BLOOD; BONE MARROW; BRAIN; DRUG EFFECT; HUMAN; IMMUNOLOGY; LIVER; MACROPHAGE ACTIVATION; METABOLISM; PATHOLOGY; PHAGOCYTOSIS; PHYSIOLOGY; SERODIAGNOSIS; SPLEEN; SURVIVAL; VIROLOGY;

ANIMALS; ANTIBODIES, NEUTRALIZING; BONE MARROW; BRAIN; CYTOKINES; HUMANS; INTERFERON-GAMMA; LIVER; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; LYMPHOHISTIOCYTOSIS, HEMOPHAGOCYTIC; MACROPHAGE ACTIVATION; MICE; NEUTRALIZATION TESTS; PHAGOCYTOSIS; PORE FORMING CYTOTOXIC PROTEINS; RAB GTP-BINDING PROTEINS; SPLEEN; SURVIVAL ANALYSIS;

EID: 70449453484     PISSN: 17574676     EISSN: 17574684     Source Type: Journal    
DOI: 10.1002/emmm.200900009     Document Type: Article

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