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Volumn 21, Issue , 1999, Pages 16S-23S

Serotonin and hallucinogens

Author keywords

5 HT2A receptors; Cerebral cortex; Excitatory postsynaptic potentials; Glutamatergic; Hallucinogens; Locus coeruleus; LSD; Serotonin

Indexed keywords

GLUTAMIC ACID; INDOLEAMINE; LYSERGIDE; MESCALINE; PHENETHYLAMINE DERIVATIVE; PSYCHEDELIC AGENT; SEROTONIN; SEROTONIN 2A AGONIST; SEROTONIN 2A RECEPTOR;

EID: 0032868038     PISSN: 0893133X     EISSN: 1740634X     Source Type: Journal    
DOI: 10.1016/S0893-133X(98)00135-3     Document Type: Article
Times cited : (336)

References (49)
  • 1
    • 0018855090 scopus 로고
    • Mescaline and LSD facilitate the acti-vation of locus coeruleus neurons by peripheral Stimuli
    • Aghajanian GK (1980): Mescaline and LSD facilitate the acti-vation of locus coeruleus neurons by peripheral Stimuli. Brain Res 186:492-498
    • (1980) Brain Res , vol.186 , pp. 492-498
    • Aghajanian, G.K.1
  • 2
    • 0002777541 scopus 로고
    • Electrophysiology of serotonin recep-tor subtypes and signal transduction mechanisms
    • Bloom FE, Kupfer DJ, New York, Raven Press
    • Aghajanian GK (1995): Electrophysiology of serotonin recep-tor subtypes and signal transduction mechanisms. In Bloom FE, Kupfer DJ (eds), Psychopharmacology: TheFourth Generation of Progress. New York, Raven Press, pp 451-460
    • (1995) Psychopharmacology: TheFourth Generation of Progress , pp. 451-460
    • Aghajanian, G.K.1
  • 3
    • 0014420460 scopus 로고
    • Lysergic acid diethylamide: Sensitive neuronal units in the midbrainraphe
    • Aghajanian GK, Foote WE, Sheard MH (1968): Lysergic acid diethylamide: Sensitive neuronal units in the midbrainraphe. Science 161:706-708
    • (1968) Science , vol.161 , pp. 706-708
    • Aghajanian, G.K.1    Foote, W.E.2    Sheard, M.H.3
  • 4
    • 0014744122 scopus 로고
    • Action of psy-chotogenic drugs on single midbrain raphe neurons
    • Aghajanian GK, Foote WE, Sheard MH (1970): Action of psy-chotogenic drugs on single midbrain raphe neurons. J PharmacolExpTher 171:178-187
    • (1970) J Pharmacolexpther , vol.171 , pp. 178-187
    • Aghajanian, G.K.1    Foote, W.E.2    Sheard, M.H.3
  • 5
    • 0016633012 scopus 로고
    • Hallucinogenic indoleamines: Preferential action upon presynaptic serotonin receptors
    • Aghajanian GK, Haigler HJ (1975): Hallucinogenic indoleamines: Preferential action upon presynaptic serotonin receptors. Psychopharmacology 1:619-629
    • (1975) Psychopharmacology , vol.1 , pp. 619-629
    • Aghajanian, G.K.1    Haigler, H.J.2
  • 6
    • 0015362013 scopus 로고
    • Lysergic acid diethylamide and serotonin: Direct actions on seroto-nin-containing neurons in rat brain
    • Aghajanian GK, Haigler HJ, Bloom FE (1972): Lysergic acid diethylamide and serotonin: Direct actions on seroto-nin-containing neurons in rat brain. Life Sci 11:615-622
    • (1972) Life Sci , vol.11 , pp. 615-622
    • Aghajanian, G.K.1    Haigler, H.J.2    Bloom, F.E.3
  • 7
    • 0031006582 scopus 로고    scopus 로고
    • Serotonin induces excita-tory postsynaptic potentials in apical dendrites of neo-cortical pyramidal cells
    • Aghajanian GK, Marek GJ (1997): Serotonin induces excita-tory postsynaptic potentials in apical dendrites of neo-cortical pyramidal cells. Neuropharmacology 36:589-599
