메뉴 건너뛰기




Volumn 355, Issue 1, 1996, Pages 20-29

Effects of longterm treatment with the α2-adrenoceptor antagonist mirtazapine on 5-HT neurotransmission

Author keywords

Dorsal raphe; Hippocampus; Locus coeruleus; Mirtazapine; Serotonin; 2 Adrenoceptor

Indexed keywords

ALPHA 2 ADRENERGIC RECEPTOR; ALPHA 2 ADRENERGIC RECEPTOR BLOCKING AGENT; CLONIDINE; MIRTAZAPINE; NORADRENALIN; ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; DRUG DERIVATIVE; MIANSERIN; SEROTONIN;

EID: 0030614734     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/PL00004913     Document Type: Article
Times cited : (68)

References (57)
  • 1
    • 0018066653 scopus 로고
    • Feedback regulation of central monoaminergic neurons: Evidence from single cell recording studies
    • Youdim MBH, Lovenberg W, Sharman DF, Lagnado JR (eds) Wiley, New York
    • Aghajanian GK (1978) Feedback regulation of central monoaminergic neurons: evidence from single cell recording studies. In: Youdim MBH, Lovenberg W, Sharman DF, Lagnado JR (eds) Essays in neurochemistry and neuropharmacology. Wiley, New York, pp 2-32
    • (1978) Essays in Neurochemistry and Neuropharmacology , pp. 2-32
    • Aghajanian, G.K.1
  • 2
    • 0017734626 scopus 로고
    • Locus coeruleus to dorsal raphe input examined by electrophysiological and morphological methods
    • Anderson CD, Pasquier DA, Forbes WB, Morgane PJ (1977) Locus coeruleus to dorsal raphe input examined by electrophysiological and morphological methods. Brain Res Bull 2:209-221
    • (1977) Brain Res Bull , vol.2 , pp. 209-221
    • Anderson, C.D.1    Pasquier, D.A.2    Forbes, W.B.3    Morgane, P.J.4
  • 3
    • 0018853233 scopus 로고
    • Suppression of firing activity of 5-HT neurons in the dorsal raphe by alpha-adrenoceptor antagonists
    • Baraban JM, Aghajanian GK (1980) Suppression of firing activity of 5-HT neurons in the dorsal raphe by alpha-adrenoceptor antagonists. Neuropharmacology 19:355-363
    • (1980) Neuropharmacology , vol.19 , pp. 355-363
    • Baraban, J.M.1    Aghajanian, G.K.2
  • 4
    • 0019365408 scopus 로고
    • Noradrenergic innervation of serotoninergic neurons in the dorsal raphe: Demonstration by electron microscopic autoradiography
    • Baraban JM, Aghajanian GK (1981) Noradrenergic innervation of serotoninergic neurons in the dorsal raphe: demonstration by electron microscopic autoradiography. Brain Res 204:1-11
    • (1981) Brain Res , vol.204 , pp. 1-11
    • Baraban, J.M.1    Aghajanian, G.K.2
  • 5
    • 0028018846 scopus 로고
    • Modulation of 5-HT release in guinea-pig brain following long-term administration of antidepressant drugs
    • Blier P, Bouchard C (1994) Modulation of 5-HT release in guinea-pig brain following long-term administration of antidepressant drugs. Br J Pharmacol 113:485-495
    • (1994) Br J Pharmacol , vol.113 , pp. 485-495
    • Blier, P.1    Bouchard, C.2
  • 6
    • 0023528585 scopus 로고
    • 1A agonist gepirone: Electrophysiological studies in the rat brain
    • 1A agonist gepirone: electrophysiological studies in the rat brain. Synapse 1:470-480
    • (1987) Synapse , vol.1 , pp. 470-480
    • Blier, P.1    De Montigny, C.2
  • 8
    • 0023684053 scopus 로고
    • 2-adrenoceptors: Pharmacological and molecular biological evidence converge
    • 2-adrenoceptors: pharmacological and molecular biological evidence converge. Trends Pharmacol 9:356-361
    • (1988) Trends Pharmacol , vol.9 , pp. 356-361
    • Bylund, D.B.1
  • 11
    • 0019508049 scopus 로고
