Presence of alternatively spliced transcripts of aromatase gene in human breast cancer

Journal of Clinical Endocrinology and Metabolism

Volumn 81, Issue 6, 1996, Pages 2344-2349

  Utsumi, Toshiaki ^a   Harada, Nobuhiro ^a   Maruta, Morito ^a   Takagi, Yasuyuki ^a  

^a FUJITA HEALTH UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AROMATASE; MESSENGER RNA;

ADULT; AGED; ALTERNATIVE RNA SPLICING; ARTICLE; BREAST CANCER; CLINICAL ARTICLE; CONTROLLED STUDY; EXON; FEMALE; GENE EXPRESSION; HUMAN; HUMAN TISSUE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADULT; AGED; AGED, 80 AND OVER; ALTERNATIVE SPLICING; AROMATASE; BASE SEQUENCE; BREAST NEOPLASMS; EXONS; FEMALE; GENES; HUMANS; IMMUNOCHEMISTRY; MIDDLE AGED; MOLECULAR SEQUENCE DATA; OLIGONUCLEOTIDE PROBES; RNA, MESSENGER; TRANSCRIPTION, GENETIC;

EID: 0029887272     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.81.6.2344     Document Type: Article

References (34)

1. McNatty KP, Baird DT, Bolton A, Chambers P, Corker CS, McLean H. 1976 Concentrations of oestrogens and androgens in human ovarian venous plasma and follicular fluid throughout the menstrual cycle. J Endocrinol. 71:77-85.
2. Thompson Jr EA, Siiteri PK. 1974 The involvement of human placental microsomal cytochrome P450 in aromatization. J Biol Chem. 249:5373-5378.
3. Ryan KJ. 1959 Biological aromatization of steroids. J Biol Chem. 234:268-272.
4. Naftolin F, Ryan KJ, Davies IJ, et al. 1975 The formation of estrogen by central neuroendocrine tissues. Recent Prog Horm Res. 31:295-315.
5. Grodin JM, Siiteri PK, MacDonald PC. 1973 Source of estrogen production in the postmenopausal woman. J Clin Endocrinol Metab. 36:207-214.
6. Ackerman GE, Smith ME, Mendelson CR, MacDonald PC, Simpson ER. 1981 Aromatization of androstenedione by human adipose tissue stromal cells in monolayer culture. J Clin Endocrinol Metab. 53:412-417.
7. Means GD, Mahendroo MS, Corbin CJ, et al. 1989 Structural analysis of the gene encoding human aromatase cytochrome P-450, the enzyme responsible for estrogen biosynthesis. J Biol Chem. 264:19385-19391.
8. Harada N, Yamada K, Saito K, Kibe N, Dohmae S, Takagi Y. 1990 Structural characterization of the human estrogen synthetase (aromatase) gene. Biochem Biophys Res Commun. 166:365-372.
9. Toda K, Terashima M, Kawamoto T, et al. 1990 Structural and functional characterization of human aromatase P450 gene. Eur J Biochem. 193:559-565.
10. Means GD, Kilgore MW, Mahendroo MS, Mendelson CR, Simpson ER. 1991 Tissue-specific promoters regulate aromatase cytochrome P450 gene expression in human ovary and fetal tissues. Mol Endocrinol. 5:2005-2013.
11. Mahendroo MS, Means GD, Mendelson CR, Simpson ER. 1991 Tissue-specific expression of human P450arom: the promoter responsible for expression in adipose tissue is different from that utilized in placenta. J Biol Chem. 266:11276-11281.
12. Mahendroo MS, Mendelson CR, Simpson ER. 1993 Tissue-specific and hormonally controlled alternative promoters regulate aromatase cytochrome P450 gene expression in human adipose tissue. J Biol Chem. 268:19463-19470.
13. Harada N, Utsumi T, Takagi T. 1993 Tissue-specific expression of the human aromatase cytochrome P-450 gene by alternative use of multiple exons 1 and promoters, and switching of tissue-specific exons 1 in carcinogenesis. Proc Natl Acad Sci USA. 90:11312-11316.
