메뉴 건너뛰기




Volumn 57, Issue 1, 2016, Pages R19-R33

Aromatase expression and regulation in breast and endometrial cancer

Author keywords

Aromatase; Breast cancer; Endometrial cancer; Estrogen

Indexed keywords

AROMATASE; ESTROGEN; PROTEIN BINDING; TRANSCRIPTION FACTOR;

EID: 84976609802     PISSN: 09525041     EISSN: 14796813     Source Type: Journal    
DOI: 10.1530/JME-15-0310     Document Type: Review
Times cited : (162)

References (115)
  • 1
    • 0029820178 scopus 로고    scopus 로고
    • Use of alternative promoters to express the aromatase cytochrome P450 (CYP19) gene in breast adipose tissues of cancer-free and breast cancer patients
    • Agarwal VR, Bulun SE, Leitch M, Rohrich R & Simpson ER 1996 Use of alternative promoters to express the aromatase cytochrome P450 (CYP19) gene in breast adipose tissues of cancer-free and breast cancer patients. Journal of Clinical Endocrinology and Metabolism 81 3843-3849.
    • (1996) Journal of Clinical Endocrinology and Metabolism , vol.81 , pp. 3843-3849
    • Agarwal, V.R.1    Bulun, S.E.2    Leitch, M.3    Rohrich, R.4    Simpson, E.R.5
  • 2
    • 84864855395 scopus 로고    scopus 로고
    • Obesity and the risk for premenopausal and postmenopausal breast cancer
    • Anderson GL & Neuhouser ML 2012 Obesity and the risk for premenopausal and postmenopausal breast cancer. Cancer Prevention Research 5 515-521. (doi:10.1158/1940-6207.CAPR-12-0091)
    • (2012) Cancer Prevention Research , vol.5 , pp. 515-521
    • Anderson, G.L.1    Neuhouser, M.L.2
  • 3
    • 84906996719 scopus 로고    scopus 로고
    • Tracking and evaluating molecular tumor markers with cancer registry data: HER2 and breast cancer
    • Anderson WF, Rosenberg PS & Katki HA 2014 Tracking and evaluating molecular tumor markers with cancer registry data: HER2 and breast cancer. Journal of National Cancer Institute 106 dju093. (doi:10.1093/jnci/dju093)
    • (2014) Journal of National Cancer Institute , vol.106
    • Anderson, W.F.1    Rosenberg, P.S.2    Katki, H.A.3
  • 4
  • 5
    • 0031058448 scopus 로고    scopus 로고
    • Risk of endometrial cancer in relation to use of oestrogen combined with cyclic progestagen therapy in postmenopausal women
    • Beresford SA, Weiss NS, Voigt LF & McKnight B 1997 Risk of endometrial cancer in relation to use of oestrogen combined with cyclic progestagen therapy in postmenopausal women. Lancet 349 458-461. (doi:10.1016/S0140-6736(96)07365-5)
    • (1997) Lancet , vol.349 , pp. 458-461
    • Beresford, S.A.1    Weiss, N.S.2    Voigt, L.F.3    McKnight, B.4
  • 7
    • 0020660717 scopus 로고
    • Two pathogenetic types of endometrial carcinoma
    • Bokhman JV 1983 Two pathogenetic types of endometrial carcinoma. Gynecologic Oncology 15 10-17. (doi:10.1016/0090-8258(83)90111-7)
    • (1983) Gynecologic Oncology , vol.15 , pp. 10-17
    • Bokhman, J.V.1
  • 8
    • 77955479427 scopus 로고    scopus 로고
    • The multiple roles of estrogens and the enzyme aromatase
    • Boon WC, Chow JD & Simpson ER 2010 The multiple roles of estrogens and the enzyme aromatase. Progress Brain Research 181 209-232. (doi:10.1016/S0079-6123(08)81012-6)
    • (2010) Progress Brain Research , vol.181 , pp. 209-232
    • Boon, W.C.1    Chow, J.D.2    Simpson, E.R.3
  • 9
    • 0032974113 scopus 로고    scopus 로고
    • Aromatase inhibitors and their antitumor effects in model systems
    • Brodie A, Lu Q, Liu Y & Long B 1999a Aromatase inhibitors and their antitumor effects in model systems. Endocrine-Related Cancer 6 205-210.