    • Supersensitivity of central noradrenergic presynaptic autoreceptors following chronic treatment with the antidepressant mianserin
    • Cerrito F, Raiteri M (1981) Supersensitivity of central noradrenergic presynaptic autoreceptors following chronic treatment with the antidepressant mianserin. Eur J Pharmacol 70:425-426
    • (1981) Eur J Pharmacol , vol.70 , pp. 425-426
    • Cerrito, F.1    Raiteri, M.2
  • 12
    • 0022503862 scopus 로고
    • In vivo electrophysiological evidence for the regulatory role of autoreceptors on serotoninergic terminals
    • Chaput Y, Blier P, de Montigny C (1986) In vivo electrophysiological evidence for the regulatory role of autoreceptors on serotoninergic terminals. J Neurosci 6:2796-2801
    • (1986) J Neurosci , vol.6 , pp. 2796-2801
    • Chaput, Y.1    Blier, P.2    De Montigny, C.3
  • 13
    • 0023727002 scopus 로고
    • 1 receptor antagonist BMY 7378 on the 5-HT neurotransmission: Electrophysiological studies in the rat central nervous system
    • 1 receptor antagonist BMY 7378 on the 5-HT neurotransmission: electrophysiological studies in the rat central nervous system. J Pharmacol Exp Ther 246:359-370
    • (1988) J Pharmacol Exp Ther , vol.246 , pp. 359-370
    • Chaput, Y.1    De Montigny, C.2
  • 14
    • 0029070521 scopus 로고
    • A double-blind, placebo-controlled study of ORG 3770 in depressed outpatients
    • Claghorn JL, Lesem MD (1995) A double-blind, placebo-controlled study of ORG 3770 in depressed outpatients. J Affect Disord 34:165-172
    • (1995) J Affect Disord , vol.34 , pp. 165-172
    • Claghorn, J.L.1    Lesem, M.D.2
  • 15
    • 0026684148 scopus 로고
    • The effect of adrenergic drugs on serotonin metabolism in the nucleus raphe dorsalis of the rat, studied by in vivo voltammetry
    • Clement H-W, Gemsa D, Weseman W (1992) The effect of adrenergic drugs on serotonin metabolism in the nucleus raphe dorsalis of the rat, studied by in vivo voltammetry. Eur J Pharmacol 217:43-48
    • (1992) Eur J Pharmacol , vol.217 , pp. 43-48
    • Clement, H.-W.1    Gemsa, D.2    Weseman, W.3
  • 16
    • 0018146337 scopus 로고
    • Presynaptic alpha-receptor subsensitivity after long-term antidepressant treatment
    • Crews FT, Smith CB (1978) Presynaptic alpha-receptor subsensitivity after long-term antidepressant treatment. Science 202:322-324
    • (1978) Science , vol.202 , pp. 322-324
    • Crews, F.T.1    Smith, C.B.2
  • 17
    • 0023754346 scopus 로고
    • Electrophysiological characterization of adrenoceptors in the rat dorsal hippocampus. I. Receptors mediating the effect of microiontophoretically applied norepinephrine
    • Curet O, de Montigny C (1988a) Electrophysiological characterization of adrenoceptors in the rat dorsal hippocampus. I. Receptors mediating the effect of microiontophoretically applied norepinephrine. Brain Res 475:35-46
    • (1988) Brain Res , vol.475 , pp. 35-46
    • Curet, O.1    De Montigny, C.2
  • 18
    • 0023708464 scopus 로고
    • Electrophysiological characterization of adrenoceptors in the rat dorsal hippocampus. II. Receptors mediating the effect of synaptically-released norepinephrine
    • Curet O, de Montigny C (1988b) Electrophysiological characterization of adrenoceptors in the rat dorsal hippocampus. II. Receptors mediating the effect of synaptically-released norepinephrine. Brain Res 475:47-57
    • (1988) Brain Res , vol.475 , pp. 47-57
    • Curet, O.1    De Montigny, C.2
  • 19
    • 0026011459 scopus 로고
    • Acute and chronic effect of the atypical antidepressant mianserin on brain noradrenergic neurons
