Subtle differences in CTL cytotoxicity determine susceptibility to hemophagocytic lymphohistiocytosis in mice and humans with Chediak-Higashi syndrome

Blood

Volumn 118, Issue 17, 2011, Pages 4620-4629

  Jessen, Birthe ^a   Maul Pavicic, Andrea ^a   Ufheil, Heike ^a   Vraetz, Thomas ^a   Enders, Anselm ^b   Lehmberg, Kai ^c   Längler, Alfred ^d   Gross Wieltsch, Ute ^e   Bay, Ali ^f   Kaya, Zuhre ^g   Bryceson, Yenan T ^h   Koscielniak, Ewa ^e   Badawy, Sherif ⁱ   Davies, Graham ^j   Hufnagel, Markus ^a,k   Schmitt Graeff, Annette ^l   Aichele, Peter ^l   Stadt, Udozur ^m   Schwarz, Klaus ^a,n   Ehl, Stephan ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

^b Biology and Environment   (Australia)

^c UNIVERSITY OF HAMBURG   (Germany)

^d UNIVERSITY OF WITTEN HERDECKE   (Germany)

^e OLGAHOSPITAL   (Germany)

^f GAZIANTEP UNIVERSITY   (Turkey)

^g GAZI UNIVERSITY   (Turkey)

^h KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

ⁱ ZAGAZIG UNIVERSITY   (Egypt)

^j GREAT ORMOND STREET HOSPITAL   (United Kingdom)

^k UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

^l UNIVERSITY OF FREIBURG   (Germany)

^m UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

ⁿ UNIVERSITY HOSPITAL ULM   (Germany)

more..

Author keywords

[No Author keywords available]

Indexed keywords

FERRITIN; GLUTAMATE DEHYDROGENASE; LACTATE DEHYDROGENASE; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1; PERFORIN; TRIACYLGLYCEROL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEIGE MOUSE; C57BL 6 MOUSE; CELLULAR IMMUNITY; CHEDIAK HIGASHI SYNDROME; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; CYTOTOXICITY; DISEASE CONTROL; DISEASE COURSE; DISEASE PREDISPOSITION; EXON; FERRITIN BLOOD LEVEL; GENE MUTATION; GENOME; HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS; HISTOPATHOLOGY; HUMAN; INTERFERON PRODUCTION; INTRON; LACTATE DEHYDROGENASE BLOOD LEVEL; LEUKOCYTE COUNT; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; LYST GENE; MAST CELL DEGRANULATION; MAXIMUM ALLOWABLE CONCENTRATION; MOUSE; MOUSE STRAIN; NATURAL KILLER CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; ONSET AGE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN SECRETION; RISK ASSESSMENT; SOURLS MOUSE; STRAIN DIFFERENCE; TRIACYLGLYCEROL BLOOD LEVEL; VIRUS INFECTION;

EID: 80055087431     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2011-05-356113     Document Type: Article

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