Structural insight into nascent polypeptide chain-mediated translational stalling

Science

Volumn 326, Issue 5958, 2009, Pages 1412-1415

  Seidelt, Birgit ^a   Innis, C Axel ^b   Wilson, Daniel N ^a   Gartmann, Marco ^a   Armache, Jean Paul ^a   Villa, Elizabeth ^c   Trabuco, Leonardo G ^c   Becker, Thomas ^a   Mielke, Thorsten ^d,e   Schulten, Klaus ^c,f   Steitz, Thomas A ^b,g   Beckmann, Roland ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b YALE UNIVERSITY   (United States)

^c UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^d MAX PLANCK INSTITUTE FOR MOLECULAR GENETICS   (Germany)

^e CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^f University of Illinois at Urbana Champaign   (United States)

^g MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

PEPTIDYLTRANSFERASE; POLYPEPTIDE; PROTEIN; PROTEIN TNAC; UNCLASSIFIED DRUG;

COLIFORM BACTERIUM; ELECTRON MICROSCOPY; ENZYME ACTIVITY; GENE EXPRESSION; INHIBITION; MICROBIAL ACTIVITY; PEPTIDE; RNA;

ACCURACY; ARTICLE; CONTROLLED STUDY; CRYOELECTRON MICROSCOPY; ESCHERICHIA COLI; GENE; NONHUMAN; PRIORITY JOURNAL; RIBOSOME; TRANSLATION INITIATION;

BINDING SITES; CRYOELECTRON MICROSCOPY; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; GENE EXPRESSION REGULATION, BACTERIAL; IMAGE PROCESSING, COMPUTER-ASSISTED; MODELS, BIOLOGICAL; MODELS, MOLECULAR; OPERON; PEPTIDYL TRANSFERASES; PROTEIN BIOSYNTHESIS; PROTEIN CONFORMATION; RIBOSOMAL PROTEINS; RIBOSOMES; RNA-BINDING PROTEINS; TRYPTOPHANASE;

ESCHERICHIA COLI;

EID: 71549124362     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1177662     Document Type: Article

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28. This research was supported by grants from the Deutsche Forschungsgemeinschaft SFB594 and SFB646 (to R.B.), SFB740 (to T.M.), and WI3285/1-1 (to D.N.W.); by NIH grants GM022778 (to T.A.S.) and P41-RR05969 (to K.S.); by NSF grant PHY0822613 (to K.S.); and by the European Union and Senatsverwal articl für Wissenschaft, Forschung und Kultur Berlin (UltraStructureNetwork, Anwenderzentrum). Computer time for MDFF was provided through an NSF Large Resources Allocation Committee grant MCA93S028. Coordinates of the atomic models of TnaC-70S complex have been deposited in the PDB under accession numbers 2WWL (30S) and 2WWQ (50S). The cryo-EM map has been deposited in the 3D-EM database under accession number EMD-1657.