Alternative 5′-untranslated first exons of the mouse Cyp19A1 (aromatase) gene

Journal of Steroid Biochemistry and Molecular Biology

Volumn 115, Issue 3-5, 2009, Pages 115-125

  Chow, Jenny D Y ^a,b   Simpson, Evan R ^a,b   Boon, Wah Chin ^a,b,c  

^a HUDSON INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b MONASH UNIVERSITY   (Australia)

^c UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

5 RACE; 5 UTR; Adipose; Aromatase; Cyp19A1; Exon I.4; Mouse; Tissue specific alternative first exon

Indexed keywords

AROMATASE; ISOENZYME;

5' UNTRANSLATED REGION; ANIMAL EXPERIMENT; AORTA; ARTICLE; BONE; CONTROLLED STUDY; CYP19A1 GENE; EXON; FAT BODY; FEMALE; GENE; GENE EXPRESSION; GENE STRUCTURE; GENOMICS; GONAD; HYPOTHALAMUS; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OVARY; PLACENTA; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TESTIS; ALTERNATIVE RNA SPLICING; ANIMAL; BRAIN; C57BL MOUSE; DNA SEQUENCE; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; HUMAN; METABOLISM; MOLECULAR GENETICS; PREGNANCY; PROMOTER REGION; TISSUE DISTRIBUTION;

MURINAE;

5' UNTRANSLATED REGIONS; ALTERNATIVE SPLICING; ANIMALS; AROMATASE; BASE SEQUENCE; BRAIN; EXONS; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; ISOENZYMES; MALE; MICE; MICE, INBRED C57BL; MOLECULAR SEQUENCE DATA; OVARY; PLACENTA; PREGNANCY; PROMOTER REGIONS, GENETIC; SEQUENCE ANALYSIS, DNA; TESTIS; TISSUE DISTRIBUTION;

EID: 67349274102     PISSN: 09600760     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2009.03.010     Document Type: Article

References (60)

