Electrophysiology of Serotonin Receptors

Handbook of Behavioral Neuroscience

Volumn 21, Issue C, 2010, Pages 163-182

  Marek, Gerard J ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

5 HT receptors; amygdala; autoreceptors; heteroceptors; hippocampus; prefrontal cortex; raphe nuclei; striatum

Indexed keywords

EID: 84977620414     PISSN: 15697339     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S1569-7339(10)70077-1     Document Type: Chapter

References (173)

1. G.K. Aghajanian G.J. Marek Serotonin induces excitatory postsynaptic potentials in apical dendrites of neocortical pyramidal cells Neuropharmacology 36 1997 589 599
2. G.K. Aghajanian G.J. Marek Serotonin and hallucinogens Neuropsychopharmacology 21 1999 16S 23S
3. 2A receptors, increases EPSCs in layer V pyramidal cells of prefrontal cortex by an asynchronous mode of glutamate release Brain Res. 825 1999 161 171
4. D.A. Amara L. Segu S. Naili M.C. Buhot Serotonin 1B receptor regulation after dorsal subiculum deafferentation Brain Res. Bull. 38 1995 17 23
5. D.A. Amara L. Segu M.C. Buhot Region-specific decrease in 5-HT1A and 5-HT1B binding sites after intrahippocampal ibotenic acid injections in the rat Neurosci. Lett. 310 2001 25 28
6. 2a receptors in pyramidal neurons of prefrontal cortex Cereb. Cortex 14 2004 281 299
7. 4-like receptors mediate the slow excitatory response to serotonin in the rat hippocampus J. Pharmacol. Exp. Ther. 257 1991 930 937
8. R. Andrade Y. Chaput 5-Hydroxytryptamine4-like receptors mediate the slow excitatory response to serotonin in the rat hippocampus J. Pharmacol. Exp. Ther. 257 1991 930 937
9. R. Andrade R.A. Nicoll Pharmacologically distinct actions of serotonin on single pyramidal neurones of the rat hippocampus recorded in vitro. J. Physiol. 394 1987 99 124
10. B receptors to the same channels in hippocampus Science 234 1986 1261 1265
11. 1A receptors mediate opposing responses on membrane excitability in rat association cortex Neuroscience 40 1991 399 412
12. F. Artigas L. Romero C. de Montigny P. Blier Acceleration of the effect of selected antidepressant drugs in major depression by 5-HT1A antagonists Trends Neurosci. 19 1996 378 383
13. C.R. Ashby E. Edwards K. Harkins R.Y. Wang Characterization of 5-hydroxytryptamine-3 receptors in the medial prefrontal cortex: a microiontophoretic study Eur. J. Pharmacol. 173 1989 193 196
14. C.R. Ashby L.H. Jiang R.Y. Wang Chronic BRL 43694, a selective 5-HT3 receptor antagonist, fails to alter the number of spontaneously active midbrain dopamine neurons Eur. J. Pharmacol. 175 1990 347 350
15. 2A receptors in the rat medial prefrontal cortex: an iontophoretic study Synapse 17 1994 173 181
16. E.C. Azmitia P.J. Gannon N.M. Kheck P.M. Whitaker-Azmitia Cellular localization of the 5-HT1A receptor in primate brain neurons and glial cells Neuropsychopharmacology 14 1996 35 46
17. W.L. Bacon S.G. Beck 5-Hydroxytryptamine(7) receptor activation decreases slow afterhyperpolarization amplitude in CA3 hippocampal pyramidal cells J. Pharmacol. Exp. Ther. 294 2000 672 679
18. F. Bai T. Yin E.M. Johnson C. Su G. Varga S.P. Little D.L. Nelson Molecular cloning and pharmacological characterization of the guinea pig 5-HT1E receptor Eur. J. Pharmacol. 484 2004 127 139
19. S.G. Beck 5-Hydroxytryptamine increases excitability of CA1 hippocampal pyramidal cells Synapse 10 1992 334 340
20. J.-C. Beique M. Imad L. Mladenovic J.A. Gingrich R. Andrade Mechanism of the 5-hydroxytryptamine2A receptor-mediated facilitation of synaptic activity in prefrontal cortex Proc. Natl. Acad. Sci. USA 104 2007 9870 9875
21. M.A. Benneyworth Z. Xiang R.L. Smith E.E. Garcia P.J. Conn E. Sanders-Bush A selective positive allosteric modulator of metabotropic glutamate receptor subtype 2 blocks a hallucinogenic drug model of psychosis Mol. Pharmacol. 72 2007 477 484
