Disrupting hypoxia-induced bicarbonate transport acidifies tumor cells and suppresses tumor growth

Cancer Research

Volumn 76, Issue 13, 2016, Pages 3744-3755

  McIntyre, Alan ^a,b   Hulikova, Alzbeta ^c   Ledaki, Ioanna ^a   Snell, Cameron ^c   Singleton, Dean ^a   Steers, Graham ^a   Seden, Peter ^c,d   Jones, Dylan ^a   Bridges, Esther ^a   Wigfield, Simon ^a   Li, Ji Liang ^a   Russell, Angela ^c,d   Swietach, Pawel ^c   Harris, Adrian L ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BICARBONATE TRANSPORTER; CARBONATE DEHYDRATASE IX; CARRIER PROTEIN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 2ALPHA; MESSENGER RNA; SLC4A4 PROTEIN; SLC4A5 PROTEIN; SLC4A9 PROTEIN; UNCLASSIFIED DRUG; BICARBONATE; BICARBONATE SODIUM COTRANSPORTER; TUMOR ANTIGEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL GROWTH; CELL PH; CELL VIABILITY; CONTROLLED STUDY; GENE; GENE EXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; HYPOXIA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SLC4A4 GENE; SLC4A9 GENE; TUMOR CELL; UPREGULATION; ANIMAL; BAGG ALBINO MOUSE; CELL PROLIFERATION; DRUG SCREENING; FEMALE; GENETICS; METABOLISM; NEOPLASMS; PATHOLOGY; PATHOPHYSIOLOGY; PH; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCID MOUSE; TUMOR CELL CULTURE; WESTERN BLOTTING;

ANIMALS; ANTIGENS, NEOPLASM; APOPTOSIS; BICARBONATES; BLOTTING, WESTERN; CARBONIC ANHYDRASE IX; CELL PROLIFERATION; FEMALE; HUMANS; HYDROGEN-ION CONCENTRATION; HYPOXIA; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MICE; MICE, INBRED BALB C; MICE, SCID; NEOPLASMS; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SODIUM-BICARBONATE SYMPORTERS; TUMOR CELLS, CULTURED; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84977472473     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-15-1862     Document Type: Article

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