Overexpression of int-5/aromatase in mammary glands of transgenic mice results in the induction of hyperplasia and nuclear abnormalities

Cancer Research

Volumn 56, Issue 14, 1996, Pages 3180-3185

  Tekmal, Rajeshwar Rao ^a   Ramachandra, Nagalakshmi ^a   Gubba, Siddeswar ^b   Durgam, Vijayender R ^c   Mantione, Jessica ^a   Toda, Katsumi ^d   Shizuta, Yutaka ^d   Dillehay, Dirck L ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

^c Univ of Texas Health Science Center ^*  (United States)

^d KOCHI MEDICAL SCHOOL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AROMATASE; ESTROGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CANCER RISK; CARCINOGENESIS; ESTROGEN SYNTHESIS; FIBROADENOMA; GENE EXPRESSION; GENE LOCUS; HYPERPLASIA; MAMMARY GLAND; MOUSE; NONHUMAN; PRIORITY JOURNAL; TRANSGENIC MOUSE;

ANIMALS; AROMATASE; CELL NUCLEUS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; MAMMARY GLANDS, ANIMAL; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, TRANSGENIC; PRECANCEROUS CONDITIONS; RNA, NEOPLASM;

EID: 0029937278     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. Gray, D. A , McGrath, C M., Jones, R. F., and Morris, V. L. A common mouse mammary tumor virus integration site in chemically induced precancerous mammary hyperplasias Virology, 30: 360-368, 1986.
2. Morris, V L., Rao, T R., Kozak, C. A., Gray, D. A., Lee Chan, E C. M., Cornell, T J , Taylor, C. B., Jones, R. F., and McGrath, C M. Characterization of int-5, a locus associated with early events in mammary carcinogenesis. Oncogene Res , 6: 53-63, 1991
3. Durgam, V. R., and Tekmal, R. R The nature and expression of int-5, a novel MMTV integration locus gene in carcinogen-induced mammary tumors. Cancer Lett , 87: 179-186, 1994.
4. Tekmal, R R., and Durgam, V R. The overexpression of int-5/aromatase, a novel MMTV integration locus gene, is responsible for D2 mammary tumor cell proliferation Cancer Lett., 88: 147-155, 1995.
5. Clarke, R , Dickson, R. B., and Lippman, M. E. Hormonal aspects of breast cancer. Growth factors, drugs and stromal interactions Crit Rev. Oncol. Hematol., 12: 1-23, 1992.
6. van Landeghem, A. A. J , Poortman, J., Nabuurs, M , and Thijssen, J H. H. Endogenous concentration and subcellular distribution of estrogens in normal and malignant human breast tissue Cancer Res , 45: 2900-2906, 1985.
7. Fishman, J., Nisselbaum, J. S , Menedez-Botet, C. J., and Schwartz, M K Estrone and estradiol content in human breast tumors: relationship to estradiol receptors J. Steroid Biochem., 8 893-896, 1977.
8. Santen R. J , Leszczynski, D., Tilson-Mallet, N., Feil, P. D., Wright, C , Manni, A , and Santner, S. J. Enzymatic control of estrogen production in human breast cancer: relative significance of aromatase versus sulfatase pathways. In: A. Angel, H. L. Bradlow, and L. Doghotti (eds.), Endocrinology of the Breast: Basic and Clinical Aspects, pp. 126-137 New York: New York Academy of Science, 1986.
9. Brodie, A. M. H , and Santen, R. J. Aromatase and its inhibitors in breast cancer: overview and perspective. Breast Cancer Res Treat., 30: 1-6, 1994.
10. Evans, T. R. J., Rowlands, M. G., Silva, M. C., Law, M., and Coombes, R. C. Prognostic significance of aromatase and estrone sulfatase enzymes in human breast cancer. J. Steroid Biochem. Mol Biol , 44: 583-587, 1993
11. Reed, M J. The role of aromatase in breast tumors. Breast Cancer Res. Treat., 30: 7-17, 1994.
12. Bulun, S. E., and Simpson, E R. Regulation of aromatase expression in human tissues. Breast Cancer Res. Treat , 30: 19-29, 1994.
13. Harda, N., Utsumi, T., and Takagi, Y. Tissue-specific expression of the human aromatase P-450 gene by alternative use of multiple exons 1 and promoters, and switching of tissue-specific exons in carcinogenesis. Proc. Natl. Acad. Sci. USA, 90: 11312-11316, 1993.
14. Warner, M. R Effect of various doses of estrogen to BALB/c Crg1 neonatal female mice on mammary growth and branching at 5 weeks of age Cell Tissue Kinet., 9: 429-438, 1976