22. M.J. Benvenga S.F. Chaney M. Baez T.C. Britton W.J. Hornback J.A. Monn G.J. Marek Attenuation of DOI-induced head twitches in mGluR2 KO mice FASEB J. 20 2006 A246
23. A. Besson N. Haddjeri P. Blier C. de Montigny Effects of the co-administration of mirtazapine and paroxetine on serotonergic neurotransmission in the rat brain Eur. Neuropsychopharmacol. 10 2000 177 188
24. M. Bijak Imipramine-induced subsensitivity to the 5-HT4 receptor activation, a possible mediation via an alteration in the postreceptor transduction mechanism involving adenylate cyclase Pol. J. Pharmacol. 49 1997 345 350
25. S. Birnstiel S.G. Beck Modulation of the 5-hydroxytryptamine4 receptor-mediated response by short-term and long-term administration of corticosterone in rat CA1 hippocampal pyramidal neurons J. Pharmacol. Exp. Ther. 273 1995 1132 1138
26. P. Blier C. Bouchard Effect of repeated electroconvulsive shocks on serotonergic neurons Eur. J. Pharmacol. 211 1992 365 373
27. P. Blier C. de Montigny Electrophysiological investigations on the effect of repeated zimelidine administration on serotonergic neurotransmission in the rat J. Neurosci. 3 1983 1270 1278
28. P. Blier C. de Montigny Modification of 5-HT neuron properties by sustained administration of the 5-HT1A agonist gepirone: electrophysiological studies in the rat brain Synapse 1 1987 470 480
29. P. Blier C. de Montigny D. Tardif Effects of the two antidepressant drugs mianserin and indalpine on the serotonergic system: single-cell studies in the rat Psychopharmacology 84 1984 242 249
30. P. Blier C. de Montigny A.J. Azzaro Modification of serotonergic and noradrenergic neurotransmissions by repeated administration of monoamine oxidase inhibitors: electrophysiological studies in the rat central nervous system J. Pharmacol. Exp. Ther. 237 1986 987 994
31. 2 receptors induced in rat frontal cortex by repeated imipramine and citalopram Naunyn Schmiedebergs Arch. Pharmacol. 367 2003 444 450
32. P. Bonsi D. Cuomo J. Ding G. Sciamanna S. Ulrich A. Tscherter G. Bernardi D.J. Surmeier A. Pisani Endogenous serotonin excites striatal cholingergic interneurons via the activation of 5-HT2C, 5-HT6, and 5-HT7 serotonin receptors: implications for extrapyramidal side effects of serotonin reuptake inhibitors Neuropsychopharmacology 32 2007 1840 1854
33. 1B receptor is localized predominantly on axon terminals Neuroscience 58 1994 167 182
34. 1F receptor messenger RNA in rodent and primate brain Neuropharmacology 33 1994 367 386
35. E.M. Chapin R. Andrade A 5-HT(7) receptor-mediated depolarization in the anterodorsal thalamus. I. Pharmacological characterization J. Pharmacol. Exp. Ther. 297 2001 395 402
36. E.M. Chapin R. Andrade A 5-HT(7) receptor-mediated depolarization in the anterodorsal thalamus. II. Involvement of the hyperpolarization-activated current I(h) J. Pharmacol. Exp. Ther. 297 2001 403 409
37. Y. Chaput C. de Montigny P. Blier Effects of a selective 5-HT reputake blocker, citalopram, on the sensitivity of 5-HT autoreceptors: electrophysiological studies in the rat brain Naunyn-Schmiedebergs Arch. Pharmacol. 333 1986 342 348
38. Y. Chaput R.C. Araneda R. Andrade Pharmacological and functional analysis of a novel serotonin receptor in the rat hippocampus Eur. J. Pharmacol. 182 1990 441 456
39. L. Chen K.K. Yung Y.S. Chan W.H. Yung 5-HT excites globus pallidus neurons by multiple receptor mechanisms Neuroscience 151 2008 439 451
40. + influx in rat basolateral amygdala via 5-HT1A receptors Eur. J. Neurosci. 10 1998 2163 2172
41. I.S. Choi J.H. Cho J.T. Kim E.J. Park M.G. Lee H.I. Shin B.J. Choi I.S. Jang Serotonergic modulation of GABAergic synaptic transmission in developing rat CA3 pyramidal neurons J. Neurochem. 103 2007 2342 2353
42. A. Colino J.V. Halliwell Differential modulation of three separate K-conductances in hippocampal CA1 neurons by serotonin Nature 328 1987 73 77