    • (1997) Neuropharmacology , vol.36 , pp. 589-599
    • Aghajanian, G.K.1    Marek, G.J.2
  • 8
    • 0008147185 scopus 로고    scopus 로고
    • Serotonin 5-HT2Arecep-tors enhance asynchronous excitatory transmission in pyramidal cells (Layer V) of prefrontal cortex
    • Aghajanian GK, Marek GJ (1998): Serotonin 5-HT2Arecep-tors enhance asynchronous excitatory transmission in pyramidal cells (layer V) of prefrontal cortex. SocNeu-rosci Abs 24:1366
    • (1998) Socneu-Rosci Abs , vol.24 , pp. 1366
    • Aghajanian, G.K.1    Marek, G.J.2
  • 9
    • 0025924342 scopus 로고
    • 5-Hydroxytryptamine and 5-hydroxytryptamine1Areceptors mediate opposing re-sponses on membrane excitability in rat association cor-tex
    • Araneda R, Andrade R (1991): 5-Hydroxytryptamine and 5-hydroxytryptamine1Areceptors mediate opposing re-sponses on membrane excitability in rat association cor-tex. Neuroscience 40:399-412
    • (1991) Neuroscience , vol.40 , pp. 399-412
    • Araneda, R.R.1
  • 10
    • 0019732445 scopus 로고
    • Norepinephrine-containing locus coeruleus neurons in behaving rats exhibit pro-nounced responses to non-noxious environmental stimuli
    • Aston-Jones G, Bloom FE (1981): Norepinephrine-containing locus coeruleus neurons in behaving rats exhibit pro-nounced responses to non-noxious environmental stimuli. J Neurosci 1:87-900
    • (1981) J Neurosci , vol.1 , pp. 87-900
    • Aston-Jones, G.1    Bloom, F.E.2
  • 11
    • 0008631917 scopus 로고
    • Acquired and crossed tol-erance to mescaline, LSD-25, and BOL-148
    • Balestrieri A, Fontanari D (1959): Acquired and crossed tol-erance to mescaline, LSD-25, and BOL-148. Arch Gen Psychiat 1:279-282
    • (1959) Arch Gen Psychiat , vol.1 , pp. 279-282
    • Balestrieri, A.1    Fontanari, D.2
  • 12
    • 0030174848 scopus 로고    scopus 로고
    • Chronic administration of serotonergic antidepressants attenu-ates the subjective effects of LSD in humans
    • Bonson KR, Buckholtz JW, Murphy DL (1996): Chronic administration of serotonergic antidepressants attenu-ates the subjective effects of LSD in humans. Neuropsy-chopharmacology 14:425-436
    • (1996) Neuropsy-Chopharmacology , vol.14 , pp. 425-436
    • Bonson, K.R.1    Buckholtz, J.W.2    Murphy, D.L.3
  • 13
    • 0018080923 scopus 로고
    • Activation of locus coeruleus neurons by peripheral stimuli: Modulation bya collateral inhibitory mechanism
    • Cedarbaum JM, Aghajanian GK (1978): Activation of locus coeruleus neurons by peripheral stimuli: Modulation bya collateral inhibitory mechanism. Life Sci 23:1383-1392
    • (1978) Life Sci , vol.23 , pp. 1383-1392
    • Cedarbaum, J.M.1    Aghajanian, G.K.2
  • 14
    • 0027335524 scopus 로고
    • A 5-hydroxytryptamine agonist augments7-aminobutyric acid and excitatoryamino acid inputs to noradrenergic locus coeruleus neurons
    • Chiang C, Aston-Jones G (1993): A 5-hydroxytryptamine agonist augments7-aminobutyric acid and excitatoryamino acid inputs to noradrenergic locus coeruleus neurons. Neuroscience 54:409-420
    • (1993) Neuroscience , vol.54 , pp. 409-420
    • Chiang, C.1    Aston-Jones, G.2
  • 15
    • 0001989283 scopus 로고
