Weight gain increases human aromatase expression in mammary gland

Molecular and Cellular Endocrinology

Volumn 355, Issue 1, 2012, Pages 114-120

  Chen, Dong ^a   Zhao, Hong ^a   Coon, John S ^a   Ono, Masanori ^a   Pearson, Elizabeth K ^a   Bulun, Serdar E ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Aromatase; Breast cancer; Mammary; Obesity; Overweight; Weight gain

Indexed keywords

AROMATASE; CCAAT ENHANCER BINDING PROTEIN BETA; MESSENGER RNA; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AROMATASE GENE; ARTICLE; BREAST CANCER; CANCER RISK; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; GENE; GENE EXPRESSION; MAMMARY GLAND; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; TISSUE DISTRIBUTION; WEIGHT GAIN;

ADIPOSE TISSUE; ANIMALS; AROMATASE; BREAST NEOPLASMS; CCAAT-ENHANCER-BINDING PROTEIN-BETA; DIET, HIGH-FAT; DISEASE MODELS, ANIMAL; ESTROGENS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GONADS; HUMANS; MAMMARY GLANDS, ANIMAL; MAMMARY GLANDS, HUMAN; MICE; PROMOTER REGIONS, GENETIC; RISK FACTORS; RNA, MESSENGER; TUMOR NECROSIS FACTOR-ALPHA; WEIGHT GAIN;

EID: 84862832275     PISSN: 03037207     EISSN: 18728057     Source Type: Journal    
DOI: 10.1016/j.mce.2012.01.027     Document Type: Article

References (22)