    • (1999) Endocrine-Related Cancer , vol.6 , pp. 205-210
    • Brodie, A.1    Lu, Q.2    Liu, Y.3    Long, B.4
  • 11
    • 75149159186 scopus 로고    scopus 로고
    • Obesity and breast cancer: Progress to understanding the relationship
    • Brown KA & Simpson ER 2010 Obesity and breast cancer: progress to understanding the relationship. Cancer Research 70 4-7. (doi:10.1158/0008-5472.CAN-09-2257)
    • (2010) Cancer Research , vol.70 , pp. 4-7
    • Brown, K.A.1    Simpson, E.R.2
  • 12
    • 67650462947 scopus 로고    scopus 로고
    • Subcellular localization of cyclic AMP-responsive element binding protein-regulated transcription coactivator 2 provides a link between obesity and breast cancer in postmenopausal women
    • Brown KA, McInnes KJ, Hunger NI, Oakhill JS, Steinberg GR & Simpson ER 2009 Subcellular localization of cyclic AMP-responsive element binding protein-regulated transcription coactivator 2 provides a link between obesity and breast cancer in postmenopausal women. Cancer Research 69 5392-5399. (doi:10.1158/0008-5472.CAN-09-0108)
    • (2009) Cancer Research , vol.69 , pp. 5392-5399
    • Brown, K.A.1    McInnes, K.J.2    Hunger, N.I.3    Oakhill, J.S.4    Steinberg, G.R.5    Simpson, E.R.6
  • 13
    • 77956150294 scopus 로고    scopus 로고
    • Metformin inhibits aromatase expression in human breast adipose stromal cells via stimulation of AMP-activated protein kinase
    • Brown KA, Hunger NI, Docanto M & Simpson ER 2010 Metformin inhibits aromatase expression in human breast adipose stromal cells via stimulation of AMP-activated protein kinase. Breast Cancer Research Treatment 123 591-596. (doi:10.1007/s10549-010-0834-y)
    • (2010) Breast Cancer Research Treatment , vol.123 , pp. 591-596
    • Brown, K.A.1    Hunger, N.I.2    Docanto, M.3    Simpson, E.R.4
  • 16
    • 0027131199 scopus 로고
    • A link between breast cancer and local estrogen biosynthesis suggested by quantification of breast adipose tissue aromatase cytochrome P450 transcripts using competitive polymerase chain reaction after reverse transcription
    • Bulun SE, Price TM, Aitken J, Mahendroo MS & Simpson ER 1993 A link between breast cancer and local estrogen biosynthesis suggested by quantification of breast adipose tissue aromatase cytochrome P450 transcripts using competitive polymerase chain reaction after reverse transcription. Journal of Clinical Endocrinology and Metabolism 77 1622-1628.
    • (1993) Journal of Clinical Endocrinology and Metabolism , vol.77 , pp. 1622-1628
    • Bulun, S.E.1    Price, T.M.2    Aitken, J.3    Mahendroo, M.S.4    Simpson, E.R.5
  • 22
    • 0037464510 scopus 로고    scopus 로고
    • Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults
    • Calle EE, Rodriguez C, Walker-Thurmond K & Thun MJ 2003 Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. New England Journal of Medicine 348 1625-1638.
    • (2003) New England Journal of Medicine , vol.348 , pp. 1625-1638
    • Calle, E.E.1    Rodriguez, C.2    Walker-Thurmond, K.3    Thun, M.J.4
  • 23
    • 84877028141 scopus 로고    scopus 로고
    • Comprehensive molecular portraits of human breast tumours
    • Cancer Genome Atlas Network 2012 Comprehensive molecular portraits of human breast tumours. Nature 490 61-70. (doi:10.1038/nature11412)
    • (2012) Nature , vol.490 , pp. 61-70
    • Cancer Genome Atlas Network1
  • 26
    • 34548731405 scopus 로고    scopus 로고
    • Prostaglandin E(2) induces breast cancer related aromatase promoters via activation of p38 and c-Jun NH(2)-terminal kinase in adipose fibroblasts
    • Chen D, Reierstad S, Lin Z, Lu M, Brooks C, Li N, Innes J & Bulun SE 2007 Prostaglandin E(2) induces breast cancer related aromatase promoters via activation of p38 and c-Jun NH(2)-terminal kinase in adipose fibroblasts. Cancer Research 67 8914-8922. (doi:10.1158/0008-5472.CAN-06-4751)
    • (2007) Cancer Research , vol.67 , pp. 8914-8922
    • Chen, D.1    Reierstad, S.2    Lin, Z.3    Lu, M.4    Brooks, C.5    Li, N.6    Innes, J.7    Bulun, S.E.8
  • 27
    • 56349144641 scopus 로고    scopus 로고
    • Regulation of breast cancer-associated aromatase promoters
    • Chen D, Reierstad S, Lu M, Lin Z, Ishikawa H & Bulun SE 2009 Regulation of breast cancer-associated aromatase promoters. Cancer Letters 273 15-27. (doi:10.1016/j.canlet.2008.05.038)
    • (2009) Cancer Letters , vol.273 , pp. 15-27
    • Chen, D.1    Reierstad, S.2    Lu, M.3    Lin, Z.4    Ishikawa, H.5    Bulun, S.E.6
  • 28
    • 79955764238 scopus 로고    scopus 로고
    • JunD and JunB integrate prostaglandin E2 activation of breast cancer-associated proximal aromatase promoters
    • Chen D, Reierstad S, Fang F & Bulun SE 2011 JunD and JunB integrate prostaglandin E2 activation of breast cancer-associated proximal aromatase promoters. Molecular Endocrinology 25 767-775. (doi:10.1210/me.2010-0368)
    • (2011) Molecular Endocrinology , vol.25 , pp. 767-775
    • Chen, D.1    Reierstad, S.2    Fang, F.3    Bulun, S.E.4
  • 32
    • 0037036456 scopus 로고    scopus 로고
    • Liver receptor homologue-1 (LRH-1) regulates expression of aromatase in preadipocytes
    • Clyne CD, Speed CJ, Zhou J & Simpson ER 2002 Liver receptor homologue-1 (LRH-1) regulates expression of aromatase in preadipocytes. Journal of Biological Chemistry 277 20591-20597. (doi:10.1074/jbc.M201117200)
    • (2002) Journal of Biological Chemistry , vol.277 , pp. 20591-20597
    • Clyne, C.D.1    Speed, C.J.2    Zhou, J.3    Simpson, E.R.4
  • 33
    • 84902316044 scopus 로고    scopus 로고
    • Melatonin modulation of crosstalk among malignant epithelial, endothelial and adipose cells in breast cancer (review)
    • Cos S, Alvarez-Garcia V, Gonzalez A, Alonso-Gonzalez C & Martinez-Campa C 2014 Melatonin modulation of crosstalk among malignant epithelial, endothelial and adipose cells in breast cancer (review). Oncology Letters 8 487-492.