    • Evidence for the existence of monoamine containing neurons in the central nervoussystem. I. Demonstration of monoamines in the cellbodies of brain stem neurons
    • Dählstrom A, Fuxe K (1964): Evidence for the existence of monoamine containing neurons in the central nervoussystem. I. Demonstration of monoamines in the cellbodies of brain stem neurons. ActaPhysiolScand 6:1-55
    • (1964) Actaphysiolscand , vol.6 , pp. 1-55
    • Dählstrom, A.1    Fuxe, K.2
  • 16
    • 0343399209 scopus 로고
    • Effects of LSD-25 on brain serotonin
    • Freedman DX (1961): Effects of LSD-25 on brain serotonin. J PharmacolExpTher 134:160-166
    • (1961) J Pharmacolexpther , vol.134 , pp. 160-166
    • Freedman, D.X.1
  • 17
    • 84959069373 scopus 로고
    • Drugs that antagonize 5-hydroxytryptamine
    • Gaddum JH, Hammeed KA (1954): Drugs that antagonize 5-hydroxytryptamine. Br J Pharmacol 9:240-248
    • (1954) Br J Pharmacol , vol.9 , pp. 240-248
    • Gaddum, J.H.1    Hammeed, K.A.2
  • 18
    • 0027472962 scopus 로고
    • Pyramidal cells in piri-form cortex receive a convergence of inputs from monoamine activated GABAergic interneurons
    • Gellman RL, Aghajanian GK (1993): Pyramidal cells in piri-form cortex receive a convergence of inputs from monoamine activated GABAergic interneurons. BrainRes 600:63-73
    • (1993) BrainRes , vol.600 , pp. 63-73
    • Gellman, R.L.1    Aghajanian, G.K.2
  • 19
    • 0025602917 scopus 로고
    • Do classical hallucinogens act as 5-HT2 agonists or antagonists?
    • Glennon RA (1990): Do classical hallucinogens act as 5-HT2 agonists or antagonists? Neuropsychopharmacology3:509-517
    • (1990) Neuropsychopharmacology , vol.3 , pp. 509-517
    • Glennon, R.A.1
  • 20
    • 0021646446 scopus 로고
    • Evidence for 5-HT2involvement in the mechanism of action of hallu-cinogenic agents
    • Glennon RA, Titeler M, McKenney JD (1984): Evidence for 5-HT2involvement in the mechanism of action of hallu-cinogenic agents. Life Sci 35:2502-2511
    • (1984) Life Sci , vol.35 , pp. 2502-2511
    • Glennon, R.A.1    Titeler, M.2    McKenney, J.D.3
  • 21
    • 0028587383 scopus 로고
    • Two components of transmitter release at a central synapse
    • Goda Y, Stevens CF (1994): Two components of transmitter release at a central synapse. Pro.NatlAcadSci USA91:12942-12946
    • (1994) Pro.Natlacadsci USA , vol.91 , pp. 12942-12946
    • Goda, Y.1    Stevens, C.F.2
  • 22
    • 0015537765 scopus 로고
    • Mescaline and LSD: Direct and indirect effects on serotonin-containing neurons in brain
    • Haigler HJ, Aghajanian GK (1973): Mescaline and LSD: Direct and indirect effects on serotonin-containing neurons in brain. Eur J Pharmacol 21:53-60
    • (1973) Eur J Pharmacol , vol.21 , pp. 53-60
    • Haigler, H.J.1    Aghajanian, G.K.2
  • 24
    • 0343406977 scopus 로고
    • Studies on the diethylamide of lysergic acid (LSD-25)
    • Isbell H, Logan CR (1957): Studies on the diethylamide of lysergic acid (LSD-25). Arch Gen Psychiat 77:350-358
    • (1957) Arch Gen Psychiat , vol.77 , pp. 350-358
    • Isbell, H.1    Logan, C.R.2
  • 25
    • 0031594813 scopus 로고    scopus 로고
    • Goldman-Rakic PS (1998): 5-Hydroxytryptamine^ serotonin receptors in the primate cerbral cortex: Possi-ble site of action of hallucinogenic and antipsychoticdrugs in pyramidal cell apical dendrites
