Adenosine preferentially suppresses serotonin2A receptor-enhanced excitatory postsynaptic currents in layer V neurons of the rat medial prefrontal cortex

Neuroscience

Volumn 105, Issue 1, 2001, Pages 55-69

  Stutzmann, G E ^a   Marek, G J ^a   Aghajanian, G K ^a,b  

^a Yale University School of Medicine   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

5 Hydroxytryptamine2A receptors; Electrophysiology; Hallucinogens; Late excitatory postsynaptic currents; Schizophrenia

Indexed keywords

2 AMINO 5 PHOSPHONOVALERIC ACID; 4 IODO 2,5 DIMETHOXYAMPHETAMINE; 6 CYANO 7 NITRO 2,3 QUINOXALINEDIONE; 6 N CYCLOPENTYLADENOSINE; 8 CYCLOPENTYL 1,3 DIPROPYLXANTHINE; ADENOSINE; ADENOSINE A1 RECEPTOR; ADENOSINE A1 RECEPTOR AGONIST; ADENOSINE A1 RECEPTOR ANTAGONIST; ALPHA (2,3 DIMETHOXYPHENYL) 1 [2 (4 FLUOROPHENYL)ETHYL] 4 PIPERIDINEMETHANOL; DIPYRIDAMOLE; SEROTONIN; SEROTONIN 2A AGONIST; SEROTONIN 2A RECEPTOR; SEROTONIN 2C AGONIST; STRONTIUM CHLORIDE; TETRODOTOXIN;

ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ELECTROPHYSIOLOGY; ENZYME ACTIVATION; EVOKED RESPONSE; EXCITATORY POSTSYNAPTIC POTENTIAL; IN VITRO STUDY; MALE; NONHUMAN; PATCH CLAMP; PREFRONTAL CORTEX; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; RAT;

ADENOSINE; ANIMALS; DIPYRIDAMOLE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; EXCITATORY AMINO ACID ANTAGONISTS; EXCITATORY POSTSYNAPTIC POTENTIALS; INDOPHENOL; MALE; ORGAN CULTURE TECHNIQUES; PHOSPHODIESTERASE INHIBITORS; PREFRONTAL CORTEX; PYRAMIDAL CELLS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, SEROTONIN, 5-HT2A; RECEPTORS, N-METHYL-D-ASPARTATE; RECEPTORS, PURINERGIC P1; RECEPTORS, SEROTONIN; SEROTONIN AGONISTS; STRONTIUM; XANTHINES;

EID: 0035898279     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4522(01)00170-1     Document Type: Article

References (78)