1. Simpson E.R. Sources of estrogen and their importance. J. Steroid Biochem. Mol. Biol. 86 3-5 (2003) 225-230
2. McNatty K.P., Baird D.T., Bolton A., Chambers P., Corker C.S., and McLean H. Concentration of oestrogens and androgens in human ovarian venous plasma and follicular fluid throughout the menstrual cycle. J. Endocrinol. 71 1 (1976) 77-85
3. Brodie A., and Inkster S. Aromatase in the human testis. J. Steroid Biochem. Mol. Biol. 44 4-6 (1993) 549-555
4. Carpino A., Romeo F., and Rago V. Aromatase immunolocalization in human ductuli efferentes and proximal ductus epididymis. J. Anat. 204 Pt 3 (2004) 217-220
5. Lambard S., Galeraud-Denis I., Saunders P.T., and Carreau S. Human immature germ cells and ejaculated spermatozoa contain aromatase and oestrogen receptors. J. Mol. Endocrinol. 32 1 (2004) 279-289
6. Kilgore M.W., Means G.D., Mendelson C.R., and Simpson E.R. Alternative promotion of aromatase P-450 expression in the human placenta. Mol. Cell. Endocrinol. 83 1 (1992) R9-16
7. Price T., Aitken J., and Simpson E.R. Relative expression of aromatase cytochrome P450 in human fetal tissues as determined by competitive polymerase chain reaction amplification. J. Clin. Endocrinol. Metab. 74 4 (1992) 879-883
8. Toda K., Simpson E.R., Mendelson C.R., Shizuta Y., and Kilgore M.W. Expression of the gene encoding aromatase cytochrome P450 (CYP19) in fetal tissues. Mol. Endocrinol. 8 2 (1994) 210-217
9. Mahendroo M.S., Mendelson C.R., and Simpson E.R. Tissue-specific and hormonally controlled alternative promoters regulate aromatase cytochrome P450 gene expression in human adipose tissue. J. Biol. Chem. 268 26 (1993) 19463-19470
10. Harada N. A unique aromatase (P-450AROM) mRNA formed by alternative use of tissue-specific exons 1 in human skin fibroblasts. Biochem. Biophys. Res. Commun. 189 2 (1992) 1001-1007
11. Nawata H., Tanaka S., Takayanagi R., Sakai Y., Yanase T., Ikuyama S., and Haji M. Aromatase in bone cell: association with osteoporosis in postmenopausal women. J. Steroid Biochem. Mol. Biol. 53 1-6 (1995) 165-174
12. Larionov A.A., Vasyliev D.A., Mason J.I., Howie A.F., Berstein L.M., and Miller W.R. Aromatase in skeletal muscle. J. Steroid Biochem. Mol. Biol. 84 4 (2003) 485-492
13. Sasano H., Murakami H., Shizawa S., Satomi S., Nagura H., and Harada N. Aromatase and sex steroid receptors in human vena cava. Endocr. J. 46 2 (1999) 233-242
14. Honda S., Harada N., and Takagi Y. Novel exon 1 of the aromatase gene specific for aromatase transcripts in human brain. Biochem. Biophys. Res. Commun. 198 3 (1994) 1153-1160
15. Steckelbroeck S., Heidrich D.D., Stoffel-Wagner B., Hans V.H., Schramm J., Bidlingmaier F., and Klingmuller D. Characterization of aromatase cytochrome P450 activity in the human temporal lobe. J. Clin. Endocrinol. Metab. 84 8 (1999) 2795-2801
16. Bulun S.E., Sebastian S., Takayama K., Suzuki T., Sasano H., and Shozu M. The human CYP19 (aromatase P450) gene: update on physiologic roles and genomic organization of promoters. J. Steroid Biochem. Mol. Biol. 86 3-5 (2003) 219-224
17. Demura M., Reierstad S., Innes J.E., and Bulun S.E. Novel promoter I. 8 and promoter usage in the CYP19 (aromatase) gene. Reprod. Sci. 15 10 (2008) 1044-1053
18. Hinshelwood M.M., Liu Z., Conley A.J., and Simpson E.R. Demonstration of tissue-specific promoters in nonprimate species that express aromatase P450 in placentae. Biol. Reprod. 53 5 (1995) 1151-1159
19. Conley A.J., Corbin C.J., Browne P., Mapes S.M., Place N.J., Hughes A.L., and Glickman S.E. Placental expression and molecular characterization of aromatase cytochrome P450 in the spotted hyena (Crocuta crocuta). Placenta 28 7 (2007) 668-675
20. Vanselow J., Furbass R., Zsolnai A., Kalbe C., Said H.M., and Schwerin M. Expression of the aromatase cytochrome P450 encoding gene in cattle and sheep. J. Steroid Biochem. Mol. Biol. 79 1-5 (2001) 279-288
21. Bouraima H., Hanoux V., Mittre H., Feral C., Benhaim A., and Leymarie P. Expression of the rabbit cytochrome P450 aromatase encoding gene uses alternative tissue-specific promoters. Eur. J. Biochem. 268 16 (2001) 4506-4512