    • Jakab RL, Goldman-Rakic PS (1998): 5-Hydroxytryptamine^ serotonin receptors in the primate cerbral cortex: Possi-ble site of action of hallucinogenic and antipsychoticdrugs in pyramidal cell apical dendrites. ProcNatlAcadSci 95:735-740
    • ProcNatlAcadSci , vol.95 , pp. 735-740
    • Jakab, R.L.1
  • 27
    • 0028973239 scopus 로고
    • Distinct Ca2+ and Sr2+ binding properties of synaptotagmins
    • Li C, Bazbek CL, Davletov A, Sudhof TC (1995): Distinct Ca2+ and Sr2+ binding properties of synaptotagmins. JBiolChem 270:24898-24902
    • (1995) JBiolChem , vol.270 , pp. 24898-24902
    • Li, C.1    Bazbek, C.L.2    Davletov, A.3    Sudhof, T.C.4
  • 29
    • 0030434487 scopus 로고    scopus 로고
    • LSD and the phenethy-lamine hallucinogen DOI are potent partial agonists at 5-HT2Areceptors on neurons in the rat piriform cortex
    • Marek GJ, Aghajanian GK (1996a): LSD and the phenethy-lamine hallucinogen DOI are potent partial agonists at 5-HT2Areceptors on neurons in the rat piriform cortex. JPharmacolExpTher 278:1373-1382
    • (1996) JPharmacolExpTher , vol.278 , pp. 1373-1382
    • Marek, G.J.1    Aghajanian, G.K.2
  • 30
    • 0343365191 scopus 로고    scopus 로고
    • Serotonergic amplifica-tion of apically derived EPSPs in neocortical pyramidal cells
    • Marek GJ, Aghajanian GK (1996b): Serotonergic amplifica-tion of apically derived EPSPs in neocortical pyramidal cells. SocNeurosci Abs 22:1323
    • (1996) Socneurosci Abs , vol.22 , pp. 1323
    • Marek, G.J.1    Aghajanian, G.K.2
  • 31
    • 0032100675 scopus 로고    scopus 로고
    • Aghajanian GK (1998a): 5-HT-induced EPSCs in neocortical layer V pyramidal cell of prefrontal cortex:Suppression by ^ opiate receptor activation
    • Marek GJ, Aghajanian GK (1998a): 5-HT-induced EPSCs in neocortical layer V pyramidal cell of prefrontal cortex:Suppression by ^ opiate receptor activation. Neuro-science 86:485-497
    • Neuro-Science , vol.86 , pp. 485-497
    • Marek, G.J.1
  • 32
    • 0008052472 scopus 로고    scopus 로고
    • Serotonin2Areceptor-induced EPSCs in layer V pyramidal cells of prefrontal cortex: Block by group II/III metabotropic glutamateagonists
    • Marek GJ, Aghajanian GK (1998b): Serotonin2Areceptor-induced EPSCs in layer V pyramidal cells of prefrontal cortex: Block by group II/III metabotropic glutamateagonists. SocNeurosci Abs 24:1366
    • (1998) Socneurosci Abs , vol.24 , pp. 1366
    • Marek, G.J.1    Aghajanian, G.K.2
  • 33
    • 0025124833 scopus 로고
    • Localization of the mRNA for the 5-HT2receptorby in situ hybridization histochemistry. Correlation withthe distribution of receptor sites
    • Mengod G, Pompeiano M, Martinez-Mir MI, Palacios JM (1990): Localization of the mRNA for the 5-HT2receptorby in situ hybridization histochemistry. Correlation withthe distribution of receptor sites. Brain Res 524:139-143
    • (1990) Brain Res , vol.524 , pp. 139-143
    • Mengod, G.1    Pompeiano, M.2    Martinez-Mir, M.I.3    Palacios, J.M.4
  • 34
    • 0022346190 scopus 로고
    • Quantitative autoradiographic mapping of serotonin receptors in the rat brain. I. Sero-tonin-1 receptors