    • Curtis AL, Valentino RJ (1991) Acute and chronic effect of the atypical antidepressant mianserin on brain noradrenergic neurons. Psychopharmacology 103:330-338
    • (1991) Psychopharmacology , vol.103 , pp. 330-338
    • Curtis, A.L.1    Valentino, R.J.2
  • 20
    • 0023929271 scopus 로고
    • Neurochemical and autonomie pharmacological profiles of the 6-aza-analogue of mianserin, org 3770 and its enantiomers
    • De Boer T, Maura G, Raiteri M, de Vos CJ, Wieringa J, Pinder RM (1988) Neurochemical and autonomie pharmacological profiles of the 6-aza-analogue of mianserin, org 3770 and its enantiomers. Neuropharmacology 27:399-408
    • (1988) Neuropharmacology , vol.27 , pp. 399-408
    • De Boer, T.1    Maura, G.2    Raiteri, M.3    De Vos, C.J.4    Wieringa, J.5    Pinder, R.M.6
  • 22
    • 0030430274 scopus 로고    scopus 로고
    • Differences in modulation of noradrenergic and serotonergic transmission by the alpha-2 adrenoceptor antagonists, mirtazapine, mianserin and idazoxan
    • De Boer T, Nefkens F, van Helvoirt A, van Delft AML (1996) Differences in modulation of noradrenergic and serotonergic transmission by the alpha-2 adrenoceptor antagonists, mirtazapine, mianserin and idazoxan. J Pharmacol Exp Ther 277:852-860
    • (1996) J Pharmacol Exp Ther , vol.277 , pp. 852-860
    • De Boer, T.1    Nefkens, F.2    Van Helvoirt, A.3    Van Delft, A.M.L.4
  • 26
    • 0021840087 scopus 로고
    • Reduced peripheral presynaptic adrenoceptor sensitivity following chronic antidepressant treatment in rats
    • Finberg J-PM, Tal A (1985) Reduced peripheral presynaptic adrenoceptor sensitivity following chronic antidepressant treatment in rats. Br J Pharmacol 84:609-617
    • (1985) Br J Pharmacol , vol.84 , pp. 609-617
    • Finberg, J.-P.M.1    Tal, A.2
  • 27
    • 0026011052 scopus 로고
    • Effects of idazoxan on dorsal raphe 5-hydroxytryptamine neuronal function
    • Garrat JC, Crespi F, Mason R, Marsden CA (1991) Effects of idazoxan on dorsal raphe 5-hydroxytryptamine neuronal function. Eur J Pharmacol 193:87-93
    • (1991) Eur J Pharmacol , vol.193 , pp. 87-93
    • Garrat, J.C.1    Crespi, F.2    Mason, R.3    Marsden, C.A.4
  • 28
    • 0019217699 scopus 로고
    • 2+-dependent 5-hydroxytryptamine release from neurones of the rat brain cortex
    • 2+-dependent 5-hydroxytryptamine release from neurones of the rat brain cortex. Naunyn-Schmiedeberg's Arch Pharmacol 314:223-230
    • (1980) Naunyn-Schmiedeberg's Arch Pharmacol , vol.314 , pp. 223-230
    • Göthert, M.1
  • 29
    • 0030431697 scopus 로고    scopus 로고
    • 2-adrenoceptor antagonist mirtazapine on the 5-hydroxytryptamine system in the rat brain
    • 2-adrenoceptor antagonist mirtazapine on the 5-hydroxytryptamine system in the rat brain. J Pharmacol Exp Ther 277:861-871
    • (1996) J Pharmacol Exp Ther , vol.277 , pp. 861-871
    • Haddjeri, N.1    Blier, P.2    De Montigny, C.3
  • 30
    • 0028294464 scopus 로고
    • Quantitative autoradiography of the serotonin transporter to assess the distribution of serotonergic projections from dorsal raphe nucleus
    • Hensler JG, Ferry RC, Labow DM, Kovashich GB, Frazer A (1994) Quantitative autoradiography of the serotonin transporter to assess the distribution of serotonergic projections from dorsal raphe nucleus. Synapse 17:1-15
    • (1994) Synapse , vol.17 , pp. 1-15
    • Hensler, J.G.1    Ferry, R.C.2    Labow, D.M.3    Kovashich, G.B.4    Frazer, A.5
  • 31
    • 0001192938 scopus 로고
    • Electrophysiology of hippocampal neurons. II. After potentials and repetitive firing