22. Ijiri S., Berard C., and Trant J.M. Characterization of gonadal and extra-gonadal forms of the cDNA encoding the Atlantic stingray (Dasyatis sabina) cytochrome P450 aromatase (CYP19). Mol. Cell. Endocrinol. 164 1-2 (2000) 169-181
23. Furbass R., Kalbe C., and Vanselow J. Tissue-specific expression of the bovine aromatase-encoding gene uses multiple transcriptional start sites and alternative first exons. Endocrinology 138 7 (1997) 2813-2819
24. Carreau S., Bourguiba S., Lambard S., Silandre D., and Delalande C. The promoter(s) of the aromatase gene in male testicular cells. Reprod. Biol. 4 1 (2004) 23-34
25. Callard G.V., and Tchoudakova A. Evolutionary and functional significance of two CYP19 genes differentially expressed in brain and ovary of goldfish. J. Steroid Biochem. Mol. Biol. 61 3-6 (1997) 387-392
26. Tong S.-K., and Chung B.-c. Analysis of zebrafish Cyp19 promoters. J. Steroid Biochem. Mol. Biol. 86 3-5 (2003) 381-386
27. Choi I., Simmen R.C., and Simmen F.A. Molecular cloning of cytochrome P450 aromatase complementary deoxyribonucleic acid from periimplantation porcine and equine blastocysts identifies multiple novel 5′-untranslated exons expressed in embryos, endometrium, and placenta. Endocrinology 137 4 (1996) 1457-1467
28. Corbin C.J., Hughes A.L., Heffelfinger J.R., Berger T., Waltzek T.B., Roser J.F., Santos T.C., Miglino M.A., Oliveira M.F., Braga F.C., Meirelles F.V., and Conley A.J. Evolution of suiform aromatases: ancestral duplication with conservation of tissue-specific expression in the collared peccary (Pecari tayassu). J. Mol. Evol. 65 4 (2007) 403-412
29. Seralini G.-E., Tomilin A., Auvray P., Nativelle-Serpentini C., Sourdaine P., and Moslemi S. Molecular characterization and expression of equine testicular cytochrome P450 aromatase*1. Biochim. et Biophysica Acta (BBA)-Gene Struct. Expr. 1625 3 (2003) 229-238
30. Simpson E.R., Mahendroo M.S., Means G.D., Kilgore M.W., Corbin C.J., and Mendelson C.R. Tissue-specific promoters regulate aromatase cytochrome P450 expression. Clin. Chem. 39 2 (1993) 317-324
31. Honda S., Harada N., and Takagi Y. The alternative exons 1 of the mouse aromatase cytochrome P-450 gene. Biochim. et Biophysica Acta 1305 3 (1996) 145-150
32. Golovine K., Schwerin M., and Vanselow J. Three different promoters control expression of the aromatase cytochrome p450 gene (cyp19) in mouse gonads and brain. Biol. Reprod. 68 3 (2003) 978-984
33. Harada N., and Yamada K. Ontogeny of aromatase messenger ribonucleic acid in mouse brain: fluorometrical quantitation by polymerase chain reaction. Endocrinology 131 5 (1992) 2306-2312
34. Moreau F., Mittre H., Benhaim A., Bois C., Bertherat J., Carreau S., and Reznik Y. Aromatase expression in the normal human adult adrenal and in adrenocortical tumors: biochemical, immunohistochemical, and molecular studies. Eur. J. Endocrinol. 160 1 (2009) 93-99
35. Pezzi V., Mathis J.M., Rainey W.E., and Carr B.R. Profiling transcript levels for steroidogenic enzymes in fetal tissues. J. Steroid Biochem. Mol. Biol. 87 2-3 (2003) 181-189
36. Nitta H., Bunick D., Hess R.A., Janulis L., Newton S.C., Millette C.F., Osawa Y., Shizuta Y., Toda K., and Bahr J.M. Germ cells of the mouse testis express P450 aromatase. Endocrinology 132 3 (1993) 1396-1401
37. Kotula-Balak M., Wojciechowska J., and Bilinska B. The site of aromatization in the mouse cryptorchid testis. Folia Biol. 49 3-4 (2001) 279-283
38. Ling S., Dai A., Dilley R.J., Jones M., Simpson E., Komesaroff P.A., and Sudhir K. Endogenous estrogen deficiency reduces proliferation and enhances apoptosis-related death in vascular smooth muscle cells: insights from the aromatase-knockout mouse. Circulation 109 4 (2004) 537-543
39. Nathan L., Shi W., Dinh H., Mukherjee T.K., Wang X., Lusis A.J., and Chaudhuri G. Testosterone inhibits early atherogenesis by conversion to estradiol: critical role of aromatase. Proc. Natl. Acad. Sci. U.S.A. 98 6 (2001) 3589-3593
40. Sengupta J., Roy S.K., and Manchanda S.K. Effect of an oestrogen synthesis inhibitor, 1,4,6,-androstatriene-3,17-dione, on mouse embryo development in vitro. J. Reprod. Fertil. 66 1 (1982) 63-66