    • (2014) Oncology Letters , vol.8 , pp. 487-492
    • Cos, S.1    Alvarez-Garcia, V.2    Gonzalez, A.3    Alonso-Gonzalez, C.4    Martinez-Campa, C.5
  • 34
    • 0342445418 scopus 로고    scopus 로고
    • Postnatal sex reversal of the ovaries in mice lacking estrogen receptors alpha and beta
    • Couse JF, Hewitt SC, Bunch DO, Sar M, Walker VR, Davis BJ & Korach KS 1999 Postnatal sex reversal of the ovaries in mice lacking estrogen receptors alpha and beta. Science 286 2328-2331. (doi:10.1126/science.286.5448.2328)
    • (1999) Science , vol.286 , pp. 2328-2331
    • Couse, J.F.1    Hewitt, S.C.2    Bunch, D.O.3    Sar, M.4    Walker, V.R.5    Davis, B.J.6    Korach, K.S.7
  • 35
    • 0031043093 scopus 로고    scopus 로고
    • Endometrial cancer: Incidence, prognostic factors, diagnosis, and treatment
    • Creasman WT 1997 Endometrial cancer: incidence, prognostic factors, diagnosis, and treatment. Seminars in Oncology 24 S1-140-S141-150.
    • (1997) Seminars in Oncology , vol.24
    • Creasman, W.T.1
  • 36
    • 84875269990 scopus 로고    scopus 로고
    • Estrogen synthesis and signaling pathways during aging: From periphery to brain
    • Cui J, Shen Y & Li R 2013 Estrogen synthesis and signaling pathways during aging: from periphery to brain. Trends in Molecular Medicine 19 197-209. (doi:10.1016/j.molmed.2012.12.007)
    • (2013) Trends in Molecular Medicine , vol.19 , pp. 197-209
    • Cui, J.1    Shen, Y.2    Li, R.3
  • 38
    • 80051700986 scopus 로고    scopus 로고
    • Comparison of increased aromatase versus ERalpha in the generation of mammary hyperplasia and cancer
    • Diaz-Cruz ES, Sugimoto Y, Gallicano GI, Brueggemeier RW & Furth PA 2011 Comparison of increased aromatase versus ERalpha in the generation of mammary hyperplasia and cancer. Cancer Research 71 5477-5487. (doi:10.1158/0008-5472.CAN-10-4652)
    • (2011) Cancer Research , vol.71 , pp. 5477-5487
    • Diaz-Cruz, E.S.1    Sugimoto, Y.2    Gallicano, G.I.3    Brueggemeier, R.W.4    Furth, P.A.5
  • 39
  • 40
    • 0033767836 scopus 로고    scopus 로고
    • Effect of single and compound knockouts of estrogen receptors alpha (ERalpha) and beta (ERbeta) on mouse reproductive phenotypes
    • Dupont S, Krust A, Gansmuller A, Dierich A, Chambon P & Mark M 2000 Effect of single and compound knockouts of estrogen receptors alpha (ERalpha) and beta (ERbeta) on mouse reproductive phenotypes. Development 127 4277-4291.