    • Pazos A, Palacios JM (1985): Quantitative autoradiographic mapping of serotonin receptors in the rat brain. I. Sero-tonin-1 receptors. Brain Re. 346:205-230
    • (1985) Brain Re , vol.346 , pp. 205-230
    • Pazos, A.1    Palacios, J.M.2
  • 35
    • 84957364672 scopus 로고
    • Serum vasocon-strictor (Serotonin). IV. Isolation and characterization
    • Rapport MM, Green AA, Page IH (1948): Serum vasocon-strictor (serotonin). IV. Isolation and characterization. J BiolChem 176:1243-1251
    • (1948) J Biolchem , vol.176 , pp. 1243-1251
    • Rapport, M.M.1    Green, A.A.2    Page, I.H.3
  • 36
    • 0022466502 scopus 로고
    • Effects of hallucino-gens on spontaneous and sensory-evoked locus coer-uleus unit activity in the rat: Reversal by selective 5-HT2antagonists
    • Rasmussen K, Aghajanian GK (1986): Effects of hallucino-gens on spontaneous and sensory-evoked locus coer-uleus unit activity in the rat: Reversal by selective 5-HT2antagonists. Brain Res 385:95-400
    • (1986) Brain Res , vol.385 , pp. 95-400
    • Rasmussen, K.1    Aghajanian, G.K.2
  • 37
    • 0024210281 scopus 로고
    • Potency of antipsy-chotics in reversing the effects of a hallucinogenic drug on locus coeruleus neurons correlates with 5-HT2binding affinity
    • Rasmussen K, Aghajanian GK (1988): Potency of antipsy-chotics in reversing the effects of a hallucinogenic drug on locus coeruleus neurons correlates with 5-HT2binding affinity. Neuropsychopharmacology 1:101-107
    • (1988) Neuropsychopharmacology , vol.1 , pp. 101-107
    • Rasmussen, K.1    Aghajanian, G.K.2
  • 38
    • 0011761658 scopus 로고
    • LSD-25 action in normal subjects treated with a monoamine oxidase inhibitor
    • Resnick O, Krus DM, Raskin M (1964): LSD-25 action in normal subjects treated with a monoamine oxidase inhibitor. Life Sci 3:1207-1214
    • (1964) Life Sci , vol.3 , pp. 1207-1214
    • Resnick, O.1    Krus, D.M.2    Raskin, M.3
  • 39
    • 0013788702 scopus 로고
    • Accentuation of the psychological effects of LSD-25 in normal subjectstreated with reserpine
    • Resnick O, Krus DM, Raskin M (1965): Accentuation of the psychological effects of LSD-25 in normal subjectstreated with reserpine. Life Sci 4:1433-1437
    • (1965) Life Sci , vol.4 , pp. 1433-1437
    • Resnick, O.1    Krus, D.M.2    Raskin, M.3
  • 40
    • 0023769782 scopus 로고
    • Lysergic acid diethylamide and 2, 5-dimethoxy-4-methylamphetamineare partial agonists at serotonin receptors linked tophosphoinositide hydrolysis
    • Sanders-Bush E, Burris KD, Knoth K (1988): Lysergic acid diethylamide and 2, 5-dimethoxy-4-methylamphetamineare partial agonists at serotonin receptors linked tophosphoinositide hydrolysis. J PharmacolExperThera-peu 246:924-928
    • (1988) J Pharmacolexperthera-Peu , vol.246 , pp. 924-928
    • Sanders-Bush, E.1    Burris, K.D.2    Knoth, K.3
  • 41
    • 0001209293 scopus 로고
    • Some serotonin-like activities of lysergic acid diethylamide
    • Shaw E, Woolley DW (1956): Some serotonin-like activities of lysergic acid diethylamide. Science 124:121-123
    • (1956) Science , vol.124 , pp. 121-123
    • Shaw, E.1    Woolley, D.W.2
  • 42
    • 0025037983 scopus 로고
    • Serotonin (5-HT) induces IPSPs in pyramidal layer cells of rat piriformcortex: Evidence for the involvement of a 5-HT2-acti-vated interneuron
