A combined cryo-EM and molecular dynamics approach reveals the mechanism of ErmBL-mediated translation arrest

Nature Communications

Volumn 7, Issue , 2016, Pages

  Arenz, Stefan ^a   Bock, Lars V ^b   Graf, Michael ^a   Innis, C Axel ^c,d,e   Beckmann, Roland ^a   Grubmüller, Helmut ^b   Vaiana, Andrea C ^b   Wilson, Daniel N ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY   (Germany)

^c UNIVERSITÉ DE BORDEAUX   (France)

^d INSERM U869   (France)

^e CNRS UMR7377   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ERMBL PEPTIDE; ERYTHROMYCIN; PEPTIDE; PEPTIDYL CARRIER PROTEIN; RIBOSOME PROTEIN; TRANSFER RNA; UNCLASSIFIED DRUG; AMINOACYL TRANSFER RNA; BACTERIAL PROTEIN; PROTEIN SYNTHESIS INHIBITOR; TRNA, PEPTIDYL-;

ANTIBIOTICS; CARBONYL COMPOUND; GENETIC ANALYSIS; MOLECULAR ANALYSIS; PEPTIDE; RNA;

ANTIBIOTIC RESISTANCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CRYOELECTRON MICROSCOPY; MOLECULAR DYNAMICS; MOLECULAR MODEL; PROTEIN CONFORMATION; PROTEIN PROCESSING; PROTEIN STRUCTURE; SIMULATION; STREPTOCOCCUS SANGUINIS; ANTAGONISTS AND INHIBITORS; CHEMISTRY; CONFORMATION; DRUG EFFECT; GENETICS; INTERNAL RIBOSOME ENTRY SITE; METABOLISM; PROTEIN SYNTHESIS; RIBOSOME; ULTRASTRUCTURE;

STREPTOCOCCUS SANGUINIS;

BACTERIAL PROTEINS; CRYOELECTRON MICROSCOPY; ERYTHROMYCIN; INTERNAL RIBOSOME ENTRY SITES; MOLECULAR DYNAMICS SIMULATION; NUCLEIC ACID CONFORMATION; PROTEIN BIOSYNTHESIS; PROTEIN CONFORMATION; PROTEIN SYNTHESIS INHIBITORS; RIBOSOMES; RNA, TRANSFER, AMINO ACYL; STREPTOCOCCUS SANGUIS;

EID: 84977651337     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms12026     Document Type: Article

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