    • (2000) Development , vol.127 , pp. 4277-4291
    • Dupont, S.1    Krust, A.2    Gansmuller, A.3    Dierich, A.4    Chambon, P.5    Mark, M.6
  • 41
    • 84907273499 scopus 로고    scopus 로고
    • Matrix production and remodeling as therapeutic targets for uterine leiomyoma
    • Fujisawa C & Castellot JJ Jr 2014 Matrix production and remodeling as therapeutic targets for uterine leiomyoma. Journal of Cell Communication and Signaling 8 179-194. (doi:10.1007/s12079-014-0234-x)
    • (2014) Journal of Cell Communication and Signaling , vol.8 , pp. 179-194
    • Fujisawa, C.1    Castellot, J.J.2
  • 42
    • 84887486404 scopus 로고    scopus 로고
    • Endometrial intracrinology-generation of an estrogen-dominated microenvironment in the secretory phase of women
    • Gibson DA, McInnes KJ, Critchley HO & Saunders PT 2013 Endometrial intracrinology-generation of an estrogen-dominated microenvironment in the secretory phase of women. Journal of Clinical Endocrinology and Metabolism 98 E1802-E1806. (doi:10.1210/ jc.2013-2140)
    • (2013) Journal of Clinical Endocrinology and Metabolism , vol.98 , pp. E1802-E1806
    • Gibson, D.A.1    McInnes, K.J.2    Critchley, H.O.3    Saunders, P.T.4
  • 43
    • 0037369735 scopus 로고    scopus 로고
    • Three different promoters control expression of the aromatase cytochrome p450 gene (cyp19) in mouse gonads and brain
    • Golovine K, Schwerin M & Vanselow J 2003 Three different promoters control expression of the aromatase cytochrome p450 gene (cyp19) in mouse gonads and brain. Biology of Reproduction 68 978-984. (doi:10.1095/biolreprod.102.008037)
    • (2003) Biology of Reproduction , vol.68 , pp. 978-984
    • Golovine, K.1    Schwerin, M.2    Vanselow, J.3
  • 45
    • 7444258476 scopus 로고    scopus 로고
    • Metabolic inactivation of estrogens in breast tissue by UDP-glucuronosyltransferase enzymes: An overview
    • Guillemette C, Belanger A & Lepine J 2004 Metabolic inactivation of estrogens in breast tissue by UDP-glucuronosyltransferase enzymes: an overview. Breast Cancer Research 6 246-254. (doi:10.1186/bcr936)
    • (2004) Breast Cancer Research , vol.6 , pp. 246-254
    • Guillemette, C.1    Belanger, A.2    Lepine, J.3
  • 48
    • 0031120061 scopus 로고    scopus 로고
    • Aberrant expression of aromatase in breast cancer tissues
    • Harada N 1997 Aberrant expression of aromatase in breast cancer tissues. Journal of Steroid Biochemistry and Molecular Biology 61 175-184. (doi:10.1016/S0960-0760(97)80010-6)
    • (1997) Journal of Steroid Biochemistry and Molecular Biology , vol.61 , pp. 175-184
    • Harada, N.1
  • 49
    • 79551711062 scopus 로고    scopus 로고
    • Body fat distribution and risk of premenopausal breast cancer in the Nurses' Health Study II
    • Harris HR, Willett WC, Terry KL & Michels KB 2011 Body fat distribution and risk of premenopausal breast cancer in the Nurses' Health Study II. Journal of National Cancer Institute 103 273-278. (doi:10.1093/jnci/djq500)
    • (2011) Journal of National Cancer Institute , vol.103 , pp. 273-278
    • Harris, H.R.1    Willett, W.C.2    Terry, K.L.3    Michels, K.B.4
  • 52
    • 0028225088 scopus 로고
    • Novel exon 1 of the aromatase gene specific for aromatase transcripts in human brain
    • Honda S, Harada N & Takagi Y 1994 Novel exon 1 of the aromatase gene specific for aromatase transcripts in human brain. Biochemical and Biophysics Research Communications 198 1153-1160. (doi:10.1006/bbrc.1994.1163)
    • (1994) Biochemical and Biophysics Research Communications , vol.198 , pp. 1153-1160
    • Honda, S.1    Harada, N.2    Takagi, Y.3
  • 53
    • 0030051126 scopus 로고    scopus 로고
    • The alternative exons 1 of the mouse aromatase cytochrome P-450 gene
    • Honda S, Harada N & Takagi Y 1996 The alternative exons 1 of the mouse aromatase cytochrome P-450 gene. Biochimica et Biophysica Acta 1305 145-150. (doi:10.1016/0167-4781(95)00200-6)
    • (1996) Biochimica et Biophysica Acta , vol.1305 , pp. 145-150
    • Honda, S.1    Harada, N.2    Takagi, Y.3
  • 55
    • 84891481542 scopus 로고    scopus 로고
    • Altered expression of ERs, aromatase, and COX2 connected to estrogen action in type 1 endometrial cancer biology
    • Jarzabek K, Koda M, Walentowicz-Sadlecka M, Grabiec M, Laudanski P & Wolczynski S 2013 Altered expression of ERs, aromatase, and COX2 connected to estrogen action in type 1 endometrial cancer biology. Tumour Biology 34 4007-4016. (doi:10.1007/s13277-013-0991-9)
    • (2013) Tumour Biology , vol.34 , pp. 4007-4016
    • Jarzabek, K.1    Koda, M.2    Walentowicz-Sadlecka, M.3    Grabiec, M.4    Laudanski, P.5    Wolczynski, S.6
  • 56
    • 78650633722 scopus 로고    scopus 로고
    • Adult body size, hormone receptor status, and premenopausal breast cancer risk in a multiethnic population: The San Francisco Bay Area breast cancer study
    • John EM, Sangaramoorthy M, Phipps AI, Koo J & Horn-Ross PL 2011 Adult body size, hormone receptor status, and premenopausal breast cancer risk in a multiethnic population: the San Francisco Bay Area breast cancer study. American Journal of Epidemiology 173 201-216. (doi:10.1093/aje/kwq345)
    • (2011) American Journal of Epidemiology , vol.173 , pp. 201-216
    • John, E.M.1    Sangaramoorthy, M.2    Phipps, A.I.3    Koo, J.4    Horn-Ross, P.L.5
  • 58
    • 0023857383 scopus 로고
    • The dose-effect relationship between 'unopposed' oestrogens and endometrial mitotic rate: Its central role in explaining and predicting endometrial cancer risk
    • Key TJ & Pike MC 1988 The dose-effect relationship between 'unopposed' oestrogens and endometrial mitotic rate: its central role in explaining and predicting endometrial cancer risk. British Journal of Cancer 57 205-212. (doi:10.1038/bjc.1988.44)
    • (1988) British Journal of Cancer , vol.57 , pp. 205-212
    • Key, T.J.1    Pike, M.C.2
  • 59
    • 84875781716 scopus 로고    scopus 로고
    • Progesterone action in endometrial cancer, endometriosis, uterine fibroids, and breast cancer
    • Kim JJ, Kurita T & Bulun SE 2013 Progesterone action in endometrial cancer, endometriosis, uterine fibroids, and breast cancer. Endocrine Reviews 34 130-162. (doi:10.1210/er.2012-1043)
    • (2013) Endocrine Reviews , vol.34 , pp. 130-162
    • Kim, J.J.1    Kurita, T.2    Bulun, S.E.3
  • 60
    • 0035266182 scopus 로고    scopus 로고
    • Overexpression of aromatase leads to hyperplasia and changes in the expression of genes involved in apoptosis, cell cycle, growth, and tumor suppressor functions in the mammary glands of transgenic mice
    • Kirma N, Gill K, Mandava U & Tekmal RR 2001 Overexpression of aromatase leads to hyperplasia and changes in the expression of genes involved in apoptosis, cell cycle, growth, and tumor suppressor functions in the mammary glands of transgenic mice. Cancer Research 61 1910-1918.