14. Watiz HH, Chattoraj JC, Kerdisch M, Muller ER. 1978 Impeded estrogens and etiology of breast cancer. Cancer Res. 38:4012-4020.
15. Miller WR, Hawkins RA, Forrest APM. 1982 Significance of aromatase activity in human breast cancer. Cancer Res. 42(Suppl):3365-3368.
16. Vermeulen A, Deslypere JP, Paridaens R, Leclercq G, Roy F, Heuson JC. 1986 Aromatase, 17β-hydroxysteroid dehydrogenase and intratissular sex hormone concentrations in cancerous and normal glandular breast tissue in postmenopausal women. Eur J Cancer Clin Oncol. 22:515-525.
17. Lipton A, Santner SJ, Santen RJ, et al. 1987 Aromatase activity in primary and metastatic human breast cancer. Cancer. 59:779-782.
18. O'Neill JS, Elton RA, Miller WR. 1988 Aromatase activity in adipose tissue from breast quadrants: a link with tumor site. Br Med J. 296:741-743.
19. Vermeulen A, Deslypere JP. 1989 Biosynthesis of active oestrogens in the breast. Proc R Soc Edinb [Biol]. 95:195-201.
20. Silva MC, Rowlands MG, Dowsett MD, et al. 1989 Intratumoral aromatase as a prognostic factor in human breast carcinoma. Cancer Res. 49:2588-2591.
21. Bulun SE, Price TM, Aitken J, Mahendroo MS, Simpson ER. 1993 A link between breast cancer and local estrogen biosynthesis suggested by quantification of breast adipose tissue aromatase cytochrome P450 transcripts using competitive polymerase chain reaction after reverse transcription. J Clin Endocrinol Metab. 77:1622-1628.
22. Esteban JM, Warsi Z, Haniu M, Hall P, Shively JE, Chen S. 1992 Detection of intratumoral aromatase in breast carcinomas. An immunohistochemical study with clinicopathologic correlation. Am J Pathol. 140:337-343.
23. Sasano H, Nagura H, Harada N, Goukon Y, Kimura M. 1994 Immunolocalization of aromatase and other steroidogenic enzymes in human breast disorders. Hum Pathol. 25:530-535.
24. Santen RJ, Martel J, Hoagland M, et al. 1994 Stromal spindle cells contain aromatase in human breast tumors. J Clin Endocrinol Metab. 79:627-632.
25. Japanese Breast Cancer Society. 1989 The general rules for clinical and pathological recording of breast cancer. Jpn J Surg. 19:612-632.
26. McGuire WL, De La Garza M, Chamness GC. 1977 Evolution of estrogen receptor assays in human breast cancer tissue. Cancer Res. 37:637-639.
27. Chirgwin JM, Przybla AE, MacDonald KJ, Utter WJ. 1979 Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry. 18:5294-5299.
28. Harada N, Yamada K. 1992 Ontogeny of aromatase messenger ribonucleic acid in mouse brain: fluorometrical quantitation by polymerase chain reaction. Endocrinology. 131:2306-2312.
29. Harada N, Yamada K, Foidart A, Balthazart J. 1992 Regulation of aromatase cytochrome P-450 (estrogen synthetase) transcripts in the quail brain by testosterone. Mol Brain Res. 15:19-26.
30. 15α): purification, regioselectivity, stereospecificity, and sex-dependent expression. J Biol Chem. 259:1265-1271.
31. Laemmli UK. 1970 Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680-685.
32. Mendelson CR, Cleland WH, Smith ME, Simpson ER. 1982 Regulation of aromatase activity of stromal cells derived from human adipose tissue. Endocrinology. 111:1077-1085.
33. Miller WR, Mullen P. 1993 Factors influencing aromatase activity in the breast. J Steroid Biochem Mol Biol. 44:597-604.
34. Yamamoto R, Iishi H, Tatsuta M, et al. 1990 Enhancement of mucus accumulation in a human gastric scirrhous carcinoma cell line (KATO-III) by fibroblast-tumor cell interaction. Virchows Arch B Cell Pathol. 59:26-31.