SB 242 084, a selective serotonin(2C) receptor antagonist, increases dopaminergic transmission in the mesolimbic system

Neuropharmacology

Volumn 38, Issue 8, 1999, Pages 1195-1205

  Di Matteo, Vincenzo ^a   Di Giovanni, Giuseppe ^a   Di Mascio, Michele ^a   Esposito, Ennio ^a  

^a MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

Author keywords

5 HT(2C) receptors; Dopamine release; Electrophysiology; Microdialysis; RO 60 0175; SB 242 084

Indexed keywords

2 (6 CHLORO 5 FLUORO 1 INDOLYL) 1 METHYLETHYLAMINE; 3,4 DIHYDROXYPHENYLACETIC ACID; 6 CHLORO 5 METHYL 1 [2 (2 METHYLPYRIDYL 3 OXY)PYRID 5 YLCARBAMOYL]INDOLINE; 6 CHLORO 5 METHYL 1 [[2 [(2 METHYL 3 PYRIDYL)OXY] 5 PYRIDYL]CARBAMOYL]INDOLINE; DOPAMINE; RECEPTOR SUBTYPE; SEROTONIN 3 ANTAGONIST; SEROTONIN 3 RECEPTOR; SEROTONIN 3A RECEPTOR; UNCLASSIFIED DRUG; AMINOPYRIDINE DERIVATIVE; ETHYLAMINE; INDOLE DERIVATIVE; SEROTONIN 2C RECEPTOR; SEROTONIN AGONIST; SEROTONIN ANTAGONIST; SEROTONIN RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORPUS STRIATUM; DOPAMINE METABOLISM; DOPAMINE RELEASE; DOPAMINERGIC NERVE CELL; ELECTROPHYSIOLOGY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INTRAPERITONEAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; MALE; MICRODIALYSIS; NONHUMAN; NUCLEUS ACCUMBENS; PRIORITY JOURNAL; RAT; SUBSTANTIA NIGRA; VENTRAL TEGMENTUM; ANIMAL; DOSE RESPONSE; DRUG EFFECT; METABOLISM; SPRAGUE DAWLEY RAT;

AMINOPYRIDINES; ANIMALS; CORPUS STRIATUM; DOPAMINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHYLAMINES; INDOLES; MALE; NUCLEUS ACCUMBENS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, SEROTONIN, 5-HT2C; RECEPTORS, SEROTONIN; SEROTONIN AGONISTS; SEROTONIN ANTAGONISTS; SUBSTANTIA NIGRA; VENTRAL TEGMENTAL AREA;

EID: 0032588764     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(99)00047-7     Document Type: Article

References (56)