    • (2001) Cancer Research , vol.61 , pp. 1910-1918
    • Kirma, N.1    Gill, K.2    Mandava, U.3    Tekmal, R.R.4
  • 62
    • 0033051051 scopus 로고    scopus 로고
    • Regulation of estrogen activity by sulfation in human Ishikawa endometrial adenocarcinoma cells
    • Kotov A, Falany JL, Wang J & Falany CN 1999 Regulation of estrogen activity by sulfation in human Ishikawa endometrial adenocarcinoma cells. Journal of Steroid Biochemistry and Molecular Biology 68 137-144. (doi:10.1016/S0960-0760(99)00022-9)
    • (1999) Journal of Steroid Biochemistry and Molecular Biology , vol.68 , pp. 137-144
    • Kotov, A.1    Falany, J.L.2    Wang, J.3    Falany, C.N.4
  • 64
    • 53149096920 scopus 로고    scopus 로고
    • Impact of androgen/estrogen ratio: Lessons learned from the aromatase over-expression mice
    • Li X & Rahman N 2008 Impact of androgen/estrogen ratio: lessons learned from the aromatase over-expression mice. General and Comparative Endocrinology 159 1-9. (doi:10.1016/j.ygcen.2008.07.025)
    • (2008) General and Comparative Endocrinology , vol.159 , pp. 1-9
    • Li, X.1    Rahman, N.2
  • 66
    • 0036775381 scopus 로고    scopus 로고
    • Mammary gland development in transgenic male mice expressing human P450 aromatase
    • Li X, Warri A, Makela S, Ahonen T, Streng T, Santti R & Poutanen M 2002 Mammary gland development in transgenic male mice expressing human P450 aromatase. Endocrinology 143 4074-4083. (doi:10.1210/en.2002-220181)
    • (2002) Endocrinology , vol.143 , pp. 4074-4083
    • Li, X.1    Warri, A.2    Makela, S.3    Ahonen, T.4    Streng, T.5    Santti, R.6    Poutanen, M.7
  • 67
    • 0022969570 scopus 로고
    • Synergism between granulosa and thecainterstitial cells in estrogen biosynthesis by gonadotropin-treated rat ovaries: Studies on the two-cell, two-gonadotropin hypothesis using steroid antisera
    • Liu YX & Hsueh AJ 1986 Synergism between granulosa and thecainterstitial cells in estrogen biosynthesis by gonadotropin-treated rat ovaries: studies on the two-cell, two-gonadotropin hypothesis using steroid antisera. Biology of Reproduction 35 27-36. (doi:10.1095/ biolreprod35.1.27)
    • (1986) Biology of Reproduction , vol.35 , pp. 27-36
    • Liu, Y.X.1    Hsueh, A.J.2
  • 69
    • 0027429548 scopus 로고
    • Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene
    • Lubahn DB, Moyer JS, Golding TS, Couse JF, Korach KS & Smithies O 1993 Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene. PNAS 90 11162-11166. (doi:10.1073/ pnas.90.23.11162)
    • (1993) PNAS , vol.90 , pp. 11162-11166
    • Lubahn, D.B.1    Moyer, J.S.2    Golding, T.S.3    Couse, J.F.4    Korach, K.S.5    Smithies, O.6
  • 70
    • 0010990573 scopus 로고
    • The utilization of plasma androstenedione for estrone production in women
    • 30 June-5 July 1968, Mexico, Excerpta Medica International Congress Series No. 184, pp 770-776. Eds C Gual & FJG Ebling. Amsterdam, The Netherlands: Excerpta Medica Foundation
    • MacDonald PC, Grodin JM & Siiteri PK 1968 The utilization of plasma androstenedione for estrone production in women. In Progress in Endocrinology, Proceedings of the Third International Congress of Endocrinology, 30 June-5 July 1968, Mexico, Excerpta Medica International Congress Series No. 184, pp 770-776. Eds C Gual & FJG Ebling. Amsterdam, The Netherlands: Excerpta Medica Foundation.
