Effect of single and compound knockouts of estrogen receptors α (ERα) and β (ERβ) on mouse reproductive phenotypes

Development

Volumn 127, Issue 19, 2000, Pages 4277-4291

  Dupont, S ^a   Krust, A ^a   Gansmuller, A ^a   Dierich, A ^a   Chambon, P ^a   Mark, M ^a  

^a UNIVERSITÉ DE STRASBOURG   (France)

Author keywords

Anti Mullerian hormone; Estrogen receptors; Functional redundancy; Knockout mice; Mast cells; Ovary; Prostate; Sertoli cells; Uterus

Indexed keywords

ESTROGEN; ESTROGEN RECEPTOR; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; RECEPTOR SUBUNIT;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL TRANSFORMATION; CONTROLLED STUDY; FEMALE; FEMALE FERTILITY; GRANULOSA CELL; GROWTH REGULATION; HORMONAL REGULATION; KNOCKOUT GENE; LEYDIG CELL; MALE; MAST CELL; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OVARY CYST; OVARY FOLLICLE DEVELOPMENT; OVULATION; PHENOTYPE; PREPUBERTY; PRIORITY JOURNAL; SERTOLI CELL; SUBFERTILITY; SUPEROVULATION;

ANIMALS; CYSTS; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; FEMALE; FERTILITY; GENITALIA, FEMALE; GENITALIA, MALE; GLYCOPROTEINS; GONADOTROPINS; GROWTH INHIBITORS; INFERTILITY, FEMALE; INTERCELLULAR JUNCTIONS; MALE; MAST CELLS; MICE; MICE, KNOCKOUT; OVARIAN FOLLICLE; OVARY; OVULATION; PHENOTYPE; RECEPTORS, ESTROGEN; SERTOLI CELLS; SEXUAL MATURATION; TESTICULAR HORMONES;

ANIMALIA;

EID: 0033767836     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (73)