43. B. Costall R.J. Naylor 5-HT3 Receptor Antagonism and Schizophrenia F.D. King B.J. Jones G.J. Sanger 5-Hydroxytryptamine-3 Receptor Antagonists 1994 CRC Press, Inc. Boca Raton, FL 183 201
44. M.J. Cumberbatch D.J. Williamson G.S. Mason R.G. Hill R.J. Hargreaves Dural vasodilation causes a sensitization of rat caudal trigeminal neurones in vivo that is blocked by a 5-HT1B/1D agonist Br. J. Pharmacol. 126 1999 1478 1486
45. 2 receptors? Pharmacol. Behav. Biochem. 36 1990 901 906
46. C. De Montigny G.K. Aghajanian Tricyclic antidepressants: long-term treatment increases responsivity of rat forebrain neurons to serotonin Science 202 1978 1303 1306
47. G. Di Giovanni V. Di Matteo M. Di Mascio E. Esposito Preferential modulation of mesolimbic vs nigrostiatal dopaminergic function by serotonin(2C/2B) receptor agonists: a combined in vivo electrophysiological and microdialysis study Synapse 35 2000 53 61
48. G. Di Giovanni V. Di Matteo V. La Grutta E. Esposito m-Chlorophenylpiperazine excites non-dopaminergic neurons in the rat substantia nigra and ventral tegmental area by activating serotonin-2C receptors Neuroscience 103 2001 111 116
49. V. Di Matteo G. Di Giovanni M. Di Mascio E. Esposito SB 242084, a selective serotonin2C receptor antagonist, increases dopaminergic transmission in the mesolimbic system Neuropharmacology 38 1999 1195 1205
50. V. Di Matteo G. Di Giovanni M. Di Mascio E. Esposito Biochemical and electrophysiological evidence that RO 60-0175 inhibits mesolimbic dopaminergic function through serotonin(2C) receptors Brain Res. 865 2000 85 90
51. 2C receptor in the control of central dopamine function TIPS 22 2001 229 232
52. 3 receptor activation on spontaneous and action potential-evoked GABA release at hippocampal synapses J. Neurochem. 100 2007 395 405
53. A. Evrard A.M. Laporte M. Chastanet R. Hen M. Hamon J. Adrien 5-HT1A and 5-HT1B receptors control the firing of serotoninergic neurons in the dorsal raphe nucleus of the mouse: studies in 5-HT1B knockout mice Eur. J. Neurosci. 11 1999 3823 3831
54. J. Feng X. Cai J. Zhao Z. Yan Serotonin receptors modulate GABAA receptor channels through activation of anchored protein kinase C in prefrontal cortical neurons J. Neurosci. 21 2001 6502 6511
55. 2 receptor-mediated excitation of interneurons in pirform cortex: antagonism by atypical antipsychotic drugs Neuroscience 58 1994 515 525
56. C. Gerard S. El Mestikawy C. Lebrand J. Adrien M. Ruat E. Traiffort M. Hamon M.P. Martres Quantitative RT-PCR distribution of serotonin 5-HT6 receptor mRNA in the central nervous system of control or 5,7-dihydroxytryptamine-treated rats Synapse 23 1996 164 173
57. C. Gerard M.P. Martres K. Lefevre M.C. Miquel D. Verge L. Lanfumey E. Doucet M. Hamon S. el Mestikawy Immuno-localization of serotonin 5-HT6 receptor-like material in the rat central nervous system Brain Res. 746 1997 207 219
58. P.J. Goadsby Y. Knight Inhibition of trigeminal neurones after intravenous administration of naratriptan through an action at 5-hydroxytryptamine (5-HT(1B/1D)) receptors Br. J. Pharmacol. 122 1997 918 922
59. A. Gobert J.M. Rivet F. Lejeune A. Newman-Tancredi A. Adhumeau-Auclair J.P. Nicolas L. Cistarelli C. Melon M.J. Millan Serotonin(2C) receptors tonically suppress the activity of mesocortical dopaminergic and adrenergic, but not serotonergic, pathwsay: a combined dialysis and electrophysiological analysis in the rat Synapse 36 2000 205 221
60. 2A receptor-mediated signalling pathways to affect behavior Neuron 53 2007 439 452
61. A.A. Grace B.S. Bunney H. Moore C.L. Todd Dopamine-cell depolarization block as a model for the therapeutic actions of antipsychotic drugs Trends Neurosci. 20 1997 31 37
62. 3 receptor antagonists Drugs 53 1997 20 39
63. 2-adrenoceptor antagonist mirtazepine on 5-HT neurotransmission Naunyn-Schmiedeberg's Arch. Pharmacol. 355 1997 20 29