    • (1968) Progress in Endocrinology, Proceedings of the Third International Congress of Endocrinology
    • MacDonald, P.C.1    Grodin, J.M.2    Siiteri, P.K.3
  • 71
    • 0035266474 scopus 로고    scopus 로고
    • Tumor necrosis factor alpha and interleukin 11 secreted by malignant breast epithelial cells inhibit adipocyte differentiation by selectively downregulating CCAAT/enhancer binding protein alpha and peroxisome proliferator-activated receptor gamma: Mechanism of desmoplastic reaction
    • Meng L, Zhou J, Sasano H, Suzuki T, Zeitoun KM & Bulun SE 2001 Tumor necrosis factor alpha and interleukin 11 secreted by malignant breast epithelial cells inhibit adipocyte differentiation by selectively downregulating CCAAT/enhancer binding protein alpha and peroxisome proliferator-activated receptor gamma: mechanism of desmoplastic reaction. Cancer Research 61 2250-2255.
    • (2001) Cancer Research , vol.61 , pp. 2250-2255
    • Meng, L.1    Zhou, J.2    Sasano, H.3    Suzuki, T.4    Zeitoun, K.M.5    Bulun, S.E.6
  • 74
    • 0024021512 scopus 로고
    • [Plasma concentration of estrogens and androgens in postmenopausal women with or without endometrial cancer]
    • Nagasako S, Asanuma N & Nagata Y 1988 [Plasma concentration of estrogens and androgens in postmenopausal women with or without endometrial cancer]. Nihon Sanka Fujinka Gakkai Zasshi 40 707-713.
    • (1988) Nihon Sanka Fujinka Gakkai Zasshi , vol.40 , pp. 707-713
    • Nagasako, S.1    Asanuma, N.2    Nagata, Y.3
  • 77
    • 34347248822 scopus 로고    scopus 로고
    • Estrogen receptors alpha and beta mediate distinct pathways of vascular gene expression, including genes involved in mitochondrial electron transport and generation of reactive oxygen species
    • O'Lone R, Knorr K, Jaffe IZ, Schaffer ME, Martini PG, Karas RH, Bienkowska J, Mendelsohn ME & Hansen U 2007 Estrogen receptors alpha and beta mediate distinct pathways of vascular gene expression, including genes involved in mitochondrial electron transport and generation of reactive oxygen species. Molecular Endocrinology 21 1281-1296. (doi:10.1210/me.2006-0497)
    • (2007) Molecular Endocrinology , vol.21 , pp. 1281-1296
    • O'Lone, R.1    Knorr, K.2    Jaffe, I.Z.3    Schaffer, M.E.4    Martini, P.G.5    Karas, R.H.6    Bienkowska, J.7    Mendelsohn, M.E.8    Hansen, U.9
  • 80
    • 0026647326 scopus 로고
    • Determination of aromatase cytochrome P450 messenger ribonucleic acid in human breast tissue by competitive polymerase chain reaction amplification
    • Price T, Aitken J, Head J, Mahendroo M, Means G & Simpson E 1992 Determination of aromatase cytochrome P450 messenger ribonucleic acid in human breast tissue by competitive polymerase chain reaction amplification. Journal of Clinical Endocrinology and Metabolism 74 1247-1252.
    • (1992) Journal of Clinical Endocrinology and Metabolism , vol.74 , pp. 1247-1252
    • Price, T.1    Aitken, J.2    Head, J.3    Mahendroo, M.4    Means, G.5    Simpson, E.6
  • 81
    • 84882736854 scopus 로고    scopus 로고
    • Estrogen biosynthesis, phase I and phase II metabolism, and action in endometrial cancer
    • Rizner TL 2013 Estrogen biosynthesis, phase I and phase II metabolism, and action in endometrial cancer. Molecular and Cellular Endocrinology 381 124-139. (doi:10.1016/j.mce.2013.07.026)
    • (2013) Molecular and Cellular Endocrinology , vol.381 , pp. 124-139
    • Rizner, T.L.1
  • 83
    • 0033535424 scopus 로고    scopus 로고
    • Estrogen, DNA damage and mutations
    • Roy D & Liehr JG 1999 Estrogen, DNA damage and mutations. Mutations Research 424 107-115. (doi:10.1016/S0027-5107(99)00012-3)
    • (1999) Mutations Research , vol.424 , pp. 107-115
    • Roy, D.1    Liehr, J.G.2
  • 84
    • 0019836937 scopus 로고
    • Suppression of estrogens with aminoglutethimide and hydrocortisone (medical adrenalectomy) as treatment of advanced breast carcinoma: A review
    • Santen RJ 1981 Suppression of estrogens with aminoglutethimide and hydrocortisone (medical adrenalectomy) as treatment of advanced breast carcinoma: a review. Breast Cancer Research Treatment 1 183-202. (doi:10.1007/BF01806259)
    • (1981) Breast Cancer Research Treatment , vol.1 , pp. 183-202
    • Santen, R.J.1
  • 85
    • 84929838884 scopus 로고    scopus 로고
    • Estrogen metabolites and breast cancer
    • Santen RJ, Yue W & Wang JP 2015 Estrogen metabolites and breast cancer. Steroids 99 61-66. (doi:10.1016/j.steroids.2014.08.003)
    • (2015) Steroids , vol.99 , pp. 61-66
    • Santen, R.J.1    Yue, W.2    Wang, J.P.3
  • 86
    • 0034751150 scopus 로고    scopus 로고
    • A highly complex organization of the regulatory region of the human CYP19 (aromatase) gene revealed by the Human Genome Project
    • Sebastian S & Bulun SE 2001 A highly complex organization of the regulatory region of the human CYP19 (aromatase) gene revealed by the Human Genome Project. Journal of Clinical Endocrinology and Metabolism 86 4600-4602. (doi:10.1210/jcem.86.10.7947)
    • (2001) Journal of Clinical Endocrinology and Metabolism , vol.86 , pp. 4600-4602
    • Sebastian, S.1    Bulun, S.E.2
  • 87
    • 0036794381 scopus 로고    scopus 로고
    • Cloning and characterization of a novel endothelial promoter of the human CYP19 (aromatase P450) gene that is up-regulated in breast cancer tissue
    • Sebastian S, Takayama K, Shozu M & Bulun SE 2002 Cloning and characterization of a novel endothelial promoter of the human CYP19 (aromatase P450) gene that is up-regulated in breast cancer tissue. Molecular Endocrinology 16 2243-2254. (doi:10.1210/me.2002-0123)
    • (2002) Molecular Endocrinology , vol.16 , pp. 2243-2254
    • Sebastian, S.1    Takayama, K.2    Shozu, M.3    Bulun, S.E.4
  • 91
    • 0018165927 scopus 로고
    • Steroid hormones and endometrial cancer
    • Siiteri PK 1978 Steroid hormones and endometrial cancer. Cancer Research 38 4360-4366.