1. Cloning and expression of the mouse pgk-1 gene and the nucleotide sequence of its promoter
2. Expression of clusterin in cell differentiation and cell death
3. Hormonal and cellular regulation of Sertoli cell anti-Mullerian hormone production in the postnatal mouse
4. Apolipoprotein J expression at fluid-tissue interfaces: Potential role in barrier cytoprotection
5. Purification of mouse immunoglobulin heavy-chain messenger RNAs from total myeloma tumor RNA
6. Anti-mullerian hormone and anti-mullerian hormone type II receptor messenger ribonucleic acid expression in rat ovaries during postnatal development, the estrous cycle, and gonadotropin-induced follicle growth
7. Abnormal sexual development in transgenic mice chronically expressing mullerian inhibiting substance
8. Role of the two activating domains of the oestrogen receptor in the cell-type and promoter-context dependent agonistic activity of the anti-oestrogen 4-hydroxytamoxifen
9. Estrogen receptor expression in prostate cancer and premalignant prostatic lesions
10. Sertoli-Sertoli cell junctions and the seminiferous epithelium barrier
11. Estrogen receptor-β mRNA expression in rat ovary: Down-regulation by gonadotropins
12. Analysis of transcription and estrogen insensitivity in the female mouse after targeted disruption of the estrogen receptor gene
13. Tissue distribution and quantitative analysis of estrogen receptor-α (ERα) and estrogen receptor-β (ERβ) messenger ribonucleic acid in the wild-type and ERα-knockout mouse
14. Estrogen receptor null mice: What have we learned and where will they lead us?
15. Prevention of the polycystic ovarian phenotype and characterization of ovulatory capacity in the estrogen receptor-α knockout mouse
16. Postnatal sex reversal of the ovaries in mice lacking estrogen receptors α and β
17. Gene targeting in embryonic stem cells
18. Impairing follicle-stimulating hormone (FSH) signaling in vivo: Targeted disruption of the FSH receptor leads to aberrant gametogenesis and hormonal imbalance
19. In vivo functional analysis of the Hoxa-1 3' retinoic acid response element (3'RARE)
20. Targeted disruption of the estrogen receptor gene in male mice causes alteration of spermatogenesis and infertility
21. Characterization of mice deficient in aromatase (ArKO) because of targeted disruption of the cyp19 gene
22. Cellular retinol-binding protein I is essential for vitamin A homeostasis
23. Human oestrogen receptor cDNA: Sequence, expression and homology to v-erb-A
24. Transcription factors 3: Nuclear receptors
25. Management of benign prostatic hyperplasia with particular emphasis on aromatase inhibitors
26. Structure of the mammalian ovary
27. A role for oestrogens in the male reproductive system
28. Mullerian inhibiting substance messenger ribonucleic acid expression in granulosa and Sertoli cells coincides with their mitotic activity
29. Histamine concentrations in normal and cystic rat ovaries
30. Number and state of rat ovarian mast cells after exogenous administration of luteinizing hormone
31. Activation of the estrogen receptor through phosphorylation by mitogen-activated protein kinase
32. Generation and reproductive phenotypes of mice lacking estrogen receptor β
33. Histamine, mast cells and ovarian function
34. The chicken oestrogen receptor sequence: Homology with v-erbA and the human oestrogen and glucocorticoid receptors
35. The behavior of heterochromatin in mouse and human nuclei
36. Cloning of a novel receptor expressed in rat prostate and ovary
37. Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors α and β
38. Antide and related antagonists of luteinizing hormone release with long action and oral activity
39. Estrogen receptor-β mRNA variants in human and murine tissues
40. Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene
41. Disruption of the Hox-1.6 homeobox gene results in defects in a region corresponding to its rostral domain of expression
42. Conditional site-specific recombination in mammalian cells using a ligand-dependent chimeric Cre recombinase
43. Tubular adenoma, ovary, mouse
44. ERβ: Identification and characterization of a novel human estrogen receptor
45. Some comparative aspects of the mammalian ovary
46. Expression of the mouse anti-mullerian hormone gene suggests a role in both male and female sexual differentiation
47. Estrogen receptors how do they control reproductive and nonreproductive functions?
48. Differential ligand activation of estrogen receptors ERα and ERβ at AP1 sites
49. The blood-testis barrier and Sertoli cell junctions: Structural considerations
50. Targeted overexpression of luteinizing hormone in transgenic mice leads to infertility, polycystic ovaries, and ovarian tumors
51. Elevated luteinizing hormone in prepubertal transgenic mice causes hyperandrogenemia, precocious puberty, and substantial ovarian pathology
52. Hormone-induced proliferation and differentiation of granulosa cells: A coordinated balance of the cell cycle regulators cyclin D2 and p27(Kip1)
53. Hormonal control of the cell cycle in ovarian cells: Proliferation versus differentiation
54. Detection of retinoid X receptors using specific monoclonal and polyclonal antibodies
55. Transcription and translation of estrogen receptor-β in the male reproductive tract of estrogen receptor-α knock-out and wild-type mice
56. Gonadotropin induction of ovulation and corpus luteum formation in young estrogen receptor-α knockout mice
57. Differential expression of estrogen receptor-β and estrogen receptor-α in the rat ovary
58. Ligand-, cell-, and estrogen receptor subtype (α/β)-dependent activation at GC-rich (Sp1) promoter elements
59. Targeted disruption of the estrogen receptor-α gene in female mice: Characterization of ovarian responses and phenotype in the adult
60. Cyclin D2 is an FSH-responsive gene involved in gonadal cell proliferation and oncogenesis
61. Mammalian sex determination: A molecular drama
62. Testicular cell differentiation in fetal mouse ovaries following transplantation into adult male mice
63. Expression of oestrogen receptor isoforms in relation to enzymes of oestrogen synthesis in rat ovary
64. Cloning, chromosomal localization, and functional analysis of the murine estrogen receptor β
65. Cellular localization of mullerian inhibiting substance in the developing rat ovary
66. Female development in mammals is regulated by Wnt-4 signalling
67. Purified bovine AMH induces a characteristic freemartin effect in fetal rat prospective ovaries exposed to it in vitro
68. A comparative study of estrogen receptors α and β in the rat uterus
69. Effects of cytochalasin D on the integrity of the Sertoli cell (blood- testis) barrier
70. Structural organization and expression of the mouse estrogen receptor