Chronic therapy with isosorbide-5-mononitrate causes endothelial dysfunction, oxidative stress, and a marked increase in vascular endothelin-1 expression

European Heart Journal

Volumn 34, Issue 41, 2013, Pages 3206-3216

  Oelze, Matthias ^a   Knorr, Maike ^a   Kröller Schön, Swenja ^a   Kossmann, Sabine ^a   Gottschlich, Anna ^a   Rümmler, Robert ^a   Schuff, Alexandra ^a   Daub, Steffen ^a   Doppler, Christopher ^a   Kleinert, Hartmut ^a   Gori, Tommaso ^a   Daiber, Andreas ^a   Münzel, Thomas ^a  

^a UNIVERSITY MEDICAL CENTER MAINZ   (Germany)

Author keywords

Bosentan therapy; Endothelial dysfunction; Endothelin 1; NADPH oxidase; Nitrate tolerance; Organic nitrate therapy; Reactive oxygen and nitrogen species; S glutathionylation of endothelial nitric oxide synthase

Indexed keywords

APOCYNIN; BOSENTAN; CYCLIC GMP; ENDOTHELIAL NITRIC OXIDE SYNTHASE; ENDOTHELIN 1; GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE I; ISOSORBIDE 5 NITRATE; NITRIC OXIDE; PLACEBO; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; TETRAHYDROBIOPTERIN;

ADVENTITIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; DRUG TOLERANCE; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM CELL; ENZYME ACTIVITY; HEART; IMMUNOHISTOCHEMISTRY; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; UPREGULATION;

BOSENTAN THERAPY; ENDOTHELIAL DYSFUNCTION; ENDOTHELIN-1; NADPH OXIDASE; NITRATE TOLERANCE; ORGANIC NITRATE THERAPY; REACTIVE OXYGEN AND NITROGEN SPECIES; S-GLUTATHIONYLATION OF ENDOTHELIAL NITRIC OXIDE SYNTHASE;

ANIMALS; AORTA; CYCLIC GMP; ENDOTHELIN-1; ENDOTHELIUM, VASCULAR; ENZYME INHIBITORS; ISOSORBIDE DINITRATE; MALE; MICE; MICE, KNOCKOUT; NADPH OXIDASE; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE DONORS; NITRIC OXIDE SYNTHASE TYPE III; OXIDATIVE STRESS; RATS; RATS, WISTAR; SIGNAL TRANSDUCTION; SUPEROXIDES;

EID: 84890051882     PISSN: 0195668X     EISSN: 15229645     Source Type: Journal    
DOI: 10.1093/eurheartj/ehs100     Document Type: Article

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