64. 1A receptors J. Neurosci. 18 1998 10150 10156
65. N. Haddjeri S.T. Szabo C. de Montigny P. Blier Increased tonic activation of rat forebrain 5-HT1A receptors by lithium addition to antidepressant treatments Neuropsychopharmacology 22 2000 346 356
66. K. Hashimoto H. Kita Serotonin activates presynaptic and postsynaptic receptors in rat globus pallidus J. Neurophysiol. 99 2008 1723 1732
67. L.A. Helton K.B. Thor M. Baez 5-hydroxytryptamine2A, 5-hydroxytryptamine2B, and 5-hydroxytryptamine2C receptor mRNA expression in the spinal cortd of rat, cat, monkey and human Neuroreport 5 1994 2617 2620
68. K.L. Hoskin G.A. Lambert C. Donaldson A.S. Zagami The 5-hydroxytryptamine1B/1D/1F receptor agonists eletriptan and naratriptan inhibit trigeminovascular input to the nucleus tractus solitarius in the cat Brain Res. 998 2004 91 99
69. R.L. Jakab P.S. Goldman-Rakic 5-HT2A serotonin receptors in the primate cerebral cortex: possible site of action of hallucinogens in pyramidal cell apical dendrites Proc. Natl. Acad. Sci. USA 95 1998 735 740
70. R.L. Jakab P.S. Goldman-Rakic Segregation of serotonin 5-HT2A and 5-HT3 receptors in inhibitory circuits of the primate cerebral cortex J. Comp. Neurol. 417 2000 337 348
71. R.D. Jeggo Y. Wang D. Jordan A.G. Ramage Activation of 5-HT1B and 5-HT1D receptors in the rat nucleus tractus solitarius: opposing action on neurones that receive an excitatory vagal C-fibre afferent input Br. J. Pharmacol. 150 2007 987 995
72. S. Katsurabayashi H. Kubota N. Tokutomi N. Akaike A distinct distribution of functional presynaptic 5-HT receptor subtypes on GABAergic nerve terminals projecting to single hippocampal CA1 pyramidal neurons Neuropharmacology 44 2003 1022 1030
73. K. Kawa Distribution and functional properties of 5-HT3 receptors in the rat hippocampus dentate gyrus: a patch-clamp study J. Neurophysiol. 71 1994 1935 1947
74. F. Kawahara H. Saito H. Katsuki Inhibition of 5-HT7 receptor stimulation of GABAA receptor-activated current in cultured rat suprachiasmatic neurons J. Physiol. 478 Pt 1 1994 67 73
75. K. Kishimoto S. Koyama N. Akaike Presynaptic modulation of synaptic gamma-aminobutyric acid transmission by tandospirone in rat basolateral amygdala Eur. J. Pharmacol. 407 2000 257 265
76. K. Kobayashi Y. Ikeda E. Haneda H. Suzuki Chronic fluoxetine bidirectionally modulates potentiating effects of serotonin on the hippocampal mossy fiber synaptic transmission J. Neurosci. 28 2008 6272 6280
77. S. Koyama N. Matsumoto C. Kubo N. Akaike Presynaptic 5-HT3 receptor-mediated modulation of synaptic GABA release in the mechanically dissociated rat amygdala neurons J. Physiol. 529 2000 373 383
78. S. Koyama N. Matsumoto N. Murakami C. Kubo J. Nabekura N. Akaike Role of presynaptic 5-HT1A and 5-HT3 receptors in modulation of synaptic GABA transmission in dissociated rat basolateral amygdala neurons Life Sci. 72 2002 375 387
79. S. Koyama N. Matsumoto K. Murakami C. Kubo J. Nabekura N. Akaike Role of presynaptic 5-HT1A and 5-HT3 receptors in modulation of synaptic GABA transmission in dissociated rat basolateral amygdala neurons Life Sci. 72 2002 375 387
80. E.K. Lambe G.K. Aghajanian The role of Kv1.2-containing potassium channels in serotonin-induced glutamate release from thalamocortical terminals in rat frontal cortex J. Neurosci. 21 2001 9955 9963
81. E.K. Lambe P.S. Goldman-Rakic G.K. Aghajanian Serotonin induces EPSCs preferentially in layer V pyramidal neurons of the frontal cortex in the rat Cereb. Cortex 10 2000 974 980
82. A. Laurent J.-M. Goaillard O. Cases C. Lebrand P. Gaspar N. Ropert Activity-dependent presynaptic effect of serotonin 1B receptors on the somatosensory thalamocortical transmission in neonatal mice J. Neurosci. 22 2002 886 900
83. C. Lebrand O. Cases C. Adelbrecht A. Doye C. Alvarez S. El Mestikawy I. Seif P. Gaspar Transient uptake nad storage of serotonin in developing thalamic neurons Neuron 17 1996 991 1003