15. Jones, L. A., and Bern, H. A. Cervicovaginal and mammary gland abnormalities in BALB/c-Crg1 mice treated neonatally with progesterone and estrogen, alone or in combination. Cancer Res , 39: 2560-2567, 1979
16. Warner, M. R., Yu, L., and, Rosen J. M. Long term effects of perinatal injection of estrogen and progesterone on the morphological and biochemical development of the mammary gland. Endocrinology, 106 823-832, 1980.
17. Tomooka, Y., and Bern, H A Growth of mouse mammary glands after neonatal sex hormone treatment. J. Natl. Cancer Inst., 69: 1347-1352, 1982
18. Lee, F., Mulligan, R., and Ringold, G Glucocorticoids regulate expression of dihydrofolate reductase cDNA in mouse mammary tumor virus chimeric plasmids Nature (Lond), 294: 228-232, 1981.
19. Chomczynski, P., and Sacchi, N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem., 162: 156-159, 1987.
20. Medina, D. Mammary tumors. In: H. L. Foster, J. D Small, and J. G. Fox (eds.), The Mouse in Biomedical Research, Vol 4, pp. 373-396. New York: Academic Press, 1982.
21. Koos, R. D., Banks, P. K , Inkster, S. E , Yue, W , and Brodie, A. M H Detection of aromatase and keratinocyte growth factor expression in breast tumors using reverse transcription polymerase chain reaction. J. Steroid Biochem. Mol Biol., 45: 217-225, 1993.
22. Medina, D , DeOme, K. B., and Young, L. Tumor-producing capabilities of hyperplastic alveolar nodules in virgin and hormone-stimulated BALB/cfC3H and C3Hf mice. J. Natl. Cancer Inst., 44 164-174, 1970.
23. Yue, W., Zhou, D., Chen, S , and Brodie, A A new nude mouse model for postmenopausal breast cancer using with MCF-7 cells transfected with the human aromatase gene Cancer Res., 54: 5092-5095, 1994.
24. Yue, W , Wang, J , Savinov, A , and Brodie. A Effect of aromatase inhibitors on growth of mammary tumors in nude mouse model. Cancer Res., 55: 3073-3077, 1995.
25. Yue, W., Wang, J-P., Hamilton, C., Demers, L., and Santen, R.J. Estrogen produced in situ by breast tumors increases estradiol level and tumor growth rate more than blood borne estradiol Proc. IV Int Aromatase Conference, Abst B3, p 26, 1996.
26. Sattin, R. W , Rubin, G. L , Wingo, P A., Webster, L. A., and Ory, H. W. The Cancer and Steroid Hormone Study of the Centers for Disease Control and the National Institute of Child Health and Human Development N Engl. J Med , 315: 405-411, 1988.
27. Furth, J. Hormones as etiological agents in neoplasia. In: F. Becker (ed), Cancer, Vol 1, pp. 89-134 New York. Plenum Press, 1982.
28. Lupulescu, A. Hormones and Carcinogenesis, pp. 89-144 New York: Praeger Scientific, 1983.
29. Lippman, M E , and Dickson, R. B. Mechanisms of growth control in normal and malignant breast epithelium. Recent Prog Horm. Res , 45: 383-440, 1989
30. Henderson, B E., Ross, R , and Bernstein, L. Estrogens as a cause of human cancer Cancer Res , 48: 246-253, 1988.
31. Toniolo, P. G , Levitz, M., Zeleniuch-Jacquotte, A., Banerjee, S., Koenig, K L., Shore, R. E , Strax, P , and Pasternack, B S A prospective study of endogenous estrogens and breast cancer in postmenopausal women J Natl. Cancer Inst., 87: 190-197, 1995.
32. Leder, A., Pattengale, P. K , Kuo, A , Stewart, T A., and Leader, P Consequences of widespread deregulation of the c-myc gene in transgenic mice: multiple neoplasms and normal development. Cell, 45: 485-495, 1986.
33. Andres, A-C., Schonenberger, C-A , Groner, B , Hennighausen, L., LeMeur, M , and Gerlinger, P. Ha-ras oncogene expression directed by a milk protein gene promoter, tissue specificity, hormonal regulation, and tumor induction in transgenic mice. Proc Natl. Acad. Sci. USA, 84: 1299-1303, 1987.
34. Muller, W. M., Lee, F S., Dickson, C , Peters, G , Pattengale, P , and Leader, P. The int-2 gene product acts as an epithelial growth factor in transgenic mice. EMBO J., 9: 907-913, 1990.