Endometrial intracrinology - Generation of an estrogen-dominated microenvironment in the secretory phase of women

Journal of Clinical Endocrinology and Metabolism

Volumn 98, Issue 11, 2013, Pages

  Gibson, D A ^a   McInnes, K J ^a   Critchley, H O D ^a   Saunders, Philippa T K ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

3(OR 17)BETA HYDROXYSTEROID DEHYDROGENASE; AROMATASE; AROMATASE INHIBITOR; ESTRADIOL; ESTROGEN; ESTRONE; MESSENGER RNA;

ARTICLE; CELL CULTURE; CONTROLLED STUDY; CYP19A1 GENE; DECIDUALIZATION; ENDOMETRIUM CELL; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; ESTROGEN RELEASE; ESTROGEN SYNTHESIS; FEMALE; GENE; GENE EXPRESSION; GENE FUNCTION; GENE IDENTIFICATION; HSD3B1 GENE; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; MENSTRUAL CYCLE; MENSTRUAL SECRETORY PHASE; MICROENVIRONMENT; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; STROMA CELL;

AROMATASE; AROMATASE INHIBITORS; CELLULAR MICROENVIRONMENT; DECIDUA; ENDOMETRIUM; ESTRADIOL; ESTRONE; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; MENSTRUAL CYCLE; MULTIENZYME COMPLEXES; NITRILES; OVARY; PREGNANCY; PREGNANCY TRIMESTER, FIRST; PRIMARY CELL CULTURE; PROGESTERONE REDUCTASE; RNA, MESSENGER; STEROID ISOMERASES; STROMAL CELLS; TRIAZOLES;

EID: 84887486404     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2013-2140     Document Type: Article

References (20)

1. Gibson DA, Saunders PT. Estrogen dependent signaling in reproductive tissues - A role for estrogen receptors and estrogen related receptors. Mol Cell Endocrinol. 2012;348: 361-372.
2. Rothman MS, Carlson NE, Xu M, et al. Reexamination of testosterone, dihydrotestosterone, estradiol and estrone levels across the menstrual cycle and in postmenopausal women measured by liquid chromatography-tandem mass spectrometry. Steroids. 2011;76: 177-182.
3. Simpson ER, Mahendroo MS, Means GD, et al. Aromatase cytochrome P450, the enzyme responsible for estrogen biosynthesis. Endocr Rev. 1994;15: 342-355.
4. Kitawaki J, Noguchi T, Amatsu T, et al. Expression of aromatase cytochrome P450 protein and messenger ribonucleic acid in human endometriotic and adenomyotic tissues but not in normal endometrium. Biol Reprod. 1997;57: 514-519.
5. Huhtinen K, Desai R, Sthåle M, et al. Endometrial and endometriotic concentrations of estrone and estradiol are determined by local metabolism rather than circulating levels. J Clin Endocrinol Metab. 2012;97: 4228-4235.
6. Tseng L, Mazella J, Sun B. Modulation of aromatase activity in human endometrial stromal cells by steroids, tamoxifen and RU 486. Endocrinology. 1986;118: 1312-1318.
7. Aghajanova L, Hamilton A, Kwintkiewicz J, Vo KC, Giudice LC. Steroidogenic enzyme and key decidualization marker dysregulation in endometrial stromal cells from women with versus without endometriosis. Biol Reprod. 2009;80: 105-114.
8. Abraham GE. Ovarian and adrenal contribution to peripheral androgens during the menstrual cycle. J Clin Endocrinol Metab. 1974; 39: 340-346.
9. Das A, Mantena SR, Kannan A, Evans DB, Bagchi MK, Bagchi IC. De novo synthesis of estrogen in pregnant uterus is critical for stromal decidualization and angiogenesis. Proc Natl Acad Sci USA. 2009;106: 12542-12547.
10. Bombail V, Gibson DA, Collins F, MacPherson S, Critchley HO, Saunders PT. A Role for the orphan nuclear receptor estrogen-related receptor α in endometrial stromal cell decidualization and expression of genes implicated in energy metabolism. J Clin Endocrinol Metab. 2010;95:E224-E228.
11. Collins F, MacPherson S, Brown P, et al. Expression of oestrogen receptors, ERα, ERβ, and ERβ variants, in endometrial cancers and evidence that prostaglandin F may play a role in regulating expression of ERα. BMC Cancer. 2009;9:330.
12. Barbier CS, Becker KA, Troester MA, Kaufman DG. Expression of exogenous human telomerase in cultures of endometrial stromal cells does not alter their hormone responsiveness. Biol Reprod. 2005;73: 106-114.
13. Thompson EA Jr, Siiteri PK. Utilization of oxygen and reduced nicotinamide adenine dinucleotide phosphate by human placental microsomes during aromatization of androstenedione. J Biol Chem. 1974;249: 5364-5372.
14. Curtis Hewitt S, Goulding EH, Eddy EM, Korach KS. Studies using the estrogen receptor α knockout uterus demonstrate that implantation but not decidualization-associated signaling is estrogen dependent. Biol Reprod. 2002;67: 1268-1277.
15. Chen JR, Cheng JG, Shatzer T, Sewell L, Hernandez L, Stewart CL. Leukemia inhibitory factor can substitute for nidatory estrogen and is essential to inducing a receptive uterus for implantation but is not essential for subsequent embryogenesis. Endocrinology. 2000;141: 4365-4372.
16. Chaen T, Konno T, Egashira M, et al. Estrogen-dependent uterine secretion of osteopontin activates blastocyst adhesion competence. PLoS One. 2012;7:e48933.
17. Mueller MD, Vigne JL, Minchenko A, Lebovic DI, Leitman DC, Taylor RN. Regulation of vascular endothelial growth factor (VEGF) gene transcription by estrogen receptors α and β. Proc Natl Acad Sci USA. 2000;97: 10972-10977.
18. Laws MJ, Taylor RN, Sidell N, et al. Gap junction communication between uterine stromal cells plays a critical role in pregnancy-associated neovascularization and embryo survival. Development. 2008;135: 2659-2668.
19. Ma WG, Song H, Das SK, Paria BC, Dey SK. Estrogen is a critical determinant that specifies the duration of the window of uterine receptivity for implantation. Proc Natl Acad Sci USA. 2003;100: 2963-2968.
20. Pellicer A, Valbuena D, Cano F, Remohí J, Simón C. Lower implantation rates in high responders: evidence for an altered endocrine milieu during the preimplantation period. Fertil Steril. 1996;65: 1190-1195.