84. L. Levita S.E. Hammack I. Mania X.Y. Li M. Davis D.G. Rainnie 5-Hydroxytryptamine1A-like receptor activation in the bed nucleus of the stria terminalis: electrophysiological and behavioral studies Neuroscience 128 2004 583 596
85. C.H. Lin Y.C. Huang J.J. Tsai P.W. Gean Modulation of voltage-dependent calcium currents by serotonin in acutely dissociated isolated rat amygdala neurons Synapse 41 2001 351 359
86. 2A serotonin receptors selectively in primate brain Neuropharmacology 37 1998 1147 1158
87. J.F. Lopez-Gimenez G. Mengod J.M. Palacios M.T. Vilaro Selective visualization of rat brain 5-HT2A receptors by autoradiography with [3H]MDL 100,907 Naunyn-Schmiedeberg's Arch. Pharmacol. 356 1997 446 454
88. J.F. Lopez-Gimenez G. Mengod J.M. Palacios M.T. Vilaro Regional distribution and cellular localization of 5-HT2C receptor mRNA in monkey brain: comparison with [3H]mesulergine binding sites and choline acetyltransferase mRNA Synapse 42 2001 12 26
89. V.L. Lucaites J.H. Krushinski J.M. Schaus J.E. Audia D.L. Nelson [3H]LY334370, a novel radioligand for the 5-HT1F receptor. II. Autoradiographic localization in rat, guinea pig, monkey and human brain Naunyn-Schmiedeberg's Arch. Pharmacol. 371 2005 178 184
90. 2A receptor interactions Eur. J. Pharmacol. 474 2003 77 83
91. G.J. Marek Regulation of rat cortical 5-hydroxytryptamine2A-receptor mediated electrophysiological responses by repeated daily treatment with electroconvulsive shock or imipramine Eur. Neuropsychopharmacol. 18 2008 498 507
92. 2A- receptor mediated excitatory synaptic currents in the rat following repeated daily fluoxetine administration Neurosci. Lett. 438 2008 312 316
93. G.J. Marek Activation of adenosine A1(A1) receptors suppreseses head shakes induced by serotonergic hallucino-genin rats Neuropharmacol. 56 2009 1082 1087
94. 2A receptor antagonist Eur. J. Pharmacol. 259 1994 137 141
95. 2A receptor-mediated excitatory effects of serotonin on interneurons in rat piriform cortex Synapse 21 1995 123 130
96. 2A receptors on neurons in the rat piriform cortex J. Pharmacol. Exp. Ther. 278 1996 1373 1382
97. G.J. Marek G.K. Aghajanian 5-HT-induced EPSCs in neocortical layer V pyramidal cells: suppression by μ-opiate receptor activation Neurosci 86 1998 485 497
98. 2A and group II metabotropic glutamate receptors in prefrontal cortex J. Pharmacol. Exp. Ther. 292 2000 76 87
99. G.J. Marek R.A. Wright J.C. Gewirtz D.D. Schoepp A major role for thalamocortical afferents in serotonergic hallucinogen receptor function in the rat neocortex Neuroscience 105 2001 379 392
100. 2A antagonists and selective serotonin reuptake inhibitors in neuropsychiatric disorders Neuropsychopharmacology 28 2003 402 412
101. M. Matsumoto H. Togashi K. Mori K. Ueno S. Ohashi T. Kojima M. Yoshioka Evidence for involvement of central 5-HT(4) receptors in cholinergic function associated with cognitive processes: behavioral, electrophysiological, and neurochemical studies J. Pharmacol. Exp. Ther. 296 2001 676 682
102. L.L. McMahon J.A. Kauer Hippocampal interneurons are excited via serotonin-gated ion channels J. Neurophysiol. 78 1997 2493 2502
103. 1C receptor mRNA in the rodent brain examined by in situ hybridization histochemistry Comparison with receptor binding distribution. Neuroscience 35 1990 577 592
104. Y. Minabe Y. Shirayama K. Hashimoto C. Routledge J.J. Hagan C.R. Ashby Jr. Effect of the acute and chronic administration of the selective 5-HT6 receptor antagonist SB-271046 on the activity of midbrain dopamine neurons in rats: an in vivo electrophysiological study Synapse 52 2004 20 28
105. 1B receptor-mediated inhibition of local excitatory synaptic transmission in the CA1 region of the rat hippocampus Br. J. Pharmacol. 138 2003 71 80