1. 2C receptor protein in human and rat brain using specific antisera. Neuropharmacology. 35:1995;1635-1645.
2. 2A antagonist MDL 100 907 on midbrain dopamine (DA) neurons in rats: an electrophysiological study. Soc. Neurosci. Abstr. 22:1996;1323.
3. Azmitia E.C., Segal M. An autoradiographic analysis of the differential ascending projections of the dorsal and median raphe nuclei in the rat. J. Comp. Neurol. 179:1978;641-668.
4. Barker E.L., Sanders-Bush E. 5-hydroxytryptamine 1C receptor density and mRNA levels in choroid plexus ephithelial cells after treatment with mianserin and (-)-1-(4-bromo-2,5-dimethoxy-phenyl)-2-aminopropane. Mol. Pharmacol. 44:1993;725-730.
5. Bean A.J., Roth R.H. Extracellular dopamine and neurotensin in rat prefrontal cortex in vivo: effects of median forebrain bundle stimulation frequency, stimulation pattern, and dopamine autoreceptors. J. Neurosci. 11:1991;2694-2702.
6. Benloucif S., Galloway M.P. Facilitation of dopamine release in vivo by serotonin agonists: studies with microdialysis. Eur. J. Pharmacol. 200:1991;1-8.
7. 2C receptors. Br. J. Pharmacol. 115:1995;622-628.
8. 4 receptor subtype involvement in the enhancement of striatal dopamine release induced by serotonin: a microdialysis study in the halothane-anesthetized rats. Neuropharmacology. 34:1995;269-279.
9. Bunney B.S., Walters J.R., Roth R.H., Aghajanian G.K. Dopaminergic neurons: effects of antipsychotic drugs and amphetamine on single cell activity. J. Pharmacol. Exp. Ther. 185:1973;560-571.
10. Cervo L., Grignaschi G., Samanin R. The role of the mesolimbic dopaminergic system in the desipramine effect in the forced swimming test. Eur. J. Pharmacol. 178:1990;129-133.
11. Cervo L., Samanin R. Evidence that dopamine mechanisms in the nucleus accumbens are selectively involved in the effect of desipramine in the forced swimming test. Neuropharmacology. 26:1987;1469-1472.
12. Cervo L., Samanin R. Repeated treatment with imipramine and amitriptyline reduced the immobility of rats in the forced swimming test by enhancing dopamine mechanisms in the nucleus accumbens. J. Pharm. Pharmacol. 40:1988;155-156.
13. Deutch A., Moghaddam B., Innis R.B., Krystal J.H., Aghajanian G.K., Bunney B.S., Charney D.S. Mechanisms of action of atypical antipsychotic drugs: implications for novel therapeutic strategies for schizophrenia. Schizophrenia Res. 4:1991;121-156.
14. 2C receptors enhances mesostriatal and mesolimbic dopaminergic function. Trends Neurosci. (Suppl.). 20:1997;59.
15. 2C/2B receptors enhances dopamine release in the rat nucleus accumbens. Neuropharmacology. 37:1998;265-272.
16. Duxon M.S., Flanigan T.P., Reaveley A.C., Baxter G.S., Blackburn T.P., Fone K.C.F. Evidence for expression of the 5-hydroxytryptamine-2B receptor protein in the rat central nervous system. Neuroscience. 76:1997;323-329.
17. 2B receptor protein in the rat. Br. J. Pharmacol. 115:1995;105P.
18. 2C receptor messenger RNA in the basal ganglia of adult rats. J. Comp. Neurol. 384:1997;233-247.
19. Ennis C., Kemp J.D., Cox B. Characterisation of inhibitory 5-hydroxytryptamine receptors that modulate dopamine release in the striatum. J. Neurochem. 36:1981;1515-1520.
20. 2B receptor mRNA in the rat brain. Br. J. Pharmacol. 115:1995;369P.
21. Glennon R.A. Central serotonin receptors as targets for drug research. J. Med. Chem. 30:1987;1-12.
22. Gonon F.G. Nonlinear relationship between impulse flow and dopamine released by rat midbrain dopaminergic neurons as studied by in vivo electrochemistry. Neuroscience. 24:1988;19-28.
23. Grace A.A., Bunney B.S. Nigral dopamine neurons: intracellular recording and identification with L-DOPA injection and histofluorescence. Science. 210:1980;654-656.
24. Grace A.A., Bunney B.S. The control of firing pattern in nigral dopamine neurons: burst firing. J. Neurosci. 4:1984;2877-2890.
25. Hamilton M.E., Mele A., Pert A. Striatal extracellular dopamine in conscious versus anesthetized rats: effects of chloral hydrate anesthetic on responses to drugs of different classes. Brain Res. 597:1992;1-7.
26. Hervé D., Pickel V.M., Tong H.J., Beaudet A. Serotonin axon terminals in the ventral tegmental area of the rat: fine structure and synaptic input to dopaminergic neurons. Brain Res. 435:1987;71-83.
27. Hoyer D., Clarke D.E., Fozard J.R., Hartig P.R., Martin G.R., Mylecharane E.J. et al. VII. International union of pharmacology classification of receptors for 5-hydroxytryptamine (serotonin). Pharmacol. Rev. 46:1994;157-203.
