Extracellular mtDNA activates NF-κB via toll-like receptor 9 and induces cell death in cardiomyocytes

Basic Research in Cardiology

Volumn 111, Issue 4, 2016, Pages

  Bliksøen, Marte ^a,b,d   Mariero, Lars Henrik ^a,b   Torp, May Kristin ^a,b   Baysa, Anton ^a,b   Ytrehus, Kirsti ^c   Haugen, Fred ^a,b   Seljeflot, Ingebjørg ^b,d   Vaage, Jarle ^b,d   Valen, Guro ^a,b   Stensløkken, Kåre Olav ^a,b  

^a UNIVERSITY OF OSLO   (Norway)

^b UNIVERSITY OF OSLO   (Norway)

^c UNIVERSITY OF TROMSØ   (Norway)

^d OSLO UNIVERSITY HOSPITAL   (Norway)

Author keywords

Inflammation; Mitochondrial DNA; mtDNA; Myocardial infarction; NF B; TLR9

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOCHONDRIAL DNA; TOLL LIKE RECEPTOR 9;

ADULT; AGED; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD SAMPLING; CARDIAC MUSCLE CELL; CELL DEATH; CELL VIABILITY; CONTROLLED STUDY; DNA FRAGMENTATION; ENZYME ACTIVATION; ENZYME ACTIVITY; HEART INFARCTION; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IN VITRO STUDY; IN VIVO STUDY; INNATE IMMUNITY; MALE; MEMBRANE DEPOLARIZATION; MITOCHONDRIAL MEMBRANE; MOUSE; NONHUMAN; PROTEIN DOMAIN; PROTEIN EXPRESSION; ST SEGMENT ELEVATION MYOCARDIAL INFARCTION; STABLE ANGINA PECTORIS; ANIMAL; C57BL MOUSE; CONFOCAL MICROSCOPY; FEMALE; IMMUNOBLOTTING; INFLAMMATION; METABOLISM; PATHOLOGY; PHYSIOLOGY; POLYMERASE CHAIN REACTION;

ANIMALS; CELL DEATH; DNA, MITOCHONDRIAL; FEMALE; HUMANS; IMMUNOBLOTTING; INFLAMMATION; MALE; MICE; MICE, INBRED C57BL; MICROSCOPY, CONFOCAL; MYOCARDIAL INFARCTION; MYOCYTES, CARDIAC; NF-KAPPA B; POLYMERASE CHAIN REACTION; TOLL-LIKE RECEPTOR 9;

EID: 84969551357     PISSN: 03008428     EISSN: 14351803     Source Type: Journal    
DOI: 10.1007/s00395-016-0553-6     Document Type: Article

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