106. R.D. Mooney M.Y. Shi R.W. Rhoades Modulation of retinotectal transmission by presynaptic 5-HT1B receptors in the superior colliculus of the adult hamster J. Neurophysiol. 72 1994 3 13
107. R.D. Mooney X. Huang M.Y. Shi C.A. Bennett-Clarke R.W. Rhoades Serotonin modulates retinotectal and corticotectal convergence in the superior colliculus Prog. Brain Res. 112 1996 57 69
108. 3 receptor is present in different subpopulations of GABAergic neurons in the rat telencephalon J. Neurosci. 17 1997 3157 3167
109. 3 receptors synthesized in the rat CNS and peripheral nervous system J. Neurosci. 22 2002 6732 6741
110. M. Morales E. Battenberg L. de Lecea F.E. Bloom The type 3 serotonin receptor is expressed in a subpopulation of GABAergic neurons in the rat neocortex and hippocampus Brain Res. 731 1996 199 202
111. 5 receptors Curr. Drug Targets CNS Neurol. Disord. 3 2004 53 58
112. D.E. Nichols Hallucinogens Pharmacol. Ther. 101 2004 131 181
113. J.E. Olijslagers T.R. Werkman A.C. McCreary R. Siarey C.G. Kruse W.J. Wadman 5-HT2 receptors differentially modulate dopamine-mediated auto-inhibition in A9 and A10 midbrain areas of the rat Neuropharmacology 46 2004 504 510
114. N.A. Otmakhova J. Lewey B. Asrican J.E. Lisman Inhibition of perforant path input to the CA1 region by serotonin and noradrenaline J. Neurophysiol. 94 2005 1413 1422
115. S.T. Patil L. Zhang F. Martenyi S.L. Lowe K.A. Jackson B.V. Andreev A.S. Avedisova L.M. Bardenstein I.Y. Gurovich M.A. Morozova S.N. Mosolov N.G. Neznanov A.M. Reznik A.B. Smulevich V.A. Tochilov B.G. Johnson J.A. Monn D.D. Schoepp Activation of mGlu2/3 receptors as a new approach to treat schizophrenia: a randomized Phase 2 clinical trial Nat. Med. 13 2007 1103 1108
116. A.M. Persico E. Mengual R. Moessner S.F. Hall R.S. Revay I. Sora J. Arellano J. DeFelipe J.M. Gimenez-Amaya M. Conciatori R. Marino A. Baldi S. Cabib T. Pascucci G.R. Uhl D.L. Murphy K.P. Lesch F. Keller Barrell pattern formation requires serotonin uptake by thalamocortical afferents, and not vesicular monoamine release J. Neurosci. 21 2001 6862 6873
117. P. Piguet M. Galvan Transient and long-lasting actions of 5-HT on rat dentate gyrus neurones in vitro. J. Physiol. (Lond.) 481 1994 629 639
118. D. Pinault Backpropagation of action potentials generated at ectopic axonal loci: hypothesis that axon terminals integrate local environmental signals Brain Res. Rev. 21 1995 42 92
119. G. Pineyro P. Blier Autoregulation of serotonin neurons: role in antidepressant drug action Pharmacol. Rev. 51 1999 533 591
120. P. Pitra K. Tokarski M. Grzegorzewska G. Hess Effects of repetitive administration of tianeptine, zinc hydroaspartate and electroconvulsive shock on the reactivity of 5-HT(7) receptors in rat hippocampus Pharmacol. Rep. 59 2007 627 635
121. M. Pompeiano J.M. Palacios G. Mengod Distribution and cellular localization of mRNA coding for 5-HT1A receptor in the rat: correlation with receptor binding J. Neurosci. 12 1992 440 453
122. A.A. Ponomarenko A. Knoche T.M. Korotkova H.L. Haas Aminergic control of high-frequency (approximately 200 Hz) network oscillations in the hippocampus of the behaving rat Neurosci. Lett. 348 2003 101 104
123. 2A receptors. Relationship to thalamocortical afferents. Cereb. Cortex 13 2003 870 882
124. E. Querejeta A. Oviedo-Chavez J.M. Araujo-Alvarez A.R. Quinones-Cardenas A. Delgado In vivo effects of local activation and blockade of 5-HT1B receptors on globus pallidus neuronal spiking Brain Res. 1043 2005 186 194
125. N.M. Ramadan V. Skljarevski L.A. Phebus K.W. Johnson 5-HT1F receptor agonists in acute migraine treatment: a hypothesis Cephalalgia 23 2003 776 785
126. 2 antagonists Brain Res. 385 1986 395 400
127. 2 binding affinity Neuropsychopharmacology 1 1988 101 107
128. 3 receptor antagonist zatosetron decreases the number of spontaneously active A10 dopamine neurons Eur. J. Pharmacol. 205 1991 113 116