    • Kandel ER, Spencer WA (1961) Electrophysiology of hippocampal neurons. II. After potentials and repetitive firing. J Neurophysiol 24:243-259
    • (1961) J Neurophysiol , vol.24 , pp. 243-259
    • Kandel, E.R.1    Spencer, W.A.2
  • 33
    • 0027452671 scopus 로고
    • 2-adrenoceptors in the locus coeruleus and its projection fields in rat brain determined by quantitative autoradiography
    • 2-adrenoceptors in the locus coeruleus and its projection fields in rat brain determined by quantitative autoradiography. Neuropsychopharmacology 8:57-65
    • (1993) Neuropsychopharmacology , vol.8 , pp. 57-65
    • Kovachich, G.B.1    Frazer, A.2    Aronson, C.E.3
  • 34
    • 0025818105 scopus 로고
    • Effects of long-term desipramine treatment of adrenoceptors and norepinephrine reuptake: Electrophysiological studies in the rat brain
    • Lacroix D, Blier P, Curet O, de Montigny C (1991) Effects of long-term desipramine treatment of adrenoceptors and norepinephrine reuptake: Electrophysiological studies in the rat brain. J Pharmacol Exp Ther 257:1081-1090
    • (1991) J Pharmacol Exp Ther , vol.257 , pp. 1081-1090
    • Lacroix, D.1    Blier, P.2    Curet, O.3    De Montigny, C.4
  • 35
    • 0014591658 scopus 로고
    • Projections of the nucleus locus coeruleus in the albino rat
    • Loizou LA (1969) Projections of the nucleus locus coeruleus in the albino rat. Brain Res 15:563-569
    • (1969) Brain Res , vol.15 , pp. 563-569
    • Loizou, L.A.1
  • 37
    • 0019971988 scopus 로고
    • Relative potencies of alpha-1 and alpha-2 antagonists in the locus coeruleus, dorsal raphe and lateral geniculate nuclei: An electrophysiological study
    • Marwaha J, Aghajanian GK (1982) Relative potencies of alpha-1 and alpha-2 antagonists in the locus coeruleus, dorsal raphe and lateral geniculate nuclei: an electrophysiological study. J Pharmacol Exp Ther 222:287-293
    • (1982) J Pharmacol Exp Ther , vol.222 , pp. 287-293
    • Marwaha, J.1    Aghajanian, G.K.2
  • 38
    • 0018838577 scopus 로고
    • Effects of chronic desipramine treatment on rat brain noradrenergic responses to alpha-adrenergic drugs
    • McMillen BA, Warnack W, German DC, Shore PA (1980) Effects of chronic desipramine treatment on rat brain noradrenergic responses to alpha-adrenergic drugs. Eur J Pharmacol 61:239-246
    • (1980) Eur J Pharmacol , vol.61 , pp. 239-246
    • McMillen, B.A.1    Warnack, W.2    German, D.C.3    Shore, P.A.4
  • 39
    • 0026778766 scopus 로고
    • Keeping an eye on the I site: Imidazoline-preferring receptors
    • Michel MC, Ernsberger P (1992) Keeping an eye on the I site: Imidazoline-preferring receptors. TiPS 13:369-370
    • (1992) TiPS , vol.13 , pp. 369-370
    • Michel, M.C.1    Ernsberger, P.2
  • 41
    • 0028335911 scopus 로고
    • Effects of long-term alpha-2 adrenergic antagonists and electroconvulsive treatments on the alpha-2 adrenoceptors modulating serotonin neurotransmission
    • Mongeau R, de Montigny C, Blier P (1994) Effects of long-term alpha-2 adrenergic antagonists and electroconvulsive treatments on the alpha-2 adrenoceptors modulating serotonin neurotransmission. J Pharmacol Exp Ther 269:1152-1159
    • (1994) J Pharmacol Exp Ther , vol.269 , pp. 1152-1159
    • Mongeau, R.1    De Montigny, C.2    Blier, P.3
  • 44
    • 0027399143 scopus 로고
    • Third-generation antidepressant
    • Pinder RM, Wieringa JH (1993) Third-generation antidepressant. Med Res Rev 13:259-325
    • (1993) Med Res Rev , vol.13 , pp. 259-325
    • Pinder, R.M.1    Wieringa, J.H.2
  • 45
    • 0020621955 scopus 로고
