Methylcitrate cycle defines the bactericidal essentiality of isocitrate lyase for survival of mycobacterium tuberculosis on fatty acids

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 13, 2014, Pages 4976-4981

  Eoh, Hyungjin ^a   Rhee, Kyu Y ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

Membrane bioenergetics; Metabolic essentiality; Metabolic homeostasis

Indexed keywords

ACETIC ACID; CYANOCOBALAMIN; FATTY ACID; ISOCITRATE LYASE; METHYLISOCITRATE LYASE; PROPIONIC ACID; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL GROWTH; BACTERIAL SURVIVAL; BACTERICIDAL ACTIVITY; CITRIC ACID CYCLE; CONTROLLED STUDY; ENZYME ACTIVITY; GLUCONEOGENESIS; MEMBRANE POTENTIAL; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PH; PRIORITY JOURNAL; PROTEIN METABOLISM;

MEMBRANE BIOENERGETICS; METABOLIC ESSENTIALITY; METABOLIC HOMEOSTASIS;

ACETATES; CARBON; CARBON ISOTOPES; CITRATES; FATTY ACIDS; ISOCITRATE LYASE; METABOLOMICS; MICROBIAL VIABILITY; MODELS, BIOLOGICAL; MYCOBACTERIUM TUBERCULOSIS; PHENOTYPE; PROPIONATES;

EID: 84897498653     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1400390111     Document Type: Article

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