    • (1978) Cancer Research , vol.38 , pp. 4360-4366
    • Siiteri, P.K.1
  • 97
    • 14544270313 scopus 로고    scopus 로고
    • Tamoxifen treatment for breast cancer and risk of endometrial cancer: A case-control study
    • Swerdlow AJ, Jones ME & British Tamoxifen Second Cancer Study G 2005 Tamoxifen treatment for breast cancer and risk of endometrial cancer: a case-control study. Journal of National Cancer Institute 97 375-384.
    • (2005) Journal of National Cancer Institute , vol.97 , pp. 375-384
    • Swerdlow, A.J.1    Jones, M.E.2
  • 98
    • 0029937278 scopus 로고    scopus 로고
    • Overexpression of int-5/aromatase in mammary glands of transgenic mice results in the induction of hyperplasia and nuclear abnormalities
    • Tekmal RR, Ramachandra N, Gubba S, Durgam VR, Mantione J, Toda K, Shizuta Y & Dillehay DL 1996 Overexpression of int-5/aromatase in mammary glands of transgenic mice results in the induction of hyperplasia and nuclear abnormalities. Cancer Research 56 3180-3185.
    • (1996) Cancer Research , vol.56 , pp. 3180-3185
    • Tekmal, R.R.1    Ramachandra, N.2    Gubba, S.3    Durgam, V.R.4    Mantione, J.5    Toda, K.6    Shizuta, Y.7    Dillehay, D.L.8
  • 99
    • 14644389506 scopus 로고    scopus 로고
    • Spontaneous fetal loss caused by placental thrombosis in estrogen sulfotransferase-deficient mice
    • Tong MH, Jiang H, Liu P, Lawson JA, Brass LF & Song WC 2005 Spontaneous fetal loss caused by placental thrombosis in estrogen sulfotransferase-deficient mice. Nature Medicine 11 153-159. (doi:10.1038/nm1184)
    • (2005) Nature Medicine , vol.11 , pp. 153-159
    • Tong, M.H.1    Jiang, H.2    Liu, P.3    Lawson, J.A.4    Brass, L.F.5    Song, W.C.6
  • 101
    • 0028873380 scopus 로고
    • Aromatase in human endometrial carcinoma and hyperplasia. Immunohistochemical, in situ hybridization, and biochemical studies
    • Watanabe K, Sasano H, Harada N, Ozaki M, Niikura H, Sato S & Yajima A 1995 Aromatase in human endometrial carcinoma and hyperplasia. Immunohistochemical, in situ hybridization, and biochemical studies. American Journal of Pathology 146 491-500.
    • (1995) American Journal of Pathology , vol.146 , pp. 491-500
    • Watanabe, K.1    Sasano, H.2    Harada, N.3    Ozaki, M.4    Niikura, H.5    Sato, S.6    Yajima, A.7
  • 103
    • 0032708073 scopus 로고    scopus 로고
    • Role of ovarian theca and granulosa cell interaction in hormone productionand cell growth during the bovine follicular maturation process
    • Yada H, Hosokawa K, Tajima K, Hasegawa Y & Kotsuji F 1999 Role of ovarian theca and granulosa cell interaction in hormone productionand cell growth during the bovine follicular maturation process. Biology of Reproduction 61 1480-1486. (doi:10.1095/biolreprod61.6.1480)
    • (1999) Biology of Reproduction , vol.61 , pp. 1480-1486
    • Yada, H.1    Hosokawa, K.2    Tajima, K.3    Hasegawa, Y.4    Kotsuji, F.5
  • 105
    • 0028919673 scopus 로고
    • Characterization of the sequences of the human CYP19 (aromatase) gene that mediate regulation by glucocorticoids in adipose stromal cells and fetal hepatocytes
    • Zhao Y, Mendelson CR & Simpson ER 1995a Characterization of the sequences of the human CYP19 (aromatase) gene that mediate regulation by glucocorticoids in adipose stromal cells and fetal hepatocytes. Molecular Endocrinology 9 340-349.