129. M. Rav-Acha H. Bergman Y. Yarom Pre- and postsynaptic serotonergic excitation of globus pallidus neurons J. Neurophysiol. 100 2008 1053 1066
130. H.L. Read S.G. Beck N.J. Dun Serotonergic suppression of interhemispheric cortical synaptic potentials Brain Res. 643 1994 17 28
131. L.M. Rorick-Kehn B.G. Johnson J.L. Burkey R.A. Wright D.O. Calligaro G.J. Marek E.S. Nisenbaum J.T. Catlow A.E. Kingston D. Giera M.F. Herin J.A. Monn D.L. McKinzie D.D. Schoepp Pharmacological and pharmacokinetic properties of a structurally novel, potent, and selective metabotropic glutamate 2/3 receptor agonist: in vitro characterization of agonist (−)-(1R,4S,5S,6S)-4-amino-2-sulfonylbicyclo[3.1.0]-hexane-4,6-dicarboxylic acid (LY404039) J. Pharmacol. Exp. Ther. 321 2007 308 317
132. L.M. Rorick-Kehn B.G. Johnson K.M. Knitowski C.R. Salhoff J.M. Witkin K.W. Perry K.I. Griffey J.P. Tizzano J.A. Monn D.L. McKinzie D.D. Schoepp In vivo pharmacological characterization of the structurally novel, potent, selective mGlu2/3 receptor agonist LY404039 in animal models of psychiatric disorders Psychopharmacol 193 2007 121 136
133. R.B. Rothman M.H. Baumann J.E. Savage L. Rauser A. McBride S.J. Hufeisen B.L. Roth Evidence for possible involvement of 5-HT(2B) receptors in the cardiac valvulopathy associated with fenfluramine and other serotonergic medications Circulation 102 2000 2836 2841
134. L.A. Rueter C. Montigny P. Blier Electrophysiological characterization of the effect of long-term duloxetine administration on the rat serotonergic and noradrenergic systems J. Pharmacol. Exp. Ther. 285 1998 404 412
135. L.E. Rueter P. Blier Electrophysiological examination of the effects of sustained flibanserin administration on serotonin receptors in rat brain Br. J. Pharmacol. 126 1999 627 638
136. 2A receptors in pyramidal and GABAergic neurons of the rat prefrontal cortex Cereb. Cortex 14 2004 1100 1109
137. Y. Sari K. Lefevre M. Bancila M. Quignon M.C. Miguel X. Langlois M. Hamon D. Verge Light and electron microscopic immunocytochemical visualization of 5-HT1B receptors in the rat brain Brain Res. 760 1997 281 286
138. Y. Sari M.C. Miquel M.J. Brisorgueil G. Ruiz E. Doucet M. Hamon D. Verge Cellular and subcellular localization of 5-hydroxytryptamine1B receptors in the rat central nervous system: immunocytochemical, autoradiographic and lesion studies Neuroscience 88 1999 899 915
139. K. Schmuck C. Ullmer P. Engels H. Lubbert Cloning and functional characterization of the human 5-HT2B serotonin receptor FEBS Lett. 342 1994 85 90
140. D.D. Schoepp Unveiling the functions of presynaptic metabotropic glutamate receptors in the central nervous system J. Pharmacol. Exp. Ther. 299 2001 12 20
141. 2A heteroceptors on thalamocortical glutamatergic neurons J. Neurosci. 20 2000 8846 8852
142. 2-activated interneuron Brain Res. 506 1990 62 69
143. 2 receptors in interneurons Synapse 9 1991 208 218
144. K.Z. Shen L.B. Kozell S.W. Johnson Multiple conductances are modulated by 5-HT receptor subtypes in rat subthalamic nucleus neurons Neuroscience 148 2007 996 1003
145. R.Y. Shen R. Andrade 5-Hydroxytryptamine2 receptor facilitates GABAergic neurotransmission in rat hippocampus J. Pharmacol. Exp. Ther. 285 1998 805 812
146. S.M. Sherman R.W. Guillery Functional organization of thalamocortical relays J. Neurophysiol. 76 1996 1367 1395
147. S.M. Sherman R.W. Guillery On the actions that one nerve cell can have on another: distinguishing ‘drivers’ from ‘modulators’ Proc. Natl. Acad. Sci. USA 95 1998 7121 7126
148. S.M. Sorensen T.M. Humphreys M.G. Palfreyman Effect of acute and chronic MDL 73,147EF, a 5-HT3 receptor antagonist, on A9 and A10 dopamine neurons Eur. J. Pharmacol. 163 1989 115 118
149. I.M. Stanford M.G. Lacey Differential actions of serotonin, mediated by 5-HT1B and 5-HT2C receptors, on GABA-mediated synaptic input to rat substantia nigra pars reticulata neurons in vitro. J Neurosci. 16 1996 7566 7573