1. Electrophysiology of serotonin receptor subtypes and signal transduction pathways
2. Serotonin induces excitatory postsynaptic potentials in apical dendrites of neocortical pyramidal cells
3. 2A receptors, increase EPSCs in layer V pyramidal cells of prefrontal cortex by an asynchronous mode of glutamate release
4. Serotonin-glutamate interactions: A new target for antipsychotic drugs
5. 1A receptors mediate opposing responses on membrane excitability in rat association cortex
6. Inhibition by adenosine receptor agonists of synaptic transmission in rat periaqueductal grey neurons
7. Intersynaptic diffusion of neurotransmitter
8. A review of central 5-HT receptors and their function
9. Adenosine A1 receptor inhibition of glutamate exocytosis and protein kinase C-mediated decoupling
10. Quantal amplitude and quantal variance of strontium-induced asynchronous EPSCs in rat dentate granule neurons
11. Release of adenosine from ischemic brain: Effect on cerebral vascular resistance and incorporation into cerebral adenine nucleotides
12. 2 receptors and serotonergic axons in rat neocortex
13. Adenosine-containing neurons in the brain localized by immunocytochemistry
14. The role of cyclic AMP as a precursor of extracellular adenosine in the rat hippocampus
15. Modulation of excitatory synaptic transmission by adenosine released from single hippocampal pyramidal neurons
16. Role of serotonin in memory impairment
17. Prolonged synaptic currents and glutamate spillover at the parallel fiber to stellate cell synapse
18. Pharmacology and function of metabotropic glutamate receptors
19. B actions in neocortical neurons of the rat in vitro
20. Extracellular adenosine concentrations in hippocampal brain slices and the tonic inhibitory modulation of evoked excitatory responses
21. Regulation of extracellular adenosine in rat hippocampal slices is temperature dependent: Role of adenosine transporters
22. Adenine nucleotides undergo rapid, quantitative conversion to adenosine in the extracellular space in rat hippocampus
23. Adenosine increases synaptic facilitation in the in vitro rat hippocampus: Evidence for a presynaptic site of action
24. Effects of adenosine and cadmium on presynaptic fiber spikes in the CA1 region of rat hippocampus
25. The distribution of adenosine A1 receptors and 5′-nucleotidase in the brain of some commonly used experimental animals
26. Adenosine A1 receptor-mediated depression of corticostriatal and thalamostriatal glutamatergic synaptic potentials in vitro
27. Purine release and inhibition of synaptic transmission during hypoxia and hypoglyceamia in rat hippocampal slices
28. Heterogeneous distribution of adenosine transport sites labelled by [3H]nitrobenzylthionosine in rat brain: An autoradiographic and membrane binding study
29. Distribution of adenosine deaminase activity in rat brain and spinal cord
30. 2+ sensor for transmitter release at a central synapse
31. i-coupled signal transduction
32. 2 involvement in the mechanism of action of hallucinogenic agents
33. Two components of transmitter release at a central synapse
34. Kolmogorov-Smirnov tests for psychological research
35. The electrophysiology of adenosine in the mammalian central nervous system
36. The modulation of excitatory synaptic transmission by adenosine in area CA1 of the rat hippocampus is temperature dependent
37. Adenosine enhances afterhyperpolarization and accomodation in hippocampal pyramidal cells
38. 2A receptor mRNA expression in frontal cortex of chronic elderly schizophrenics with varying histories of neuroleptic treatment
39. Permeation of calcium through excitatory amino acid receptor channels is cultured rat hippocampal neurones
40. Structure and function of brain serotonin systems
41. 2A serotonin receptors in the primate cerebral cortex: Possible site of action of hallucinogenic and antipsychotic drugs in pyramidal cell apical dendrites
42. Predominant information transfer from layer III pyramidal neurons to corticospinal neurons
43. Serotonergic and cholinergic inhibition of mesopontice cholinergic neurons controlling REM sleep: An in vitro electrophysiological study
44. 2+ binding properties of synaptotagmins
45. Adenosine inhibition of synaptic transmission in the substantia gelatinosa
46. Serotonin neurons and sleep. I. Long term recordings of dorsal raphe discharge frequency and PGO waves
47. Control of NMDA receptor-mediated activity by GABAergic mechanisms in mature and developing rat neocortex
48. 2A receptors on neurons in the rat piriform cortex
49. 5-Hydroxytryptamine-induced EPSCs in neocortical layer V pyramidal cell of prefrontal cortex: Suppression by μ opiate receptor activation
50. 2A receptor-induced EPSCs in layer V pyramidal cells of the prefrontal cortex: Block by lesions of the medial thalamus
51. 2A and group II metabotropic glutamate receptors in prefrontal cortex
52. Temperature-dependent modulation of excitatory transmission in hippocampal slices is mediated by extracellular adenosine
53. Dopamine D1, D2 and serotonin2 receptor occupation by typical and atypical antipsychotic drugs in vivo
54. Permeation and block of N-methyl-D-aspartic acid receptor channels by divalent cations in mouse cultured central neurones
55. Comparitive electrophysiology of pyramidal and sparsely spiny neurons of the neocortex
56. The role of serotonin in antipsychotic drug action
57. i values
58. o
59. Cellular localization of adenosine A1 receptors in rat forebrain: Immunohistochemical analysis using adenosine A1-receptor-specific monoclonal antibody
60. Delayed clearance of transmitter and the role of glutamate transporters at synapses with multiple release sites
61. Long-term potentiation in frontal cortex: Role of NMDA-modulated polysynaptic excitatory pathways
62. Effects of adenosine and adenine nucleotides on synaptic transmission in the cerebral cortex
63. Immunohistochemical detection of A1 adenosine receptors in rat brain with emphasis on localization in the hippocampal formation, cerebral cortex, cerebellum, and basal ganglia
64. Relationship between adenosine concentration and oxygen supply in rat brain
65. 2-activated interneuron
66. Receptors for adenosine and adenine nucleotides
67. Patch-clamp recordings from the soma and dendrites of neurons in brain slices using infrared video microscopy
68. EPSPs in rat neocortical neurons in vitro. II. Involvement of N-methyl-D-aspartate receptors in the generation of EPSPs
69. Actions of 5-hydroxytryptamine on neurons of the rat cingulate cortex
70. Comparison of the actions of adenosine at pre- and postsynaptic receptors in the rat hippocampus in vitro
71. 2 receptor as a site of action for LSD and phenylisopropylamine hallucinogens
72. The regulation of quantal size
73. 2A receptors are expressed on pyramidal cells and interneurons in the rat cortex
74. Adenosine inhibits evoked synaptic transmission primarily by reducing presynaptic calcium influx in area CA1 of hippocampus
75. Probing fundamental aspects of synaptic transmission with strontium
76. Subcellular, regional and immunohistochemical localization of adenosine deaminase in various species
77. Two components of transmitter release from the chick ciliary presynaptic terminal and their regulation by protein kinase C
78. Activation of serotonin receptors modulates synaptic transmission in rat cerebral cortex