41. Stromstedt M., Keeney D.S., Waterman M.R., Paria B.C., Conley A.J., and Dey S.K. Preimplantation mouse blastocysts fail to express CYP genes required for estrogen biosynthesis. Mol. Reprod. Dev. 43 4 (1996) 428-436
42. Kamat A., Graves K.H., Smith M.E., Richardson J.A., and Mendelson C.R. A 500-bp region, approximately 40 kb upstream of the human CYP19 (aromatase) gene, mediates placenta-specific expression in transgenic mice. Proc. Natl. Acad. Sci. U.S.A. 96 8 (1999) 4575-4580
43. Hinshelwood M.M., and Mendelson C.R. Tissue-specific expression of the human CYP19 (aromatase) gene in ovary and adipose tissue of transgenic mice*1. J. Steroid Biochem. Mol. Biol. 79 1-5 (2001) 193-201
44. Hinshelwood M.M., Smith M.E., Murry B.A., and Mendelson C.R. A 278 bp region just upstream of the human CYP19 (aromatase) gene mediates ovary-specific expression in transgenic mice. Endocrinology 141 6 (2000) 2050-2053
45. Shozu M., Zhao Y., Bulun S.E., and Simpson E.R. Multiple splicing events involved in regulation of human aromatase expression by a novel promoter, I.6. Endocrinology 139 4 (1998) 1610-1617
46. Lew D.J., Decker T., Strehlow I., and Darnell J.E. Overlapping elements in the guanylate-binding protein gene promoter mediate transcriptional induction by alpha and gamma interferons. Mol. Cell. Biol. 11 1 (1991) 182-191
47. Ma T., Copland J.A., Brasier A.R., and Thompson E.A. A novel glucocorticoid receptor binding element within the murine c-myc promoter. Mol. Endocrinol. 14 9 (2000) 1377-1386
48. Ghosh D. Status of the transcription factors database (TFD). Nucleic. Acids. Res. 21 13 (1993) 3117-3118
49. Zhao Y., Mendelson C.R., and Simpson E.R. Characterization of the sequences of the human CYP19 (aromatase) gene that mediate regulation by glucocorticoids in adipose stromal cells and fetal hepatocytes. Mol. Endocrinol. 9 3 (1995) 340-349
50. Silandre D., Delalande C., Durand P., and Carreau S. Three promoters PII, PI.f, and PI.tr direct the expression of aromatase (cyp19) gene in male rat germ cells. J. Mol. Endocrinol. 39 2 (2007) 169-181
51. Fisher C.R., Graves K.H., Parlow A.F., and Simpson E.R. Characterization of mice deficient in aromatase (ArKO) because of targeted disruption of the cyp19 gene. Proc. Natl. Acad. Sci. U.S.A. 95 12 (1998) 6965-6970
52. Murata Y., Robertson K.M., Jones M.E., and Simpson E.R. Effect of estrogen deficiency in the male: the ArKO mouse model. Mol. Cell. Endocrinol. 193 1-2 (2002) 7-12
53. Peaker M., and Taylor E. Oestrogen production by the goat mammary gland: transient aromatase activity during late pregnancy. J. Endocrinol. 125 1 (1990) R1-3
54. Lu A., and West S. Multiplicity of mammalian microsomal cytochromes P-45. Pharmacol. Rev. 31 4 (1979) 277-295
55. Sebastian S., Takayama K., Shozu M., and Bulun S.E. Cloning and characterization of a novel endothelial promoter of the human CYP19 (aromatase P450) gene that is up-regulated in breast cancer tissue. Mol. Endocrinol. 16 10 (2002) 2243-2254
56. Bakker J., Honda S., Harada N., and Balthazart J. The aromatase knock-out mouse provides new evidence that estradiol is required during development in the female for the expression of sociosexual behaviors in adulthood. J. Neurosci. 22 20 (2002) 9104-9112
57. Bakker J., Honda S., Harada N., and Balthazart J. Sexual partner preference requires a functional aromatase (CyP19) gene in male mice. Horm. Behav. 42 2 (2002) 158-171
58. Agarwal V.R., Bulun S.E., and Simpson E.R. Quantitative detection of alternatively spliced transcripts of the aromatase cytochrome P450 (CYP19) gene in aromatase-expressing human cells by competitive RT-PCR. Mol. Cell. Probes 9 6 (1995) 453-464
59. Gurates B., Amsterdam A., Tamura M., Yang S., Zhou J., Fang Z., Amin S., Sebastian S., and Bulun S.E. WT1 and DAX-1 regulate SF-1-mediated human P450arom gene expression in gonadal cells. Mol. Cell. Endocrinol. 208 1-2 (2003) 61-75
60. Meeks J.J., Russell T.A., Jeffs B., Huhtaniemi I., Weiss J., and Jameson J.L. Leydig cell-specific expression of DAX1 improves fertility of the Dax1-deficient mouse. Biol. Reprod. 69 1 (2003) 154-160