A new class of organic nitrates: Investigations on bioactivation, tolerance and cross-tolerance phenomena

British Journal of Pharmacology

Volumn 158, Issue 2, 2009, Pages 510-520

  Schuhmacher, S ^a   Schulz, E ^a   Oelze, M ^a   Konig A ^b   Roegler, C ^b   Lange, K ^b   Sydow, L ^a   Kawamoto, T ^c   Wenzel, P ^a   Munzel T ^a   Lehmann, J ^b   Daiber, A ^a  

^a UNIVERSITY MEDICAL CENTER MAINZ   (Germany)

^b FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^c UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

Author keywords

Bioactivation; Mitochondrial aldehyde dehydrogenase; Mitochondrial oxidative stress; Organic nitrates; Vascular function

Indexed keywords

2 NITROOXYETHYLAMMONIIUM NITRATE; 3 METHYL NITROOXYPROPANOATE; ACETYLCHOLINE; ALDEHYDE DEHYDROGENASE ISOENZYME 2; AMINOETHYL NITRATE; CYCLIC GMP; CYTOCHROME P450; GLYCERYL TRINITRATE; ISOPROPYL NITRATE; NITRIC OXIDE; ORGANIC NITRATE; PENTAERYTHRITYL TETRANITRATE; TROLNITRATE; UNCLASSIFIED DRUG; XANTHINE OXIDASE;

ADOLESCENT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHEMOLUMINESCENCE; CONTINUOUS INFUSION; CONTROLLED STUDY; DRUG CROSS TOLERANCE; DRUG MECHANISM; DRUG POTENCY; DRUG TOLERANCE; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; MUSCLE ISOMETRIC CONTRACTION; NITRATION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; VASODILATATION;

ACETYLCHOLINE; ALDEHYDE DEHYDROGENASE; ANIMALS; DRUG TOLERANCE; ETHANOLAMINES; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MITOCHONDRIA; NITRATES; NITROGLYCERIN; OXIDATIVE STRESS; VASODILATION;

EID: 69549121873     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2009.00303.x     Document Type: Article

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