150. I.M. Stanford M.A. Kantaria H.S. Chahal K.C. Loucif C.L. Wilson 5-Hydroxytryptamine induced excitation and inhibition in the subthalamic nucleus: action at 5-HT(2C), 5-HT(4), 5-HT(1A) receptors Neuropharmacology 49 2005 1228 1234
151. M. Steriade E.G. Jones D.A. McCormick Thalamus: Organization and Function 1997 Elsevier New York, NY
152. G.E. Stutzman G.J. Marek G.K. Aghajanian Adenosine preferentially suppresses serotonin2A receptor-enhanced excitatory postsynaptic currents in layer V neurons of the rat medial prefrontal cortex Neuroscience 105 2001 55 69
153. S.N. Sudweeks J.A. Hooft J.L. Yakel Serotonin 5-HT(3) receptors in rat CA1 hippocampal interneurons: functional and molecular characterization J. Physiol. 544 2002 715 726
154. 3 receptors in rat amygdala Neuron 8 1992 199 203
155. E. Tanaka R.A. North Actions of 5-hydroxytryptamine on neurons of the rat cingulate cortex J. Neurophysiol. 69 1993 1749 1757
156. E. Tanaka R.A. North Opioid actions on rat anterior cingulate cortex neurons in vitro. J. Neurosci. 14 1994 1106 1113
157. 2 receptor as a site of action for LSD and phenethylamine hallucinogens Psychopharmacology 94 1988 213 216
158. K. Toharski A. Zahorodna B. Bobula M. Grzegorzewska P. Pitra G. Hess Repeated administration of citalopram and imipramine alters the responsiveness of rat hippocampal circuitry to the activation of 5-HT7 receptors Eur. J. Pharmacol. 524 2005 60 66
159. K. Tokarski M. Bijak Antidepressant-induced adaptive changes in the effects of 5-HT, 5-HT1A and 5-HT4 agonists on the population spike recorded in hippocampal CA1 cells do not involve presynaptic effects on excitatory synaptic transmission Pol. J. Pharmacol. 48 1996 565 573
160. K. Tokarski A. Zahorodna B. Bobula G. Hess 5-HT7 receptors increase the excitability of rat hippocampal CA1 pyramidal neurons Brain Res. 993 2003 230 234
161. G.E. Torres I.L. Holt R. Andrade Antagonists of 5-HT4 receptor-mediated responses in adult hippocampal neurons J. Pharmacol. Exp. Ther. 271 1994 255 261
162. 4 receptors reduce afterhyperpolarization in hippocampus by inhibiting calcium-induced calcium release Mol. Pharmacol. 50 1996 1316 1322
163. K. Varnas D.R. Thomas E. Tupala J. Tiihonen H. Hall Distribution of 5-HT7 receptors in the human brain: a preliminary autoradiographic study using [3 H]SB-269970 Neurosci. Lett. 367 2004 313 316
164. S.J. Wang L.L. Cheng P.W. Gean Cross-modulation of synaptic plasticity by beta-adrenergic and 5-HT1A receptors in the rat basolateral amygdala J. Neurosci. 19 1999 570 577
165. 2A receptor signalling modulates anxiety-like behaviors in mice Science 313 2006 536 540
166. D.L. Willins H.Y. Meltzer Direct injection of 5-HT2A receptor agonists into the medial prefrontal cortex produces a head-twitch response in rats J. Pharmacol. Exp. Ther. 282 1997 699 706
167. D.L. Willins A.Y. Deutch B.L. Roth Serotonin 5-HT2A receptors are expressed on pyramidal cells and interneurons in the rat cortex Synapse 27 1997 79 82
168. 2 receptor subtype mRNAs in rat brain J. Comp. Neurol. 351 1995 357 373
169. Z. Xiang D.A. Prince Heterogenous actions of serotonin on interneurons in rat visual cortex J. Neurophysiol. 89 2003 1278 1287
170. Z. Xiang L. Wang S.T. Kitai Modulation of spontaneous firing in rat subthalamic neurons by 5-HT receptor subtypes J. Neurophysiol. 93 2005 1145 1157
171. 3 receptors mediate rapid responses in cultured hippocampus and a clonal cell line Neuron 1 1988 615 621
172. 2A receptor-mediated prefrontal cortical excitatory synaptic currents and DOI-induced head shakes Prog. Neuropsychopharmacol. Biol. Psychiatry 32 2008 62 71
173. F.-M. Zhou J.J. Hablitz Activation of serotonin receptors modulates synaptic transmission in rat cerebral cortex J. Neurophysiol. 82 1999 2989 2999