    • (1995) Molecular Endocrinology , vol.9 , pp. 340-349
    • Zhao, Y.1    Mendelson, C.R.2    Simpson, E.R.3
  • 106
    • 0029002074 scopus 로고
    • Aromatase P450 gene expression in human adipose tissue. Role of a Jak/STAT pathway in regulation of the adipose-specific promoter
    • Zhao Y, Nichols JE, Bulun SE, Mendelson CR & Simpson ER 1995b Aromatase P450 gene expression in human adipose tissue. Role of a Jak/STAT pathway in regulation of the adipose-specific promoter. Journal of Biological Chemistry 270 16449-16457.
    • (1995) Journal of Biological Chemistry , vol.270 , pp. 16449-16457
    • Zhao, Y.1    Nichols, J.E.2    Bulun, S.E.3    Mendelson, C.R.4    Simpson, E.R.5
  • 107
    • 0030444771 scopus 로고    scopus 로고
    • Estrogen biosynthesis proximal to a breast tumor is stimulated by PGE2 via cyclic AMP, leading to activation of promoter II of the CYP19 (aromatase) gene
    • Zhao Y, Agarwal VR, Mendelson CR & Simpson ER 1996a Estrogen biosynthesis proximal to a breast tumor is stimulated by PGE2 via cyclic AMP, leading to activation of promoter II of the CYP19 (aromatase) gene. Endocrinology 137 5739-5742.
    • (1996) Endocrinology , vol.137 , pp. 5739-5742
    • Zhao, Y.1    Agarwal, V.R.2    Mendelson, C.R.3    Simpson, E.R.4
  • 108
    • 0030458403 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha stimulates aromatase gene expression in human adipose stromal cells through use of an activating protein-1 binding site upstream of promoter 1.4
    • Zhao Y, Nichols JE, Valdez R, Mendelson CR & Simpson ER 1996b Tumor necrosis factor-alpha stimulates aromatase gene expression in human adipose stromal cells through use of an activating protein-1 binding site upstream of promoter 1.4. Molecular Endocrinology 10 1350-1357.
    • (1996) Molecular Endocrinology , vol.10 , pp. 1350-1357
    • Zhao, Y.1    Nichols, J.E.2    Valdez, R.3    Mendelson, C.R.4    Simpson, E.R.5
  • 111
    • 0033571658 scopus 로고    scopus 로고
    • Identification and characterization of a cAMPresponsive element in the region upstream from promoter 1.3 of the human aromatase gene
    • Zhou D & Chen S 1999 Identification and characterization of a cAMPresponsive element in the region upstream from promoter 1.3 of the human aromatase gene. Archives of Biochemistry and Biophysics 371 179190. (doi:10.1006/abbi.1999.1454)
    • (1999) Archives of Biochemistry and Biophysics , vol.371 , pp. 179190
    • Zhou, D.1    Chen, S.2
  • 112
    • 0030266161 scopus 로고    scopus 로고
    • Aromatase gene expression and its exon I usage in human breast tumors. Detection of aromatase messenger RNA by reverse transcription-polymerase chain reaction
    • Zhou C, Zhou D, Esteban J, Murai J, Siiteri PK, Wilczynski S & Chen S 1996 Aromatase gene expression and its exon I usage in human breast tumors. Detection of aromatase messenger RNA by reverse transcription-polymerase chain reaction. Journal of Steroid Biochemistry and Molecular Biology 59 163-171. (doi:10.1016/S0960-0760(96)00100-8)
    • (1996) Journal of Steroid Biochemistry and Molecular Biology , vol.59 , pp. 163-171
    • Zhou, C.1    Zhou, D.2    Esteban, J.3    Murai, J.4    Siiteri, P.K.5    Wilczynski, S.6    Chen, S.7
  • 113
    • 0031126187 scopus 로고    scopus 로고
    • Gene regulation studies of aromatase expression in breast cancer and adipose stromal cells
    • Zhou D, Zhou C & Chen S 1997 Gene regulation studies of aromatase expression in breast cancer and adipose stromal cells. Journal of Steroid Biochemistry and Molecular Biology 61 273-280. (doi:10.1016/ S0960-0760(97)80023-4)
    • (1997) Journal of Steroid Biochemistry and Molecular Biology , vol.61 , pp. 273-280
    • Zhou, D.1    Zhou, C.2    Chen, S.3
  • 114
    • 0035266249 scopus 로고    scopus 로고
    • Malignant breast epithelial cells stimulate aromatase expression via promoter II in human adipose fibroblasts: An epithelial-stromal interaction in breast tumors mediated by CCAAT/enhancer binding protein beta
    • Zhou J, Gurates B, Yang S, Sebastian S & Bulun SE 2001 Malignant breast epithelial cells stimulate aromatase expression via promoter II in human adipose fibroblasts: an epithelial-stromal interaction in breast tumors mediated by CCAAT/enhancer binding protein beta. Cancer Research 61 2328-2334.
    • (2001) Cancer Research , vol.61 , pp. 2328-2334
    • Zhou, J.1    Gurates, B.2    Yang, S.3    Sebastian, S.4    Bulun, S.E.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.