28. 1C receptors in the antiserotonergic properties of some antidepressant drugs. Eur. J. Pharmacol. 231:1993;223-229.
29. Kelland M.D., Freeman A.S., Chiodo L.A. Serotonergic afferent regulation of the basic physiology and pharmacological responsiveness of nigrostriatal dopamine neurons. J. Pharmacol. Exp. Ther. 253:1990;803-811.
30. Kelland M.D., Freeman A.S., Rubin J., Chiodo L.A. Ascending afferent regulation of rat midbrain dopamine neurons. Brain Res. Bull. 31:1993;539-546.
31. 1C receptors. Br. J. Pharmacol. 94:1988;137-147.
32. 2B receptor antagonist with anxiolytic-like properties. Br. J. Pharmacol. 117:1996;427-434.
33. 2C receptor antagonist. Neuropharmacology. 36:1997;609-620.
34. 2C receptors inhibit the activity of mesocortical and mesolimbic dopaminergic pathways: a combined dialysis and electrophysiological analysis. Soc. Neurosci. Abstr. 23:1997;975.
35. 2C receptor agonists: pharmacological characteristics and therapeutical potential. J. Pharmacol. Exp. Ther. 286:1998;913-924.
36. Mengod G., Nguyen H., Le H., Waeber C., Lübbert H., Palacios J.M. The distribution and cellular localization of the serotonin 1C receptor mRNA in the rodent brain examined by in situ hybridization histochemistry. Comparison with receptor binding distribution. Neuroscience. 35:1990;577-591.
37. Merlo Pich E., Samanin R. Disinhibitory effects of buspirone and low doses of sulpiride and haloperidol in two experimental anxiety models in rats: possible role of dopamine. Psychopharmacology. 89:1986;125-130.
38. 2C receptors tonically inhibit dopamine (DA) and noradrenaline (NA), but not 5-HT, release in the frontal cortex in vivo. Neuropharmacology. 37:1998;953-955.
39. Moghaddam B., Bunney B.S. Ionic composition of microdialysis perfusing solution alters the pharmacological responsiveness and basal outflow of striatal dopamine. J. Neurochem. 53:1989;652-654.
40. 1C receptor is a prominent serotonin receptor subtype in the central nervous system. Proc. Natl. Acad. Sci. USA. 86:1989;6793-6797.
41. 2C receptor agonists exhibit antidepressant-like properties in the anhedonia model of depression in rats. Eur. Neuropsychopharmacol. 6, 169-175.
42. Mori S., Matsuura T., Takino T., Sano Y. Light and electron microscopic immunohistochemical studies of serotonin nerve fibers in the substantia nigra of the rat, cat and monkey. Anal. Embryol. 176:1987;13-18.
43. Moukhles H., Bosler O., Bolam J.P., Vallée A., Umbriaco D., Geffard M. et al. Quantitative and morphometric data indicate precise cellular interactions between serotonin and postsynaptic tergets in rat substantia nigra. Neuroscience. 76:1996;1159-1171.
44. Paxinos G., Watson C. The Rat Brain in Stereotaxic Coordinates. 1986;Academic, New York.
45. Pazos A., Cortés R., Palacios J.M. Quantitative autoradiographic mapping of serotonin receptors in the rat brain. II. Serotonin-2 receptors. Brain Res. 346:1985;231-249.
46. Phillipson O.T. Afferent projections to the ventral tegmental area of Tsai and interfascicular nucleus: a horseradish peroxidase study in the rat. J. Comp. Neurol. 187:1979;117-144.
47. 2C receptors. Mol. Brain Res. 23:1994;163-178.
48. 1C/2 receptor agonists and antagonists. Eur. J. Pharmacol. Mol. Pharm. 244:1993;1-5.
49. Prisco S., Pagannone S., Esposito E. Serotonin-dopamine interaction in the rat ventral tegmental area: an electrophysiological study in vivo. J. Pharmacol. Exp. Ther. 271:1994;83-90.
50. Steinbusch H.W.M. Serotonin-immunoreactive neurons and their projections in the CNS. Classical transmitters and transmitter receptors in the CNS, Part II. Björklund A., Hökfelt T., Kuhar M.J. Handbook of Chemical Neuroanatomy. 3:1984;68-125 Elsevier, Amsterdam.
51. 4 receptor ligands to modulate rat striatal dopamine release in vitro and in vivo. Br. J. Pharmacol. 117:1996;55-62.
52. Van Wijngaarden I., Tulp M.Th.M., Soudijn W. The concept of selectivity in 5-HT receptor research. Eur. J. Pharmacol. 188:1990;301-312.
53. Wang R.Y. Dopaminergic neurons in the rat ventral tegmental area. I. Identification and characterization. Brain Res. Rev. 3:1981;123-140.
54. 6 with neuropeptides in rat striatum. J. Comp. Neurol. 370:1996;405-414.
55. Waters N., Hansson L., Löfberg L., Carlsson A. Intracerebral infusion of (+)-AJ76 and (+)-UH232: effects on dopamine release and metabolism in vivo. Eur. J. Pharmacol. 251:1994;181-190.
56. Zetterström T., Sharp T., Ungerstedt U. Effect of dopamine D-1 and D-2 receptor selective drugs on dopamine release and metabolism in rat striatum in vivo. Naunyn-Schmiedeberg's Arch. Pharmacol. 334:1986;117-124.