    • Chronic drug treatments induce changes in the sensitivity of presynaptic autoreceptors but not of presynaptic heteroreceptors
    • Raiteri M, Marchi G, Maura G (1983) Chronic drug treatments induce changes in the sensitivity of presynaptic autoreceptors but not of presynaptic heteroreceptors. Eur J Pharmacol 91:141-143
    • (1983) Eur J Pharmacol , vol.91 , pp. 141-143
    • Raiteri, M.1    Marchi, G.2    Maura, G.3
  • 46
    • 0001797297 scopus 로고
    • Behavioral correlates and firing repertoires of neurons in the dorsal hippocampal formation and septum of unrestrained rats
    • Isaacson RL, Pribram KH (eds) Plenum Press, New York
    • Ranck JB (1975) Behavioral correlates and firing repertoires of neurons in the dorsal hippocampal formation and septum of unrestrained rats. In: Isaacson RL, Pribram KH (eds) The hippocampus. Plenum Press, New York, pp 207-244
    • (1975) The Hippocampus , pp. 207-244
    • Ranck, J.B.1
  • 47
    • 0024308538 scopus 로고
    • A, serotonin, or opiate receptors, augments responsiveness of locus coeruleus neurons to excitory stimulation
    • A, serotonin, or opiate receptors, augments responsiveness of locus coeruleus neurons to excitory stimulation. Neuropharmacology 28:651-660
    • (1989) Neuropharmacology , vol.28 , pp. 651-660
    • Simson, P.E.1    Weiss, J.M.2
  • 48
    • 0025082572 scopus 로고
    • Mirtazapine vs. amitriptyline vs. placebo in the treatment of major depressive disorder
    • Smith WT, Glaudin V, Panagides J, Gilvary E (1990) Mirtazapine vs. amitriptyline vs. placebo in the treatment of major depressive disorder. Psychopharmacol Bull 26:191-196
    • (1990) Psychopharmacol Bull , vol.26 , pp. 191-196
    • Smith, W.T.1    Glaudin, V.2    Panagides, J.3    Gilvary, E.4
  • 49
    • 0019293073 scopus 로고
    • 2-receptors after chronic desipramine treatment
    • 2-receptors after chronic desipramine treatment. Life Sci 47:1863-1867
    • (1980) Life Sci , vol.47 , pp. 1863-1867
    • Spyraky, C.1    Fibiger, H.C.2
  • 51
    • 0015845053 scopus 로고
    • Involvement of alpha-receptors in clonidine induced inhibition of transmitter release from central monoamine neurons
    • Starke K, Montel H (1973) Involvement of alpha-receptors in clonidine induced inhibition of transmitter release from central monoamine neurons. Neuropharmacology 12:1073-1080
    • (1973) Neuropharmacology , vol.12 , pp. 1073-1080
    • Starke, K.1    Montel, H.2
  • 53
    • 0016593641 scopus 로고
    • Inhibition of both NA and 5-HT neurons in brain by the α-adrenergic agonist clonidine
    • Svensson TH, Bunney BS, Aghajanian GK (1975) Inhibition of both NA and 5-HT neurons in brain by the α-adrenergic agonist clonidine. Brain Res 92:291-306
    • (1975) Brain Res , vol.92 , pp. 291-306
    • Svensson, T.H.1    Bunney, B.S.2    Aghajanian, G.K.3
  • 54
    • 0026586428 scopus 로고
    • Alpha-adrenoceptor modulation of rat ventral hippocampal 5-hydroxytryptamine release in vivo
    • Tao R, Hjorth S (1992) Alpha-adrenoceptor modulation of rat ventral hippocampal 5-hydroxytryptamine release in vivo. Naunyn-Schmiedeberg's Arch Pharmacol 345:137-143
    • (1992) Naunyn-Schmiedeberg's Arch Pharmacol , vol.345 , pp. 137-143
    • Tao, R.1    Hjorth, S.2
  • 56
    • 0019224027 scopus 로고
    • 2 receptors: Light microscopic autoradiographic localization
    • 2 receptors: Light microscopic autoradiographic localization. Proc Natl Acad Sci USA 77:1696-1700
    • (1980) Proc Natl Acad Sci USA , vol.77 , pp. 1696-1700
    • Young, W.S.1    Kuhar, M.J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.