1. Anderson G.L., Limacher M., Assaf A.R., Bassford T., Beresford S.A., Black H., Bonds D., Brunner R., Brzyski R., Caan B., Chlebowski R., Curb D., Gass M., Hays J., Heiss G., Hendrix S., Howard B.V., Hsia J., Hubbell A., Jackson R., Johnson K.C., Judd H., Kotchen J.M., Kuller L., LaCroix A.Z., Lane D., Langer R.D., Lasser N., Lewis C.E., Manson J., Margolis K., Ockene J., O'Sullivan M.J., Phillips L., Prentice R.L., Ritenbaugh C., Robbins J., Rossouw J.E., Sarto G., Stefanick M.L., Van Horn L., Wactawski-Wende J., Wallace R., Wassertheil-Smoller S. Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: the Women's Health Initiative randomized controlled trial. Jama 2004, 291:1701-1712.
2. Baum M., Budzar A.U., Cuzick J., Forbes J., Houghton J.H., Klijn J.G., Sahmoud T. Anastrozole alone or in combination with tamoxifen versus tamoxifen alone for adjuvant treatment of postmenopausal women with early breast cancer: first results of the ATAC randomised trial. Lancet 2002, 359:2131-2139.
3. Bulun S.E., Price T.M., Aitken J., Mahendroo M.S., Simpson E.R. A link between breast cancer and local estrogen biosynthesis suggested by quantification of breast adipose tissue aromatase cytochrome P450 transcripts using competitive polymerase chain reaction after reverse transcription. J. Clin. Endocrinol. Metab. 1993, 77:1622-1628.
4. Bulun S.E., Lin Z., Imir G., Amin S., Demura M., Yilmaz B., Martin R., Utsunomiya H., Thung S., Gurates B., Tamura M., Langoi D., Deb S. Regulation of aromatase expression in estrogen-responsive breast and uterine disease: from bench to treatment. Pharmacol. Rev. 2005, 57:359-383.
5. Chen D., Reierstad S., Lu M., Lin Z., Ishikawa H., Bulun S.E. Regulation of breast cancer-associated aromatase promoters. Cancer Lett. 2009, 273:15-27.
6. Chen D., Reierstad S., Fang F., Bulun S.E. JunD and JunB integrate prostaglandin E2 activation of breast cancer-associated proximal aromatase promoters. Mol. Endocrinol. 2011, 25:767-775.
7. Flegal K.M., Carroll M.D., Ogden C.L., Curtin L.R. Prevalence and trends in obesity among US adults, 1999-2008. Jama 2010, 303:235-241.
8. Ghosh S., Choudary A., Musi N., Hu Y., Li R. IKKbeta mediates cell shape-induced aromatase expression and estrogen biosynthesis in adipose stromal cells. Mol. Endocrinol. 2009, 23:662-670.
9. Hotamisligil G.S., Shargill N.S., Spiegelman B.M. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science 1993, 259:87-91.
10. Hotamisligil G.S., Arner P., Caro J.F., Atkinson R.L., Spiegelman B.M. Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance. J. Clin. Invest. 1995, 95:2409-2415.
11. Huang Z., Hankinson S.E., Colditz G.A., Stampfer M.J., Hunter D.J., Manson J.E., Hennekens C.H., Rosner B., Speizer F.E., Willett W.C. Dual effects of weight and weight gain on breast cancer risk. Jama 1997, 278:1407-1411.
12. Key T.J., Appleby P.N., Reeves G.K., Roddam A., Dorgan J.F., Longcope C., Stanczyk F.Z., Stephenson H.E., Falk R.T., Miller R., Schatzkin A., Allen D.S., Fentiman I.S., Wang D.Y., Dowsett M., Thomas H.V., Hankinson S.E., Toniolo P., Akhmedkhanov A., Koenig K., Shore R.E., Zeleniuch-Jacquotte A., Berrino F., Muti P., Micheli A., Krogh V., Sieri S., Pala V., Venturelli E., Secreto G., Barrett-Connor E., Laughlin G.A., Kabuto M., Akiba S., Stevens R.G., Neriishi K., Land C.E., Cauley J.A., Kuller L.H., Cummings S.R., Helzlsouer K.J., Alberg A.J., Bush T.L., Comstock G.W., Gordon G.B., Miller S.R. Body mass index, serum sex hormones, and breast cancer risk in postmenopausal women. J. Natl. Cancer Inst. 2003, 95:1218-1226.
13. O'Neill J.S., Elton R.A., Miller W.R. Aromatase activity in adipose tissue from breast quadrants: a link with tumour site. Br. Med. J. (Clin Res Ed). 1988, 296:741-743.
14. Sestak I., Distler W., Forbes J.F., Dowsett M., Howell A., Cuzick J. Effect of body mass index on recurrences in tamoxifen and anastrozole treated women: an exploratory analysis from the ATAC trial. J. Clin. Oncol. 2010, 28:3411-3415.
15. Simpson E.R., Misso M., Hewitt K.N., Hill R.A., Boon W.C., Jones M.E., Kovacic A., Zhou J., Clyne C.D. Estrogen - the good, the bad, and the unexpected. Endocr. Rev. 2005, 26:322-330.
16. Subbaramaiah K., Howe L.R., Bhardwaj P., Du B., Gravaghi C., Yantiss R.K., Zhou X.K., Blaho V.A., Hla T., Yang P., Kopelovich L., Hudis C.A., Dannenberg A.J. Obesity is associated with inflammation and elevated aromatase expression in the mouse mammary gland. Cancer Prev. Res. (Phila). 2011, 4:329-346.
17. Trentham-Dietz A., Newcomb P.A., Storer B.E., Longnecker M.P., Baron J., Greenberg E.R., Willett W.C. Body size and risk of breast cancer. Am. J. Epidemiol. 1997, 145:1011-1019.
18. Wenten M., Gilliland F.D., Baumgartner K., Samet J.M. Associations of weight, weight change, and body mass with breast cancer risk in Hispanic and non-Hispanic white women. Ann. Epidemiol. 2002, 12:435-444.
19. Yoo K., Tajima K., Park S., Kang D., Kim S., Hirose K., Takeuchi T., Miura S. Postmenopausal obesity as a breast cancer risk factor according to estrogen and progesterone receptor status (Japan). Cancer Lett. 2001, 167:57-63.
20. Zhao H., Innes J., Brooks D.C., Reierstad S., Yilmaz M.B., Lin Z., Bulun S.E. A novel promoter controls Cyp19a1 gene expression in mouse adipose tissue. Reprod. Biol. Endocrinol. 2009, 7:37.
21. Zhao Y., Nichols J.E., Valdez R., Mendelson C.R., Simpson E.R. Tumor necrosis factor-alpha stimulates aromatase gene expression in human adipose stromal cells through use of an activating protein-1 binding site upstream of promoter 1.4. Mol. Endocrinol. 1996, 10:1350-1357.
22. Zhou J., Gurates B., Yang S., Sebastian S., Bulun S.E. Malignant breast epithelial cells stimulate aromatase expression via promoter II in human adipose fibroblasts: an epithelial-stromal interaction in breast tumors mediated by CCAAT/enhancer binding protein beta. Cancer Res. 2001, 61:2328-2334.