Nitroglycerin induces DNA damage and vascular cell death in the setting of nitrate tolerance

Basic Research in Cardiology

Volumn 111, Issue 4, 2016, Pages

  Mikhed, Yuliya ^a   Fahrer, Jörg ^a   Oelze, Matthias ^a   Kröller Schön, Swenja ^a   Steven, Sebastian ^a   Welschof, Philipp ^a   Zinßius, Elena ^a   Stamm, Paul ^a   Kashani, Fatemeh ^a   Roohani, Siyer ^a   Kress, Joana Melanie ^a   Ullmann, Elisabeth ^a   Tran, Lan P ^a   Schulz, Eberhard ^a   Epe, Bernd ^b   Kaina, Bernd ^a   Münzel, Thomas ^a,c   Daiber, Andreas ^a,c  

^a UNIVERSITY MEDICAL CENTER MAINZ   (Germany)

^b JOHANNES GUTENBERG UNIVERSITY   (Germany)

^c DZHK GERMAN CENTRE FOR CARDIOVASCULAR RESEARCH   (Germany)

Author keywords

DNA damage; Nitrate tolerance; Oxidative stress; Vascular dysfunction

Indexed keywords

6 O METHYLGUANINE; 8 HYDROXYGUANINE; GLYCERYL TRINITRATE; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; PROTEIN P53; VASODILATOR AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA; APOPTOSIS; ARTICLE; CARDIOVASCULAR FUNCTION; CELL DEATH; COMET ASSAY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA ADDUCT; DNA STRAND BREAKAGE; DOSE RESPONSE; DOT HYBRIDIZATION; DRUG TOLERANCE; ENDOTHELIAL DYSFUNCTION; HEART; HYBRIDOMA CELL CULTURE; HYBRIDOMA CELL LINE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; ISOMETRIC TENSION; KNOCKOUT MOUSE; MALE; MOUSE; MUTAGENIC ACTIVITY; NITRATE TOLERANCE; NITROSATIVE STRESS; NONHUMAN; OXIDATIVE STRESS; PROTEIN STABILITY; RAT; TENSION; WISTAR RAT; ANIMAL; DISEASE MODEL; DNA DAMAGE; DRUG EFFECTS; IMMUNOBLOTTING; PHYSIOLOGY; VASCULAR ENDOTHELIUM; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; COMET ASSAY; DISEASE MODELS, ANIMAL; DNA DAMAGE; DRUG TOLERANCE; ENDOTHELIUM, VASCULAR; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; MICE; NITROGLYCERIN; OXIDATIVE STRESS; RATS; RATS, WISTAR; VASODILATOR AGENTS;

EID: 84977111746     PISSN: 03008428     EISSN: 14351803     Source Type: Journal    
DOI: 10.1007/s00395-016-0571-4     Document Type: Article

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