    • Sheldon PW, Aghajanian GK (1990): Serotonin (5-HT) induces IPSPs in pyramidal layer cells of rat piriformcortex: Evidence for the involvement of a 5-HT2-acti-vated interneuron. Brain Res 506:62-69
    • (1990) Brain Res , vol.506 , pp. 62-69
    • Sheldon, P.W.1    Aghajanian, G.K.2
  • 43
    • 0027311307 scopus 로고
    • Actions of 5-hydroxytryptamine on neurons of the rat cingulate cortex
    • Tanaka E, North RA (1993): Actions of 5-hydroxytryptamine on neurons of the rat cingulate cortex. J Neurophys69:1749-1757
    • (1993) J Neurophys , vol.69 , pp. 1749-1757
    • Tanaka, E.1    North, R.A.2
  • 44
    • 0023882042 scopus 로고
    • Radioligand bind-ing evidence implicates the brain 5-HT2receptor as a site of action for LSD and phenylisopropylaminehallu-cinogens
    • Titeler M, Lyon RA, Glennon RA (1988): Radioligand bind-ing evidence implicates the brain 5-HT2receptor as a site of action for LSD and phenylisopropylaminehallu-cinogens. Psychopharmacology 94:213-216
    • (1988) Psychopharmacology , vol.94 , pp. 213-216
    • Titeler, M.1    Lyon, R.A.2    Glennon, R.A.3
  • 45
    • 0000100860 scopus 로고
    • Serotonin content of some mammalian tissues and urine and a method for itsdetermination
    • Twarog BM, Page IH (1953): Serotonin content of some mammalian tissues and urine and a method for itsdetermination. Am J Physiol 175:157-161
    • (1953) Am J Physiol , vol.175 , pp. 157-161
    • Twarog, B.M.1    Page, I.H.2
  • 46
    • 0030916849 scopus 로고    scopus 로고
    • Positron emission tomog-raphy and fluorodeoxyglucose studies of metabolic hyper-frontality and psychopathology in the psilocybin modelof psychosis
    • Vollenweider FX, Leenders KL, Scharfetter C, Maguire P, Stadelmann O, Angst J (1997): Positron emission tomog-raphy and fluorodeoxyglucose studies of metabolic hyper-frontality and psychopathology in the psilocybin modelof psychosis. Neuropsychopharmacology 16:357-372
    • (1997) Neuropsychopharmacology , vol.16 , pp. 357-372
    • Vollenweider, F.X.1    Leenders, K.L.2    Scharfetter, C.3    Maguire, P.4    Stadelmann, O.5    Angst, J.6
  • 47
    • 0030612257 scopus 로고    scopus 로고
    • Serotonin 5-HT2Areceptors are expressed on pyramidal cells and interneurons in the rat cortex
    • Willins DL, Deutch AY, Roth BL (1997): Serotonin 5-HT2Areceptors are expressed on pyramidal cells and interneurons in the rat cortex. Synapse 27:79-82
    • (1997) Synapse , vol.27 , pp. 79-82
    • Willins, D.L.1    Deutch, A.Y.2    Roth, B.L.3
  • 48
    • 0011840426 scopus 로고
    • Comparison of psilo-cin with psilocybin, mescaline, and LSD-25
    • Wolbach AB, Miner EJ, Isbell H (1962): Comparison of psilo-cin with psilocybin, mescaline, and LSD-25. Psycho-pharmacologia 3:219-223
    • (1962) Psycho-Pharmacologia , vol.3 , pp. 219-223
    • Wolbach, A.B.1    Miner, E.J.2    Isbell, H.3
  • 49
    • 0000358118 scopus 로고
    • A biochemical and pharmaco-logical suggestion about certain mental disorders
    • Woolley DW, Shaw W (1954): A biochemical and pharmaco-logical suggestion about certain mental disorders. ProcNatlAcadSci 40:228-231
    • (1954) Procnatlacadsci , vol.40 , pp. 228-231
    • Woolley, D.W.1    Shaw, W.2


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